PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Obstructive sleep apnea disrupts gene activity throughout the day in mice

Tracking time-dependent changes may lead to better diagnosis and understanding of health risks

Obstructive sleep apnea disrupts gene activity throughout the day in mice
2023-05-30
(Press-News.org) The low blood oxygen levels of obstructive sleep apnea cause widespread changes in gene activity throughout the day, according to a new study in the open-access journal PLOS Biology by David Smith of Cincinnati Children’s Hospital Medical Center, US, and colleagues. The finding may lead to tools for earlier diagnosis and tracking of the disorder.

Obstructive sleep apnea (OSA) occurs when the airway becomes blocked (usually by soft tissue, associated with snoring and interrupted breathing during the night), resulting in intermittent hypoxia (low blood oxygen) and disrupted sleep. It affects over one billion people worldwide and costs $150 billion per year in direct medical costs in the United States alone. OSA increases the risk for cardiovascular, respiratory, metabolic, and neurologic complications.

The activity of many genes varies naturally throughout the day, partially in response to activity of circadian clock genes, whose regular oscillations drive circadian variation in up to half the genome. Gene activity also varies in response to external factors, including decreases in oxygen levels, which causes production of “hypoxia-inducible factors,” which influence activity of many genes, including clock genes. To better understand how OSA may affect gene activity throughout the day, the authors exposed mice to intermittent hypoxic conditions and examined whole-genome transcription in six tissues—lung, liver, kidney, muscle, heart, and cerebellum—throughout the day. The authors then evaluated variation in the circadian timing of gene expression in these same tissues.

The largest changes were found in lung, where intermittent hypoxia affected transcription of almost 16% of all genes, most of which were upregulated. Just under 5% of genes were affected in heart, liver, and cerebellum. The subset of genes that normally exhibit circadian rhythmicity were even more strongly affected by intermittent hypoxia, with significant changes seen in 74% of such genes in the lung and 66.9% of such genes in the heart. Among the genes affected in each tissue were known clock genes, an effect that likely contributed to the large changes in circadian activity of other genes seen in these tissues.

“Our findings provide novel insight into the pathophysiological mechanisms that could be associated with end-organ damage in patients with chronic exposure to intermittent hypoxia,” Smith said, “and may be useful to identify targets for future mechanistic studies evaluating diagnostic or therapeutic approaches;” for instance, through a blood test tracking one of the dysregulated gene products to detect early OSA.

Bala S. C. Koritala adds, “Our study using an animal model of Obstructive Sleep Apnea unveils time- and tissue-specific variations of the whole genome transcriptome and associated hallmark pathways. These unique findings uncover early biological changes linked to this disorder, occurring across multiple organ systems.”

#####

In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002139

Citation: Koritala BSC, Lee YY, Gaspar LS, Bhadri SS, Su W, Wu G, et al. (2023) Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression. PLoS Biol 21(5): e3002139. https://doi.org/10.1371/journal.pbio.3002139

Author Countries: United States, Portugal

Funding: see manuscript

END


[Attachments] See images for this press release:
Obstructive sleep apnea disrupts gene activity throughout the day in mice

ELSE PRESS RELEASES FROM THIS DATE:

Researchers use ‘natural’ system to identify proteins most useful for developing an effective HIV vaccine

Researchers use ‘natural’ system to identify proteins most useful for developing an effective HIV vaccine
2023-05-30
Since it was identified in 1984 as the cause of Acquired Immune Deficiency Syndrome (AIDS), the human immunodeficiency virus (HIV) has infected more than 80 million people and been responsible for some 40 million deaths worldwide, according to the World Health Organization (WHO). Currently, the WHO reports more than 38 million people globally live with the retrovirus, and each year, another 1 million new cases are diagnosed. While antiretroviral therapy helps keep HIV in check, patients must stay on their medication to prevent the development of AIDS. Scientists have spent years trying to develop an ...

Researchers identify link between alternative gene splicing and risk of alcohol use disorder

2023-05-30
INDIANAPOLIS—Researchers at Indiana University School of Medicine have discovered alternative gene splicing, which occurs during gene expression, can impact a person’s risk of alcohol use disorder (AUD). They recently published their findings in Molecular Psychiatry. “AUD is a common and complex genetic disorder that happens people experience problems related to excessive alcohol consumption,” said Rudong Li, PhD, a postdoctoral fellow in the YunLong Liu, PhD Laboratory and lead author of the paper. “This discovery has revealed ...

Novel approach significantly improves access, decreases wait times for autism screening

2023-05-30
FOR IMMEDIATE RELEASE, May 30, 2023 Contact: Gina DiGravio, 617-358-7838, ginad@bu.edu Novel Approach Significantly Improves Access, Decreases Wait Times for Autism Screening Developmentally Trained-Primary Care Clinicians can reduce disparities for children referred for developmental evaluation (Boston)—Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and the presence of repetitive and restricted behaviors or interests. The American Academy of Pediatrics (AAP) recommends autism-specific screening at 18- and 24-month well-child visits, yet earlier diagnosis has been shown to ...

Illinois professor examines lasting legacy of al-Andalus for Arabs, Muslims today

Illinois professor examines lasting legacy of al-Andalus for Arabs, Muslims today
2023-05-30
CHAMPAIGN, Ill. — Before it was home to Spain and Portugal, much of the Iberian Peninsula was ruled by a succession of Islamic dynasties for almost 800 years during the Middle Ages. Known as al-Andalus, its influence is still reflected in art and politics today – not only in Spain and North Africa, but also in places far from the historical site of al-Andalus. Eric Calderwood, a comparative and world literature professor at the University of Illinois Urbana-Champaign, wrote about that influence and how it is used to make sense of the present in his new book, “On Earth or in Poems: ...

Astronomers discover planets in NASA Kepler's final days of observations

Astronomers discover planets in NASA Keplers final days of observations
2023-05-30
A team of astrophysicists and citizen scientists have identified what may be some of the last planets NASA’s retired Kepler space telescope observed during its nearly decade-long mission. The trio of exoplanets – worlds beyond our solar system – are all between the size of Earth and Neptune and closely orbit their stars. ''These are fairly average planets in the grand scheme of Kepler observations,” said Elyse Incha, a senior at the University of Wisconsin-Madison. “But they’re exciting because Kepler observed them during its last few days of operations. It showcases just how good Kepler was at planet hunting, even at the end of its ...

Matthew Bailes, Duncan Lorimer and Maura McLaughlin receive the 2023 Shaw Prize in Astronomy

Matthew Bailes, Duncan Lorimer and Maura McLaughlin receive the 2023 Shaw Prize in Astronomy
2023-05-30
The Shaw Prize in Astronomy 2023 is awarded in equal shares to Matthew Bailes, Director of the Australian Research Council (ARC) Centre of Excellence for Gravitational Wave Discovery, Duncan Lorimer, Professor and Interim Chair of Physics and Astronomy and Associate Dean for Research at Eberly College of Arts and Sciences at West Virginia University, USA and Maura McLaughlin, Eberly Family Distinguished Professor at the Department of Physics and Astronomy, West Virginia University, USA, for the discovery ...

Are pandemic lockdowns and vaccinations complements or substitutes? Lessons learned from COVID-19 should be considered in future pandemics

2023-05-30
Worldwide, one of the initial responses to the COVID-19 virus was locking down parts of the economy to reduce social interactions and the virus’s spread. Now, the development and production of vaccines have largely replaced broad lockdowns. In a new study that considered epidemiology and economics, researchers sought to determine how the arrival of vaccines should affect the duration and intensity of lockdown policies. They concluded that boosting the rate of vaccine use influences intensity and duration of lockdowns, depending on a variety of factors. The study was conducted by researchers at Carnegie Mellon University (CMU), the International Institute for Applied Systems Analysis, ...

To boost health care teams’ effectiveness, integrate organizational sciences research with technology development

2023-05-30
Health care organizations today are caring for patients with increasingly complex needs and leveraging larger teams that include clinicians with diverse and specialized expertise. At the same time, high turnover and labor shortages mean that facilities frequently employ a more temporary and mobile workforce. In a new commentary, researchers point out that, as a result, “the structure of health care teams often defies decades of wisdom from team-design research about the conditions that support the best possible performance.” The article was written ...

Reusable packaging revolution is close - experts say

2023-05-30
30 May 2023 - A detailed plan to transform product packaging and significantly cut plastic production and pollution has been developed by researchers. The study comes as government representatives meet in Paris to negotiate a legally binding global plastics treaty with a mandate to end plastic pollution.  The research, published today by the University of Portsmouth’s Global Plastics Policy Centre, commissioned by the Break Free From Plastic movement, consolidates 320 articles and papers, plus 55 new interviews with reuse experts from around the world [1], to suggest a universal definition of reuse systems and, for the ...

Silent zoo tours can generate new perspectives on animals, study suggests

2023-05-30
Visiting zoos in silence can generate a range of novel experiences, helping people to connect to animals in a more intimate way and giving visits more gravitas, according to new research. Experts ran special silent events at Paignton and Bristol zoos as part of a wider project on the auditory culture of zoos. Visitors were better able to focus, concentrate and even meditate on specific animals and their behaviour, which sometimes fostered feelings of intimacy with and attachment to particular zoo animals. The research, published in TRACE: Journal for Human-Animal Studies, was conducted by Professor Tom Rice, Dr Alexander Badman-King, Professor Sam ...

LAST 30 PRESS RELEASES:

Study finds senescent immune cells promote lung tumor growth

Study examines benefits and obstacles of library data storytelling

Cost of living crisis set to cut UK lives short and significantly widen wealth-health gap

Flawed body of research indicates true ‘long COVID’ risk likely exaggerated

Wealthier kids in UK may have experienced steepest fall in mental health during pandemic

Stem cell therapy can safely slow progression of relapsing-remitting MS

NASA’s Interstellar Mapping and Acceleration Probe passes system integration review

National Science Foundation taps Worcester Polytechnic Institute fire protection expertise and resources for the Wildfire Interdisciplinary Research Center

Doctor and pharmacist revamp standard processes for ordering and documenting mifepristone use

Screening for adverse childhood experience can improve trauma-informed care, though time constraints and limited referral resources present challenges

Understanding parents’ care expectations for a child with gastroenteritis could prevent after-hours care requests

Learning collaborative promotes mifepristone education and utilization training in federally qualified health centers

Men who trust their doctors, receive adequate time and general information about prostate cancer screening are more likely to have productive discussions

Study identifies patient and clinician-level characteristics associated with sexual history screening administration

Researchers identify important strategies for diabetes care and quality improvements in the primary care setting

Attentiveness to resting leg cramps may afford greater insight into advancing age and declining health

Staffing challenges and general time constraints may harm primary care teams’ ability to implement quality improvement efforts

Primary care investigators, clinicians, patients and community members reflect on NAPCRG’s 50 years of leadership and service

September/October Annals of Family Medicine 2023 tip sheet

Combination radiation with immunotherapy shows promise against “cold” breast cancer tumors

A new AI model has been developed to improve accuracy of breast cancer tumor removal

Finding the balance: Opioids and pain control after surgery

UC Irvine scientists reveal what fuels wildfires in Sierra Nevada Mountains

US Department of Energy Office of Science awards $115M for High Rigidity Spectrometer project at FRIB

Algorithm would predict disease relapses

Exercise-mimicking drug sheds weight, boosts muscle activity in mice

Did life exist on Mars? Other planets? With AI's help, we may know soon

Wind energy projects in North America are more likely to be opposed by white, wealthy communities

Naming and shaming can be effective to get countries to act on climate

Scientists develop method of identifying life on other worlds

[Press-News.org] Obstructive sleep apnea disrupts gene activity throughout the day in mice
Tracking time-dependent changes may lead to better diagnosis and understanding of health risks