The aging mouse prostate: kinetics of lymphocyte infiltration
2023-05-23
(Press-News.org)
“This dataset presents the most comprehensive profiling of the aging adult mouse prostate immune profile to date.”
BUFFALO, NY- May 23, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Highly multiplexed immune profiling throughout adulthood reveals kinetics of lymphocyte infiltration in the aging mouse prostate.”
Aging is a significant risk factor for disease in several tissues, including the prostate. Defining the kinetics of age-related changes in these tissues is critical for identifying regulators of aging and evaluating interventions to slow the aging process and reduce disease risk. An altered immune microenvironment is characteristic of prostatic aging in mice, but whether features of aging in the prostate emerge predominantly in old age or earlier in adulthood has not previously been established.
In this study, researchers Jonathan J. Fox, Takao Hashimoto, Héctor I. Navarro, Alejandro J. Garcia, Benjamin L. Shou, and Andrew S. Goldstein from the University of California Los Angeles tracked the abundance of 29 immune cell clusters in the aging mouse prostate using highly multiplexed immune profiling and time-course analysis.
“In this study, we characterized how the inflammatory microenvironment of the adult mouse prostate changes during aging using highly-multiplexed single-cell mass cytometry.”
Early in adulthood, myeloid cells comprise the vast majority of immune cells in the 3-month-old mouse prostate. Between 6 and 12 months of age, there is a profound shift towards a T and B lymphocyte-dominant mouse prostate immune microenvironment. Comparing the prostate to other urogenital tissues, the researchers found similar features of age-related inflammation in the mouse bladder but not the kidney.
“In summary, our study offers new insight into the kinetics of prostatic inflammaging and the window when interventions to slow down age-related changes may be most effective.”
Read the full study: DOI: https://doi.org/10.18632/aging.204708
Corresponding Author: Andrew S. Goldstein
Corresponding Email: AGoldstein@mednet.ucla.edu
Keywords: prostate, immune microenvironment, mass cytometry, inflammation, lymphocyte
Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204708
About Aging-US:
Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at www.Aging-US.com and connect with us:
SoundCloud
Facebook
Twitter
Instagram
YouTube
LabTube
LinkedIn
Reddit
Pinterest
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker Str., Suite 1B
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
###
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2023-05-23
Organisations must enable mid-life women to thrive in the workplace by taking inspiration from societies such as China and Japan to encourage positive conversations around the impact of menopause, a new study reveals.
But as they support older women in pursuing their ambitions and accessing career opportunities, organisations must ensure they do not hinder career progression through overlooked promotions, undervalued work, and lost opportunities.
In Western countries, the menopause is traditionally viewed as a managed medical condition that creates physiological challenges which women must overcome if they are to function as effectively in the workplace ...
2023-05-23
Session: C98, Risky Business: Predicting Consequences of OSA
Date and Time: 2:51 p.m. ET, Tuesday, May 23, 2023
Location: Marriott Marquis Washington, Independence Ballroom, Salons E-H (Level M4)
ATS 2023, Washington, DC – Chronic obstructive pulmonary disease patients newly prescribed non-benzodiazepine benzodiazepine receptor agonists (NBZRAs) such as zolpidem (Ambien, Intermezzo and other brands), a class of hypnotic drugs prescribed for insomnia, did not have an increased risk of exacerbations requiring hospitalizations or of death than those prescribed ...
2023-05-23
Powerful magnetic pulses applied to the scalp to stimulate the brain can bring fast relief to many severely depressed patients for whom standard treatments have failed. Yet it’s been a mystery exactly how transcranial magnetic stimulation, as the treatment is known, changes the brain to dissipate depression. Now, research led by Stanford Medicine scientists has found that the treatment works by reversing the direction of abnormal brain signals.
The findings also suggest that backward streams of neural activity between key areas of the brain could be used as a biomarker to help diagnose depression.
“The leading ...
2023-05-23
Carefully planned restoration of agricultural coffee landscapes can increase both farmers’ profit and forest cover over a 40-year period, according to a study publishing May 23rd in the open access journal PLOS Biology by Dr. Sofía López-Cubillos at the University of Queensland in Australia, and colleagues.
Restoring patches of natural vegetation in agricultural land presents a trade-off for farmers: while the lost cropland can reduce profitability, increases in ecosystem services like pollination can improve crop yield. To investigate how conservation priorities can be balanced with economic needs, researchers developed a novel planning framework to model the ...
2023-05-23
For the first time, researchers have shown that reduced oxygen intake, or “oxygen restriction”, is associated with longer lifespan in lab mice, highlighting its anti-aging potential. Robert Rogers of Massachusetts General Hospital in Boston, US, and colleagues present these findings in a study publishing May 23rd in the open access journal PLOS Biology.
Research efforts to extend healthy lifespan have identified a number of chemical compounds and other interventions that show promising effects in mammalian lab animals— ...
2023-05-23
Three studies now published in the open-access journal The Seismic Record offer an initial look at the February 6, 2023 earthquakes in south-central Türkiye and northwestern Syria, including how, where, and how fast the earthquakes ruptured and how they combined as a “devastating doublet” to produce damaging ground shaking.
The two earthquakes, a magnitude 7.8 followed approximately nine hours later by a magnitude 7.6, took place at the tectonically active and complex junction between the Anatolian, Arabian, and ...
2023-05-23
Rural Patients With Diabetes Experience Worse Health Outcomes Than Urban Patients
Mayo Clinic researchers conducted a study within their health care system to identify factors associated with quality of care among rural and urban patients with diabetes. The study evaluated patient attainment of a five-component diabetic care metric, known as the D5 metric. This metric includes no tobacco use, hemoglobin A1C <8%, blood pressure <140/90, statin use, and aspirin use. Researchers considered age, sex, race, Adjusted Clinical Group score (a series of mutually exclusive, health status categories defined by morbidity, age, and sex), insurance type, primary care clinician type, ...
2023-05-23
Focusing on Satiety and Satiation May Aid Long-Term Weight Loss Compared to Calorie Counting Diets
Researchers hypothesized that focusing on satiety (feeling free of hunger) and satiation (feeling satisfied with a meal) through the consumption of fruits and vegetables may be better targets for weight loss success. The researchers compared the impact of two diets — Diabetes Prevention Program Calorie Counting versus MyPlate — on satiation (feeling satisfied with a meal), satiety (feeling free of hunger) and on body fat composition in primary care patients. Two hundred and sixty-one overweight, adult, low-income ...
2023-05-23
Too Few Primary Care Doctors Address Obesity With Their Patients, Highlighting Need for Weight Loss Tool
After finding that few to no clinicians provided weight management care, researchers developed a weight loss tool called PATHWEIGH. This tool was designed to remove clinician barriers in providing patient care that addressed weight. Early success with the tool led to PATHWEIGH being implemented in the health system’s 57 primary care clinics.
Researchers describe the characteristics of patients to determine ...
2023-05-23
Researchers from Iceland trained a machine learning model with artificial intelligence to triage patients with respiratory symptoms before the patients visit a primary care clinic. To train the machine learning model, the researchers used only questions that a patient might be asked about before a clinic visit. Information was extracted from 1,500 clinical text notes that included a physician's interpretation of the patient's symptoms and signs, as well as reasons for clinical decisions made during the consultation, such as imaging referrals and prescriptions. Patients were categorized into one of five diagnostic categories based on information in clinical notes. Patients from all ...
LAST 30 PRESS RELEASES:
[Press-News.org] The aging mouse prostate: kinetics of lymphocyte infiltration
