(Press-News.org) Researchers with the ongoing Arizona CoVHORT research study at the University of Arizona Mel and Enid Zuckerman College of Public Health were awarded $3.2 million by the National Institute of Diabetes and Digestive and Kidney Diseases for a five-year study of gastrointestinal symptoms, specifically irritable bowel syndrome, as a condition of long COVID.
Led by epidemiologist Kristen Pogreba-Brown, PhD, MPH, the CoVHORT study is a longitudinal research study of COVID-19 and post-COVID conditions. The research team is tracking more than 9,000 participants in Arizona to assess long COVID symptoms, post-COVID-19 health impacts and treatments.
“We have an outstanding team of researchers, staff and students working on the CoVHORT study and investigating a range of long COVID symptoms,” Pogreba-Brown said. “And, we have a large, diverse group of participants, so we gather crucial data that deliver answers about specific symptoms, such as irritable bowel syndrome, and help find effective treatments.”
Irritable bowel syndrome, or IBS, affects an estimated 10-15% of the U.S population and can significantly impair quality of life. It is the most common diagnosis of a group of gastrointestinal disorders and is thought to be related to gut-brain interaction.
IBS has been linked to numerous bacterial, protozoan and viral infections. The risk of developing IBS following an acute gastrointestinal, or GI, infection is approximately 9%. Notably, COVID-19 infection elicits a wide range of GI symptoms, including diarrhea, nausea and vomiting, with reports of acute GI symptoms occurring in more than 60% of patients.
Understanding how COVID-19 impacts the incidence of IBS or exacerbates IBS symptoms has the potential to benefit millions of people, given the scale of the pandemic and ongoing waves of infection with many reports of chronic GI symptoms after acute COVID-19 infection.
The study, “Determining the Incidence, Risk Factors and Biological Drivers of Irritable Bowel Syndrome (IBS) as Part of the Constellation of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Outcomes,” will take advantage of the Arizona CoVHORT study’s unique scope and infrastructure to deliver vital data to better evaluate and treat COVID-19-related IBS.
The new research will:
Estimate the incidence of IBS and other GI conditions in participants after COVID-19 infections compared with participants who have not had COVID-19.
Determine the role of pre-existing IBS on the development and severity of post-COVID-19 symptoms.
Establish mechanisms of IBS following COVID-19 infections, including differences in the fecal microbiome composition and function, the individual’s anti-commensal immune response to the fecal microbiome, and targeted/untargeted serum protein biomarkers among participants who were exposed to COVID-19 and those who were not and participants who do and do not develop IBS.
“The awareness of long-COVID and post-COVID-19 health complications has diminished since the pandemic has receded, and yet millions of people still suffer,” said Iman Hakim, MD, PhD, MPH, dean of the Zuckerman College of Public Health, “The CoVHORT research study continues to find answers about long COVID and the symptoms that follow infection – knowledge we can use to find treatments. This is public health in action. I’m so proud of Dr. Pogreba-Brown and her team for the work they do that will improve health for people in the United States and around the world.”
END
New study will examine irritable bowel syndrome as long COVID symptom
Researchers will use a $3.2 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases to study gastrointestinal symptoms as a condition of long COVID.
2023-09-30
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Department of Energy announces up to $500 million for basic research to advance the frontiers of science
2023-09-29
WASHINGTON, D.C. - The U.S. Department of Energy (DOE) today announced up to $500 million in funding for basic research in support of DOE’s clean energy, economic, and national security goals. The funding will advance the priorities of DOE’s Office of Science and its major programs, including Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production, and Accelerator R&D and Production. This funding opportunity will help achieve the Biden Administration’s ...
Neural activity associated with motor commands changes depending on context
2023-09-29
Standing at a crosswalk, the signal changes from “don’t walk,” to “walk.” You might step out into the street straight away, or you might look both ways before you cross.
In either scenario, you see the light change, you cross the street. But the context is different; in one case, you didn’t think twice. In the other, you waited; looked to the left and right; saw the coast was clear; then stepped into the street.
Researchers have known that certain brain activity when you see the light change and certain brain activity when you step out into the street are the same no matter the context -- there’s a known “pathway” ...
Argonne joins Illinois manufacturers for “Makers on the Move” tour
2023-09-29
Manufacturers throughout Illinois will have the chance to learn about working with the Materials Manufacturing Innovation Center (MMIC) at the U.S. Department of Energy’s (DOE) Argonne National Laboratory, when the MMIC gets on the bus for the second annual Makers on the Move tour.
The Illinois Manufacturing Association and Illinois Manufacturing Excellence Center (IMEC) sponsor the eight-day, 1,000-mile tour, designed to showcase high-tech, clean, diverse and sustainable modern manufacturing. The branded Makers on the Move bus will stand out on the state’s roadways as it visits facilities, colleges ...
High cure rate, low toxicity maintained with shortened radiation treatment for intermediate risk prostate cancer, study finds
2023-09-29
ARLINGTON, Va., September 29, 2023 — People with intermediate risk, localized prostate cancer can be treated as effectively using fewer and higher doses of radiation therapy delivered over five treatment sessions as they can with lower doses delivered over several weeks, a new phase III randomized trial suggests. The findings, which are the latest from a series of studies investigating the benefits of stereotactic body radiation therapy (SBRT) for people diagnosed with prostate cancer, will be presented Monday at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
The PACE ...
True progression or pseudoprogression in glioblastoma patients?
2023-09-29
MIAMI, FLORIDA (STRICTLY EMBARGOED UNTIL SEPT. 29, 2023 AT 5PM ET) – Is it true progression or pseudoprogression in tumor growth?
That’s the critical question for radiation and medical oncologists treating patients with glioblastoma, the most common and aggressive form of brain cancer. Distinguishing between these types of progression is vitally important for treatment management.
“Knowing if it’s true progression, indicative of a poor response to treatment, or pseudoprogression, a favorable response that may look worse due to swelling or tumor necrosis, is essential for clinicians,” said Eric Mellon, MD, PhD, a radiation oncologist and researcher ...
ASTRO 2023 Session shines spotlight on physician burnout
2023-09-29
MIAMI, FLORIDA (EMBARGOED UNTIL SEPT. 29, 2023, AT 5 PM ET, 2023) – Physician burnout was already a trending topic within the medical community before 2020, when the COVID-19 pandemic brought national attention to the issue.
Typical stressors such as long hours, poor work-life balance, frustrating insurance denials and cumbersome medical documentation were compounded by new challenges from a novel, deadly virus that killed millions worldwide and necessitated a paradigm shift in care delivery.
The side effects were widespread and readily apparent. By late 2021, research by the American Medical Association, Mayo Clinic and Stanford ...
Embargoed Sylvester Comprehensive Cancer Center ASTRO 2023 Tip Sheet
2023-09-29
ALL INFORMATION EMBARGOED UNTIL 5 P.M. ET ON SEPT. 29, 2023
Panel Discussion
Getting it All Done – Strategies for Coping With Professional Burnout
Crystal Seldon Taswell, MD, Sylvester radiation oncologist and researcher, will co-moderate a panel discussion on physician burnout within radiation oncology and medicine. The discussion, titled “Getting It All Done -- Practical Strategies at All Career Stages,” will include background on the extent of the problem, as well as the curriculum gap for residents regarding time management, balancing ...
University of Cincinnati radiation oncology experts present at national conference
2023-09-29
University of Cincinnati Cancer Center researchers will present abstracts at the American Society for Radiation Oncology (ASTRO) Annual Meeting, held Oct. 1-4 in San Diego.
Lattice therapy shows promise for safer, more effective treatment
In standard radiation treatment, entire tumors receive the same dose of radiation. Cancer Center researchers including Andrew Frankart, MD, are testing the application of a different method called lattice therapy, and he will present three posters detailing research into lattice therapy ...
MD Anderson Research Highlights: ASTRO 2023 Special Edition
2023-09-29
SAN DIEGO ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
This special edition features presentations by MD Anderson researchers at the 2023 American Society for Radiation Oncology (ASTRO) Annual Meeting. Information on all MD Anderson ASTRO Annual Meeting content can be found at MDAnderson.org/ASTRO.
Read ...
University of Virginia team’s research offers hope for pulmonary fibrosis patients
2023-09-29
Using a new recipe for growing blood vessels from living lung tissue in the lab, a University of Virginia School of Engineering and Applied Science research team has developed an analytical tool that could lead to a cure for idiopathic pulmonary fibrosis, or IPF, a lung-destroying disease.
Fibrosis is chronic scarring of tissue and it can strike nearly every system in the body. According to the National Institutes of Health, the government estimates that 45% of deaths in the United States can be attributed to fibrotic disorders. In the lungs, fibrosis restricts breathing, so understanding how scarring occurs, and ultimately how to stop it, ...
LAST 30 PRESS RELEASES:
Could strawberry tree extract prevent and treat gastrointestinal disorders?
Can engaging in social activities prolong life?
Has marijuana legalization affected traditional drug prescriptions?
Scientists’ study of white-tailed deer could help control chronic wasting disease
More than half of US workers say job insecurity causing stress
A one-pixel camera for recording holographic movies
Biodiversity in Antarctic soils may be greatly underestimated after surprising discovery
Taking the guesswork out birdsong evolution
Light-powered artificial muscles for underwater robots with reversible, high-stroke actuation
On the origin (and fate) of plants that never bloom
Male bodybuilders face high risk of sudden cardiac death, especially those who compete professionally
For galaxies forming stars, it’s not about how much gas there is but where you find it
Landmark report reveals key challenges facing adolescents
How serious is your brain injury? New criteria will reveal more
Cold sore viral infection implicated in development of Alzheimer’s disease
Thousands of young children worldwide still swallowing magnets despite increased regs
Standardising disposable vape devices may curb young people’s desire to try them
The Lancet: Globally the health of adolescents is at a tipping point; action needed to tackle rising threats to young people’s health and wellbeing
New genetic test can diagnose brain tumors in as little as two hours
Pulmonary embolism in children more common than previously thought
Combined oral contraceptives triple risk of cryptogenic stroke in young women, new study shows
Simple process extends lifetime of perovskite solar cells
Candidate drug that boosts protective brain protein in mice has potential to treat Alzheimer’s Disease
Scientists discover one of the world’s thinnest semiconductor junctions forming inside a quantum material
Illinois researchers explore COVID-19 vaccine attitudes and motivations, finding common values
Study identifies new mechanism for reducing female post-operative pain
Changes in BMI during adolescence may explain link between air pollution exposure and insulin resistance, study shows
Marshall University researchers identify promising treatment for fentanyl-xylazine overdoses
Research team homes in on genetics behind blackberry thorns
UF water researchers develop prediction system for harmful algae
[Press-News.org] New study will examine irritable bowel syndrome as long COVID symptomResearchers will use a $3.2 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases to study gastrointestinal symptoms as a condition of long COVID.