PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Tiny nanopores can contribute to faster identification of diseases

Researchers discover new, fast, and precise method for detecting indicators of COVID-19 and breast cancer in a blood sample. By using tiny nanopores and nanobodies, we may face fast and accurate disease diagnosis using a simple blood test.

Tiny nanopores can contribute to faster identification of diseases
2023-06-15
(Press-News.org)

In a collaboration with Groningen University, Professor Jørgen Kjems and his research group at Aarhus University have achieved a remarkable breakthrough in developing tiny nano-sized pores that can contribute to better possibilities for, among other things, detecting diseases at an earlier stage. Their work, recently published in the scientific journal ACS Nano, shows a new innovative method for finding specific proteins in complex biological fluids, such as blood, without having to label the proteins chemically. The research is an important milestone in nanopore technology, and could revolutionise medical diagnostics.

Nanopores are tiny channels formed in materials, that can be used as sensors. The researchers, led by Jørgen Kjems and Giovanni Maglia (Groningen Univ.), have taken this a step further by developing a special type of nanopore called ClyA with scanner molecules, called nanobodies, attached to it. These nanobodies, derived from antibodies, are capable of recognizing different proteins with astonishing accuracy. In this study, the researchers attached nanobodies to ClyA, using a DNA adapter. By using a series of nanobodies, they were able to create many different nanopore sensors, which could detect a variety of proteins of different sizes.

The research team created nanopores with specialized nanobodies attached, which have the ability to detect the Spike protein of SARS-CoV-2 (the virus that causes COVID-19) and a protein marker for breast cancer called urokinase-type plasminogen activator (uPA), respectively. By measuring changes in electrical currents that are caused by the presence of these proteins, the researchers can find and identify individual proteins and even determine their concentrations. What makes this breakthrough even more remarkable is that the nanopores remained highly accurate and sensitive even when tested with complex samples like blood.

Although the nanopores are invisible to the naked eye, the signficance of this research is palpable. The existing technologies already allowed the integration of nanopores into a portable device that can utilise the nanopores' ability to scan liquids for specific molecules. Therefore, we can envision a future where patients can rapidly and accurately detect diseases like cancer or infectious diseases with a simple blood test. This could lead to earlier interventions, improved treatment outcomes, and overall improved healthcare.

Although further studies and validation are needed before this technology becomes widely available, the collaboration between these two universities brings us one step closer to this reality. The breakthrough exemplifies the power of scientific collaboration and innovation in transforming healthcare.

END


[Attachments] See images for this press release:
Tiny nanopores can contribute to faster identification of diseases Tiny nanopores can contribute to faster identification of diseases 2 Tiny nanopores can contribute to faster identification of diseases 3

ELSE PRESS RELEASES FROM THIS DATE:

Healthy sex life during pandemic tied to an array of sexual coping strategies

Healthy sex life during pandemic tied to an array of sexual coping strategies
2023-06-15
CHAMPAIGN, Ill. — New research suggests that people who maintained healthy sexual and intimate lives early in the pandemic used sex as a coping mechanism to enhance their relationship with their partners, explore new sexual activities and in an array of other ways to adapt to the restrictions, stress and the changes in their daily lives. One year into the pandemic, Liza Berdychevsky, a professor of recreation, sport and tourism at the University of Illinois Urbana-Champaign, conducted an online survey of 675 people to explore the differences between people whose sex lives had fizzled and those whose sex lives had flourished. The sample ...

Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer

Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
2023-06-15
“[...] here we reveal a link between short telomere length in ATII cells and post-viral lung fibrosis outcome in post-COVID-19 patients.” BUFFALO, NY- June 15, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 11, entitled, “Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer.” The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. The severity of COVID-19 increases with each decade of life, ...

Legal recreational cannabis use and binge drinking is on the rise for older adults

2023-06-15
June 15, 2023 --New research at Columbia University Mailman School of Public Health examined changes in binge drinking after the implementation of recreational cannabis laws. Analysis of national survey data from Americans aged 12 and older showed that past-month binge drinking increased overall among people aged 31 and over from 2008 to 2019. At the same time, binge drinking declined overall among people aged 12-30. The results are published online in the International Journal of Drug Policy. The most substantial declines in binge drinking were observed ...

New study gives clues on why exercise helps with inflammation

2023-06-15
TORONTO, CANADA, June 15, 2023 - Researchers have long known that moderate exercise has a beneficial impact on the body’s response to inflammation, but what’s been less understood is why. New research coming out of York University done on a mouse model suggests that the answers may lie at the production level of macrophages — white blood cells responsible for killing off infections, healing injury and otherwise acting as first responders in the body.   “Much like if you train your muscles through ...

Climate change likely led to violence in early Andean populations

2023-06-15
Climate change in current times has created problems for humans such as wildfires and reduced growing seasons for staple crops, spilling over into economic effects. Many researchers predict, and have observed in published literature, an increase in interpersonal violence and homicides when temperatures increase. Violence during climatic change has evidence in history. University of California, Davis, researchers said they have have found a pattern of increased violence during climatic change in the south central Andes between A.D. 470 and 1500. During that time, which includes the Medieval Climatic ...

Carbon mitigation payments can make bioenergy crops more appealing for farmers

Carbon mitigation payments can make bioenergy crops more appealing for farmers
2023-06-15
URBANA, Ill. — Bioenergy crops such as miscanthus and switchgrass provide several environmental benefits, but low returns and profit risks are barriers for investment by farmers. A new study from the University of Illinois Urbana-Champaign shows that carbon mitigation payments could increase net returns and reduce income risk, potentially enticing more farmers to grow these crops. “We were interested in looking at the returns to farmers and the risks to farm income of adopting bioenergy crops compared to conventional corn and soybean crops. We ...

Grant awarded to investigate antifungal therapies in Crohn’s patients

2023-06-15
Dr. Iliyan D. Iliev, an associate professor of immunology in medicine in the Division of Gastroenterology and Hepatology, co-director of the Microbiome Core and a member of the Jill Roberts Institute for Research in Inflammatory Bowel Disease (IBD) at Weill Cornell Medicine, is the lead investigator on a grant to Weill Cornell Medicine from The Leona M. and Harry B. Helmsley Charitable Trust to target pathogenic fungi in patients with Crohn’s disease. Dr. Iliev teamed up with Dr. Randy Longman, ...

FAMU-FSU College of Engineering researchers want drivers to see clearly on the road

FAMU-FSU College of Engineering researchers want drivers to see clearly on the road
2023-06-15
Every year, sun glare contributes to around 3,000 crashes in the United States. FAMU-FSU College of Engineering researchers are helping to mitigate this problem by examining what drivers are likely to do when faced with sun glare. Their work was published in Transportation Research Record. “We want drivers to be safer on the road,” said study co-author Eren Ozguven, director of the Resilient Infrastructure and Disaster Response Center. “At certain times of day, the sun can be blinding, so as scientists and engineers, we want to find solutions.” The first step is to understand where problems are most likely to occur. ...

Scientists discover how Golden staph hides and thrives in human cells using state-of-the-art research tool

Scientists discover how Golden staph hides and thrives in human cells using state-of-the-art research tool
2023-06-15
Nearly one in three people globally unknowingly carries Golden staph, or Staphylococcus aureus, in their nose or on their skin. While the bacterium is harmless to most, it can lead to serious infection and even death if it enters the bloodstream through a cut, surgical wound or catheter. The major breakthrough, led by the University of Melbourne’s Dr Abdou Hachani, a Senior Researcher at the Peter Doherty Institute for Infection and Immunity (Doherty Institute), published in the online medical journal eLife, was made possible by a new state-of-the-art ...

Massive underwater plateau near Solomon Islands is younger and its eruption was more protracted than previously thought, research suggests

2023-06-15
CORVALLIS, Ore. – The Ontong Java Plateau, a volcanically-formed underwater plateau located in the Pacific Ocean north of the Solomon Islands, is younger and its eruption was more protracted than previously thought, new research led by Oregon State University suggests. The findings, just published in Science, also cast doubt on long-held assumptions that the formation of the plateau, which is roughly the size of Alaska, was the cause of a global deposit of black shale throughout the world’s oceans. “This type of shale is formed when there is very limited oxygen in the ocean. This layer was formed about 120 million years ago and can be found preserved ...

LAST 30 PRESS RELEASES:

Cal Poly Chemistry professor among three U.S. faculty to be honored for contributions to chemistry instruction

Stoichiometric crystal shows promise in quantum memory

Study sheds light on why some prostate tumors are resistant to treatment

Tree pollen reveals 150,000 years of monsoon history—and a warning for Australia’s northern rainfall

Best skin care ingredients revealed in thorough, national review

MicroRNA is awarded an Impact Factor Ranking for 2024

From COVID to cancer, new at-home test spots disease with startling accuracy

Now accepting submissions: Special Collection on Cognitive Aging

Young adult literature is not as young as it used to be

Can ChatGPT actually “see” red? New results of Google-funded study are nuanced

Turning quantum bottlenecks into breakthroughs

Cancer-fighting herpes virus shown to be an effective treatment for some advanced melanoma

Eliminating invasive rats may restore the flow of nutrients across food chain networks in Seychelles

World’s first: Lithuanian scientists’ discovery may transform OLED technology and explosives detection

Rice researchers develop superstrong, eco-friendly materials from bacteria

Itani studying translation potential of secure & efficient software updates in industrial internet of things architectures

Elucidating the source process of the 2021 south sandwich islands tsunami earthquake

Zhu studying use of big data in verification of route choice models

Common autoimmune drug may help reverse immunotherapy-induced diabetes, UCLA study finds

Quantum battery device lasts much longer than previous demonstrations

Gamma knife stereotactic radiosurgery for brain metastases from ovarian cancer

Meet the “plastivore” caterpillars that grow fat from eating plastic

Study identifies postoperative delirium as preventable “acute brain failure” with major health and financial implications

Climate change linked to decline in nutritional quality of food

Abdominal fat linked to reduced strength and mobility in adults

Mount Sinai implements Own the Bone® program for fragility fracture patients

Is Earth inside a huge void? 'Sound of the Big Bang' hints at possible solution to Hubble tension

When stem cells feel the squeeze, they start building bone

Revealing Myanmar earthquake as a unique event comprising multiple sub-events, including boomerang-like reverse rupture propagation and supershear rupture

AI helps radiologists spot more lesions in mammograms

[Press-News.org] Tiny nanopores can contribute to faster identification of diseases
Researchers discover new, fast, and precise method for detecting indicators of COVID-19 and breast cancer in a blood sample. By using tiny nanopores and nanobodies, we may face fast and accurate disease diagnosis using a simple blood test.