(Press-News.org) An abstract unveiling a new mouse model for brain arteriovenous malformations (AVMs) developed by UTHealth Houston researchers has been selected for a poster presentation at the second annual National Institutes of Health (NIH) Investigator Meeting for Interoception Research in November.
Eunsu Park, PhD, assistant professor in the Vivian L. Smith Department of Neurosurgery with McGovern Medical School at UTHealth Houston, will present the abstract at the meeting, hosted by the National Center for Complementary and Integrative Health (NCCIH) at the NIH campus in Bethesda, Maryland, on Nov. 11 to highlight recent advances in interoception research. Interoception refers to the communication between the brain and body by the peripheral nervous or non-neuronal systems.
“I hope the presentation will be an excellent chance to publicize our study to all researchers and the general public who don’t know what brain AVMs are and how vital this new model is,” said Park, whose abstract was among 20 selected for a poster presentation.
Brain AVMs are a tangle of vessels in the brain that carry a high risk for hemorrhagic stroke and neurological deficits in children and young adults. Mutations of KRAS – a subfamily of proteins that regulate cell functions – are closely linked with sporadic brain AVMs, which account for 95% of all cases. The excessive, uncontrolled formation of new blood vessels is also a key process in brain AVM formation.
Using the discovery of KRAS mutations in human patients with brain AVMs, the UTHealth Houston research team established and characterized a new brain AVM mouse model over a three-year period, from 2018 to 2020.
In the abstract, Park proposed that humoral (antibody-related) immune mediators circling throughout the body’s bloodstream interact with cells surrounding the brain AVM. His research explored how the mutant KRAS in endothelial cells changes humoral immunity and causes brain AVM-associated hemorrhage.
“Ultimately, we believe this research can illuminate what is happening in human brain AVMs and give insights into finding therapeutic methods for these patients,” Park said.
Park’s co-collaborators on the research with McGovern Medical School’s neurosurgery department included Eunhee Kim, PhD; Peng Roc Chen, MD; Minjung Lee, PhD; Hyejin Park, PhD; Jaeyeong Jeong, PhD. Jaroslaw (Jarek) Aronowski, MD, PhD, with the medical school’s Department of Neurology, also contributed to the research. The study was supported by grant R01NS126415 from the NIH/National Institute of Neurological Disorders and Stroke.
END
UTHealth Houston researcher to present abstract detailing new mouse model for brain arteriovenous malformations at NIH meeting
2023-09-12
ELSE PRESS RELEASES FROM THIS DATE:
Combination of stressors key to testing perovskite solar cells
2023-09-12
Perovskite solar cells should be subjected to a combination of stress tests simultaneously to best predict how they will function outdoors, according to researchers at the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL).
Solar cells must endure a set of harsh conditions—often with variable combinations of changing stress factors—to judge their stability, but most researchers conduct these tests indoors with a few fixed stressing conditions. While these tests provide some necessary insight, understanding which stressor applied during indoor tests provided predictive correlations ...
Communicating stability, strong connections to stakeholders versus shareholders are priorities in Chinese financial reporting, Rotman research finds
2023-09-12
September 12, 2023 Toronto - It’s commonly accepted that U.S. and Chinese companies treat financial reporting and disclosure differently.
New research not only confirms that but digs into the motivations behind the distinction, using surveys with more than 200 Chinese executives who hold reporting responsibility. An overriding interest in communicating long-term stability and inspiring confidence in the company’s prospects among a diverse range of stakeholders, and not primarily shareholders, as in the U.S., was a signature driver for the Chinese business leaders.
“Acknowledging differences in approaches and incentives ...
Morris Animal Foundation funds 6 new studies to advance canine cancer research
2023-09-12
DENVER/Sept. 12, 2023 – Recent findings from the Golden Retriever Lifetime Study confirm the enormous impact of hemangiosarcoma on golden retrievers. To address critical gaps in disease detection and treatment, Morris Animal Foundation announced it is funding six studies focused on this deadly form of canine cancer.
“We are committed to providing resources to the top research teams in the world that can advance our understanding of hemangiosarcoma," said Dr. Kathy Tietje, Chief Program Officer at Morris Animal Foundation. "These innovative research ...
ReMDO grants support commercialization of regenerative medicine therapies
2023-09-12
WINSTON-SALEM, NC, September 12, 2023 - When the RegenMed Development Organization (ReMDO) offered its grant opportunity related to regenerative medicine manufacturing and commercialization, the result exceeded expectations.
The Regenerative Medicine Manufacturing grant call encouraged small, medium, and large companies to submit letters of interest with an accompanying white paper that addressed a gap in technical capabilities for one or more of the following topic areas: Cell and Biomaterial Manufacturing, Standards and Quality Control, Additive Manufacturing and Artificial Intelligence (AI) and Automation.
The grant opportunity will ...
Breast cancer recurrence may be triggered by chemotherapy injury to non-cancer cells
2023-09-12
A standard chemotherapy drug injures surrounding non-cancer cells, which can then awakens dormant cancer cells and promotes cancer growth, according to a new study publishing September 12th in the open access journal PLOS Biology by Ramya Ganesan of Emory University, US, and colleagues. The finding is important for understanding cancer recurrence and may point to important new targets to prevent it.
Advances in cancer treatment, including chemotherapy, have dramatically reduced mortality for many types of cancer, including breast cancer. Nonetheless, up to 23% of breast cancer patients experience recurrence within the first five years. Treatment is meant to kill all cancer cells, ...
Disease-resistant rice and wheat plants may modulate disease susceptibility in their neighbors
2023-09-12
Growing several plant varieties in the same field for disease resistance is a longstanding agricultural practice, but can have unpredictable results. A study publishing September 12th in the open access journal PLOS Biology by Jean-Benoit Morel at Institut National de Recherche pour l'Agriculture l'Alimentation et l'Environnement, Montpellier, France, and colleagues suggests that plant-to-plant interactions may confer disease immunity in both wheat and rice.
Neighbor-Modulated Susceptibility (NMS) occurs when healthy, same-species ...
Umass Amherst research finds benefits, risks in state-mandated school-based BMI assessments
2023-09-12
A University of Massachusetts Amherst resource economist finds mandated in-school Body Mass Index (BMI) assessments adopted in varying forms by 24 states to combat childhood obesity have the potential to improve the health of some students while introducing body-image issues for others. The research is believed to be the first to assess these policies as a whole, rather than in single states or school districts.
“In states that passed these laws, overweight and obese teens were more likely to correctly describe their bodies as such, compared to states ...
UNIST and University of Ulsan College of Medicine to introduce groundbreaking HST curriculum in Korea!
2023-09-12
In a significant collaboration, UNIST and the University of Ulsan College of Medicine (hereinafter ‘U of U College of Medicine’) have successfully developed a joint curriculum aimed at cultivating professionals with interdisciplinary expertise. This unique program seeks to bridge the gap between engineering and medicine, producing graduates who possess both medical knowledge and engineering understanding. The collaboration aims to contribute effectively to advancements in healthcare technology and innovation.
The jointly developed curriculum consists of seven courses, including ‘Introductions to Medical Science AI‘ and ‘Brain and Cognitive ...
How the respiratory tract microbiome influences the severity of bacterial pneumonia
2023-09-12
Pneumonia is an infection of the lung alveoli caused by bacteria, viruses or fungi. It is one of the leading causes of morbidity and mortality worldwide, representing a clinical and economic burden and a global public health problem. The microbial ecosystem (or microbiome) of the human respiratory tract colonizes different niches. The respiratory tract microbiome is of interest to scientists as it contributes to human health by stimulating the immune system and protecting against infection by pathogens. Scientists ...
Researchers develop new method for mapping the auditory pathway
2023-09-12
Researchers have developed a non-invasive method for mapping the human auditory pathway, which could potentially be used as a tool to help clinicians decide the best surgical strategy for patients with profound hearing loss.
The findings, published today in eLife, highlight the importance of early interventions to give patients the ability to hear and understand speech, so that their auditory-language network can develop properly and their long-term outcomes are improved.
Sensorineural hearing loss (SNHL) occurs when the sensitive hair cells inside the cochlea are damaged, or when there is damage to the auditory nerve which transmits sound to the brain. A person with profound hearing ...