PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

New guidance: antibiotics should be halted upon closure of incisions

Medical organizations update strategies for preventing surgical site infections

2023-05-04
(Press-News.org) ARLINGTON, Va. (May 4, 2023) — Antibiotics administered before and during surgery should be discontinued immediately after a patient’s incision is closed, according to updated recommendations for preventing surgical site infections. Experts found no evidence that continuing antibiotics after a patient’s incision has been closed, even if it has drains, prevents surgical site infections. Continuing antibiotics does increase the patient’s risk of C. difficile infection, which causes severe diarrhea, and antimicrobial resistance.

Strategies to Prevent Surgical Site Infections in Acute Care Hospitals: 2022 Update, published in the journal Infection Control and Healthcare Epidemiology, provides evidence-based strategies for preventing infections for all types of surgeries from top experts from five medical organizations led by the Society for Healthcare Epidemiology of America.

“Many surgical site infections are preventable,” said Michael S. Calderwood, MD, MPH, lead author on the updated guidelines and Chief Quality Officer at Dartmouth Hitchcock Medical Center in Lebanon, New Hampshire. “Ensuring that healthcare personnel know, utilize, and educate others on evidence-based prevention practices is essential to keeping patients safe during and after their surgeries.”

Surgical site infections are among the most common and costly healthcare-associated infections, occurring in approximately 1% to 3% of patients undergoing inpatient surgery. Patients with surgical site infections are up to 11 times more likely to die compared to patients without such infections.

Other recommendations:

Obtain a full allergy history from patients who self-report penicillin allergy. Many patients with a self-reported penicillin allergy can safely receive cefazolin, a cousin to penicillin, rather than alternate antibiotics that are less effective against surgical infections. For high-risk procedures, especially orthopedic and cardiothoracic surgeries, decolonize patients with an anti-staphylococcal agent in the pre-operative setting. Decolonization, which was elevated to an essential practice in this guidance, can reduce post-operative S. aureus infections. For patients with an elevated blood glucose level, monitor and maintain post-operative blood glucose levels between 110 and 150 mg/dL regardless of diabetes status. Higher glucose levels in the post-operative setting are associated with higher infection rates. However, more intensive post-operative blood glucose control targeting levels below 110 mg/dL has been associated with a risk of significantly lowering the blood glucose level and increasing the risk of stroke or death. Use antimicrobial prophylaxis before elective colorectal surgery. Mechanical bowel preparation without use of oral antimicrobial agents has been associated with significantly higher rates of surgical site infection and anastomotic leakage. The use of parenteral and oral antibiotics prior to elective colorectal surgery is now considered an essential practice. Consider negative-pressure dressings, especially for abdominal surgery or joint arthroplasty patients. Placing negative-pressure dressings over closed incisions was identified as a new option because evidence has shown these dressings reduce surgical site infections in certain patients. Negative pressure dressings are thought to work by reducing fluid accumulation around the wound. Additional topics covered in the update include specific risk factors for surgical site infections, surveillance methods, infrastructure requirements, use of antiseptic wound lavage, and sterile reprocessing in the operating room, among other guidance.    

Hospitals may consider these additional approaches when seeking to further improve outcomes after they have fully implemented the list of essential practices. The document classifies tissue oxygenation, antimicrobial powder, and gentamicin-collagen sponges as unresolved issues according to current evidence.  

The document updates the 2014 Strategies to Prevent Surgical Site Infections in Acute Care Hospitals. The Compendium, first published in 2008, is sponsored by the Society for Healthcare Epidemiology (SHEA). It is the product of a collaborative effort led by SHEA, with the Infectious Diseases Society of America, the Association for Professionals in Infection Control and Epidemiology, the American Hospital Association, and The Joint Commission, with major contributions from representatives of several organizations and societies with content expertise. The Compendium is a multiyear, highly collaborative guidance-writing effort by over 100 experts from around the world.

Upcoming Compendium updates will cover strategies to prevent catheter-associated urinary tract infections, methicillin-resistant Staphylococcus aureus infections, and implementation strategies for the prevention of healthcare-associated infections. Strategies for preventing central line-associated bloodstream infections, ventilator and non-ventilator associated pneumonia and events, and C. difficile infections as well as strategies to prevent healthcare-associated infections through hand hygiene were updated recently. Each Compendium article contains infection prevention strategies, performance measures, and approaches to implementation. Compendium recommendations are derived from a synthesis of systematic literature review, evaluation of the evidence, practical and implementation-based considerations, and expert consensus.

###

About Infection Control & Hospital Epidemiology
Published through a partnership between the Society for Healthcare Epidemiology of America and Cambridge University Press, Infection Control & Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. ICHE is ranked 24th out of 94 Infectious Disease Journals in the latest Web of Knowledge Journal Citation Reports from Thomson Reuters.

About the Society for Healthcare Epidemiology of America (SHEA) 

The Society for Healthcare Epidemiology of America (SHEA) is a professional society representing more than 2,000 physicians and other healthcare professionals around the world who possess expertise and passion for healthcare epidemiology, infection prevention, and antimicrobial stewardship. The society’s work improves public health by establishing infection-prevention measures and supporting antibiotic stewardship among healthcare providers, hospitals, and health systems. This is accomplished by leading research studies, translating research into clinical practice, developing evidence-based policies, optimizing antibiotic stewardship, and advancing the field of healthcare epidemiology. SHEA and its members strive to improve patient outcomes and create a safer, healthier future for all. Visit SHEA online at shea-online.org, facebook.com/SHEApreventingHAIs and twitter.com/SHEA_Epi.

END



ELSE PRESS RELEASES FROM THIS DATE:

Red flags indicate risk for early-onset colorectal cancer

2023-05-04
Researchers at Washington University School of Medicine in St. Louis have identified four important signs and symptoms that signal an elevated risk of early-onset colorectal cancer. These red flags may be key to earlier detection and diagnosis of early-onset colorectal cancer among younger adults. The number of young adults with colorectal cancer has nearly doubled in recent years. Studying de-identified health insurance data on more than 5,000 patients with early-onset colorectal cancer — cancer that occurs before a person turns 50 — the researchers found that in the period between ...

Reviving exhausted T cells to tackle immunotherapy-resistant cancers

Reviving exhausted T cells to tackle immunotherapy-resistant cancers
2023-05-04
LA JOLLA, CALIF. – May 03, 2023 – When the cells of our immune system are under constant stress due to cancer or other chronic diseases, the T cells of the immune system shut down in a process called T cell exhaustion. Without active T cells, which kill tumor cells, it’s impossible for our bodies to fight back against cancer. One of the biggest goals of immunotherapy is to reverse T cell exhaustion to boost the immune system’s ability to destroy cancerous cells. Researchers at Sanford Burnham Prebys studying melanoma have found a new way to make this ...

MD Anderson researchers Helen Piwnica-Worms and Richard Wood elected to National Academy of Sciences

MD Anderson researchers Helen Piwnica-Worms and Richard Wood elected to National Academy of Sciences
2023-05-03
HOUSTON ― Two researchers from The University of Texas MD Anderson Cancer Center have been elected to the prestigious National Academy of Sciences (NAS). Helen Piwnica-Worms, Ph.D., professor of Experimental Radiation Oncology, and Richard Wood, Ph.D., professor of Epigenetics and Molecular Carcinogenesis, are recognized for their respective contributions to advancing our understanding of cancer genetics, biochemistry and cell biology. Piwnica-Worms and Wood are among 120 new members ...

Purdue startup Aerovy Mobility develops cloud software to support infrastructure for electric aircraft

Purdue startup Aerovy Mobility develops cloud software to support infrastructure for electric aircraft
2023-05-03
WEST LAFAYETTE, Ind. – The advanced air mobility sector, which includes electric-powered urban and regional aircraft, may become a $1.5 trillion market by 2040. A new Purdue University-connected startup could benefit airport and vertiport operators and real estate developers looking to establish advanced air mobility technology at existing and potential sites. Purdue University postgraduate students have launched Aerovy Mobility, a startup company that commercializes cloud-based software solutions to plan and operate infrastructure ...

Retinol disruption and the role of vitamin a metabolism in colon cancer

Retinol disruption and the role of vitamin a metabolism in colon cancer
2023-05-03
“Retinoids are known to inhibit tumor-promoting IL-6 production.” BUFFALO, NY- May 3, 2023 – A new research perspective was published in Oncotarget's Volume 14 on April 26, 2023, entitled, “Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism.” Colon cancer (CRC) is one of the most common malignancies and is a leading cause of cancer-related deaths worldwide. While the tumor microenvironment (TME) supports tumor growth and immune escape through tumor-promoting ...

INRS celebrates the careers of two eminent researchers

INRS celebrates the careers of two eminent researchers
2023-05-03
INRS' graduation ceremony will be a wonderful event again this year! In addition to the175 students who will be receiving their master’s or doctorate degrees, two distinguished scholars will be honoured. During the 2023 ceremony, the Institut national de la recherche scientifique (INRS) is pleased to announce that it will be awarding two honorary doctorates. Researchers Jamal Deen, an expert in electrical engineering and applied physics and a professor at McMaster University, and Mordechai (Moti) Segev, a professor ...

Disparities in telehealth utilization among Medicare beneficiaries

Disparities in telehealth utilization among Medicare beneficiaries
2023-05-03
A new study of telehealth utilization among Medicare beneficiaries in Arkansas showed race/ethnicity and rural/urban disparities. The study, which reported that the association between the number of chronic conditions and telehealth was strongest among White and rural beneficiaries, is published in the peer-reviewed journal Telemedicine and e-Health. Click here to read the article now. Innovative technologies such as telehealth can improve health care access in underserved areas and in aging populations with growing and complex medical needs. However, the use of telecommunications in clinical settings faces ...

Moffitt researchers develop CAR T cells that fight prostate cancer in bone

2023-05-03
TAMPA, Fla. – Prostate cancer frequently metastasizes to the bone and is incurable. Moffitt Cancer Center researchers are working to identify new treatment options for this subset of patients. In a new article published today in Science Advances, a team of Moffitt scientists demonstrates that chimeric antigen receptor T-cell (CAR T) therapy is an effective antitumor approach in mouse models of bone metastatic prostate cancer. “Bone metastatic prostate cancer is an incurable disease that significantly impacts patient ...

Journal of Dental Research to publish special issue on aging and oral health

2023-05-03
Alexandria, VA, USA – The International Association for Dental Research (IADR) and American Association for Dental, Oral, and Craniofacial Research (AADOCR) have announced the publication in July 2023 of a Special Issue of Journal of Dental Research (JDR) entitled, “Aging and Oral Health.” It will feature Bei Wu, New York University, USA and Ana Paula Vieira Colombo, Federal University of Rio de Janeiro, Brazil as Guest Editors. Several articles that will be included in the issue are currently available for viewing Online First at the JDR website, including:    Diabetes, Edentulism, and Cognitive Decline: ...

Rapid onsite FFR-CT algorithm helps facilitates clinical adoption

Rapid onsite FFR-CT algorithm helps facilitates clinical adoption
2023-05-03
Leesburg, VA, May 3, 2023—According to an accepted manuscript published in ARRS’ own American Journal of Roentgenology (AJR), a high-speed onsite deep-learning based fractional flow reserve (FFR)-CT algorithm yielded excellent diagnostic performance for the presence of hemodynamically significant stenosis, with both high interobserver and intraobserver reproducibility. “A rapid and accurate onsite approach for determining FFR-CT should address challenges encountered in the clinical ...

LAST 30 PRESS RELEASES:

People who are autistic and transgender/gender diverse have poorer health and health care

Gene classifier tests for prostate cancer may influence treatment decisions despite lack of evidence for long-term outcomes

KERI, overcomes the biggest challenge of the lithium–sulfur battery, the core of UAM

In chimpanzees, peeing is contagious

Scientists uncover structure of critical component in deadly Nipah virus

Study identifies benefits, risks linked to popular weight-loss drugs

Ancient viral DNA shapes early embryo development

New study paves way for immunotherapies tailored for childhood cancers

Association of waist circumference with all-cause and cardiovascular mortalities in diabetes from the National Health and Nutrition Examination Survey 2003–2018

A new chapter in Roman administration: Insights from a late Roman inscription

Global trust in science remains strong

New global research reveals strong public trust in science

Inflammation may explain stomach problems in psoriasis sufferers

Guidance on animal-borne infections in the Canadian Arctic

Fatty muscles raise the risk of serious heart disease regardless of overall body weight

HKU ecologists uncover significant ecological impact of hybrid grouper release through religious practices

New register opens to crown Champion Trees across the U.S.

A unified approach to health data exchange

New superconductor with hallmark of unconventional superconductivity discovered

Global HIV study finds that cardiovascular risk models underestimate for key populations

New study offers insights into how populations conform or go against the crowd

Development of a high-performance AI device utilizing ion-controlled spin wave interference in magnetic materials

WashU researchers map individual brain dynamics

Technology for oxidizing atmospheric methane won’t help the climate

US Department of Energy announces Early Career Research Program for FY 2025

PECASE winners: 3 UVA engineering professors receive presidential early career awards

‘Turn on the lights’: DAVD display helps navy divers navigate undersea conditions

MSU researcher’s breakthrough model sheds light on solar storms and space weather

Nebraska psychology professor recognized with Presidential Early Career Award

New data shows how ‘rage giving’ boosted immigrant-serving nonprofits during the first Trump Administration

[Press-News.org] New guidance: antibiotics should be halted upon closure of incisions
Medical organizations update strategies for preventing surgical site infections