PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Meta-analysis finds that omega-3 fatty acids improved cardiovascular outcomes

Reduction in cardiovascular risk was greatest for eicosapentaenoic acid (EPA) alone rather than combination of EPA and another omega-3 fatty acid

2021-07-08
(Press-News.org) For decades, there has been great interest in whether omega-3 fatty acids can lower rates of cardiovascular events. In 2018, results from the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT) were published in the New England Journal of Medicine and showed that a high dose of a purified ethyl ester of eicosapentaenoic acid (EPA) in patients at elevated cardiac risk significantly reduced cardiovascular events. Results from the trial led to US. Food and Drug Administration, Health Canada, and European Medicines Agency approval of the prescription drug icosapent ethyl for reducing cardiovascular risk in patients with elevated triglycerides, as well as updates to worldwide guidelines. But prior and subsequent studies of omega-3 fatty acid supplements that combine EPA and docosahexaenoic acid (DHA) have had mixed results. Investigators from Brigham and Women's Hospital and elsewhere conducted a systematic review and meta-analysis of 38 randomized controlled trials of omega-3 fatty acids. Overall, they found that omega-3 fatty acids improved cardiovascular outcomes. Results, now published in eClinical Medicine, showed a significantly greater reduction in cardiovascular risk in studies of EPA alone rather than EPA+DHA supplements.

"REDUCE-IT has ushered in a new era in cardiovascular prevention," said senior author Deepak L. Bhatt, MD, MPH, the executive director of Interventional Cardiovascular Programs at the Brigham and lead investigator of the REDUCE-IT trial. "REDUCE-IT was the largest and most rigorous contemporary trial of EPA, but there have been other ones as well. Now, we can see that the totality of evidence supports a robust and consistent benefit of EPA."

Bhatt and colleagues performed a meta-analysis of 38 randomized clinical trials of omega-3 fatty acids, including trials of EPA monotherapy and EPA+DHA therapy. In total, these trials included more than 149,000 participants. They evaluated key cardiovascular outcomes, including cardiovascular mortality, non-fatal cardiovascular outcomes, bleeding, and atrial fibrillation. Overall, omega-3 fatty acids reduced cardiovascular mortality and improved cardiovascular outcomes. The trials of EPA showed higher relative reductions in cardiovascular outcomes compared to those of EPA+DHA.

The researchers note that there are crucial biological differences between EPA and DHA -- while both are considered omega-3 fatty acids, they have different chemical properties that influence their stability and strength of the effect that they can have on cholesterol molecules and cell membranes. No trials to date have studied the effects of DHA alone on cardiovascular outcomes.

"This meta-analysis provides reassurance about the role of omega-3 fatty acids, specifically prescription EPA," said Bhatt. "It should encourage investigators to explore further the cardiovascular effects of EPA across different clinical settings."

INFORMATION:

REDUCE-IT was sponsored by Amarin. Brigham and Women's Hospital receives research funding from Amarin for the work Bhatt did as the trial chair and as the international principal investigator. The present analysis was unfunded.

Paper cited: Khan SU et al. "Effect of Omega-3 Fatty Acids on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis" eClinical Medicine DOI: 10.1016/j.eclinm.2021.100997



ELSE PRESS RELEASES FROM THIS DATE:

A summary of myocarditis cases following COVID-19

2021-07-08
Myocarditis-or inflammation around the heart--has been reported in some patients with COVID-19. After searching the medical literature, researchers have now summarized the results of 41 studies describing myocarditis in 42 patients with COVID-19. The analysis, which is published in the END ...

How does endometriosis influence women's work life?

2021-07-08
In women in their mid-40s to early 50s, endometriosis--a condition in which tissue that normally lines the uterus grows outside the uterus--was linked with poor work ability and more sick days, but not with unemployment or early retirement. The findings, which are published in END ...

Yoga helps reduce work-related stress

2021-07-08
Physical relaxation through yoga or other practices can help reduce work-related stress, according to an analysis of studies conducted in healthcare staff. The analysis, which is published in the END ...

Has the COVID-19 pandemic lessened bullying at school?

2021-07-08
Students reported far higher rates of bullying at school before the COVID-19 pandemic than during the pandemic across all forms of bullying--general, physical, verbal, and social--except for cyber bullying, where differences in rates were less pronounced. The findings come from a study published in END ...

What is the evidence on how to improve older adults' functional abilities at home?

2021-07-08
A new analysis called an evidence and gap map has mapped what we know about improving the functional ability of older adults living at home or in nursing homes, retirement homes, or other long-term care facilities. A total of 548 studies were included in the map, which is published in END ...

How can counselors address social justice amid climate change?

2021-07-08
We're currently living in what many scientists are calling the Anthropocene, the period during which human activity has been the dominant influence on climate and the environment. An article published in the END ...

How experiencing diverse emotions impacts students

2021-07-08
Experiencing a variety of positive emotions--or emodiversity--may benefit high school students, according to a study published in the END ...

Improving transparency of integrated assessment models related to climate change

2021-07-08
Integrated Assessment Models (IAMs) connect trends in future socio-economic and technological development with impacts on the environment, such as global climate change. Critics have taken issue with the transparency of IAM methods and assumptions as well as the transparency of assessments of IAMs by the Intergovernmental Panel on Climate Change (IPCC), the United Nations body for assessing the science related to climate change. An article published in END ...

Study: Hospitalizations for eating disorders spike among adolescents during COVID

2021-07-08
ANN ARBOR, Mich. - The number of adolescents admitted to the hospital for severe illness from eating disorders has increased significantly during the COVID-19 pandemic, new research suggests. At one center, the number of hospital admissions among adolescents with eating disorders more than doubled during the first 12 months of the pandemic, according to the study that appears in a pre-publication of Pediatrics. The 125 hospitalizations among patients ages 10-23 at Michigan Medicine in those 12 months reflect a significant increase over previous years, as admissions related to eating disorders ...

Cell-type-specific insight into the function of risk factors in coronary artery disease

Cell-type-specific insight into the function of risk factors in coronary artery disease
2021-07-08
Using single cell technology, a new study sheds light on the significance of genetic risk factors for, and the diversity of cells involved in, the development of coronary artery disease. The researchers analysed human atherosclerotic lesions to map the chromatin accessibility of more than 7,000 cells. The chromatin accessibility is known to reflect active regions and genes in the genome. The findings were published in Circulation Research. Genome-wide association studies of the human genome have identified over 200 loci associated with coronary artery disease. More than 90% of them ...

LAST 30 PRESS RELEASES:

Fig trees convert atmospheric CO2 to stone

Intra-arterial tenecteplase for acute stroke after successful endovascular therapy

Study reveals beneficial microbes that can sustain yields in unfertilized fields

Robotic probe quickly measures key properties of new materials

Climate change cuts milk production, even when farmers cool their cows

Frozen, but not sealed: Arctic Ocean remained open to life during ice ages

Some like it cold: Cryorhodopsins

Demystifying gut bacteria with AI

Human wellbeing on a finite planet towards 2100: new study shows humanity at a crossroads

Unlocking the hidden biodiversity of Europe’s villages

Planned hydrogen refuelling stations may lead to millions of euros in yearly losses

Planned C-sections increase the risk of certain childhood cancers

Adults who have survived childhood cancer are at increased risk of severe COVID-19

Drones reveal extreme coral mortality after bleaching

New genetic finding uncovers hidden cause of arsenic resistance in acute promyelocytic leukemia

Native habitats hold the key to the much-loved smashed avocado’s future

Using lightning to make ammonia out of thin air

Machine learning potential-driven insights into pH-dependent CO₂ reduction

Physician associates provide safe care for diagnosed patients when directly supervised by a doctor

How game-play with robots can bring out their human side

Asthma: patient expectations influence the course of the disease

UNM physician tests drug that causes nerve tissue to emit light, enabling faster, safer surgery

New study identifies EMP1 as a key driver of pancreatic cancer progression and poor prognosis

XPR1 identified as a key regulator of ovarian cancer growth through autophagy and immune evasion

Flexible, eco-friendly electronic plastic for wearable tech, sensors

Can the Large Hadron Collider snap string theory?

Stuckeman professor’s new book explores ‘socially sustainable’ architecture

Synthetic DNA nanoparticles for gene therapy

New model to find treatments for an aggressive blood cancer

Special issue of Journal of Intensive Medicine analyzes non-invasive respiratory support

[Press-News.org] Meta-analysis finds that omega-3 fatty acids improved cardiovascular outcomes
Reduction in cardiovascular risk was greatest for eicosapentaenoic acid (EPA) alone rather than combination of EPA and another omega-3 fatty acid