PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

VUMC receives $7 million award from PCORI to compare breathing tube sedation

VUMC receives $7 million award from PCORI to compare breathing tube sedation
2023-07-18
(Press-News.org) Vanderbilt University Medical Center has received a $7 million, five-year funding award from PCORI (Patient-Centered Outcomes Research Institute) to compare two sedatives used to place breathing tubes in the emergency department (ED) or intensive care unit (ICU).

 

To provide support with a breathing machine, doctors must place a breathing tube into a patient’s mouth and throat, and they are given a medication to make them sleep during this procedure. The two medications doctors most often give are ketamine and etomidate. 

 

Millions of critically ill adults require placement of a breathing tube each year (tracheal intubation) in the ED or ICU. Of these, up to 30% die from their critical illness and up to one-third of survivors develop post-traumatic stress disorder (PTSD). 

 

The Randomized trial of Sedative choice for Intubation (RSI) study will compare the effectiveness of ketamine versus etomidate during tracheal intubation of 2,364 critically ill adults at five centers (Vanderbilt, Hennepin, University of Alabama Birmingham, University of Colorado, and Wake Forest). Researchers will meet with patients in the hospital, then call patients at three and 12 months afterward.

 

“Even though these two medications have been around for decades, we still don’t know which one is best for patients,” said Matthew Semler, MD, MSc, assistant professor of Medicine in the Division of Allergy, Pulmonary and Critical Care Medicine and co-principal investigator of the study along with Jin Han, MD, MSc. “Knowing which of the two medications helps patients survive or prevents symptoms of PTSD could save lives and improve mental health for tens of thousands of seriously ill patients every year,” Semler said.

 

“Preliminary evidence suggests that the sedative used to relax the patient in preparation for tracheal intubation may affect the risk of death or PTSD,” Han said.  “Although millions of patients receive ketamine and etomidate each year, it is unknown which is best for the prevention of death or PTSD, which can last for months or years and impair survivors’ ability to work, perform everyday tasks and have healthy relationships,” he said. 

 

The RSI trial will compare the effectiveness of the two medications with regard to mortality at one month among critically ill adults undergoing emergency tracheal intubation, compare the effectiveness of the two medications with regard to PTSD symptoms at 12 months and use analyses of heterogeneity of treatment effect to predict the effect of ketamine vs. etomidate on death and PTSD symptoms for individual patients.

 

The study’s main outcome is the number of patients who are alive at one month.  The secondary outcome will be patients’ symptoms of PTSD at 12 months.  Members of the research group will ask patients about their PTSD symptoms over the phone. They will also ask questions about how patients are thinking and feeling.

 

The study will be led by a team of five patients who have experienced serious illness, five doctors who care for patients with serious illness, and researchers from five hospitals with experience in serious illness, mental health, and involving patients and community members in research. 

 

An independent group of patients and community members from the five cities will help oversee and direct the study. Every four months, additional patients and clinicians with diverse backgrounds will share their experiences, answer questions, and advise the study’s design and conduct. Patient and clinician advocacy organizations will help design and shape the study.

 

VUMC’s funding award has been approved pending completion of a business and programmatic review by PCORI staff and issuance of a formal award contract.

 

 

 

 

 



 

 

END

[Attachments] See images for this press release:
VUMC receives $7 million award from PCORI to compare breathing tube sedation

ELSE PRESS RELEASES FROM THIS DATE:

Lewy body disease can be detected before symptoms

2023-07-18
Lewy body disease is the second most common neurodegenerative disease after Alzheimer's disease. A research group from Lund University has now shown that the disease can be detected before symptoms appear, using a spinal fluid test. The studies are published in Nature Medicine, where the researchers also demonstrate that reduced sense of smell is strongly linked to Lewy body disease even before other clear symptoms have developed. The findings are also reported simultaneously at the Alzheimer’s Association International Conference. Lewy ...

Interracial relationships don’t always make people less racist

2023-07-18
The landmark United States Supreme Court ruling in Loving v. Commonwealth of Virginia abolished bans on interracial marriage in the United States in 1967, but a new academic paper from Rice University and Texas A&M University said an uptick in interracial relationships since then has not ended discriminatory tendencies, even among individuals who are in these romantic partnerships. The paper, “Mixing races, maintaining racism? Considering the connection between interracial families, social distance and racial inequality,” is online and will appear in an upcoming edition ...

Quantitative analysis of cell organelles with artificial intelligence

Quantitative analysis of cell organelles with artificial intelligence
2023-07-18
BESSY II's high-brilliance X-rays can be used to produce microscopic images with spatial resolution down to a few tens of nanometres. Whole cell volumes can be examined without the need for complex sample preparation as in electron microscopy. Under the X-ray microscope, the tiny cell organelles with their fine structures and boundary membranes appear clear and detailed, even in three dimensions. This makes cryo x-ray tomography ideal for studying changes in cell structures caused, for example, by external triggers. Until now, however, the evaluation of 3D tomograms has required largely manual and labour-intensive data ...

Bifacial perovskite solar cells point to higher efficiency

2023-07-18
A bifacial perovskite solar cell, which allows sunlight to reach both sides of the device, holds the potential to produce higher energy yields at lower overall costs, according to scientists at the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL). The dual nature of a bifacial solar cell enables the capture of direct sunlight on the front and the capture of reflected sunlight on the back, allowing this type of device to outperform its monofacial counterparts. “This perovskite cell can operate very ...

Medical College of Wisconsin scientist and international team awarded $13 million NIH program project grant to study calcifications in diseases of aging

Medical College of Wisconsin scientist and international team awarded $13 million NIH program project grant to study calcifications in diseases of aging
2023-07-18
FOR IMMEDIATE RELEASE Contact: Colleen McDonald, Sr. Consultant - Earned Media 414.801.3146 | cmcdonald@mcw.edu   Medical College of Wisconsin scientist and international team awarded $13 million NIH program project grant to study calcifications in diseases of aging Dr. Francesca Marassi and collaborators garner $13 million NIH grant to study misplaced calcified deposits that are a misunderstood factor in common diseases of aging Milwaukee, Wis., July 18, 2023 – Francesca Marassi, PhD, professor and chair of ...

Study finds similar health outcomes for pregnant patients receiving in-person prenatal care or a combination of virtual and in-office visits

2023-07-18
Pregnant patients who received some of their prenatal care during the COVID-19 pandemic in a combination of virtual and in-office visits — known as multimodal prenatal care — had similar health outcomes as those who were seen mostly in person before the pandemic, according to a large new study of more than 151,000 births from the Kaiser Permanente Division of Research. The analysis compared pregnancy care, delivery, and outcomes for 3 different time periods: delivery before the pandemic (July 2018 to February 2020), early pandemic (March 2020 to December 2020), and mid-pandemic (December 2020 to October 2021). ...

Freshwater management techniques benefit both inland and coastal wetlands stressed by climate change

Freshwater management techniques benefit both inland and coastal wetlands stressed by climate change
2023-07-18
Climates are changing in wetland ecosystems around the world. A research collaboration between the U.S. Geological Survey and Clayton State University examined the impact of historical land use on these key environments and proposed employing freshwater delivery techniques developed for inland wetlands to help manage coastal systems. In a recently published paper, the research team emphasized the impact of human use of land over time, focusing specifically on water delivery to inland wetlands. The ...

Developing novel & safe contrast agent platform for photoacoustic imaging

2023-07-18
Developing Novel & Safe Contrast Agent Platform For Photoacoustic Imaging   Remi Veneziano, Assistant Professor, Bioengineering, received funding from the National Science Foundation I-Corps Program for the project: "Towards a clinically translatable and standardized tissue ‘paint/contrast agent’ for photoacoustic imaging."   Veneziano is collaborating with Shrishti Singh, Postdoctoral Research Fellow, Bioengineering, and Elizabeth Pyle, Life Science Business Mentor, Innovation Commercialization Assistance Program (ICAP), Virginia Small Business Development ...

Lowder receives funding for Indiana Justice Reinvestment Advisory Council Racial Equity Project

2023-07-18
Lowder Receives Funding For Indiana Justice Reinvestment Advisory Council Racial Equity Project  Evan Lowder, Assistant Professor, Criminology, Law and Society, received funding for: "Indiana Justice Reinvestment Advisory Council Racial Equity Project."  The goals of this study are to understand criminal-legal decision points that may be contributing to racially disparate outcomes and to further data collection efforts at the state and local levels that can facilitate improved tracking of decisions and outcomes in the criminal-legal system.   The broader ...

Droplet levitation is a new way to explore airborne viruses and microorganisms

Droplet levitation is a new way to explore airborne viruses and microorganisms
2023-07-18
WASHINGTON, July 18, 2023 – Self-sustained levitation of millimeter-sized droplets was recently discovered by researchers at Tyumen State University, in Russia, during an experiment to select combinations of immiscible liquids, which don’t form homogeneous mixtures. Researchers Natalia Ivanova and Denis Klyuev noticed something amazing happen: Droplets of butyl alcohol, after being detached from the syringe needle, levitated above the surface of the layer of another liquid without collapsing onto it for a long period of time. In Applied Physics Letters, from AIP Publishing, ...

LAST 30 PRESS RELEASES:

FAU receives $3M federal grant to prevent substance use in at-risk youth

New report shows action to improve gender equity linked to career gains and better business performance

Kiwis could help manage chronic constipation

Breast, lung, and bladder cancer phase 3 trials led by Dana-Farber presented at ESMO Congress 2025

New open-source software allows for efficient 3D printing with multiple materials

Decoding the secrets of ‘chemo brain’

‘Far from negligible’: New Australian fossil fuel site will have major impact on people and the planet

UK heatwaves overwhelm natural ecological safeguards to increase wildfire risk

Key ExoMars Rover part ships from Aberystwyth

90% of Science Is Lost: Frontiers’ revolutionary AI-powered service transforms data sharing to deliver breakthroughs faster

Skin symptoms may forewarn mental health risks

Brain test predicts ability to achieve orgasm – but only in patients taking antidepressants

‘New reality’ as world reaches first climate tipping point

Non-English primary language may raise risk of delirium after surgery, study finds

Children fast from clear liquids much longer before surgery than guidelines recommend, large study shows

Food insecurity, loneliness can increase the risk of developing chronic pain after surgery

Cesarean delivery linked to higher risk of pain and sleep problems after childbirth

New global burden of disease study: Mortality declines, youth deaths rise, widening health inequities

Chemobiological platform enables renewable conversion of sugars into core aromatic hydrocarbons of petroleum

Individualized perioperative blood pressure management in patients undergoing major abdominal surgery

Proactive vs reactive treatment of hypotension during surgery

Different types of depression linked to different cardiometabolic diseases

Ketogenic diet may protect against stress experienced in the womb

Adults 65 years and older not immune to the opioid epidemic, new study finds

Artificial intelligence emerging as powerful patient safety tool in pediatric anesthesia

Mother’s ZIP code, lack of access to prenatal care can negatively impact baby’s health at birth, new studies show

American Society of Anesthesiologists honors John M. Zerwas, M.D., FASA, with Distinguished Service Award

A centimeter-scale quadruped piezoelectric robot with high integration and strong robustness

Study confirms that people with ADHD can be more creative. The reason may be that they let their mind wander

Research gives insight into effect of neurodegenerative diseases on speech rhythm

[Press-News.org] VUMC receives $7 million award from PCORI to compare breathing tube sedation