Phase I trial demonstrates lasting responses and encouraging safety profile in two aggressive thyroid cancer subtypes, suggesting further progress for CAR T cell therapy in solid tumors One patient experienced a complete response, and one patient had a partial response This type of cancer has limited treatment options, and most patients have a poor prognosis of six months or less AIC100 is a CAR T cell therapy that targets the ICAM-1 protein on tumor cells ABSTRACT: CT206 CHICAGO, APRIL 29, 2025 ― A new chimeric antigen receptor (CAR) T cell therapy called AIC100, which targets the ICAM-1 protein, demonstrated encouraging responses and an acceptable safety ...

In a recent development in the field of unmanned aircraft systems (UAS), a research team from the University of Salento in Italy has designed and tested a novel platform named AcrOSS. The details of this platform are published in Engineering, aiming to enhance the safety and efficiency of UAS operations in critical areas. The widespread use of UAS in civil airspace, especially for beyond visual line-of-sight (BVLOS) operations, faces numerous challenges. The AcrOSS project, funded by the Italian Ministry for Research, focuses on developing ...

A new study published in Engineering presents an innovative approach to building energy management that combines quantum computing with model predictive control (MPC), aiming to enhance energy efficiency and drive decarbonization in buildings. Buildings are major energy consumers, contributing significantly to global energy use and greenhouse gas emissions. To address these issues, researchers Akshay Ajagekar and Fengqi You from Cornell University developed an adaptive quantum approximate optimization-based MPC strategy. This strategy is designed for buildings equipped with battery energy storage and renewable energy generation systems, such as photovoltaic (PV) panels. The heart ...

PHOENIX, Ariz. — April 30, 2025 — HonorHealth Research Institute’s new downtown Phoenix laboratory has produced its first study, centered on a promising new treatment for pancreatic cancer, one of the most aggressive and difficult to treat of all malignancies. Study results were presented April 29 in Chicago at the annual meeting of the 58,000-member American Association for Cancer Research (AACR), the world’s largest professional organization of cancer investigators, caregivers and patient advocates. Study findings indicate that a newly discovered drug, RMC-6236, also known as Daraxonrasib, is a powerful inhibitor of RAS (including KRAS, NRAS and HRAS). These ...

SCOTTSDALE, Ariz. — April 29, 2025 — HonorHealth Research Institute recently treated the first patient in a 50-site international clinical trial that will test a new type of therapy aimed at difficult-to-treat melanoma, an aggressive type of skin cancer. This new therapy targets PRAME, a peptide commonly found in melanoma tumors. The therapy uses the patient’s own manufactured and enhanced immune system T cells to create billions of new patient specific cells to attack melanoma, even after the cancer has spread to other parts of the body. “We are excited about the potential of this new type of cellular therapy,” said Justin Moser, M.D., an associate ...

Over 70% said mental health was not addressed during treatment Less than a third had information about survivorship care Northwestern oncologists are launching new survivorship clinic based on findings Findings apply broadly to survivors of many cancers CHICAGO --- More Americans are beating cancer than ever, yet many still grapple with treatment’s long shadow — especially on their mental health. A new Northwestern Medicine study found most head-and-neck cancer survivors who underwent ...

WASHINGTON, April 29, 2025 – The beloved Italian pasta cacio e pepe is perhaps best known for two things: being delicious and being frustratingly difficult to cook. At first glance, it looks like a simple recipe, containing only three ingredients: pasta, pecorino romano cheese, and black pepper. But as anyone who has tried to make it will know, the cheese will often clump when added to the hot pasta water, turning what is supposed to be a smooth, creamy sauce into a stringy, sticky mess. In Physics of Fluids, by AIP Publishing, researchers from the University of Barcelona, the Max Planck Institute for the Physics of Complex Systems, the University of Padova, and the Institute of Science ...

About The Study: Semaglutide and tirzepatide prescriptions within Epic-affiliated health care systems increased slightly between 2021 and 2024, but their uptake remained limited, with only 3% of eligible patients having ever received a prescription during that period. Furthermore, there were disparities in prescribing of varying magnitude based on race and ethnicity, social vulnerability, and urbanicity, although the absolute differences were small compared with the overall underutilization. Corresponding Author: To contact the corresponding author, Yuan Lu, ScD, email y.lu@yale.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.4735) Editor’s ...

(Toronto, April 28, 2025) A team of Canadian researchers has developed a curriculum framework to help train future family physicians in the use of artificial intelligence (AI), addressing a critical gap in medical training as digital tools become more common in patient care. Published in JMIR Medical Education, the study, “Curriculum Framework for AI Training in Postgraduate Family Medicine Education (AIFM-ed): Mixed Methods Study,” introduces the AIFM-ed framework to guide the integration of AI into family medicine training programs. As the health care system evolves, many medical professionals feel unprepared for the growing influence of AI in diagnostics, treatment, ...

About The Study: Pre-pregnancy overweight or obesity, smoking during pregnancy, and formula-feeding in the first 6 months of life were each associated with adverse cardiovascular health trajectories early in life in this cohort study. Future work should examine whether interventions that address these factors would be effective in optimizing cardiovascular health in children. Corresponding Author: To contact the corresponding author, Izzuddin M. Aris, PhD, email izzuddin_aris@hphci.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.7774) Editor’s ...

About The Study: In this preterm cohort study, maternal hypertensive disorders of pregnancy were independently associated with adverse cognitive and language development, with accentuated associations observed in preeclampsia-exposed preterm infants, emphasizing the clinical importance of recognizing hypertensive disorders of pregnancy as a risk, enabling targeted risk management strategies for closer monitoring and aggressive early intervention in affected populations. Corresponding Author: To contact the corresponding author, Nehal A. Parikh, DO, MS, email nehal.parikh@cchmc.org. To access the embargoed study: Visit our For The Media website at this ...

About The Study: In this cohort study of individuals with regular menstrual cycles, influenza vaccine given alone or in combination with a COVID-19 vaccine was associated with a small but temporary change in menstrual cycle length. These findings may help clinicians confirm the utility of vaccination for patients with concerns about menstrual adverse effects of vaccination. Corresponding Author: To contact the corresponding author, Alison Edelman, MD, MPH, email edelmana@ohsu.edu. To access the embargoed study: ...

Social singing and dance are often assumed to be hard-wired into the human condition; studies have supported the conclusion that these are common across cultures. But new research from a University of California, Davis, anthropologist challenges the idea that dance and lullabies are universal among humans. The study, published April 29 in Current Biology, draws on 43 years of research with the Northern Aché, an Indigenous population in Paraguay. “Aside from church singing introduced by missionaries, Northern Aché adults sing alone and in a limited number of contexts,” said study author Manvir Singh, an assistant ...

Miami (April 29, 2025) – Increased perceived stress may cause worsened respiratory symptoms and decreased quality of life in people with chronic obstructive pulmonary disease (COPD), according to a new study. The study is published in the March 2025 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open-access journal. Perceived stress is used to describe how overwhelmed or stressed a person feels based on their personal understanding of the situation. It is a psychosocial factor, along with loneliness, social isolation and emotional support, which have been shown to impact health outcomes in ...

COLUMBUS, Ohio – A satisfying intimate relationship may help diminish chemotherapy-related cognitive problems experienced by patients with breast cancer, a new study suggests. General social support was also protective, but the association was less robust and lasting than a satisfying intimate partnership, which was characterized by fewer declines in both objective measures of cognitive setbacks and patient self-reports of subtle changes such as forgetting grocery list items and being unable to multitask. The findings suggest that ...

ATLANTA, Georgia, USA, 29 April 2025 -- In a comprehensive Genomic Press research report published today, Emory University investigators have uncovered the complex motivations driving spiritual health practitioners (SHPs) – also known as healthcare chaplains – to pursue careers in the rapidly expanding field of psychedelic-assisted therapy (PAT). The findings shed light on the deeply personal nature of facilitator engagement in psychedelic care and introduce novel training approaches aimed at improving therapeutic outcomes. As psychedelic treatments gain traction for conditions like treatment-resistant depression, PTSD, and existential distress ...

Cross Country Healthcare (NASDAQ: CCRN), a leader in workforce solutions and tech-enabled staffing, recruitment and advisory services, today released its fourth annual survey, “Beyond the Bedside: The State of Nursing in 2025” report. In partnership with Florida Atlantic University’s Christine E. Lynn College of Nursing, the study paints a sobering picture of a profession at a breaking point – where stress, burnout and chronic short staffing continue to jeopardize the well-being ...

Astronomers have discovered a previously unknown birthplace of some of the universe’s rarest elements: a giant flare unleashed by a supermagnetized star. The astronomers calculated that such flares could be responsible for forging up to 10 percent of our galaxy’s gold, platinum and other heavy elements. The discovery also resolves a decades-long mystery concerning a bright flash of light and particles spotted by a space telescope in December 2004. The light came from a magnetar — a type of star wrapped in magnetic fields trillions of times as strong as Earth’s — that had unleashed a giant flare. The powerful blast of radiation only lasted a few ...

CHICAGO – From 2010 to 2020, breast cancer deaths among women ages 20-49 declined significantly across all breast cancer subtypes and racial/ethnic groups, with marked declines starting after 2016, according to an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) registry presented at the American Association for Cancer Research (AACR) Annual Meeting 2025, held April 25-30. Breast cancer incidence rates in women aged 20 to 49 years have been increasing over the past 20 ...

CHICAGO – Cancer survivors who reported feeling cancer-related fatigue or depression reduced their recreational activities nearly twofold, with females more likely than males to report feeling either cancer-related fatigue or depression, according to a retrospective study presented at the American Association for Cancer Research (AACR) Annual Meeting 2025, held April 25-30. Cancer-related fatigue affects more than 80% of patients who receive chemotherapy or radiation therapy, while depression affects around 25% of cancer patients. Unlike typical fatigue, cancer-related fatigue doesn’t go away with rest and can persist for weeks, months, or even years, explained ...

A research paper by scientists at University of Rome Tor Vergata represented proof of principle of the use of optically-induced dielectrophoresis (ODEP) analysis for the classification of patient-derived endometrial stromal cells, which could be exploited to help clinicians to stratify patients experiencing reproductive failure. The new research paper, published on Mar. 6 in the journal Cyborg and Bionic Systems, provided the ground for devising a robotic micromanipulation and analysis system for single-cell phenotyping ...

CHICAGO – Patients with advanced solid tumors experienced significantly improved survival outcomes when receiving a tailored therapy based on the detection of the same genomic alteration in both tissue and liquid biopsies compared with both standard-of-care treatment and tailored therapy that was based on either biopsy on its own, according to results from the phase II, multicenter ROME trial presented at the American Association for Cancer Research (AACR) Annual Meeting 2025, held April 25-30. Genomic profiling is used as part of precision oncology to help identify specific alterations in a tumor that can be targeted with a therapeutic. While tests can be performed ...

A research paper by scientists at Westlake University presented a novel 3D cell culturing and noninvasive characterization technique of neural spheroids, holding a potential application in development of brain organoids. The new research paper, published on Mar. 5 in the journal Cyborg and Bionic Systems, designed a wire-embedded 3D neural spheroid culture device that not only supports the culture and growth of neural spheroids but also facilitates real-time monitoring of both interior and exterior neural signals without damage. “In recent years, the field of in vitro neural tissue modeling has undergone substantial advancements, providing researchers with powerful tools ...

A research team led by Dr. Ju-Yul Lee and Dr. Seil Kim from the Energy & Environment Materials Research Division at the Korea Institute of Materials Science (KIMS) has developed the world’s first eco-friendly silver (Ag) plating technology using a phosphorus (P) compound as a key plating component. This breakthrough technology enables silver plating without the use of highly toxic cyanide, by formulating an acidic plating solution based on phosphorus compounds that successfully produces uniform and stable silver thin films. Silver plating is an essential process for enhancing electrical signal transmission in semiconductors, electronic components, and circuit boards. Conventional ...

Microbial research suggests that biodiversity does not always increase ecosystem stability. Although many conservationists believe biodiversity is intrinsically valuable, the protection of biodiversity has also been argued for on the basis that diversity makes ecosystems healthier and more stable. But are highly diverse ecosystems more stable and productive than ecosystems with low diversity? The question has been investigated in plants and animals, where some evidence suggests a link between biodiversity and various measures of ecosystem function, but few studies have investigated the hypothesis’ applicability among microbes, ...