PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Research analyzes kidney functions and predictors of disease

Researchers find indicators while studying hundreds of donor samples

2023-07-19
(Press-News.org) Research is shedding light on kidneys, their critical functions, and predictors of disease.

The research co-led by Matthias Kretzler, M.D. describes the creation of a cellular atlas of the kidney describing nearly 100 cell types and states. It represents the most comprehensive study of cellular states, neighborhoods, and outcome-associated signatures in the kidney.

Researchers from more than twenty institutions collaborated on this project.

Kidneys monitor and maintain the internal balance in the body, filter out waste and excess fluids in the urine. In order to perform these functions, specialized cell types and surrounding cells (neighborhoods) work in concert.

Researchers defined interactions within tissue neighborhoods by studying more than 400,000 individual cells and nuclei from kidney biopsy tissue samples provided by kidney donors and patients with kidney diseases.

By comparing data from donor and disease samples, 28 cellular states were found altered in injured kidneys. Neighborhoods were then mapped in the kidneys where these injury patterns were found.

Large-scale 3D imaging analysis of nearly 1.2 million neighborhoods provided corresponding connections between kidney cells and active immune responses. These analyses defined the pathways relevant to injuries or predictors of a decline in kidney function and establish a rich data source for therapeutic development.

Data sharing and visualization tools have been developed, in parallel, to facilitate access for researchers around the world at KPMP.org.

The study was performed by the Kidney Precision Medicine Project (KPMP), funded by the National Institute of Diabetes and Digestive and Kidney Diseases, in close collaborations with the Nephrotic Syndrome Study Network (NEPTUNE), the Human Cell Altas and the Human BioMolecular Atlas Program  (HubMap). NEPTUNE is part of the National Institutes of Health-funded Rare Diseases Clinical Research Network.

The study was performed by the Kidney Precision Medicine Project (KPMP), funded by the National Institute of Diabetes and Digestive and Kidney Diseases, in close collaborations with the Nephrotic Syndrome Study Network (NEPTUNE), the Human Cell Altas and the Human BioMolecular Atlas Program  (HubMap).

Paper cited: An atlas of healthy and injured cell states and niches in the human kidney, NATURE. DOI: 10.1038/s41586-023-05769-3

END


ELSE PRESS RELEASES FROM THIS DATE:

SARS-CoV-2 infects liver, stimulating glucose production and contributing to severe form of COVID-19

2023-07-19
Research conducted at the University of São Paulo (USP) in Brazil shows that SARS-CoV-2, the virus that causes COVID-19, can infect liver cells (hepatocytes), stimulating glucose production and leading to a condition similar to diabetes (hyperglycemia) in hospitalized patients, even if their blood sugar level was normal before they were admitted to hospital. An article on the study is published in Proceedings of the National Academy of Sciences (PNAS). The findings describe part of the mechanism used by the virus to infect liver cells and impair glucose metabolism, and point ...

Research could pave way to greener, more sustainable products made with renewable carbon

2023-07-19
Carbon-based materials have several qualities that make them attractive as catalysts for speeding up chemical reactions. They are low-cost, lightweight and their high surface area provides a good scaffold on which to anchor catalysts, keeping them stable and dispersed far apart, while providing molecules a lot of surface area to work. This makes carbons useful for energy storage and sensors. Over the last 10 years, carbons have been used in electrochemistry to catalyze reactions to make chemicals and fuel cells. However, ...

Unlocking the power of molecular crystals: a possible solution to nuclear waste

2023-07-19
In a world increasingly concerned about the environmental and geopolitical implications of fossil fuel usage, nuclear energy has resurfaced as a subject of great interest. Its ability to generate electricity at scale without greenhouse gas emissions holds promise as a sustainable clean energy source that could bridge society’s transition away from fossil fuels to a net-zero future. However, nuclear power generation does produce radioactive waste. The safe management of nuclear waste remains a crucial challenge that must be addressed to gain public confidence in this transformative power solution. Now, a team of University of Houston researchers has come up with an innovative ...

refget v2.0 links the hidden dictionaries of DNA

refget v2.0 links the hidden dictionaries of DNA
2023-07-19
  A widely-used tool that finds the exact references needed to pinpoint differences in our DNA just got a refresh. On 17 July, the Standards Steering Committee of the Global Alliance for Genomics and Health (GA4GH) voted to release refget v2.0. With better compatibility for a range of reference genome names, formats, and systems, the new version of refget makes it easier than ever to retrieve verified genomic reference sequences.   A vital infrastructure You may not even realise that you’re using refget already. “Almost ...

Do certain amino acids modify the risk of dementia linked to air pollution?

2023-07-19
EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, JULY 19, 2023 MINNEAPOLIS – Higher levels of vitamin B-related amino acids may be linked to the risk of dementia associated with a certain type of air pollutants called particulate matter, according to a study published in the July 19, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that pollution or amino acids cause dementia, but it suggests a possible link among them. Researchers ...

CHOP and Penn researchers find behavioral economics strategies can help patients quit smoking after a cancer diagnosis

2023-07-19
Philadelphia, July 19, 2023 – Researchers from Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania found that cancer patients who continued to smoke after their diagnosis were significantly more likely to receive treatment for tobacco use when “nudges” to provide tobacco treatment were directed at clinicians through the electronic health record. The findings strengthen the case for using behavioral economics, or targeting predictable patterns in human decision-making to overcome ...

Hepatitis cases and heart valve infection deaths tied to early OxyContin marketing

2023-07-19
New Haven, Conn. — Decades after Purdue Pharma began to push physicians to prescribe addictive pain pills, the opioid crisis has been a slow-motion disaster, with overdoses destroying lives and families across the country. Now, it appears the consequences of those early marketing efforts are even more devastating. In a new study, researchers at the Yale School of Public Health show that infectious disease rates in the United States also climbed as a direct long-term result of the marketing of OxyContin. By ...

Treatment at the first signs of MS could mean lower risk of disability later

2023-07-19
EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, JULY 19, 2023 MINNEAPOLIS – People who start taking medication soon after the first signs of multiple sclerosis (MS) may have a lower risk of disability later, according to a study published in the July 19, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. MS is a disease in which the body’s immune system attacks myelin, the fatty white substance that insulates and protects the nerves. Symptoms of MS may include fatigue, numbness, ...

Teaching robots to teach other robots

2023-07-19
You’re a poker wizard. A friend knows all about French cuisine. Another friend is a Mozart expert. The three of you get together and share knowledge about your respective expertise. Each of you leaves learning something from the other two. People learn a lot by sharing and exchanging information. Can computers do the same with other computers—can robots, in effect, teach other robots how to learn by sharing knowledge? A team of researchers led by computer science Professor Laurent Itti and one of his Ph.D. students, Yunhao Ge, address this question in ...

Molecular biologists identify framework for understanding RNA editing in a disease-causing parasite

Molecular biologists identify framework for understanding RNA editing in a disease-causing parasite
2023-07-19
As molecular biologists at Boston University and as husband and wife, Ruslan Afasizhev and Inna Afasizheva, have worked together for decades. Together, they have published dozens of papers on the mechanics of mitochondrial DNA and RNA in a single-celled, disease-causing parasite called Trypanosoma brucei. Now, years of breakthroughs have led to their latest paper published in Science, which provides a detailed look at a mystifying process called RNA editing and could potentially help treat a deadly disease. In ...

LAST 30 PRESS RELEASES:

Resistance training may improve nerve health, slow aging process, study shows

Common and inexpensive medicine halves the risk of recurrence in patients with colorectal cancer

SwRI-built instruments to monitor, provide advanced warning of space weather events

Breakthrough advances sodium-based battery design

New targeted radiation therapy shows near-complete response in rare sarcoma patients

Does physical frailty contribute to dementia?

Soccer headers and brain health: Study finds changes within folds of the brain

Decoding plants’ language of light

UNC Greensboro study finds ticks carrying Lyme disease moving into western NC

New implant restores blood pressure balance after spinal cord injury

New York City's medical specialist advantage may be an illusion, new NYU Tandon research shows

Could a local anesthetic that doesn’t impair motor function be within reach?

1 in 8 Italian cetacean strandings show evidence of fishery interactions, with bottlenose and striped dolphins most commonly affected, according to analysis across four decades of data and more than 5

In the wild, chimpanzees likely ingest the equivalent of several alcoholic drinks every day

Warming of 2°C intensifies Arctic carbon sink but weakens Alpine sink, study finds

Bronze and Iron Age cultures in the Middle East were committed to wine production

Indian adolescents are mostly starting their periods at an earlier age than 25 years ago

Temporary medical centers in Gaza known as "Medical Points" (MPs) treat an average of 117 people daily with only about 7 staff per MP

Rates of alcohol-induced deaths among the general population nearly doubled from 1999 to 2024

PLOS One study: In adolescent lab animals exposed to cocaine, High-Intensity Interval Training boosts aversion to the drug

Scientists identify four ways our bodies respond to COVID-19 vaccines

Stronger together: A new fusion protein boosts cancer immunotherapy

Hidden brain waves as triggers for post-seizure wandering

Music training can help the brain focus

Researcher develop the first hydride ion prototype battery

MIT researchers find a more precise way to edit the genome

‘Teen’ pachycephalosaur butts into fossil record

Study finds cocoa extract supplement reduced key marker of inflammation and aging

Obesity treatment with bariatric surgery vs GLP-1 receptor agonists

Nicotinamide for skin cancer chemoprevention

[Press-News.org] Research analyzes kidney functions and predictors of disease
Researchers find indicators while studying hundreds of donor samples