(Press-News.org) ARLINGTON, Va., September 27, 2023 — The American Society for Radiation Oncology (ASTRO) today announced the three winning research proposals for the 2022 ASTRO-Myovant Sciences (now known as Sumitomo Pharma)-Pfizer Alliance New Combination (Relugolix-Radiation) Therapy Challenge. The Challenge aims to identify research that addresses ways prostate cancer treatments can be improved with the gonadotropin-releasing hormone (GnRH) receptor antagonist relugolix in patients who received radiation therapy.
The Challenge invited researchers to propose the study of relugolix in different scenarios: with definitive radiotherapy (concomitant/adjuvant/neoadjuvant) in patients with high/very high risk, unfavorable intermediate risk and locally advanced prostate cancer; with radiotherapy as salvage therapy following treatment with curative intent; as concomitant treatment with other oral oncolytics; for synchronous oligometastatic/metastatic and oligoprogressive disease; and beyond. Proposed studies could focus on a range of areas including clinical outcome evaluations, testosterone kinetics, patient-reported outcomes, safety/adverse events, compliance/adherence and translational research.
The Sumitomo Pharma-Pfizer Alliance will award up to a cumulative $2,500,000 in research funding, approximately $800,000 to each of the three winning proposals, over the next four to five years. The winning proposals and their principal investigators are:
“Quantifying Optimal Relugolix Duration with Radiation in High-Risk Prostate Cancer,” Xinglei Shen, MD, MS; University of Kansas Medical Center
“A comparison of Orgovyx (relugolix) vs Eligard (leuprolide) on cardiovascular function and biomarkers during standard of care combined ADT (androgen deprivation therapy)-radiation for prostate cancer,” Shang-Jui Wang, MD, PhD; The Ohio State University
“Phase III SUGAR Study: (SBRT and Ultrashort GnRH Antagonist‐Relugolix) for Clinicogenomic Unfavorable Intermediate Risk Prostate Cancer,” James Yu, MD, MHS, FASTRO; Yale School of Medicine
Paul L. Nguyen, MD, Chair of the Challenge scientific advisory team noted, “We are thrilled to support these three outstanding submissions that will advance our understanding of how best to optimize the use of relugolix with radiation to improve outcomes for patients with prostate cancer. We are grateful that Sumitomo Pharma America, Inc. and Pfizer launched this effort with ASTRO to fund new research by radiation oncologists and our ASTRO members.”
A panel of ASTRO members with clinical, research, diversity and inclusion, and statistical expertise served on the Challenge’s scientific advisory team and judging panel to ensure that proposals were science-driven, identified the most promising research and were reviewed with an equity lens.
###
ABOUT THE ASTRO SCIENTIFIC CHALLENGES PROGRAM
The ASTRO Advancing-Medicine-Together Scientific Challenges program seeks to introduce and catalyze new collaborative research opportunities for ASTRO members and to facilitate radiation oncology leadership in scientific discovery and engagement with industry partners. This program seeks to forge new collaborations, increase radiation oncology research funding, and enhance the visibility for radiation oncology researchers to demonstrate their scientific research capabilities and excellence. Funding awards for ASTRO’s inaugural scientific challenge are made possible through the Pfizer Global Medical Grants’ Investigator Sponsored Research program. More information about the ASTRO-Sumitomo Pharma-Pfizer Alliance New Combination Therapy Challenge can be found online.
ABOUT ASTRO
The American Society for Radiation Oncology (ASTRO) is the largest radiation oncology society in the world, with nearly 10,000 members who are physicians, nurses, biologists, physicists, radiation therapists, dosimetrists and other health care professionals who specialize in treating patients with radiation therapies. For information on radiation therapy, visit RTAnswers.org. To learn more about ASTRO, visit our website and follow us on social media.
END
Winners of the ASTRO-Sumitomo Pharma-Pfizer Alliance new combination therapy challenge announced
Researchers seek new ways to treat prostate cancer using relugolix in combination with radiation therapy
2023-09-27
ELSE PRESS RELEASES FROM THIS DATE:
New evidence for sub-network specializations within the Default Mode Network and the Special Role of Facial Movements in Brain Activation and Self-Perception
2023-09-27
Recent advancements in neuroscience have unveiled new insights into the neural processes responsible for self-referential cognition. This research has brought particular attention to a critical neural network known as the Default Mode Network (DMN), comprising brain regions such as the medial prefrontal cortex (mPFC), posterior cingulate cortex, temporoparietal junction (TPJ), and both lateral and medial temporal lobes.
Central to self-related processing, is the information associated with one’s ...
Ultrasound enables gene delivery throughout the brain
2023-09-27
HOUSTON – (Sept. 27, 2023) – Rice University researchers tested the safety and feasibility of gene delivery to multiple brain regions using a noninvasive, ultrasound-based technique in rodents, and their findings suggest that the efficiency of gene delivery improves within each targeted site when more sites are opened.
Shirin Nouraein, a doctoral student working in the lab of Rice bioengineer Jerzy Szablowski, is the lead author on the study recently published in the journal Gene Therapy.
The paper, “Acoustically Targeted Noninvasive Gene Therapy in Large Brain Volumes,” ...
Elevating biogas upgrading performance on renewable aqueous ammonia solution via a novel “membrane method”
2023-09-27
Biogas is usually produced by anaerobic digestion of organic waste such as animal manures and straw wastes, which is a typical green renewable energy and can be used as a fuel for power generation and heat production. China has owned large scale of biogas production, with an annual output of about 15 billion m3 biogas, and the biogas development and utilization provide a new choice for coping with the energy crisis. Factually, biogas contains about 60% CH4 and about ...
Golden Goose Award announces 2023 awardees for discoveries in DNA sequencing technique, a bacteria-inspired method that saves crops and chicken pedigree lines
2023-09-27
WASHINGTON, D.C. – The Golden Goose Award, which celebrates federally funded research that sounds silly, but ultimately benefits society, has selected five researchers across the fields of biology, agriculture and genomics for their unexpected breakthroughs as 2023 awardees. On September 27, 2023, the American Association for the Advancement of Science (AAAS), the world’s largest multidisciplinary scientific society, will co-host the 12th annual Golden Goose Award ceremony with the Association of American Universities, a founding member of the Golden Goose Award, at the Library ...
Inventors of nanopore sequencing honored at Library of Congress
2023-09-27
Two UC Santa Cruz researchers were honored on September 27 at the Library of Congress for the invention of nanopore sequencing, which became a new and revolutionary method to read DNA and RNA.
David Deamer and Mark Akeson, both emeritus professors of biomolecular engineering at the Baskin School of Engineering, received the American Association for the Advancement of Science’s (AAAS) Golden Goose Award for the invention. Their colleague and friend Daniel Branton, a Havard biologist and co-inventor of the technology, was also honored.
The Golden Goose award is given to scientists whose federally-funded research ...
Experimental nasal spray may offer quick, easy remedy for treating rapid heartbeat
2023-09-27
Research Highlights:
In a new study, etripamil, a rapid- and short-acting investigational medication formulated to be delivered via nasal spray, restored a normal heart rhythm in less than 30 minutes in most users with intermittent rapid heartbeats, sparing them a trip to the emergency room to receive intravenous medication.
Participants were able to detect when they were experiencing tachycardia (heart rate over 100 beats/minute) and use the medication appropriately and safely.
The self-administered treatment may help the approximately 1 in 300 adults in the U.S. ...
Sperm swimming is caused by the same patterns that are believed to dictate zebra stripes
2023-09-27
Patterns of chemical interactions are thought to create patterns in nature such as stripes and spots. This new study shows that the mathematical basis of these patterns also governs how sperm tail moves.
The findings, published today in Nature Communications, reveal that flagella movement of, for example, sperm tails and cilia, follow the same template for pattern formation that was discovered by the famous mathematician Alan Turing.
Flagellar undulations make stripe patterns in space-time, generating waves that travel along the tail to drive the sperm and microbes forward.
Alan Turing is most well-known for helping ...
New insights into soil liquefaction during earthquakes research reveals
2023-09-27
In a new study, the conventional understanding of soil liquefaction is being challenged, significantly reshaping our comprehension of earthquake-related soil deformation. Traditionally, soil liquefaction has been linked to undrained conditions near earthquake epicenters, but this research reveals that liquefaction can take place under drained conditions, even at considerably lower seismic-energy density levels. This discovery sheds new light on far-field liquefaction events that have long perplexed scientists. The study highlights how seismic shaking, even in drained conditions, triggers interstitial fluid flow within the soil, leading ...
Byzantine Greek inscription of Psalms 86 found in Hyrcania: unearthing ancient faith
2023-09-27
A Koine Greek inscription paraphrasing Psalms 86 was discovered by Hebrew University archaeologists at the site of Hyrcania Fortress in the Judean Desert. Adorned with a cross, the Byzantine-era inscription was likely made by a knowledgeable monk and holds significance as a well-known prayer in the Masoretic text and Christian liturgy. Analysis of the script's style suggests a dating no later than the first half of the 6th century CE, the height of the Byzantine era, with minor grammatical errors revealing the scribe’s ...
Why an unusual global export industry keeps growing in a developing country
2023-09-27
The global citrus export industry based in South Africa is a surprising outlier in many ways, not least for its vigorous growth. Somehow, the diverse industry has emerged as the second biggest in the world after Spain.
Researchers Ms Shingie Chisoro and Prof Simon Roberts unpack the key factors driving this exceptional success in a study published in The European Journal of Development Research.
Chisoro is a PhD candidate and Roberts the Lead Researcher at the Centre for Competition, Regulation and Economic Development (CCRED), within the College of Business & Economics at the University of Johannesburg.
Resilient ...
LAST 30 PRESS RELEASES:
Insulin resistance is linked to over 30 diseases – and to early death in women, study of people in the UK finds
Innovative semaglutide hydrogel could reduce diabetes shots to once a month
Weight loss could reduce the risk of severe infections in people with diabetes, UK research suggests
Long-term exposure to air pollution and a lack of green space increases the risk of hospitalization for respiratory conditions
Better cardiovascular health in early pregnancy may offset high genetic risk
Artificial intelligence method transforms gene mutation prediction in lung cancer: DeepGEM data releases at IASLC 2024 World Conference on Lung Cancer
Antibody–drug conjugate I-DXd shows clinically meaningful response in patients with extensive-stage small cell lung cancer
IASLC Global Survey on biomarker testing reveals progress and persistent barriers in lung cancer biomarker testing
Research shows pathway to developing predictive biomarkers for immune checkpoint inhibitors
Just how dangerous is Great Salt Lake dust? New research looks for clues
Maroulas appointed Associate Vice Chancellor, Director of AI Tennessee
New chickadee research finds cognitive skills impact lifespan
Cognitive behavioral therapy enhances brain circuits to relieve depression
Terasaki Institute awarded $2.3 Million grant from NIH for organ transplantation research using organs-on-a-chip technology
Atoms on the edge
Postdoc takes multipronged approach to muon detection
Mathematical proof: Five satellites needed for precise navigation
Scalable, multi-functional device lays groundwork for advanced quantum applications
Falling for financial scams? It may signal early Alzheimer’s disease
Integrating MRI and OCT for new insights into brain microstructure
Designing a normative neuroimaging library to support diagnosis of traumatic brain injury
Department of Energy announces $68 million in funding for artificial intelligence for scientific research
DOE, ORNL announce opportunity to define future of high-performance computing
Molecular simulations, supercomputing lead to energy-saving biomaterials breakthrough
Low-impact yoga and exercise found to help older women manage urinary incontinence
Genetic studies reveal new insights into cognitive impairment in schizophrenia
Researcher develops technology to provide cleaner energy and cleaner water
Expect the unexpected: nanoscale silver unveils intrinsic self-healing abilities
nTIDE September 2024 Jobs Report: Gains in employment for people with disabilities appear to level off after reducing gaps with non-disabled workers
Wiley enhances NMR Spectral Library Collection with extensive new databases
[Press-News.org] Winners of the ASTRO-Sumitomo Pharma-Pfizer Alliance new combination therapy challenge announcedResearchers seek new ways to treat prostate cancer using relugolix in combination with radiation therapy