Rare inherited variants in previously unsuspected genes may confer significant risk for autism
New Study in Nature Genetics uses SPARK database to investigate variants that are less damaging than de novo mutations, but contribute almost as much risk
Published 2021-07-26 · Original archive entry · Explore research explainers
New York, NY (July 26, 2021) - Researchers have identified a rare class of genetic differences transmitted from parents without autism to their affected children with autism and determined that they are most prominent in "multiplex" families with more than one family member on the spectrum. These findings are reported in Recent ultra-rare inherited variants implicate new autism candidate risk genes, END