(Press-News.org) St. Jude Children’s Research Hospital scientist Madan Babu Mohan, Ph.D., Center of Excellence in Data-Driven Discovery director and member of the Department of Structural Biology, has been elected a Fellow of the Royal Society of London. The Royal Society is the oldest scientific academy in continuous existence.
Babu was selected to join the Royal Society for his pioneering data science-based strategies to reveal fundamental principles in biological systems. His scientific accomplishments include determining the molecular mechanisms governing G-protein-coupled receptor (GPCR) signaling, uncovering the roles of disordered protein regions in biology and disease, and establishing genome-scale principles of gene regulation.
One-third of all Food and Drug Administration-approved drugs target GPCRs, membrane proteins found on the surface of cells. Babu’s work has shown how genetic and isoform variability of GPCRs can influence drug responses. His most recent work investigated how GPCR selectivity for G-proteins is determined. Understanding this family of proteins is of tremendous interest to the development of novel therapeutics.
“I am honored for our work to receive this recognition,” Babu said. “The science we have achieved is possible because of long-term support for fundamental research and the collaborative environment at St. Jude and the MRC Laboratory of Molecular Biology in Cambridge, England. I am grateful for the many contributions of my past and current colleagues, as well as my mentors and family.”
“Dr. Babu’s election to the Royal Society is well-earned, and we are all honored to call him a colleague,” said James R. Downing, M.D., president and CEO of St. Jude. “His investigations of GPCRs have the potential to have profound implications for pharmaceutical development. Through these discoveries, we can advance cures for pediatric cancer and other catastrophic diseases.”
“I am delighted to welcome our newest cohort of Fellows,” said Sir Adrian Smith, President of the Royal Society. “They are pioneering scientists and innovators from around the world who have confounded expectations and transformed our thinking.”
Founded in the 1660s, the Royal Society is an independent scientific academy of the U.K. and the Commonwealth. Its Fellows have included many of the world’s most eminent scientists and technologists, representing a range of personalities, from Sir Isaac Newton and Benjamin Franklin to Dorothy Hodgkin and Robert Webster (St. Jude Infectious Diseases, emeritus).
This year sees 59 Fellows, 19 Foreign Members and two Honorary Fellows elected. Babu’s fellow U.S.-based new Fellows and Foreign Members include researchers at Google DeepMind, Harvard University, the Howard Hughes Medical Institute, the Institute for Advanced Study, Stanford University and the University of Chicago.
Babu joined the faculty of St. Jude in 2020, following a 14-year tenure as a program leader at the MRC Laboratory of Molecular Biology in Cambridge, England. He earned his Ph.D. in computational genomics from Cambridge University and his undergraduate degree from Anna University, Chennai, India. Babu completed a postdoctoral fellowship with the National Institutes of Health, Bethesda, Maryland.
St. Jude Children’s Research Hospital
St. Jude Children's Research Hospital is leading the way the world understands, treats and cures childhood cancer, sickle cell disease, and other life-threatening disorders. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. Treatments developed at St. Jude have helped push the overall childhood cancer survival rate from 20% to 80% since the hospital opened more than 60 years ago. St. Jude shares the breakthroughs it makes to help doctors and researchers at local hospitals and cancer centers around the world improve the quality of treatment and care for even more children. To learn more, visit stjude.org, read St. Jude Progress blog, and follow St. Jude on social media at @stjuderesearch.
END
St. Jude scientist M. Madan Babu elected to the Royal Society of London
Director of the Center of Excellence for Data-Driven Discovery at St. Jude Children’s Research Hospital named a Fellow of the leading, 360-year-old British scientific organization.
2023-05-10
ELSE PRESS RELEASES FROM THIS DATE:
Sleep-tracker study finds fatigued officers struggle with investigations
2023-05-10
AMES, IA — Like many first responders, law-enforcement investigators and detectives often struggle with sleep. Late-night shifts, stress, and the 24-hour nature of crime can throw off biological clocks and cut sleep cycles short. Along with the negative health implications, new research indicates officers who are fatigued have a harder time collecting information that could bring justice to victims.
Zlatan Križan, a sleep scientist and psychology professor at Iowa State University, led the study. He ...
Cheese experiments show fungal antibiotics can influence microbiome development
2023-05-10
Washington, DC – Fungi produce metabolites that humans have used to improve health. For example, they secrete penicillin, which is then purified and used as an antibiotic for humans, leading to the development of many other antibiotics. However, the ecology of fungal metabolites in microbial communities is not well understood. In a new study, researchers use cheese rinds to demonstrate that fungal antibiotics can influence how microbiomes develop. The study is published in mBio, an open-access journal of the American Society for Microbiology.
“My lab is interested in how ...
Broad climate change concern in Florida linked with recent extreme weather
2023-05-10
An increasing number of Floridians agree that human actions are causing climate change, including a record number of Florida Republicans, according to a new survey from Florida Atlantic University. This finding reinforces the trend observed in the prior seven Florida Climate Resilience Surveys, conducted by FAU’s Center for Environmental Studies within the Charles E. Schmidt College of Science.
Three main messages emerge from this latest poll. First, climate change is no longer an effective partisan wedge issue. Virtually all respondents (90 percent) ...
Niraula wins 2023 Endocrine Images Art Competition
2023-05-10
WASHINGTON—Anzela Niraula, Ph.D., of the University of Washington in Seattle, won the Endocrine Society's 2023 Endocrine Images Art Competition for her image of the microglia mandala.
This contest celebrates the beauty of endocrine science, and entries were judged based on aesthetic value and significance to endocrine research.
Niraula’s image of the microglia won the grand prize this year out of more than 25 entries. The image shows microglia and POMC neurons in close proximity within the arcuate nucleus of the hypothalamus. Microglial regulation of POMC neurons holds significant implications ...
Looking to introduce a new brand extension? Be sure to leverage the brand equity of the parent brand as well as the extension fit
2023-05-10
Researchers from University of International Business and Economics, University of Groningen, University of Cologne, and University of Chinese Academy of Sciences published a new Journal of Marketing article that examines the drivers of brand extension success.
The study, forthcoming in the Journal of Marketing, is titled “A Meta-Analysis of Brand Extension Success: The Effects of Parent Brand Equity and Extension Fit” and is authored by Chenming Peng, Tammo H.A. Bijmolt, ...
Why buses can’t get wheelchair users to most areas of cities
2023-05-10
COLUMBUS, Ohio – Imagine you could travel to only 1% of the city where you live – areas that were easily accessible to other residents.
That’s the situation for manual wheelchair users traveling by public buses in Columbus, a first-of-its-kind study finds. The situation for those with powered wheelchairs is only somewhat better – the study found they have access to about 25% of the areas available to the general bus ridership.
But the main problem isn’t with the bus system itself – the key obstacle is with the sidewalks and other infrastructure that wheelchair users need to get from ...
Historic $100 million gift to Brigham and Women’s Hospital to establish Institute of Immunology and Inflammation of the Brigham, Massachusetts General Hospital, and Harvard Medical School
2023-05-10
Brigham and Women’s Hospital, a founding member of Mass General Brigham, today announces a historic $100 million gift from eminent biotechnology entrepreneur Gene Lay, MS, DVM, founder and CEO of BioLegend, Inc., through the Laygend Foundation. The landmark gift—the largest in the Brigham’s history—will establish The Gene Lay Institute of Immunology and Inflammation of Brigham and Women’s Hospital, Massachusetts General Hospital (MGH), also a founding member of Mass General Brigham, and Harvard Medical School (HMS). Vijay Kuchroo, DVM, PhD, an immunologist and principal investigator at the Brigham, will serve as inaugural director of the institute, which will be ...
Oxygen therapy improves heart function in patients with long COVID
2023-05-10
Barcelona, Spain – 10 May 2023: A small randomised trial in patients with post-COVID syndrome has found that hyperbaric oxygen therapy promotes restoration of the heart’s ability to contract properly. The research is presented at EACVI 2023, a scientific congress of the European Society of Cardiology (ESC).1
“The study suggests that hyperbaric oxygen therapy can be beneficial in patients with long COVID,” said study author Professor Marina Leitman of the Sackler School of Medicine, Tel Aviv University and Shamir Medical Centre, Be'er Ya'akov, Israel. “We used a sensitive measure of cardiac function which is ...
One step closer to eliminating latency, the real challenge in combating HIV
2023-05-10
An international study led by MELIS-UPF researchers from the Infection Biology and Molecular Virology laboratories has identified and characterized Schlafen 12 (SLFN 12) as a novel HIV restriction factor. SLFN 12 shuts down viral protein production and helps virus-infected cells to escape from anti-HIV therapy and immune responses. These findings pave the way for improving therapeutic strategies that aim to cure HIV infections.
Human Immunodeficiency Virus (HIV) infections, if left untreated, lead to the gradual destruction of the immune system, AIDS, in its final stages. Worldwide, some 650,000 ...
Delivery of antioxidants to liver mitochondria
2023-05-10
A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.
Mitochondria are microscopic organelles found within cells, and are well-known as the “powerhouse of the cell.” They are by far the largest producer of the molecule adenosine triphosphate (ATP), which provides energy to many processes in living cells. The process by which mitochondria synthesize ATP generates a large amount of reactive oxygen species (ROS), chemical groups that are highly reactive.
In a healthy cell, the ROS are controlled by the mitochondria; however, when this balance is lost, the excess ROS damages the mitochondria ...
LAST 30 PRESS RELEASES:
Novel self-cleaning electrode developed for alkaline-earth metal peroxide synthesis
New report demands greater understanding of the impact of change on academia
Discovery of key mechanism in Huntington’s Disease could pave the way for early detection and treatment
Humans and AI: Do they work better together or alone?
Childhood attention issues and genetic factors may predict psychosis risk
Amsterdam UMC study proves impact of rapid first shock after cardiac arrest
Children’s BMI can affect their future lung function
Don't worry. Study shows you're likely a more creative writer than ChatGPT. For now
Heart failure mortality declining in Sweden
Understanding how mutations affect diseases
Quality control in artificial photosynthesis: validating natural antenna mimicry
When science speaks in extremes
Will the ocean suffer an epidemic?
A single thin film perfectly absorbs all electromagnetic waves!
Teens who made history with Pythagoras’ theorem discovery publish their first academic paper with new proofs
More social species live longer, Oxford study finds
Magicians don’t mind sharing the secrets behind tricks – if they are their own
No incentive for older birds to make new friends
Development and validation of a new prognostic model for predicting survival outcomes in patients with acute-on-chronic liver failure
Identification and validation of the Hsa_circ_0001726/miR-140-3p/KRAS axis in hepatocellular carcinoma based on microarray analyses and experiments
New study warns that melting Arctic sea-ice could affect global ocean circulation
Researchers test imlifidase enzyme versus plasma exchange in removing donor-specific antibodies in kidney transplant rejection trial
Preclinical studies test novel gene therapy for treating IgA nephropathy
Trial assesses antibody therapy for chronic active antibody-mediated kidney transplant rejection
High-impact clinical trials generate promising results for improving kidney health: Part 2
Expression of carbonic anhydrase IX as a novel diagnostic marker for differentiating pleural mesothelioma from non-small cell lung carcinoma
In silico assessment of photosystem I P700 chlorophyll a apoprotein A2 (PsaB) from Chlorella vulgaris (green microalga) as a source of bioactive peptides
Association between TLR10 rs10004195 gene polymorphism and risk of Helicobacter pylori infection
The usefulness of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in the diagnosis of onychomycosis in patients with nail psoriasis
Liver characterization of a cohort of alpha-1 antitrypsin deficiency patients with and without lung disease
[Press-News.org] St. Jude scientist M. Madan Babu elected to the Royal Society of LondonDirector of the Center of Excellence for Data-Driven Discovery at St. Jude Children’s Research Hospital named a Fellow of the leading, 360-year-old British scientific organization.