Body composition changes after bariatric surgery or treatment with GLP-1 receptor agonists

JAMA Network Open

2026-01-09

(Press-News.org) About The Study: In this single-center cohort study, both bariatric surgery and semaglutide or tirzepatide treatment were associated with substantial fat mass loss, moderate fat-free mass (FFM) loss, and improved FFM to fat mass ratio. These findings provide evidence to guide interventions aimed at preserving FFM while promoting fat loss.

Corresponding Authors: To contact the corresponding authors, email Jason M. Samuels, MD, (jason.m.samuels@vumc.org) and Danxia Yu, PhD, (danxia.yu@vumc.org).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.53323)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Body composition changes after bariatric surgery or treatment with GLP-1 receptor agonists

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