(Press-News.org)
“These observations support that accumulation of senescent cells may contribute to fibrotic lung disease [...]”
BUFFALO, NY- July 31, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, “Human senescent fibroblasts trigger progressive lung fibrosis in mice.”
Cell senescence has recently emerged as a potentially relevant pathogenic mechanism in fibrosing interstitial lung diseases (f-ILDs), particularly in idiopathic pulmonary fibrosis. In a new study, researchers Fernanda Hernandez-Gonzalez, Neus Prats, Valentina Ramponi, José Alberto López-Domínguez, Kathleen Meyer, Mònica Aguilera, María Isabel Muñoz Martín, Daniel Martínez, Alvar Agusti, Rosa Faner, Jacobo Sellarés, Federico Pietrocola, and Manuel Serrano from Hospital Clinic Barcelona, The Barcelona Institute of Science and Technology (BIST), Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), University of Barcelona, Karolinska Institute, Catalan Institution for Research and Advanced Studies (ICREA), and Altos Labs hypothesized that senescent human fibroblasts may suffice to trigger a progressive fibrogenic reaction in the lung.
“Here we: (1) explored this hypothesis in vivo; (2) investigated the potential underlying biological mechanisms in vitro; and (3) studied the effects of one experimental senolytic compound (navitoclax) and two anti-fibrotic drugs currently used in the treatment of IPF in humans (nintedanib and pirfenidone), both in vivo and in vitro.”
To address this, senescent human lung fibroblasts, or their secretome (SASP), were instilled into the lungs of immunodeficient mice. The researchers found that human senescent fibroblasts engraft in the lungs of immunodeficient mice and trigger progressive lung fibrosis associated to increasing levels of mouse senescent cells, whereas non-senescent fibroblasts do not trigger fibrosis. They also found that the SASP of human senescent fibroblasts is pro-senescence and pro-fibrotic both in vitro when added to mouse recipient cells and in vivo when delivered into the lungs of mice, whereas the conditioned medium (CM) from non-senescent fibroblasts lacks these activities. Finally, navitoclax, nintedanib and pirfenidone were found to ameliorate lung fibrosis induced by senescent human fibroblasts in mice, while only navitoclax displayed senolytic activity.
“We conclude that human senescent fibroblasts, through their bioactive secretome, trigger a progressive fibrogenic reaction in the lungs of immunodeficient mice that includes the induction of paracrine senescence in the cells of the host, supporting the concept that senescent cells actively contribute to disease progression in patients with f-ILDs.”
Read the full study: DOI: https://doi.org/10.18632/aging.204825
Corresponding Authors: Manuel Serrano, Federico Pietrocola - mserrano@altoslabs.com, federico.pietrocola@ki.se
Keywords: mouse model, cellular senescence, pulmonary fibrosis, antifibrotics, senolytic
Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204825
About Aging:
Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at www.Aging-US.com and connect with us:
SoundCloud
Facebook
Twitter
Instagram
YouTube
LabTube
LinkedIn
Reddit
Pinterest
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker Str., Suite 1B
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
###
END
Plant-based diets confer various health benefits, including lowering the risk of cardiovascular disease and certain cancers. However, the relationship between plant protein intake and the risk of chronic kidney disease (CKD) remains unclear. This study led by Ga Young Heo aimed to investigate the association between plant protein intake and the development of CKD. Using the UK biobank study data, the researchers found that participants with a higher plant protein intake had a lower risk of developing CKD. This finding suggests that a higher dietary intake of plant-based protein may be beneficial for kidney health and provide insight into ...
CHAPEL HILL, N.C. – Cases of human papillomavirus (HPV)-associated cancers of the head and neck, known as head and neck squamous cell carcinoma (HNSCC), are rapidly increasing throughout the United States. Unfortunately, relatively little is known about the factors that contribute to these tumors and what makes some tumors more aggressive and treatment-resistant than others.
To determine why some patients respond better to radiation therapy than others, researchers in UNC School of Medicine’s Department of Otolaryngology/Head and Neck ...
WASHINGTON—The Endocrine Society and Matchbox Virtual Media are pleased to announce today that the organizations formed a joint venture that will bring exciting new opportunities for medical, healthcare, and scientific associations to better customize the experiences of their customers relative to producing meetings, organizing communities, and disseminating educational products.
The new joint venture will benefit from the Endocrine Society’s initial financial investments and its robust networking within the medical and scientific fields. Matchbox Virtual Media brings its proven platform, technologies, ...
JUPITER, Fla. — A new scientist joining The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology invents creative and efficient ways to build complex, potentially useful molecules, studying their activity so that compounds found in nature may eventually become useful products, such as medications.
Synthetic chemist and associate professor Masayuki Wasa, Ph.D., joins the institute from Boston College, where he was an assistant professor of chemistry. Synthetic chemists specialize in assembling larger molecules from smaller parts, like a child assembling a Lego spaceship from a basket of oddly shaped pieces.
But the work is far from child’s ...
At the NRG Oncology Summer Meeting on Thursday, July 20, 2023, at approximately 5:44pm EDT, Larry J. Copeland, MD passed the presidential gavel to Thomas J. Herzog, MD at The GOG Foundation, Inc. (GOG-F) Board of Directors meeting.
Dr. Herzog brings a comprehensive background in clinical trials, the integral business aspects and acumen to this important position. A practicing gynecologic oncologist and member of the Board of Directors of GOG-F, he has served as the Treasurer of GOG-F from 2014-2023 and prior ...
Embargoed for release until 5:00 p.m. ET on Monday 31 July 2023
Annals of Internal Medicine Tip Sheet
@Annalsofim
Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf ...
Declawing house cats to keep them from scratching people and furniture is controversial – and even banned in some countries and areas in the U.S. – but the practice is not limited to house cats. In a new study, researchers looked at the effects of declawing on larger cat species and found that declawing disproportionately impacts their muscular capabilities as compared to their smaller brethren.
While it is illegal in the U.S. to surgically modify an exotic animal, declawing is still done on large cats like lions and tigers, often in an effort to allow cubs to more safely ...
BIRMINGHAM, Ala. – Birmingham’s Pepper Place has a striking new addition to its teeming farmers’ market and noted food offerings — a multimillion-dollar cancer research laboratory.
The lab is IN8bio’s new research and development facility in the Martin Biscuit Building at Pepper Place. This R&D space has about 6,000 square feet of wet lab space and around 4,000 square feet for offices, conferences and break areas. IN8bio is a biotechnology company focused on developing novel cellular therapies for cancer, with deep roots in cutting-edge cancer research developed at ...
Neurons produce rhythmic patterns of electrical activity in the brain. One of the unsettled questions in the field of neuroscience is what primarily drives these rhythmic signals, called oscillations. University of Arizona researchers have found that simply remembering events can trigger them, even more so than when people are experiencing the actual event.
The researchers, whose findings are published in the journal Neuron, specifically focused on what are known as theta oscillations, which emerge in the brain's hippocampus region during activities like exploration, navigation and sleep. The hippocampus plays ...
Every protein in your body is made up of the same 20 building blocks called amino acids. But just because nature is stuck with a limited toolkit doesn’t mean humans can’t expand it.
A study published in Science on July 27 by a team including Pitt chemists describes a powerful new way to create “unnatural” amino acids, which could find use in protein-based therapies and open up novel branches of organic chemistry.
“This is a completely new transformation: new to nature and new to chemistry,” ...
