PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Dectin-1 stimulation promotes distinct inflammatory signature in HIV and aging

Dectin-1 stimulation promotes distinct inflammatory signature in HIV and aging
2023-08-31
(Press-News.org)

“To our knowledge, our study is the first to evaluate the specific function of Dectin-1 in the setting of aging and HIV-infection.”

BUFFALO, NY- August 31, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, “Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging.”

Dectin-1 is an innate immune receptor that recognizes and binds β-1, 3/1, 6 glucans on fungi. In this new study, researchers Archit Kumar, Jiawei Wang, Allen Esterly, Chris Radcliffe, Haowen Zhou, Brent Vander Wyk, Heather G. Allore, Sui Tsang, Lydia Barakat, Subhasis Mohanty, Hongyu Zhao, Albert C. Shaw, and Heidi J. Zapata from Yale University evaluated Dectin-1 function in myeloid cells in a cohort of HIV-positive and HIV-negative young and older adults. 

“The HIV-positive and HIV-negative groups were comparable in age and gender distribution, incidence of comorbidities such as diabetes, metabolic syndrome, cardiovascular disease and pulmonary disease.”

Stimulation of monocytes with β-D-glucans induced a pro-inflammatory phenotype in monocytes of HIV-infected individuals that was characterized by increased levels of IL-12, TNF-α, and IL-6, with some age-associated cytokine increases also noted. Dendritic cells showed a striking HIV-associated increase in IFN-α production. These increases in cytokine production paralleled increases in Dectin-1 surface expression in both monocytes and dendritic cells that were noted with both HIV and aging. Differential gene expression analysis showed that HIV-positive older adults had a distinct gene signature compared to other cohorts characterized by a robust TNF-α and coagulation response (increased at baseline), a persistent IFN-α and IFN-γ response, and an activated dendritic cell signature/M1 macrophage signature upon Dectin-1 stimulation. 

Dectin-1 stimulation induced a strong upregulation of MTORC1 signaling in all cohorts, although increased in the HIV-Older cohort (stimulation and baseline). In sum, this study demonstrates that the HIV Aging population has a distinct immune signature in response to Dectin-1 stimulation. This signature may contribute to the pro-inflammatory environment that is associated with HIV and aging.

“Overall, this study demonstrates that age, HIV-infection and co-morbidities can alter the individual immune response. In particular our study showed a unique immune signature in the setting of both HIV and aging in response to Dectin-1 stimulation.”

 

Read the full study: DOI: https://doi.org/10.18632/aging.204927 

Corresponding Author: Heidi J. Zapata - heidi.zapata@yale.edu 

Keywords: immune response, innate immune cells, HIV-infection, aging, dectin-1

Sign up for free Altmetric alerts about this article:  https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204927

 

About Aging:

Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

SoundCloud Facebook Twitter Instagram YouTube LabTube LinkedIn Reddit Pinterest  

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###

END


[Attachments] See images for this press release:
Dectin-1 stimulation promotes distinct inflammatory signature in HIV and aging

ELSE PRESS RELEASES FROM THIS DATE:

Excess ceramide and disrupted iron metabolism in neuronal mitochondria found to be the cause for MEPAN syndrome

2023-08-31
A recent study published in Nature Metabolism has revealed the pathogenic mechanism underlying a rare pediatric neurodegenerative disorder known as mitochondrial enoyl reductase protein-associated neurodegeneration (MEPAN) syndrome. The study was led by Dr. Hugo J. Bellen, distinguished service professor at Baylor College of Medicine, and Chair of Neurogenetics at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital (Duncan NRI), and Dr. Debdeep Dutta, a postdoctoral fellow in the Bellen lab. The Duncan NRI team found that in patients and animal models of this disorder, a large number of neurons ...

A new approach to stop cancer growth?

A new approach to stop cancer growth?
2023-08-31
CLEVELAND– Case Western Reserve University biochemical researchers have identified a new function of a key protein that leads to cancer–a finding they believe could lead to more effective treatments for a range of cancers and other diseases.   The protein is LSD1 (lysine-specific histone demethylase 1A), which functions as a type of traffic cop inside human cells. It controls gene activity during embryonic development and regulating gene expression throughout life.   Scientists have also identified in recent years that the overexpression of LSD1—in this instance, producing too many proteins—can ...

Study: ‘Suicidal’ mechanism discovered in ion channel receptors enables the sensing of heat and pain

2023-08-31
BUFFALO, N.Y. – The ability to accurately detect heat and pain is critical to human survival, but scientists have struggled to understand on a molecular level exactly how our bodies sense these potential risks. Now, University at Buffalo researchers have unraveled the complex biological phenomena that drive these critical functions. Their research, published in the Proceedings of the National Academy of Sciences on Aug. 28, has uncovered a previously unknown and completely unexpected “suicidal” reaction in ion channel receptors that explains the complicated mechanisms that underlie sensitivity to temperature and pain. The ...

Scientists unpick how lung cells induce immune response to influenza

2023-08-31
Researchers from Trinity College Dublin have discovered some new and surprising ways that viral RNA and influenza virus are detected by human lung cells, which has potential implications for treating people affected by such viruses. Influenza viruses remain a major threat to human health and can cause severe symptoms in young, elderly, and immuno-compromised populations, leading to annual epidemics which endanger between 3 and 5 million people of severe illness and cause 290,000 to 650,000 deaths worldwide. These viruses primarily target respiratory epithelial cells ...

Expanding the impact of CAR T cell therapy: An immunotherapy strategy against all blood cancers

2023-08-31
PHILADELPHIA – A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. Scientists in the Perelman School of Medicine at the University of Pennsylvania have demonstrated the potential efficacy of this approach in preclinical tests. In the study, published today in Science Translational Medicine, the researchers used engineered CAR T cells to target CD45—a surface marker found on nearly all blood cells, including nearly all blood cancer cells. Because CD45 is found on healthy blood cells too, the research team used CRISPR base-editing to develop a method ...

New project to make data curation accessible

2023-08-31
JooYoung Seo, assistant professor in the School of Information Sciences at the University of Illinois Urbana-Champaign, has been awarded a $649,921 Early Career Development grant from the Institute of Museum and Library Services (IMLS grant RE-254891-OLS-23), under the Laura Bush 21st Century Librarian Program, which supports “developing a diverse workforce of librarians to better meet the changing learning and information needs of the American public by enhancing the training and professional development of librarians, developing faculty and library leaders, and recruiting and ...

A step closer to digitizing the sense of smell: Monell Center, Osmo model describes odors better than human panelists

A step closer to digitizing the sense of smell: Monell Center, Osmo model describes odors better than human panelists
2023-08-31
PHILADELPHIA (August 31, 2023) – A main crux of neuroscience is learning how our senses translate light into sight, sound into hearing, food into taste, and texture into touch.  Smell is where these sensory relationships get more complex and perplexing.    To address this question, a research team co-led by the Monell Chemical Senses Center and start-up Osmo, a Cambridge, Mass.-based company spun out of machine learning research done at Google Research, Google DeepMind (formerly known as Google Brain), are investigating how airborne chemicals connect to odor perception in the brain. To this end they discovered that a machine-learning ...

New odor map helps match perceptions of smells with their chemical structure

2023-08-31
Brian K. Lee and colleagues have developed a Principal Odor Map (POM) that models the connections between an odorant’s chemical structure with its perceptual property of smell. The map performed as well as some highly trained human “sniffers” in describing odor quality, and could be used for predicting odor intensity and perceptual similarity between odorants. The map moves researchers closer to being able to match molecular properties of odorants to their perceptual properties, a challenge that has proved difficult for olfactory science. (For other senses, neuroscientists have been able to map light wavelengths ...

Early ancestral bottleneck could’ve spelled the end for modern humans

Early ancestral bottleneck could’ve spelled the end for modern humans
2023-08-31
How a new method of inferring ancient population size revealed a severe bottleneck in the human population which almost wiped out the chance for humanity as we know it today. An unexplained gap in the African/Eurasian fossil record may now be explained thanks to a team of researchers from China, Italy and the United States. Using a novel method called FitCoal (fast infinitesimal time coalescent process), the researchers were able to accurately determine demographic inferences by using modern-day human genomic sequences from 3,154 individuals. These findings indicate that early human ancestors went through a prolonged, severe bottleneck in which approximately 1,280 ...

Genomic model suggests population decline in human ancestors

2023-08-31
Between 800,000 and 900,000 years ago, the population of human ancestors crashed, according to a new genomic model by Wangjie Hu and colleagues. They suggest that there were only about 1280 breeding individuals during this transition between the early and middle Pleistocene, and that the population bottleneck lasted for about 117,000 years. The researchers say about 98.7% of the ancestral population was lost at the beginning of the bottleneck. This decline coincided with climate changes that turned glaciations into long-term events, a decrease ...

LAST 30 PRESS RELEASES:

Flipping the switch on sperm motility offers new hope for male infertility

Twisting sound: Scientists discover a new way to control mechanical vibrations in metamaterial

Drip by drip: The hidden blueprint for stalagmite growth

mRNA therapy restores sperm production and fertility in mice

New way to weaken cancer cells could supercharge prostate cancer treatment

How sound—but not touch—shapes rhythm in the brain

Exploring the therapeutic potential of hypothermia

Research alert: Bioengineering breathes new life into failed cancer treatment

AI, health, and health care today and tomorrow – the JAMA Summit Report on artificial intelligence

Large genetic study links cannabis use to psychiatric, cognitive and physical health

Social media use trajectories and cognitive performance in adolescents

Music for the brain: Study tests the effect of slow-tempo relaxing music to address delirium in critically ill older adults 

AI models predict sepsis in children, allow preemptive care

Liraglutide vs semaglutide vs dulaglutide in veterans with type 2 diabetes

Antenatal corticosteroids and infectious diseases throughout childhood

New lab-grown human embryo model produces blood cells

Life after near death: Research reveals how to improve support for near-death experiencers

Illinois Chat is launched for campus community

FAU receives $3M federal grant to prevent substance use in at-risk youth

New report shows action to improve gender equity linked to career gains and better business performance

Kiwis could help manage chronic constipation

Breast, lung, and bladder cancer phase 3 trials led by Dana-Farber presented at ESMO Congress 2025

New open-source software allows for efficient 3D printing with multiple materials

Decoding the secrets of ‘chemo brain’

‘Far from negligible’: New Australian fossil fuel site will have major impact on people and the planet

UK heatwaves overwhelm natural ecological safeguards to increase wildfire risk

Key ExoMars Rover part ships from Aberystwyth

90% of Science Is Lost: Frontiers’ revolutionary AI-powered service transforms data sharing to deliver breakthroughs faster

Skin symptoms may forewarn mental health risks

Brain test predicts ability to achieve orgasm – but only in patients taking antidepressants

[Press-News.org] Dectin-1 stimulation promotes distinct inflammatory signature in HIV and aging