'Roadmaps' of the brain reveal regions vulnerable to Alzheimer's disease
(Press-News.org) GRAND RAPIDS, Mich. (JUNE 10, 2021) -- Much like a supply truck crossing the countryside, the misfolded proteins that damage neurons in Alzheimer's disease travel the "roads" of the brain, sometimes stopping and sometimes re-routing to avoid roadblocks, reports a study published in END
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COVID-19 creates hearing, balance disorders, aggravates tinnitus symptoms
MELVILLE, N.Y., June 10, 2021 -- The physiological impacts of COVID-19 seem almost limitless. Complications can range from loss of taste to respiratory distress, with many effects lasting for months. Evidence suggests auditory and vestibular effects should be added to the growing list of symptoms. During the 180th Meeting of the Acoustical Society of America, which will be held virtually June 8-10, Colleen Le Prell, from the University of Texas at Dallas, will talk about hearing and balance disorders associated with coronavirus infection and how pandemic-related stress ...
First AI-based tool for predicting genomic subtypes of pancreatic cancer from histology slides
Paris, France and New York, NY June 10, 2021 - AP-HP Greater Paris University Hospitals, the leading European clinical trial center with the largest amount of healthcare data in France dedicated to research and Owkin, a startup pioneering Federated Learning and AI technologies for medical research and clinical development, announced the recent results of their ongoing strategic collaboration at ASCO 2021. The abstract and poster entitled "Identification of pancreatic adenocarcinoma molecular subtypes on histology slides using deep learning models" demonstrates the first ...
AMP recommends minimum set of pharmacogenetic alleles to guide clinical CYP2D6 genotype testing, pro
ROCKVILLE, Md. - June 10, 2021 - The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today published consensus recommendations to aid in the design and validation of clinical CYP2D6 assays, promote standardization of testing across different laboratories and improve patient care. The manuscript, "Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and European Society for Pharmacogenomics and Personalized Therapy," was released online ahead of publication in The Journal ...
New method to measure milk components has potential to improve dairy sustainability
Champaign, IL, June 10, 2021 - Present in blood, urine, and milk, the chemical compound urea is the primary form of nitrogen excretion in mammals. Testing for urea levels in dairy cows helps scientists and farmers understand how effectively nitrogen from feed is used in cows' bodies, with important economic implications for farmers in terms of feed costs, physiological effects for cows such as reproductive performance, and environmental impacts from excretion of nitrogen in dairy cow waste. Thus, accuracy in testing dairy cow urea levels is essential. Since the 1990s, mid-infrared testing of milk urea nitrogen (MUN) has been the most efficient and least invasive way to measure nitrogen use by dairy cows in large numbers. In a recent ...
Combating maritime litter
Plastic bottles drifting in the sea; bags in the stomachs of turtles; Covid-19 masks dancing in the surf: few images are as unpleasant to look at as those that show the contamination of our oceans. And few environmental issues are as urgent and as present in the public awareness. "Most people have an emotional connection to the sea. They think of ocean pollution as an attack on a place they long for," said Nikoleta Bellou, marine scientist at Hereon's Institute of Coastal System - Analysis and Modeling. Between 1990 and 2015 alone, an estimated 100 million metric tons of mostly plastic waste entered the oceans. For that instance the study fits to the UN Decade of Ocean Science for Sustainable Development, which started this year to emphasize a sustainable use of ...
BU researchers create novel curriculum assessment tool to improve medical education about sexual and gender minority (LGBTQI) populations
(Boston)--Medical education aspires to mitigate bias in future professionals by providing a robust curriculum that includes perspectives and practices for caring for sexual and gender minority (SGM) populations, including lesbian, gay, bisexual, transgender and intersex (LGBTQI) persons. To provide medical schools with a more systematic, uniform approach to teaching these topics in their curriculum, the Association of American Medical Colleges (AAMC) in 2014 published 30 SGM competencies and topics that curricula should address. However, implementation of these ideals remains challenging. Building off the AAMC's comprehensive ...
Researchers turned transparent calcite into artificial gold
Breakthrough in metamaterials: for the first time in the world, researchers at Tel Aviv University developed an innovative nanotechnology that transforms a transparent calcite nanoparticle into a sparkling gold-like particle. In other words, they turned the transparent particle into a particle that is visible despite its very small dimensions. According to the researchers the new material can serve as a platform for innovative cancer treatments. In a new paper published in Advanced Materials, an international team of scientists, coordinated by Dr. Roman Noskov and Dr. Pavel Ginzburg from the Iby and Aladar Fleischman Faculty of Engineering at Tel Aviv University, Prof. Dmitry Gorin from the Center ...
Binding of a second CO molecule observed
Through the biological fixation of the element nitrogen by the enzyme nitrogenase, organisms gain access to molecular nitrogen (N2) in the Earth's atmosphere, which is essential for building cellular structures. In addition, a vanadium-dependent variant of nitrogenase can reduce the toxic gas carbon monoxide (CO) to hydrocarbons. These reductions of N2 and CO are among the most important processes in industrial chemistry, as they are used to produce both fertilizers and synthetic fuels. However, researchers have not yet been able to decipher the different pathways of the two reactions. Dr. Michael Rohde from Prof. Dr. Oliver Einsle's team at the Institute of Biochemistry at the ...
More sustainable mortars and concrete with optimal thermal and mechanical efficiency
The consumption of raw materials has increased notably in industry in general, and in the construction industry in particular, amidst growing concerns over sustainability issues. Concrete and mortar are the most commonly used materials in construction, and many studies are currently under way to try and reduce the harmful effects of their manufacture. Concrete and mortar are made by mixing water, sand, cement and aggregates. "The main problem is the amount of cement used to produce this type of material; cement manufacturing uses a huge amount of energy and natural resources, which implies a high level of CO2 emissions. Diverse studies are under way aimed at reducing the quantity of cement required. We are working to replace cement and aggregates ...
University of Minnesota Medical School identifies placental protein as possible birthweight regulator
MINNEAPOLIS/ST.PAUL (06/10/2021) -- New findings from the University of Minnesota Medical School are helping uncover why some people are more likely to be overweight and develop Type 2 diabetes -- and it starts in the womb. Previous association studies have shown that low birthweight among infants is a strong determinant for eventual obesity and Type 2 diabetes. The placenta of infants with a low birthweight have reduced levels of mTOR (mechanistic target of rapamycin), and the placenta of bigger infants have increased levels of mTOR. Building off of that research, a U of M Medical ...