Aging alters pancreatic circadian rhythm
2023-09-05
(Press-News.org)
“Overall, our study identified previously unknown circadian transcriptome reorganization of pancreas by aging [...]”
BUFFALO, NY- September 5, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, “Reorganization of pancreas circadian transcriptome with aging.”
The evolutionarily conserved circadian system allows organisms to synchronize internal processes with 24-h cycling environmental timing cues, ensuring optimal adaptation. Like other organs, the pancreas function is under circadian control. Recent evidence suggests that aging by itself is associated with altered circadian homeostasis in different tissues which could affect the organ’s resiliency to aging-related pathologies.
Pancreas pathologies of either endocrine or exocrine components are age-related. Whether pancreas circadian transcriptome output is affected by age is still unknown. In their new study, researchers Deepak Sharma, Caitlin R. Wessel, Mahboobeh Mahdavinia, Fabian Preuss, and Faraz Bishehsari from Rush University and University of Wisconsin-Parkside profiled the impact of age on the pancreatic transcriptome over a full circadian cycle and elucidated a circadian transcriptome reorganization of pancreas by aging.
“Here we carried out a 24-h circadian transcriptomic analysis of pancreas from male mice at young and old ages.”
The researchers defined a comprehensive circadian transcriptome landscape and identified biological pathways that are reflective of aging pancreas. Additionally, analysis of the pancreatic microenvironment revealed novel mechanistic insights into the fibroblast-mediated regulation of rhythmicity in aged pancreas. The team suggests that the circadian transcriptome in aging pancreas re-organizes in response to age-specific signals from the cellular microenvironment, primarily modulated by fibroblasts.
“Our study highlights gain of rhythms in the extrinsic cellular pathways in the aged pancreas and extends a potential role to fibroblast-associated mechanisms.”
Read the full study: DOI: https://doi.org/10.18632/aging.204929
Corresponding Author: Faraz Bishehsari
Corresponding Email: Faraz_Bishehsari@rush.edu
Keywords: circadian rhythms, aging, RNA transcriptomics, pancreas
Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.https://doi.org/10.18632/aging.204929
About Aging:
Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at www.Aging-US.com and connect with us:
SoundCloud
Facebook
Twitter
Instagram
YouTube
LabTube
LinkedIn
Reddit
Pinterest
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker Str., Suite 1B
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
###
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2023-09-05
Invasive medical procedures, such as surgery requiring local anesthesia, often involve the risk of nerve injury. During operation, surgeons may accidentally cut, stretch, or compress nerves, especially when mistaking them for some other tissue. This can lead to long-lasting symptoms in the patient, including sensory and motor problems. Similarly, patients receiving nerve blockades or other types of anesthesia can suffer from nerve damage if the needle is not placed at the correct distance from the targeted peripheral nerve.
Consequently, researchers have been trying to develop medical imaging techniques to mitigate the risk of nerve damage. For instance, ultrasound and magnetic resonance ...
2023-09-05
LOS ANGELES – Almost one-third of government appointees to the Department of Health and Human Services (HHS) leave to take jobs in private industry, according to a study by the USC Schaeffer Center for Health Policy & Economics and Harvard University.
The study, published in Health Affairs, is the first to quantify the personnel movement between health-care industries and the government agencies that regulate them, according to the authors. Although there are understandable reasons for people to move between the public and private sectors, the study notes that such a revolving door could make government agencies more vulnerable to pro-industry bias.
“Laws passed ...
2023-09-05
The use of direct oral anticoagulants (DOACs) was associated with a reduction in dementia risk compared to traditional blood thinners—like warfarin—in atrial fibrillation patients, particularly in Asian patients. According to a study published today in JACC: Asia, this benefit may reverse with increased age and necessitates further follow-up study.
“Asian patients are more likely to be sensitive to vitamin K antagonism, which puts them at high risk for bleeding events, contributing to dementia development ...
2023-09-05
ITHACA, N.Y. – Male fruit flies don’t usually like each other. Socially, they reject their fellow males and zero in on the females they discern via chemical receptors – or so scientists thought.
New research from Cornell University biologists suggests the fruit fly’s visual system, not just chemical receptors, are deeply involved with their social behaviors. The work sheds light on the possible origin of differences in human social behaviors, such as those seen in people with bipolar disorder ...
2023-09-05
New research from Tulane University may shed light on how parasite strain diversity can impact Chagas disease progression and severity.
Chagas, a lesser-known and studied tropical disease, is caused by Trypanosoma cruzi parasites, which are transmitted by kissing bugs. In the Americas, the disease affects 6 million people in 21 countries, with approximately 30,000 new cases each year. While most infected patients remain asymptomatic, about 20-40 percent of those infected will develop chronic heart disease ...
2023-09-05
New simulations model traffic-related air pollution over the region surrounding Chicago, North America’s largest freight hub
In the simulations, the researchers modeled a scenario in which 30% of current on-road heavy-duty vehicles (HDVs) were replaced by electric HDVs
Electrifying HDVs would substantially reduce air pollution and save hundreds of lives annually in the region, with particularly large health benefits in predominantly Black, Hispanic and Latinx communities
The region also would save nearly $6 billion annually in avoided ...
2023-09-05
The diagnosed severity of aortic stenosis strongly correlates with clinical outcomes, new Kaiser Permanente research shows. But the study also suggests that fine-tuning physician assessment of those patients with moderate aortic stenosis could help improve outcomes and better determine which patients might benefit from surgery.
The study found that patients diagnosed with moderate aortic stenosis have outcomes most similar to those categorized with mild aortic stenosis while only those with moderate-to-severe aortic stenosis had outcomes similar to those with ...
2023-09-05
The University of Miami School of Nursing and Health Studies (SONHS) has been awarded an unprecedented $23.57 million grant from the National Institutes of Health (NIH) to join the Environmental influences on Child Health Outcomes (ECHO) Program.
The interdisciplinary grant, the largest award to date in the Coral Gables Campus’ history, is funding an ambitious project spearheaded by Hudson Santos, RN, PhD, FABMR, FAAN, the lead Principal Investigator and Vice Dean for Research Affairs, with Professor Michael Paidas, MD, chair of the University of Miami Miller School of Medicines Department of Obstetrics, ...
2023-09-05
New research shows that Allied Health Professions (AHPs) are significantly underrepresented in senior leadership roles despite being the third largest workforce in the NHS.
Ranging from paramedics to podiatrists, the AHPs encompass various healthcare disciplines, constituting a workforce of 185,000 within the NHS.
However AHPs have historically been underrepresented in strategic leadership positions, often occupied by medical professionals. To address this, NHS England advocated for the establishment of a Chief AHP role in every Trust to harness the untapped potential of this workforce and increase diversity in leadership ...
2023-09-05
WASHINGTON, D.C.—Food costs decrease 16% on a low-fat vegan diet, a savings of more than $500 a year, compared to a diet that includes meat, dairy, and other animal products, according to a new analysis from the Physicians Committee for Responsible Medicine published in JAMA Network Open.
“We knew that a vegan diet significantly reduces your risk of conditions like heart disease, diabetes, and obesity—and now we have proof that opting for beans instead of beef will also lead to significant savings on your grocery bill,” says study co-author Hana Kahleova, ...
LAST 30 PRESS RELEASES:
[Press-News.org] Aging alters pancreatic circadian rhythm
