PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Common meat-free proteins may trigger soybean and peanut allergies in some people

Scientists find that allergies to soy and peanuts can be activated by common meat-free alternatives based on other legumes, but most people won’t experience a reaction

2023-03-16
(Press-News.org) Many people keen to reduce their meat consumption are turning to substitutes made of legumes packed with protein, vitamins, and fiber. But allergies to legumes like soy or peanuts are both common and dangerous. Are patients allergic to particular legumes at risk from meat-free proteins made of legumes even if they contain different legumes? Dr Mark Smits and a team of scientists at University Medical Center Utrecht set out to investigate.

“Both protein consumption and the world’s population are increasing which leads to an urgent demand for sustainable protein sources,” said Dr Thuy-My Le, senior author of the study published in Frontiers in Allergy. “An increase in the consumption of legumes may increase the number of allergies to these foods. Furthermore, these new legumes may elicit allergic complaints in already legume-allergic patients. Therefore, we investigated how often sensitization and allergy to different legumes occurs in these patients.”

An allergy by any other name

People develop food allergies when their immune systems confuse food proteins with a threat and produce Immunoglobulin E (IgE) antibodies. Sensitized individuals can, upon re-exposure to the same food, develop symptoms of an allergy. Patients that react to one food may also react to another: this is a co-allergy. Co-allergies are accompanied by co-sensitization, in which patients produce IgE antibodies against several foods. Co-sensitization may be caused by cross-reactivity, where IgE antibodies bind to proteins from multiple foods because the proteins share similar structures.

Co-sensitization can lead to a diagnosed co-allergy, but doesn’t always: it’s possible for someone to be co-sensitized to a food, but not experience a reaction when they eat it. So, do patients with specific legume allergies react to other legumes?

Smits and colleagues recruited legume-allergic patients from the Allergology Clinic at the University Medical Center Utrecht and split them into six groups according to allergies: peanuts, soybeans, green peas, lupines, lentils, and beans. All patients had allergies validated by an oral food challenge or a positive IgE test combined with a history of reactions. Each different group was tested for IgE antibodies against the other legumes. 

“We showed that a large number of patients produced antibodies against more than one legume,” said Dr Kitty Verhoeckx, second author of the study. “However, clinical data showed that only a small part of these patients had actual symptoms.”

High co-sensitization rate between legumes, but not always co-allergy

All six patient groups showed co-sensitization to additional legumes, and almost a quarter of patients were sensitized to all legumes. Nearly all the patients in the bean allergy group were sensitized to other legumes. Patients allergic to green peas, lupines, or lentils were also likely to be sensitized to other legumes, while patients with diagnosed allergies to peanuts or soybeans were not. 

The team also looked at which of these patients had documented co-allergies for several legumes. The high co-sensitization rate was associated with clinical symptoms in only a relatively small number of patients. In peanut and soybean-allergic patients, co-allergies for green pea, lupine, lentil and bean were uncommon, but patients who had allergies to this second group of legumes were likely to be co-allergic to peanuts or soybeans. Patients with peanut allergies were also often co-allergic to soybeans, and vice versa. Co-sensitization for peanuts was associated with clinically relevant co-allergy in almost all the other legume groups. However, the team cautioned that it will be necessary to expand the study to a larger group and confirm co-allergies with oral food challenges to determine how clinically relevant this co-sensitization is in practice.

“Legumes are an attractive sustainable protein source, but allergic reactions in the already legume-allergic population cannot be excluded as antibodies in the blood of legume-allergic patients frequently react to different legumes,” said Le. “However, this reaction does not always lead to a clinically relevant food allergy. Introduction of novel foods into the market should be accompanied by appropriate assessment of the risk of developing (new) food allergies.”

END


ELSE PRESS RELEASES FROM THIS DATE:

A comprehensive circuit mapping study reveals many unexpected facts about the norepinephrine neurons in the brainstem

2023-03-16
A small nucleus in the brainstem called locus coeruleus (literally the “blue spot,”) is the primary source of a major neuromodulator, norepinephrine (NE), an important mediator of the ‘fight or flight’ response in animals. However, very little is known about the local connections of this small albeit critically important group of neurons. A recent pioneering study published in eLife from the laboratory of Dr. Xiaolong Jiang, investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) ...

Maintaining heart function in donors declared ‘dead by circulatory criteria’ could improve access to heart transplantation

2023-03-16
More donated hearts could be suitable for transplantation if they are kept functioning within the body for a short time following the death of the donor, new research has concluded. The organs are kept functioning by restarting local circulation to the heart, lungs and abdominal organs – but, crucially, not to the brain – of patients whose hearts have stopped beating for five minutes or longer and have been declared dead by circulatory criteria (donation after circulatory death, or DCD). It is hoped that this technique could increase the number of usable donated hearts by as much as 30% in the future, helping address ...

Not enough new antibiotics in the pipeline, concludes WHO review – especially those targeting deadly drug-resistant microbes

2023-03-16
**Note: the release below is a special early release from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen, 15-18 April). Please credit the congress if you use this story** Embargo – 2301H UK time Wednesday 15 March A review from WHO on the number of new antibiotics currently in the pipeline shows that just 12 new antibiotics have entered the market in the five years from 2017-21.  And there are far too few (just 27) under development in clinical trials against pathogens considered critical* by WHO such as Acinetobacter baumannii and Pseudomonas aeruginosa. ...

Short night-time sleep linked with nearly doubled risk of clogged leg arteries

2023-03-16
Sophia Antipolis, 16 March 2023:  Sleeping less than five hours a night is associated with a 74% raised likelihood of developing peripheral artery disease (PAD) compared with seven to eight hours. That’s the finding of a study published today in European Heart Journal – Open, a journal of the ESC.1   “Our study suggests that sleeping for seven to eight hours a night is a good habit for lowering the risk of PAD,” said study author Dr. Shuai Yuan of the Karolinska Institute, Stockholm, ...

New global ranking for life expectancy shows decades-long UK decline

2023-03-16
A new analysis of global rankings of life expectancy over seven decades shows the UK has done worse than all G7 countries except the USA. Researchers writing in the Journal of the Royal Society of Medicine say that while UK life expectancy has increased in absolute terms over recent decades, other, similar countries are experiencing larger increases. In 1952, when Queen Elizabeth II came to the throne, the UK had one of the longest life expectancies in the world, ranking seventh globally behind countries such as Norway, Sweden and Denmark. ...

Humans are altering the diet of Tasmanian devils, which may accelerate their decline

2023-03-16
The Tasmanian devil roams the island state of Australia as the apex predator of the land, feeding on whatever it pleases as the top dog – or the top devil. But some of these marsupial scavengers could be starting to miss out on a few items from the menu. According to a study led by UNSW Sydney, living in human-modified landscapes could be narrowing the diet of the Tasmanian devil. The research, published recently in Scientific Reports, suggests devils have access to vastly different cuisines depending on the type of environment they live in. “We found Tasmanian devil ...

Utah’s graphics pioneers

2023-03-16
They were a group of young, scrappy, but brilliant University of Utah computer science students and professors who changed the world. Ed Catmull. John Warnock. Jim Clark. Alan Kay. Ivan Sutherland. Martin Newell. They are a just a handful of the luminaries in the late 1960s and 1970s who revolutionized computer graphics by inventing technologies that have aided and shaped countless industries today. For the first time ever, these and other legends of that time will be reuniting on the U campus Thursday, March 23, and Friday March 24, to commemorate their roles as ...

Humans are not just big mice: Study identifies science’s muscle-scaling problem

2023-03-16
CHICAGO — March 16, 2023 — In science, findings generated from studying small animals often are generalized and applied to humans, which are orders of magnitude larger. New research, which was led by Shirley Ryan AbilityLab and will be published in a forthcoming issue of the Journal of Physiology, not only is the first to directly measure human muscle contractile properties; it also is the first to show that extrapolating such information to humans based on animal measurements generates incorrect predictions. The discovery occurred initially when researchers leveraged a unique surgical technique in which a human patient’s ...

U.S. opioid crisis best viewed as a connected ecosystem

2023-03-16
The nation’s opioid crisis, which kills thousands of Americans annually, is best viewed as an ecosystem where all parts of the vexing problem are interconnected, underscoring the need for holistic solutions that address the broad needs of those battling addiction, their families and the communities where they live, according to a new report from the nonprofit RAND Corporation.   Too often different actors in the ecosystem focus primarily on addressing just one part of the problem, with each component of the system having its own priorities and initiatives ...

Trust in cancer information declined among Black Americans during the pandemic

2023-03-16
Trust in information given out by the government on cancer fell sharply among the Black population, by almost half, during the COVID-19 pandemic findings of a national US study have shown.  Experts are warning the vital need to monitor if this mistrust has persisted beyond the pandemic and whether it could potentially cause an upsurge in late or fatal diagnoses – following a lack of uptake of important cancer prevention measures such as routine screening and human papilloma virus (HPV) vaccinations.   The findings, published today in the peer-reviewed ...

LAST 30 PRESS RELEASES:

A unified account of Darwinism’s varieties

Marketers can manage 'feature creep'

Intermittent fasting shows promise in improving gut health, weight management

Scientists identify gene that could lead to resilient ‘pixie’ corn

Utilizing medical assistants to manage patient portal messages shown to support practice and physician efficiency

Study shows clinic continuity associated with reduced hospital and emergency visits

Recognizing the range of experiences among individuals of Latino, Hispanic, and/or Spanish origin is an essential step toward health equity

study reveals decline in reported medicare outpatient procedures by family physicians amid an aging population

COVID-19 pandemic leads to drop in breast cancer screenings, especially among older and racial minority women

Translating the Surgeon General’s framework on social isolation and loneliness to actionable steps in primary care

Point/counterpoint: Is prediabetes overdiagnosed?

Primary care clinics can help low-income families receive nutritional support benefits

The wall of evidence for continuity of care

Parents of children with serious illness from Somali, Hmong, and Latin American communities desire better communication and support in pediatric health care

Primary care can improve hygienic practices while reducing waste

HKUST researchers enhance performance of eco-friendly cooling applications by developing sustainable strategy to manipulate interfacial heat transfer

Variations in medical assistant to primary care clinician staffing ratios may reflect differences in practice ownership and organizational culture

Better disciplinary structures in schools can help reduce hate speech directed against Asian American students

Bringing back an ancient bird

Wistar research identifies mechanisms for selective multiple sclerosis treatment strategy

Fatherhood’s hidden heart health toll

The importance of integrated therapies on cancer: Silibinin, an old and new molecule

Texas A&M-led team creates first global map of seafloor biodiversity activity

Light therapy increases brain connectivity following injury

Power imbalance in health care reveals impact of race and role on team dynamics and DEI efforts

NRG Oncology appoints new vice-chairs for their patient advocate committee

Why do Dyeing poison frogs tap dance?

UC Irvine study reveals circadian clock can be leveraged to enhance cancer immunotherapy

Cell-targeting technology allows researchers to isolate neuronal subpopulations and link them to behavioral states

When should you neuter or spay your dog?

[Press-News.org] Common meat-free proteins may trigger soybean and peanut allergies in some people
Scientists find that allergies to soy and peanuts can be activated by common meat-free alternatives based on other legumes, but most people won’t experience a reaction