Niigata, Japan - The research group of Professor Kamimura in Niigata University have applied the novel, liver lobe-specific hydrodynamic delivery procedure to primates (baboons) for the first time. “Delivery of a plasmid that expresses a therapeutic gene for human hemophilia achieved therapeutic levels of human factor IX gene expression lasting for 200 days after the delivery of a plasmid”, says Prof. Kamimura. In addition, the results demonstrated the efficacy of repeated hydrodynamic gene delivery into the same liver lobes. Furthermore, no plasmid was introduced into organs other than the livers of the baboons treated with gene therapy, and other than a transient increase in blood concentration of liver enzymes right after the injection, no significant adverse events were observed in animals during the study period. Prof. Kamimura concluded that this procedure can be safely applied to the clinic and will show the therapeutic effect in various intractable diseases.
END
Liver lobe-specific hydrodynamic gene delivery to baboons: A preclinical trial for hemophilia gene therapy
Development of a novel non-viral gene therapy procedure
2023-06-08
(Press-News.org)
ELSE PRESS RELEASES FROM THIS DATE:
One-month of COVID-19 lockdown cost heart attack patients up to two years of life
2023-06-08
Sophia Antipolis, 8 June 2023: Patients who had heart attacks during the first COVID-19 lockdown in the UK and Spain are predicted to live 1.5 and 2 years less, respectively, than their pre-COVID counterparts. That’s the finding of a study published today in European Heart Journal – Quality of Care and Clinical Outcomes, a journal of the European Society of Cardiology (ESC).1 The additional costs to the UK and Spanish economies are estimated at £36.6 million (€41.3 million) and €88.6 million, respectively, largely due to absence from work.
“Restrictions to treatment of life-threatening conditions have immediate and long-term ...
Long Covid can impact fatigue and quality of life worse than some cancers
2023-06-08
Fatigue is the symptom that most significantly impacts the daily lives of long Covid patients, and can affect quality of life more than some cancers, finds a new study led by researchers at UCL and the University of Exeter.
The research, published in BMJ Open and funded by the National Institute for Health and Care Research (NIHR), examines the impact of long Covid on the lives of over 3,750 patients who were referred to a long Covid clinic and used a digital app as part of their NHS treatment for the condition.
Patients were asked to complete questionnaires on the app about how long Covid was affecting them – considering the impact of long Covid on their day-to-day activities, ...
Gradual supported release of primates into the wild shown as effective
2023-06-08
Gradually re-introducing primates into the wild with post-release support has, for the first time, been scientifically shown to improve their well-being.
Every year, rescue centres release animals, that are deemed ready, into the wild, based on the assumption that the animals will thrive most in their natural habitat, but this assumption has never been scientifically tested with primates.
A team from Durham University, Disney’s Animals, Science and Environment and the Jane Goodall Institute ...
Essential investment in plant and microbial research in Norwich, UK, confirmed
2023-06-08
Development of an exciting, ground-breaking plant and microbial science and innovation hub can go ahead with confirmation of funding announced today.
The transformational investment will fund new cutting-edge, world-class facilities for the John Innes Centre (JIC) and The Sainsbury Laboratory (TSL) at the heart of the Norwich Research Park. This will deliver a step change in our capability to translate scientific knowledge into bio-based solutions in response to some of society’s most pressing challenges.
As well as transforming the existing capabilities of the John Innes Centre and The Sainsbury Laboratory, both internationally recognised ...
Despite major progress nationally, two mercury emissions hotspots remain
2023-06-07
Missing from partisan political debates over regulations affecting the energy sector is the stunning success of the federal government’s signature environmental laws. A prime example: the U.S. Environmental Protection Agency’s rules aimed at reducing the harmful effects of hazardous air pollutant (HAP) emissions from fossil fuel-fired power plants known as the Mercury and Air Toxics Standards, or MATS.
A new study from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) shows that in the decade since the standard was ...
What your likes, posts really say about you
2023-06-07
The myriad ways in which we use social media can be grouped into four broad categories, each of which is associated with a cluster of specific personality and behavioral traits, suggests new research from Washington University in St. Louis.
“Social media is here to stay, so clarifying how people use social media and raising awareness of these findings are crucial first steps toward ultimately helping people understand how they can avoid the negative aspects of social networking and engage in healthier social media usage,” said Alison B. Tuck, first author of the study and a PhD candidate in clinical psychology in Arts & Sciences.
The study, published online ...
Scientists develop inorganic resins for generating and purifying radium and actinium
2023-06-07
The Science
Targeted alpha therapy can destroy cancerous cells without harming healthy cells. It’s especially useful for treating metastasized cancers. The Department of Energy (DOE) Office of Science’s Isotope Program is developing and marketing novel radioactive isotopes for targeted alpha therapy. One method of making one isotope, actinium-225, involves bombarding radium targets with neutrons. This method poses a challenge: how to chemically separate the radium from the actinium. This can destroy typical separation equipment due to a radioactive process called alpha decay. Now, researchers ...
New research: Maybe crying in baseball is a good thing?
2023-06-07
ITHACA, N.Y. – Venturing out of one’s comfort zone to perform a task – and then performing poorly in that task, such as a baseball pitcher trying to hit – can lead to better performance when returning to one’s specialty, according to new research.
Brittany Bond, an assistant professor of organizational behavior in the Cornell School of Industrial and Labor Relations, and Ethan J. Poskanzer of the University of Colorado argue that this phenomenon occurs through a process they call “forced task inferiority,” in which underperformance in tasks outside their specialty frustrates ...
Electronic health records can contain bias, potentially impacting clinical trials
2023-06-07
Results of clinical trials are only as good as the data upon which they rest. This is especially true in terms of diversity — if most people in a trial are from a certain race or socioeconomic group, then the results may not be broadly applicable.
This form of potential bias is not a novel concept. But a group of researchers at the University of Illinois Chicago and colleagues have identified a potential hidden source of bias: electronic health records.
In a recent Contemporary Clinical ...
Yale-led study shows ‘significant overall survival benefit’ when lung-cancer drug is taken after surgery
2023-06-07
New Haven, Conn. — A clinical trial led by Yale Cancer Center shows that the drug osimertinib, a targeted therapy for non-small cell lung cancer, improved rates of survival and reduced risk of recurrence in patients after surgery.
The results, published June 4 in the New England Journal of Medicine, were presented this week by Dr. Roy Herbst, deputy director of Yale Cancer Center and principal investigator of the ADAURA Phase III clinical trial, during the 2023 annual meeting of the American Society of Clinical Oncology. Herbst is also assistant dean for translational research, ensign professor of medicine (medical oncology), ...
LAST 30 PRESS RELEASES:
UT San Antonio School of Public Health: The People’s School
‘Preventable deaths will continue’ without action to make NHS more accessible for autistic people, say experts
Scientists shoot lasers into brain cells to uncover how illusions work
Your ecosystem engineer was a dinosaur
New digital cognitive test for diagnosing Alzheimer's disease
Parents of children with health conditions less confident about a positive school year
New guideline standardizes consent for research participants in Canada
Research as reconciliation: Oil sands and health
AI risks overwriting history and the skills of historians have never been more important, leading academic outlines in new paper
The Lancet Diabetes & Endocrinology: Higher doses of semaglutide can safely enhance weight loss and improve health for adults living with obesity, two new clinical trials confirm
Trauma focused therapy shows promise for children struggling with PTSD
School meals could drive economic growth and food system transformation
Home training for cerebellar ataxias
Dry eyes affect over half the general population, yet only a fifth receive diagnosis and treatment
Researchers sound warning about women with type 2 diabetes taking oral HRT
Overweight and obesity don’t always increase the risk of an early death, Danish study finds
Cannabis use associated with a quadrupling of risk of developing type 2 diabetes, finds study of over 4 million adults
Gestational diabetes linked to cognitive decline in mothers and increased risk of developmental delays, ADHD and autism among children
Could we use eye drops instead of reading glasses as we age?
Patients who had cataracts removed or their eyesight corrected with a new type of lens have good vision over all distances without spectacles
AI can spot which patients need treatment to prevent vision loss in young adults
Half of people stop taking popular weight-loss drug within a year, national study finds
Links between diabetes and depression are similar across Europe, study of over-50s in 18 countries finds
Smoking increases the risk of type 2 diabetes, regardless of its characteristics
Scientists trace origins of now extinct plant population from volcanically active Nishinoshima
AI algorithm based on routine mammogram + age can predict women’s major cardiovascular disease risk
New hurdle seen to prostate screening: primary-care docs
MSU researchers explore how virtual sports aid mental health
Working together, cells extend their senses
Cheese fungi help unlock secrets of evolution
[Press-News.org] Liver lobe-specific hydrodynamic gene delivery to baboons: A preclinical trial for hemophilia gene therapyDevelopment of a novel non-viral gene therapy procedure