Updated: AAV Treatment Recommendations

2022 update published in the Annals of the Rheumatic Diseases

2023-03-20

(Press-News.org) AAV is a multi-organ disease, which can be complex and may vary from person to person. Types of AAV include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). This variety can make management challenging. Comorbidities, an individual’s history, toxicities, medication availability and cost, and patient preferences should all be considered in the process of informed decision making.

EULAR first wrote recommendations for small and medium vessel vasculitis in 2009; this was subsequently updated in 2016 with more of a focus on AAV. The new 2022 update includes substantial alterations, including the introduction of overarching principles and new recommendations on ANCA-testing, glucocorticoid treatment, the use of agents with novel modes of action, and preventative measures against infection. In addition, new data has allowed the development of some separate recommendations for people with specific AAV subtypes – namely GPA, MPA, and EGPA.

The updated EULAR recommendations were developed by a multidisciplinary task force that included rheumatologists, internists, nephrologists, and methodologists, as well as patient representatives. The information is based on evidence collected from the literature and a survey among the task force members.

The new paper developed by EULAR and published in the March 2023issue of the Annals of the Rheumatic Diseases includes 4 overarching principles and 17 recommendations. The principles say that people with AAV should be offered best care based on shared decision making between the patient and the physician. People with AAV should have access to education so that they understand the impact of their disease, and be able to recognize key symptoms and complications. They also recommend that people with AAV be screened for treatment-related adverse effects and comorbidities, and offered appropriate preventative treatment or lifestyle advice. Finally, the overarching principles stress that AAV are rare, heterogeneous, and potentially life-and organ-threatening diseases which require multidisciplinary management that includes vasculitis experts. The individual recommendations outline the various treatment options for people to induce and maintain remission, depending on their specific diagnosis and manifestations.

One additional key element of these updated recommendations is inclusion of definition of disease activity states. These can vary between different clinical trials, but EULAR recommend these consensus definitions to further understanding and make it easier to compare results. This includes definitions of active disease, remission, relapse, and refractory disease.

EULAR believes that these recommendations will help to streamline the management of people with AAV – while they are not intended to be used as a one-size-fits-all strategy, and may need to be used alongside other recommendations and treatment algorithms, depending on each person’s disease, manifestations, and comorbidities. It is hoped these recommendations will be incorporated into everyday clinical practice to effectively manage AAV and to improve quality of care.

Source
Hellmich B, Sanchez-Alamo B, Schirmer JH, et al. EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update. Annals of the Rheumatic Diseases Published Online First: 16 March 2023. doi: 10.1136/ard-2022-223764

About EULAR
EULAR is the European umbrella organisation representing scientific societies, health professional associations and organisations for people with rheumatic and musculoskeletal diseases (RMDs). EULAR aims to reduce the impact of RMDs on individuals and society, as well as improve RMD treatments, prevention, and rehabilitation. To this end, EULAR fosters excellence in rheumatology education and research, promotes the translation of research advances into daily care, and advocates for the recognition of the needs of those living with RMDs by EU institutions.

Contact
EULAR Communications, communications@eular.org

Notes to Editors
EULAR Recommendations
EULAR School of Rheumatology
EULAR Press Releases

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Updated: AAV Treatment Recommendations

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