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Artificial intelligence outperforms clinical tests at predicting progress of Alzheimer’s disease

2024-07-13
Cambridge scientists have developed an artificially-intelligent tool capable of predicting in four cases out of five whether people with early signs of dementia will remain stable or develop Alzheimer’s disease. The team say this new approach could reduce the need for invasive and costly diagnostic tests while improving treatment outcomes early when interventions such as lifestyle changes or new medicines may have a chance to work best. Dementia poses a significant global healthcare challenge, affecting over 55 million people worldwide ...

ReMDO announces inaugural Piedmont Triad Regenerative Medicine Engine Ecosystem Summit in Winston-Salem, North Carolina

ReMDO announces inaugural Piedmont Triad Regenerative Medicine Engine Ecosystem Summit in Winston-Salem, North Carolina
2024-07-12
Winston-Salem, North Carolina – July 12, 2024 - The RegenMed Development Organization (ReMDO) invites researchers, industry and academia to the inaugural Piedmont Triad Regenerative Medicine Engine Ecosystem Summit (The Summit) on Monday, August 12th in Winston-Salem, North Carolina. Registration is open to new and current partners, with required onboarding for prospective organizations to be completed by August 12. The summit will consist of speaker sessions, discussion panels, breakouts, and networking events with complete details ...

HarvestHub app tackles supply chain, food insecurity issues

HarvestHub app tackles supply chain, food insecurity issues
2024-07-12
The COVID-19 pandemic infiltrated almost every aspect of society and life in 2020, even in ways people wouldn’t have immediately expected. Stores that typically have no problem stocking shelves were struggling to keep pace with the sudden demand for cleaning supplies along with everything from toilet paper to Sriracha chili sauce. While these issues aren’t as devastating as the larger health ramifications, they did shed new light on supply chain weaknesses and how that system adapts to rapid and vast market shifts. Factory closures ...

Mathematics outreach program awarded Dolciani grant

2024-07-12
Two years after launching a new mathematics outreach program, a team of Texas A&M University professors has been awarded a Dolciani Mathematics Enrichment Grant to support their program's efforts to promote math enrichment for high school students. The Program for Research in Mathematics (PReMa) was established in 2022 by four members of Texas A&M’s Department of Mathematics: Dr. Sherry Gong, Dr. Wencai Liu, Dr. Kun Wang and Dr. Zhizhang Xie. The program, directed by Wang, targets high school students living in Texas and neighboring states. Designed to cultivate a deep appreciation and understanding of advanced ...

Groundbreaking study reveals insights into Alzheimer's disease mechanisms through novel hydrogel matrix

Groundbreaking study reveals insights into Alzheimers disease mechanisms through novel hydrogel matrix
2024-07-12
Los Angeles, California - May 20, 2024 - Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have unveiled a pioneering study shedding light on the intricate mechanisms underlying Alzheimer's disease (AD). The study, titled "Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype," represents a significant leap forward in understanding the interplay between amyloid-like structures and neuronal cells. Led by Natashya Falcone and co-first authors Tess Grett Mathes and Mahsa Monirizad, the research team delved into the realm of self-assembling ...

Study examines urban forests across the United States

2024-07-12
In recent years, tree-planting campaigns have been underway in the United States, especially in cities, as part of climate mitigation efforts.  Urban forests can help improve air quality, generate cooling effects, and provide green spaces for outdoor recreation while also serving as an ecological habitat.  Just last year, the U.S. Forest Service announced a $1 billion campaign to expand access to trees and green spaces throughout the country, including in cities. But a new Dartmouth-led study finds that some areas within urban forests in the U.S., may be more capable than trees growing around city home lawns in adapting to a warmer climate. The findings are published ...

2023 Rolling Hills Estates landslide likely began the winter before

2024-07-12
Key takeaways Landslides triggered by intense rainfall can sometimes be predicted along with incoming storms, but dry-season landslides often take people by surprise. The July 2023 Rolling Hills Estates landslide that destroyed 12 homes seemed to come out of nowhere, but new research shows it began as early as December 2022. Researchers are developing a database that will enable scientists to plug in new data to monitor potential landslides in real time and possibly predict them. Californians are familiar with landslides that occur around storms, when saturated soil and ...

Rutgers researchers spot potential hazard with private well water treatment

2024-07-12
Systems designed to treat arsenic in private well water may be malfunctioning and endangering the health of people who count on them to keep their water safe, according to Rutgers researchers. Megan Rockafellow-Baldoni, an assistant professor of environmental and occupational health and justice at the Rutgers School of Public Health, together with co-authors including Rutgers alum Steven Spayd, a retired research scientist formerly with the New Jersey Department of Environmental Protection, tested the water of 62 New Jersey homes with whole-house arsenic-removing water treatment systems. Their study was ...

When to trust an AI model

2024-07-12
CAMBRIDGE, MA – Because machine-learning models can give false predictions, researchers often equip them with the ability to tell a user how confident they are about a certain decision. This is especially important in high-stake settings, such as when models are used to help identify disease in medical images or filter job applications. But a model’s uncertainty quantifications are only useful if they are accurate. If a model says it is 49% confident that a medical image shows a pleural effusion, then 49% of the time, the model should be right. MIT ...

Research shows gamified investment sites have risks for novice investors

2024-07-12
TORONTO - What happens when online investment trading platforms start to resemble games that keep people playing for hours, with badges and exploding confetti to reward investors for their engagement? For those who know what they’re doing, it won’t make much of a difference. New research from the University of Toronto engaging nearly 1,000 volunteers in artificial investment scenarios shows that more informational features such as price change notifications might even help savvy investors execute ...

Specially equipped natural killer cells show effectiveness against the most common form of ovarian cancer

2024-07-12
RESEARCH SUMMARY Study Title: CAR memory-like NK cells targeting the membrane proximal domain of mesothelin demonstrate promising activity in ovarian cancer Publication: Science Advances Dana-Farber Cancer Institute authors include: Rizwan Romee, MD, senior author; and Mubin Tarannum, PhD, KhanhLinh Dinh, and Juliana Vergara, MD, MMSc, co-first authors Summary: Natural killer, or NK, cells endowed with memory-like abilities and armed with a novel chimeric antigen receptor (CAR) have generated encouraging results in experiments in epithelial ovarian cancer ...

Entering the golden age for antibody-drug conjugates in gynecologic cancer

Entering the golden age for antibody-drug conjugates in gynecologic cancer
2024-07-12
“We are optimistic that the incorporation of ADCs into the treatment of aggressive tumors and treatment refractory gynecologic cancers will improve quality of life and survival outcomes in our patients.” BUFFALO, NY- July 12, 2024 – A new editorial paper was published in Oncoscience (Volume 11) on May 20, 2024, entitled, “Entering the golden age for antibody-drug conjugates in gynecologic cancer.” In this new editorial, researchers Michelle Greenman, Blair McNamara, Levent Mutlu, and Alessandro D. Santin from Yale University School of Medicine discuss gynecologic cancers. Biologically aggressive ...

Judge: Texas university must release records on research study that resulted in deaths of dozens of animals

2024-07-12
SAN ANGELO, Texas —Tom Green County District Court Judge Barbara L. Walther ruled Thursday, July 11, 2024, that Angelo State University must release public records relating to an experiment conducted on dozens of mice that resulted in the animals’ unnecessary suffering and death, reportedly to study the impact of the foster care system on human children. The ruling overturns Texas Attorney General Ken Paxton’s Nov. 17, 2022 decision to side with the university in denying the records. On July 13, 2023, the Physicians Committee for Responsible Medicine, a Washington, D.C. based health advocacy group of more than 17,000 doctor members that encourages higher standards ...

UMass Amherst food scientist rises to the challenge of giving marbled fatty feel and taste to plant-based meat

UMass Amherst food scientist rises to the challenge of giving marbled fatty feel and taste to plant-based meat
2024-07-12
One of the challenges of creating realistic-looking and delectable plant-based meat is mimicking the marbled effect of animal fat that many carnivores expect and enjoy. A University of Massachusetts Amherst food scientist has a plan to tackle this quandary by developing new technology supported by a $250,000 grant from the Good Food Institute. The not-for-profit think tank promotes plant-based alternatives to meat, dairy and eggs, as well as cultivated “clean meat” grown from animal cells in a facility. The technology proposed ...

Complex impact of large wildfires on ozone layer dynamics unveiled by new study

2024-07-12
In a revelation that highlights the fragile balance of our planet's atmosphere, scientists from China, Germany, and the USA have uncovered an unexpected link between massive wildfire events and the chemistry of the ozone layer. Published in Science Advances, this study reveals how wildfires, such as the catastrophic 2019/20 Australian bushfires, impact the stratosphere in previously unseen ways. The ozone layer, a crucial shield protecting life on Earth from harmful ultraviolet (UV) radiation, has been on a path to ...

Brain inflammation triggers muscle weakness after infections

Brain inflammation triggers muscle weakness after infections
2024-07-12
Infections and neurodegenerative diseases cause inflammation in the brain. But for unknown reasons, patients with brain inflammation often develop muscle problems that seem to be independent of the central nervous system. Now, researchers at Washington University School of Medicine in St. Louis have revealed how brain inflammation releases a specific protein that travels from the brain to the muscles and causes a loss of muscle function. The study, in fruit flies and mice, also identified ways to block this process, which could have ...

Research alert: All stem cell therapies are not created equal

2024-07-12
Researchers from University of California San Diego have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells. The results challenge the current “one-cell-cures-all” paradigm in orthopedic stem cell therapeutics and highlight the need for more informed and rigorous characterization of injectable stem cell therapies before they are marketed for use in patients. The researchers analyzed cell populations of autologous bone marrow aspirate concentrate (BMAC) and adipose-derived ...

Complex impact of large wildfires on ozone layer dynamics

2024-07-12
The ozone layer, a crucial shield protecting life on Earth from harmful ultraviolet (UV) radiation, has been on a path to recovery thanks to the Montreal Protocol. This landmark international treaty, adopted in 1987, successfully led to phasing out the production of numerous substances responsible for ozone depletion. Over the past decades, the ozone layer has shown significant signs of healing, a testament to global cooperation and environmental policy. However, the stability of this vital atmospheric layer is now facing a new and unexpected challenge. During the 2019/20 Australian wildfires, ...

AI found to boost individual creativity – at the expense of less varied content

2024-07-12
Stories written with AI assistance have been deemed to be more creative, better written and more enjoyable. A new study published in the journal Science Advances finds that AI enhances creativity by boosting the novelty of story ideas as well as the ‘usefulness’ of stories – their ability to engage the target audience and potential for publication. It finds that AI “professionalizes” stories, making them more enjoyable, more likely to have plot twists, better written and less boring. In ...

Texas A&M research collaboration uncovers how domestic rabbits become feral in the wild

2024-07-12
Researchers at the Texas A&M School of Veterinary Medicine and Biomedical Sciences (VMBS) have uncovered how natural selection “rewilds” domestic rabbits. The study, published in Nature Ecology and Evolution, helps answer the question of how normally tame rabbits — which have many natural predators — can become a force of ecological destruction when purposefully or accidentally reintroduced to the wild. Here Comes Peter Cottontail Every gardener knows how much of a nuisance rabbits can be, but ...

Scientists find new way global air churn makes particles

2024-07-12
By Leah Shaffer You can think of our atmosphere as a big chemistry set, a global churn of gaseous molecules and particles that constantly bounce off and change each other in complicated ways. While the particles are very small, often less than 1% of the thickness of human hair, they have outsized impacts. For example, particles are the seeds of cloud droplets, and the abundance of the particles changes the reflectivity and the amount of clouds, rainfall and climate. Now, researchers at Washington University in St. ...

Researchers discover a new neural biomarker for OCD

2024-07-12
A recent study from Baylor College of Medicine and Texas Children’s Hospital has identified a specific neural activity pattern as a novel biomarker to accurately predict and monitor the clinical status of individuals with obsessive-compulsive disorder (OCD) who have undergone deep brain stimulation (DBS),  a rapidly emerging therapeutic approach for severe psychiatric disorders. The study, led by led by Drs. Sameer Sheth and Wayne Goodman along with co-lead authors, Drs. Nicole Provenza, ...

Vivid portrait of interacting galaxies marks Webb’s second anniversary

Vivid portrait of interacting galaxies marks Webb’s second anniversary
2024-07-12
Two for two! A duo of interacting galaxies commemorates the second science anniversary of NASA’s James Webb Space Telescope, which takes constant observations, including images and highly detailed data known as spectra. Its operations have led to a “parade” of discoveries by astronomers around the world. “Since President Biden and Vice President Harris unveiled the first image from the James Webb Space Telescope two years ago, Webb has continued to unlock the mysteries of the universe,” said NASA Administrator Bill Nelson. “With remarkable images from the ...

UMass Amherst awarded $2.1 million to advance the science of engagement in community-academic research partnerships

UMass Amherst awarded $2.1 million to advance the science of engagement in community-academic research partnerships
2024-07-12
University of Massachusetts Amherst researcher Thomas Mackie has received a $2.1 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) to advance the meaningful engagement of communities that are affected by mental health disparities and underrepresented in research partnerships. The study, entitled “Improving Research Partnership With Engagement Mapping: A Pilot Study to Advance Engagement Science” and co-led by Karen Tabb, a University of Illinois Urbana-Champaign researcher, is designed to empower community partners to have a greater role ...

With gene editing, mice with a form of inherited deafness can hear again

2024-07-12
Researchers have used gene editing to restore hearing in adult mice with a type of inherited hearing loss. They showed that shutting down a damaged copy of a gene called a microRNA (miRNA) enabled the animals to regain hearing. The approach by a research team supported by the National Institutes of Health (NIH), reported in Science Translational Medicine, may eventually lead to potential treatments for inherited hearing loss in people. Zheng-Yi Chen, DPhil., and his colleagues at Mass Eye and Ear in Boston and other institutions studied a rare form of genetic deafness called autosomal dominant deafness-50 (DFNA50). ...
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