(Press-News.org)
“We have discussed in detail the clinical implications of ER in avoiding overtreatment and undertreatment in DCIS.”
BUFFALO, NY- August 1, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on July 20, 2023, entitled, “Multiclonality of ER expression in DCIS – Implications for clinical practice and future research.”
Estrogen receptor (ER) expression is not routinely evaluated in ductal carcinoma in situ (DCIS). This may be because the prognostic role of ER in DCIS was unclear until the UK/ ANZ DCIS trial in 2021 showed that lack of ER expression in DCIS was associated with a greater than 3-fold risk of ipsilateral recurrence. This was the largest (to date) case-control study nested in a DCIS randomized trial.
The meticulous study design eliminated treatment allocation bias as well as treatment-related confounding. This was also the first-ever study to show that ER expression in DCIS is multi-clonal — having very important clinical and research implications. A small proportion of otherwise ER-positive DCIS also contained carcinoma in situ (CIS) duct/s that completely lacked ER expression.
“This admixture of clearly ER-positive and ER-negative ducts is not the same as heterogeneity in ER expression and I labeled such DCIS cases as multiclonal DCIS even if just one CIS duct in the entire section lacked ER expression.”
In his new editorial, Dr. Mangesh A. Thorat from Guy's and St Thomas' NHS Foundation Trust, Queen Mary University of London and King's College London discusses this study in greater detail, the clinical implications of ER status in DCIS, the potential for avoiding overtreatment and undertreatment based on ER expression, and the importance of simple clinical observations in research.
“In summary, ER is a strong and independent prognostic biomarker in DCIS and our novel clonal method is a more accurate method to assess ER status in DCIS.”
Read the full editorial: DOI: https://doi.org/10.18632/oncotarget.28450
Correspondence to: Mangesh A. Thorat
Email: thoratmangesh@gmail.com, m.thorat@qmul.ac.uk
Keywords: ductal carcinoma in situ (DCIS), invasive breast cancer, ER, recurrence, clonality
About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:
Twitter
Facebook
YouTube
Instagram
LinkedIn
Pinterest
LabTube
Soundcloud
Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28450
Click here to subscribe to Oncotarget publication updates.
For media inquiries, please contact: media@impactjournals.com.
Oncotarget Journal Office
6666 East Quaker Str., Suite 1A
Orchard Park, NY 14127
Phone: 1-800-922-0957 (option 2)
###
END
The public funding of science is responsible for many of the biomedical and other scientific breakthroughs on which our lives depend. However, the process through which funding decisions are made, the peer review of grant proposals, has been historically understudied, and current approaches can lead to undesirable outcomes. Writing in Research Integrity and Peer Review, Stephen A. Gallo, then affiliated with the American Institute of Biological Sciences, and Michael Pearce, Carole J. Lee, and Elena A. Erosheva from the University of ...
In the peak heat of summer, beachgoers don’t want their plans thwarted by harmful algal blooms (HABs). But current methods to remove or kill toxin-producing algae and cyanobacteria aren’t efficient or practical for direct applications in waterways. Now, researchers reporting in ACS ES&T Water have coated a floating sponge in a charcoal-like powder, and when paired with an oxidizing agent, the technique destroyed over 85% of algal cells from lake and river water samples.
Swaths of electric green and bright orange-red HABs, or the less brilliantly colored cyanobacteria Microcystis aeruginosa, can produce toxins that can sicken humans ...
An evaluation of 17 previously published studies suggests that exposure to lead in the womb or in childhood is associated with an increased risk of engaging in criminal behavior in adulthood—but more evidence is needed to strengthen understanding. Maria Jose Talayero Schettino of the George Washington University, U.S., and colleagues present these findings in the open-access journal PLOS Global Public Health.
Lead exposure can cause a variety of health challenges, such as cardiac issues, kidney ...
Biofilms are highly resistant communities of bacteria that pose a major challenge in the treatment of infections. While studying biofilm formation in laboratory conditions has been extensively conducted, understanding their development in the complex environment of the human respiratory tract has remained elusive.
A team of researchers led by Alexandre Persat at EPFL have now cracked the problem by successfully developing organoids called AirGels. Organoids are miniature, self-organized 3D tissues grown from stem cells to mimic actual body tissues and organs in the human body. They represent ...
Many of the answers for effectively responding to a pathogen lie in its genome. Understanding the genetic code of a pathogen like Ebola or the virus that causes COVID-19 allows scientists to track its movement, predict future behavior, identify the source of the outbreak and, most importantly, develop effective vaccines and treatments. This technology was critical during the pandemic, and it will be even more so with future outbreaks.
That makes the continued development of genomic sequencing one of the most ...
Scientists at Washington University in St. Louis have developed a breath test that quickly identifies those who are infected with the virus that causes COVID-19. The device requires only one or two breaths and provides results in less than a minute.
The study is available online in the journal ACS Sensors. The same group of researchers recently published a paper in the journal Nature Communications about an air monitor they had built to detect airborne SARS-CoV-2 — the virus that causes COVID-19 — within about ...
Researchers from the UvA and North Carolina State University have identified the specific mixture of pheromone chemicals that male moths use during courtship. The findings provide more detail about the complex blend of chemicals that males and females of this group of moths use in fundamental short-range communication. The publication in the scientific journal Current Biology appeared on 1 August.
Scent compounds are essential for male moths to entice female conspecifics to mate. Both partners need to find and recognize each other in the dark. This is done by sex pheromones secreted by the female. Then it is up to the male to convince the female ...
Immune checkpoint inhibitor (ICI) therapies used to treat cancer come with the risk of adverse autoimmune responses, including arthritis that can persist for years and require joint replacement surgery. Little is known about the specific cells responsible for these events. Researchers at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, and collaborators led a study to investigate these immune adverse events and identified a specific type of CD8 T cell that characterizes inflammatory arthritis induced by ICI therapies.
Researchers ...
Even vulnerable people, who are at risk of severe Covid-19, achieved good antibody levels after three doses of mRNA vaccine. This is shown by a study from the University of Gothenburg on patients having undergone a bone marrow transplant or with liver disease, including cirrhosis.
The aim of the study, which has been published in the journal Infectious Diseases, was to investigate the effects of repeated vaccinations and hybrid immunity against Covid-19 among particularly vulnerable individuals. Hybrid immunity refers to the protection provided by vaccination in combination with SARS-CoV-2 ...
UCSF Medical Center Is Among Nation’s Top Hospitals for 2023-24
U.S. News & World Report ranks UCSF Health adult care among nation’s top 10 hospitals in 7 specialties, Best in the West for neurology/neurosurgery and rheumatology
UCSF Medical Center has been named to the Honor Roll of the nation’s top hospitals for adult care in U.S. News & World Report’s 2023-24 Best Hospitals rankings, representing the highest quality of care and safety standards in the country.
The distinction was earned by only 22 medical ...
