GLP-1 RAs and risk of nonarteritic anterior ischemic optic neuropathy in older patients with diabetes

JAMA Ophthalmology

2025-07-31

(Press-News.org) About The Study: This study of Medicare enrollees age 65 or older with type 2 diabetes found an association between semaglutide use and an increased risk of nonarteritic anterior ischemic optic neuropathy. There was risk variation among the glucagon-like peptide-1 receptor agonists (GLP-1 RAs); semaglutide and liraglutide were associated with higher risks.

Corresponding Author: To contact the corresponding author, Kin Wah Fung, MD, email kfung@mail.nih.gov.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaophthalmol.2025.2299)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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GLP-1 RAs and risk of nonarteritic anterior ischemic optic neuropathy in older patients with diabetes

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