Novel virtual coronary roadmap tool reduces volume of iodinated contrast needed during percutaneous coronary interventions

Global, randomized controlled trial demonstrates dynamic coronary roadmap may increase PCI safety

2023-05-18

(Press-News.org) Phoenix, AZ (May 18, 2023)- Results from Dynamic Coronary Roadmap for Contrast Reduction (DCR4Contrast), a multi-center prospective, unblinded, randomized controlled trial were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions. The trial found that Dynamic Coronary Roadmap (DCR), a percutaneous coronary intervention (PCI) navigation support tool developed by health technology company Philips, effectively reduces iodinated contrast during PCI.

Iodinated contrast is used to enhance the ability to see blood vessels and organs during medical imaging and during procedures like PCI. Contrast induced nephropathy (CIN) is a serious complication during PCI which leads to a sharp decrease in kidney function over 48-72 hours and has similar symptoms as kidney disease. The incidence of CIN for patients undergoing PCI ranges from three to twenty percent, depending on patient co-morbidities.

In a multi-center, prospective, unblinded, stratified 1:1 randomized controlled trial, DCR4Contrast enrolled 371 patients from six centers in the U.S, Belgium, Israel and Spain. Patients undergoing PCI were randomized to either DCR- or conventional angiographic guidance. Investigators scored the overall quality (representation of the coronary artery tree is complete) and accuracy (location of the roadmap is in the correct location during majority of the procedure) of the roadmap during PCI.

The roadmap was used in 98% of the cases in the DCR arm. The quality of the roadmap was rated very good or good in 79% of cases which resulted in a related reduction in contrast volume. Compared to the control arm, there was a 28.8% reduction in contract used during PCI using DCR.

“We are encouraged by the contrast-sparing effect our study demonstrated and points to DCR as a potential solution to reduce the risk of CIN during a PCI, which has the potential to increase patient safety,” said John C. Messenger, MD, FSCAI, Professor of Medicine, Director, Interventional Cardiology at the University of Colorado School of Medicine University of Colorado Hospital Aurora, CO and lead author of the study. “Looking ahead, DCR could also have potential applications in Ultra Low Contrast PCI for complex procedures. We are excited to see the further capabilities and use of this software.”

The secondary endpoint results follow the primary endpoints presentation at EuroPCR 2023 on Tuesday, May 16.

Session Details:

“Real-world evaluation of the feasibility and quality of PCI guidance using Dynamic Coronary Roadmap: A secondary analysis of the DCR4Contrast Multicenter, International Randomized Control Trial” [Thursday, May 18, 2023, 4:30 – 5:30 PM MST, West 103, First Floor, Phoenix Convention Center]

About SCAI:

The Society for Cardiovascular Angiography & Interventions (SCAI) is a non-profit professional association with over 4,500 members representing interventional cardiologists and cardiac catheterization teams in the United States. SCAI promotes excellence in interventional cardiovascular medicine for both adults and children through education, representation, and the advancement of quality standards to enhance patient care.

For more information about the SCAI 2023 Scientific Sessions, visit https://scai.org/scai-2023-scientific-sessions. Follow @SCAI on Twitter for the latest heart health news and use #SCAI2023 to follow the latest discussions.

END

ELSE PRESS RELEASES FROM THIS DATE:

First-of-its-kind study confirms safety of distal radial artery access for cardiac catheterization

2023-05-18

Phoenix, AZ (May 18, 2023)- One-year findings from the Distal versus Proximal Radial Artery Access for Cardiac Catheterization and Intervention (DIPRA) study were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions. The single-center, randomized-controlled trial evaluated outcomes of hand function and effectiveness of conventional proximal radial artery (PRA) access compared to distal radial artery (DRA) access for cardiac catheterization. Current guidelines for patients undergoing percutaneous intervention recommend PRA access. A complication of PRA is radial artery occlusion, ...

Historical memories have long reach in consumer preferences, study finds

2023-05-18

Toronto - Zachary Zhong had heard his grandparents’ stories about the Japanese invasion in 1944 of neighbouring counties in his hometown in China. As the Japanese army continued their advance civilians were killed and injured, while others fled the invaders’ path, some taking shelter in his family’s ancestral home. Those events lodged deep into locals’ memory. Curious about the impact of a re-ignited territorial dispute between Japan and China in 2012, Zhong, now an assistant professor of marketing at the University of Toronto’s Rotman School of Management looked at what happened to car sales in the province of Guangxi around ...

Forgetfulness, even fatal cases, can happen to anyone, study shows

2023-05-18

Since 1998, approximately 496 children have died of pediatric vehicular heatstroke in the United States because their caregiver forgot they were in the car, according to recent data from NoHeatStroke.org. Advocacy groups have been lobbying Congress to enact laws to help protect against this particular forgetfulness by requiring certain safety mechanisms be installed into automobiles. Researchers at the University of Notre Dame set out to understand how and why this kind of forgetfulness is even possible. Nathan Rose, the William P. and Hazel ...

FSU researchers analyze carbon sequestration in California Current Ecosystem

2023-05-18

Florida State University researchers have analyzed the carbon exported from surface waters of the California Current Ecosystem — the first-ever study to quantify the total carbon sequestration for a region of the ocean. The study, published in Nature Communications, serves as a framework for assessing how the processes that sequester carbon might change in a warmer world, while also creating a blueprint for similar budgets in other ocean regions. Understanding the carbon cycle — the sources and reservoirs of carbon — is an important focus of Earth sciences. Many studies have examined the carbon sequestered ...

Smart material prototype challenges Newton’s laws of motion

2023-05-18

COLUMBIA, Mo. – For more than 10 years, Guoliang Huang, the Huber and Helen Croft Chair in Engineering at the University of Missouri, has been investigating the unconventional properties of “metamaterials” — an artificial material that exhibits properties not commonly found in nature as defined by Newton’s laws of motion — in his long-term pursuit of designing an ideal metamaterial. Huang’s goal is to help control the “elastic” energy waves traveling through larger structures — such as an aircraft — without light and small “metastructures.” “For ...

MSU researchers uncover the hidden complexity of the Montmorency tart cherry genome

2023-05-18

Highlights: Michigan State University researchers sequenced the Montmorency tart cherry genome for the first time. This will have a major impact on all future tart cherry research and breeding efforts worldwide. Michigan is the nation’s leading producer of tart cherries. EAST LANSING, Mich. – Since Michigan is the nation's leading producer of tart cherries, Michigan State University researchers were searching for the genes associated with tart cherry trees that bloom later in the season to meet the needs of a changing climate. They started by comparing DNA sequences from late-blooming ...

Historical fiction: a guarantee of critical success or a trap? 

2023-05-18

For 21st century authors, the odds of writing a critical hit are much higher if the novel takes place in the past, not the present or future. Between 2000 and 2020, about three quarters of the novels shortlisted for the National Book Award, the Pulitzer Prize, and the National Book Critics Circle Award took place in the historical past. “As a reader, you may not have even noticed the growing infatuation with history in literature because the historical novel has become such a diversely practiced form by such a wide array of writers, it's almost become invisible to us as a genre in itself,” ...

Using 3D printing to improve implantable biomedical devices, touchscreens and more

2023-05-18

McGill researchers are exploring a new technique that uses 3D printing and hydrogels. It has the potential not only to improve biomedical implants but could also be useful in the development of human-machine interfaces such as touch screens and neural implants. Biomedical devices like pacemakers or blood pressure sensors that are implanted into the human body need to be fabricated in such a way that they conform and adhere to the body – and then dissolve at the right time. Using 3D printing and hydrogel technology, researchers in McGill University’s Department of Engineering ...

Amputees feel warmth in their missing hand

2023-05-18

“When I touch the stump with my hand, I feel tingling in my missing hand, my phantom hand. But feeling the temperature variation is a different thing, something important... something beautiful,” says Francesca Rossi. Rossi is an amputee from Bologna, Italy. She recently participated in a study to test the effects of temperature feedback directly to the skin on her residual arm. She is one of 17 patients to have felt her phantom, missing hand, change in temperature thanks to new EPFL technology. More importantly, she reports feeling reconnected to her missing hand. “Temperature feedback is a nice ...

In years after El Niño, global economy loses trillions

2023-05-18

In the years it strikes, the band of warm ocean water spanning from South America to Asia known as El Niño triggers far-reaching changes in weather that result in devastating floods, crop-killing droughts, plummeting fish populations, and an uptick in tropical diseases. With El Niño projected to return this year, Dartmouth researchers report in the journal Science that the financial toll of the recurring climate pattern can persist for several years after the event itself—and cost trillions in lost income worldwide. The study is among the first to evaluate the long-term costs of El Niño and projects losses that far exceed ...

LAST 30 PRESS RELEASES:

Need for psychology referrals increasing for children with food allergies

Anaphylaxis treatment remains confusing for patients, caregivers and emergency personnel

Penicillin allergy delabeling in syphilis patients assists in furthering treatment

Burning incense can pose health risks for those with allergies and asthma

Study: Parents’ understanding of atopic dermatitis may influence child’s diet

Vaccine refusal lower in minorities in new study

Risk of developing EoE high when other allergic conditions factored in

Study shows rates of sensitization in Chicago to outdoor allergens increased post-COVID

Phase Two results with CRISPR-Cas9 gene editing support further development as treatment for hereditary angioedema (HAE)

Take aim at the pause!

Pistachios may help improve eye health, new study finds

Transcriptomic landscape analysis reveals a persistent DNA damage response in metabolic dysfunction-associated steatohepatitis post-dietary intervention