(Press-News.org) A new analysis of SURMOUNT-1, the first Phase 3 study of tirzepatide in adults for chronic weight management shows that tirzepatide improves body composition across a range of adult age groups. The analysis is presented by Dr Louis Aronne, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, New York, USA, and colleagues.
The efficacy and safety of tirzepatide, a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, in people with obesity was investigated in SURMOUNT-1, the complete trial for which was published in NEJM in July 2022.
GIP and GLP-1 are hormones that are involved in blood sugar control and body weight regulation. After a person has eaten, these hormones are secreted by cells of the intestines and in turn cause the secretion of insulin. Tirzepatide activates both the GLP-1 and GIP receptors, leading to improved blood sugar control and enhanced satiety.
Tirzepatide is approved in the USA and the European Union to treat type 2 diabetes, but is not yet approved for obesity treatment in any country. The manufacturer of tirzepatide, Eli Lilly and Company, intends to seek approval for the drug as an obesity treatment from the US Food and Drug Administration (FDA), the European Union, and other territories beginning in 2023.
In this phase 3, double-blind, randomised, controlled trial, 2539 adults with BMI of 30 kg/m² or higher (with obesity), or 27 to 30 kg/m² (with overweight) with at least one weight-related complication, excluding diabetes, were assigned to receive once-weekly, subcutaneous tirzepatide (5 mg, 10 mg, or 15 mg) or placebo for 72 weeks. The percent change from baseline body weight and proportion of participants with body weight reduction of at least 5% were assessed across BMI categories: 27 to <30 (overweight), 30 to 35 (Class 1 obesity), 35 to 40 (Class 2 obesity), and 40 kg/m² and over (Class 3 obesity).
Body composition was evaluated in a subpopulation that underwent dual-energy x-ray absorptiometry. This new post-study analysis assessed change from baseline body composition within age subgroups under 50 years (n=99), 50 to 64.9 years (n=41), and 65 years and older (n=20).
Fat mass was reduced 33-36% and lean mass 10-11% depending upon age group. Thus, only one-quarter of the weight lost was lean mass, as has been observed in trials of diet and physical activity, resulting in an overall improvement in body composition. Across the age subgroups (under 50 years, 50 to 64.9 years, and 65 years and over), the change was almost identical, indicating no evidence of excess lean mass loss in older age groups.
The other published results from SURMOUNT-1 can be seen in the abstract link below and the full paper published in NEJM.
The authors conclude: “In this 72-week trial in participants with obesity, tirzepatide once weekly provided substantial reductions in body weight, consistent across all BMI categories, with improvement in body composition that was clinically meaningful and consistent across age groups.”
Dr. Aronne adds: “Obesity is a chronic disease, like diabetes, hypertension, and the many other illnesses caused by obesity. The fact that chronic treatment is required is not surprising, and should be expected. It is relevant to understand the effect of weight loss on fat mass and lean mass, particularly in the elderly. This new analysis shows that around three quarters of the weight lost was fat mass, which is consistent across different ages."
Dr Louis Aronne, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, New York, USA. Please e-mail first to arrange interview. E) ljaronne@med.cornell.edu
Tony Kirby in ECO Media Centre T) +44 7834 385827 E) tony.kirby@tonykirby.com
Conflicts of interest: Dr Aronne is a consultant to Eli-Lilly and investigator on Surmount -1 and other trials of tirzepatide. He also has other industry relationships to manufacturers of diabetes and obesity medications.
This press release is based on late breaking oral abstract AD09.02 at the European Congress on Obesity (ECO). The material has been peer reviewed by the congress selection committee. There is no full paper at this stage. As it is an oral presentation, there is no poster.
END
New analysis shows improved body composition with tirzepatide is consistent across adult age groups with overweight or obesity
2023-05-19
ELSE PRESS RELEASES FROM THIS DATE:
Whole body cryostimulation may be a useful extra treatment for obesity
2023-05-19
Whole body cryostimulation is a useful “add-on” treatment for obesity, research being presented at the European Congress on Obesity (ECO) in Dublin, Ireland (17-20 May) suggests.
Levels of cholesterol and other blood fats improved twice as much in individuals living with obesity who were exposed to extreme cold for a short period of time, compared with individuals given a sham treatment.
Those who had whole body cryostimulation (WBC) also experienced a greater reduction in waist circumference and in blood sugar levels.
Dr Jacopo Fontana, of the Istituto Auxologico ...
Boys need ‘lessons in bromance’ to tackle mental health crisis in schools
2023-05-19
Teenage boys are twice as likely as girls to die by suicide, and, when boys become men, they are three times more likely than women to die by suicide.
After years on the frontline of teaching and observing, first-hand, a decline in teenage mental health, a teacher has warned that we need to deal better with male anger, friendships, and attitudes towards sex in order to combat the male suicide crisis.
Official statistics for England, Scotland, and Wales show that in 2020, 264 people aged 10–19 died by suicide – 72% of these were boys. In England, suicide is the single biggest killer of men under ...
A ribosomal traffic jam that breaks the heart
2023-05-19
Fukuoka, Japan—A team of researchers have discovered that a mutation in a ribosomal protein found specifically in heart and skeletal muscle leads to impaired cardiac contractility in mice.
The mutation was found to delay the rate of translating mRNA, leading to ribosomes colliding and causing protein folding abnormalities. The abnormal proteins would then be targeted and degraded by the cell's quality control system. Moreover, while the deficiency in the ribosomal protein, known as RPL3L, altered translation dynamics for the entire tissue, ...
Illinois Tech project receives $1.6 million contract to develop system for authorship attribution and anonymization
2023-05-18
CHICAGO—May 18, 2023—Researchers at Illinois Institute of Technology have secured a $1.6 million contract to develop a groundbreaking system for authentic authorship attribution and anonymization. Using natural language processing and machine learning, the program, known as AUTHOR, promises to create “stylistic fingerprints” for reliable identification, while also providing robust solutions for anonymization. With broad applications including counterintelligence, combating misinformation, and even investigating the origins of ancient religious texts, the project marks a significant leap in computational analysis.
The project—a collaboration ...
Wayne State University receives grant to address health care and costs in state prisons
2023-05-18
DETROIT – Wayne State University faculty member Rodlescia Sneed, Ph.D. has been awarded a five-year Career Development grant from the National Institute on Aging of the National Institutes of Health. Sneed joined the Institute of Gerontology at WSU in 2022 as an assistant professor jointly appointed with the Department of Psychology in the College of Liberal Arts and Sciences. The nearly $600,000 award, Maximizing the Scalability of the Chronic Disease Self-Management Program (CDSMP) Among Older Adults in State Correctional Settings, is aimed to deepen her training ...
Catching foodborne illness early
2023-05-18
Produce such as lettuce and spinach is routinely tested for foodborne pathogenic bacteria like salmonella, listeria monocytogenes and pathogenic types of E. coli in an effort to protect consumers from getting sick.
Rapid testing of foods may occur, but it still takes time to figure out who is sick and from where the contaminated product originated. That’s far too late for the many Americans who already ate the produce. The current solution, often a multi-state recall, then becomes damage control.
University of Delaware researchers want to spot these bacteria before anyone ever falls ill. As detailed in an article published ...
NASA releases new solar eclipse educational materials
2023-05-18
To help learners of all ages understand how to safely observe the Oct. 14, 2023, annular solar eclipse and the April 8, 2024, total solar eclipse, NASA has released a new set of resources for educators.
My NASA Data, in collaboration with the NASA Heliophysics Education Activation Team (NASA HEAT), has released a new set of resources for educators centered around solar eclipses. My NASA Data allows students in grades 3 through 12 and their teachers to analyze and interpret NASA mission data. It also supports educators in the integration of authentic Earth systems data into their instruction.
The My NASA Data solar eclipse ...
Study reveals novel action mechanism of corticosteroids in combating inflammation caused by COVID-19
2023-05-18
Since the start of the COVID-19 pandemic, a class of corticosteroids called glucocorticoids (GCs) have become established as one of the main treatment options, especially for severe cases, thanks to their anti-inflammatory and immunosuppressant action. Brazilian researchers recently discovered new ways in which these drugs influence the organism’s inflammatory response during an infection: they raise levels of endocannabinoids (eCBs), molecules produced by the organism itself and that bind to the same receptor as cannabidiol; and they lower blood levels of platelet-activating factor (PAF), a lipidic mediator of inflammation and clotting.
The ...
Study: Wildfire spread risk increases where trees, shrubs replace grasses
2023-05-18
Across the United States over the past decade, an average of over 61,000 wildfires have burned some 7.2 million acres per year. Once a wildfire starts spreading, the firefighting task is exacerbated by issues like spot fires, where winds carry lofted sparks and start new fires outside of the original fire perimeter. The greater the potential spot fire distance, the more difficult wildfires are to monitor, control and suppress.
A new study, led by University of Florida forest management researcher Victoria Donovan, found that as woody ...
Novel virtual coronary roadmap tool reduces volume of iodinated contrast needed during percutaneous coronary interventions
2023-05-18
Phoenix, AZ (May 18, 2023)- Results from Dynamic Coronary Roadmap for Contrast Reduction (DCR4Contrast), a multi-center prospective, unblinded, randomized controlled trial were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions. The trial found that Dynamic Coronary Roadmap (DCR), a percutaneous coronary intervention (PCI) navigation support tool developed by health technology company Philips, effectively reduces iodinated contrast during PCI.
Iodinated contrast is used to enhance the ability ...