Unexpected proteome plasticity in response to persistent temperature rise

Common yeast are able to adapt and thrive in response to a long-term rise in temperature by changing the shape, location and function of some of their proteins. The surprising findings demonstrate the unappreciated plasticity in the molecular and conformational level of proteins and bring the power of molecular biology to the organismal response to climate change. Results from the Zhou lab at the Buck Institute in collaboration with the Si lab from the Stowers Institute are published in Molecular Cell.

Temperature is an unstable parameter in the wild, affecting almost all aspects of life by modifying protein stability and the speed of metabolism. Buck Institute Fellow Chuankai END