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Embargoed Sylvester Comprehensive Cancer Center ASTRO 2023 Tip Sheet

Sylvester physician-scientists to present findings at ASTRO 2023 Oct. 1-4


Panel Discussion Getting it All Done – Strategies for Coping With Professional Burnout Crystal Seldon Taswell, MD, Sylvester radiation oncologist and researcher, will co-moderate a panel discussion on physician burnout within radiation oncology and medicine. The discussion, titled “Getting It All Done -- Practical Strategies at All Career Stages,” will include background on the extent of the problem, as well as the curriculum gap for residents regarding time management, balancing clinical and research work and learning boundaries for work-life balance in an always-connected world. Other speakers will explain how they navigate work-life balance, pursue career interests, build core values into daily routines, mentor residents and attendings and juggle multiple challenges among their clinical and academic careers and personal lives.

Panel 05 – ASTRO/SWRO Joint Session

Date/time/location – Monday, Oct. 2, 8-9 am, Room 2


Oral Presentations Testosterone Recovery and Prostate Cancer Outcomes Alan Dal Pra, MD, director of the Radiation Oncology Clinical Research Program at Sylvester, and collaborators will present a secondary analysis of the NRG/RTOG 0534 SPPORT phase 3 trial in which patients were treated with salvage radiotherapy and short-term androgen suppression for rising PSA levels after radical prostatectomy. The trial was conducted in the U.S., Canada and Israel from 2008 to 2015. It showed improved outcomes with salvage radiotherapy to the prostate bed, pelvic lymph nodes and androgen suppression as opposed to prostate bed radiotherapy alone.

Dal Pra and his team assessed the testosterone measurements of more than 1,000 patients enrolled in the SPPORT trial to investigate the impact of testosterone recovery on clinical outcomes. This study represents the largest study of testosterone dynamics in patients treated with salvage radiation and androgen suppression. Although testosterone is known to “feed” the growth of prostate cancer cells, the authors showed that a faster normalization of testosterone levels after treatment does not worsen patients’ outcomes. The results have potential clinical implications for using androgen suppression drugs that can provide a faster testosterone recovery. They may also shed light on a possible benefit of testosterone replacement therapies for some prostate cancer patients who experience significant side effects due to low testosterone levels after cancer treatment.

Abstract: 55528

Abstract title: Impact of Testosterone Recovery on Clinical Outcomes of Patients Treated With Salvage Radiotherapy and Androgen Suppression: A Secondary Analysis of the NRG/RTOG SPPORT Phase 3 Trial.

SS 28 - GU 4

Date/time: Oct. 3, 5:35-5:42 pm, Room 6B

  Predicting Tumor Response During Radiation Therapy for Glioblastoma Patients  Distinguishing between true progression and pseudoprogression of tumors after radiotherapy (RT) is critically important for treating patients with glioblastoma, the most common and aggressive form of brain cancer. New research to be presented by Kaylie Cullison, Eric Mellon, MD, PhD, and their Sylvester colleagues identified differences in tumor growth behavior for true progression and pseudoprogression, and these volume changes during treatment may be early markers of treatment response. Next steps, the researchers say, include automating real-time tumor volume monitoring by using a deep-learning solution for volume delineation on daily treatment scans.

Title: “Pattern Analysis of Daily Lesion Volume Trajectories for Early Prediction of Glioblastoma Progression During MR-Linac Radiotherapy”

Date/time/location: Oct. 3, 1:05-1:12 pm, Room 29

  Is It True Progression or Pseudoprogression of Tumor Growth? Cullison, Mellon and Sylvester colleagues also will present results from another study looking at the predictive value of weekly delta-radiomic features extracted from MRI-guided linear accelerator radiation therapy for determining true progression or pseudoprogression of tumors in glioblastoma patients. They concluded that these features may help distinguish between real and pseudoprogression, thereby allowing physicians to adapt or intensify treatment in real time.

Title: “Prognostic Value of Weekly Delta-Radiomics During MR-Linac Radiotherapy of Glioblastoma”

Date/time/location: Oct. 3, 5:35-5:40 pm, Room 7


Poster Presentations AI Model for Beam Angle Selection Similar to Human Choices in Proton Therapy Beam angles can have a major impact on treatment of brain cancers with proton therapy, but manual beam selection can be a time-consuming, cumbersome task. Robert Kaderka, PhD, Sylvester researcher and assistant professor of radiation oncology with UM’s Miller School of Medicine, and collaborators will lead a poster session showing that an AI model for beam selection was comparable to human choices for a small group of patients receiving proton therapy. Kaderka says the results serve as “proof-of-concept” for an expanded study currently underway that will add the prediction of couch angles into the AI model.      

Title: “AI Beam Angle Prediction in Proton Therapy for Brain Patients”

PQA 07

Date/time/location: Tuesday, Oct. 3, 4-5 pm, Hall B2


Spectroscopic MRI May Better Detect Glioblastoma Invasion Conventional MRI may not fully capture the extent of disease in patients undergoing chemoradiation for primary glioblastoma, the most common and aggressive brain cancer. New research led by Jonathan Bell, MD, PhD, senior resident, Department of Radiation Oncology at Sylvester and others suggests that whole-brain spectroscopic MRI (sMRI) provides better visualization of invasive tumor cells and the potential to improve target delineation compared with conventional MRI.

Title: Spectroscopic MRI Detects Occult Glioblastoma Radiation During Chemoradiation

PQA 02

Date/time/location: Monday, Oct. 2, 10:45 am-Noon, Hall B2


Novel Nipple-Preservation Approach for Breast Cancer Patients Sylvester physician-scientist Crystal Seldon Taswell, MD, and collaborating researchers will present long-term results from a phase I study of a new approach to nipple-preserving therapy for patients with early-stage breast cancer or ductal carcinoma in situ who are not candidates for nipple-sparing mastectomy. The approach, which uses delayed radiotherapy after breast surgery, resulted in 100% nipple preservation without compromise of local control, as well as excellent patient-reported satisfaction with the treatment. Seldon Taswell believes study results support further exploration of this nipple preservation technique with broader patient-inclusion criteria.

Title: Delayed Nipple-Areola Complex Radiotherapy After Nipple-Sparing Mastectomy and Immediate Reconstruction for Invasive Breast Cancer or DCIS: Long-Term Results of a Phase I Study


Date/time/location: Monday, Oct. 2, 3-4 pm, Hall B2


Preventing Kidney Disease, Cholesterol Dysfunction from Cancer Treatment

Radiation therapy alone or combined with chemotherapy reduces cholesterol metabolism, or efflux, and causes chronic kidney disease, often leading to dialysis or kidney transplantation. Researchers from Sylvester and UM’s Miller School of Medicine, led by Anis Ahmad, PhD, will present results from their laboratory study showing that LXR agonist treatment not only prevents cholesterol dysregulation, but also protects vital kidney cells and prevents chemotherapy- or radiotherapy-induced kidney injury.   

Title: Role of ATP Binding Cassette Subfamily A Member 1 (ABCA1) in Chemoradiotherapy-Induced Renal Injury

PQA 04

Date/time/location: Monday, Oct. 2, 5-6 pm, Hall B2


Miscellaneous Sylvester Physician to Moderate Scientific Session on Patient Safety Laura Freedman, MD, director of radiation oncology at Sylvester’s Deerfield Beach location, will co-moderate a scientific session addressing patient safety. The session will cover various safety issues in radiation oncology, including terminating treatment during radiation therapy, minimizing patient delays via insurance preauthorization, optimizing workup pathways to reduce radiotherapy wait times and improving quality of care provided to cervical cancer patients.

SS 33 – Patient Safety 2

Date/time/location: Wednesday, Oct. 4, 10:30-11:45 am, Room 2


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University of Cincinnati radiation oncology experts present at national conference

University of Cincinnati radiation oncology experts present at national conference
University of Cincinnati Cancer Center researchers will present abstracts at the American Society for Radiation Oncology (ASTRO) Annual Meeting, held Oct. 1-4 in San Diego.  Lattice therapy shows promise for safer, more effective treatment  In standard radiation treatment, entire tumors receive the same dose of radiation. Cancer Center researchers including Andrew Frankart, MD, are testing the application of a different method called lattice therapy, and he will present three posters detailing research into lattice therapy ...

MD Anderson Research Highlights: ASTRO 2023 Special Edition

SAN DIEGO ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. This special edition features presentations by MD Anderson researchers at the 2023 American Society for Radiation Oncology (ASTRO) Annual Meeting. Information on all MD Anderson ASTRO Annual Meeting content can be found at Read ...

University of Virginia team’s research offers hope for pulmonary fibrosis patients

University of Virginia team’s research offers hope for pulmonary fibrosis patients
Using a new recipe for growing blood vessels from living lung tissue in the lab, a University of Virginia School of Engineering and Applied Science research team has developed an analytical tool that could lead to a cure for idiopathic pulmonary fibrosis, or IPF, a lung-destroying disease. Fibrosis is chronic scarring of tissue and it can strike nearly every system in the body. According to the National Institutes of Health, the government estimates that 45% of deaths in the United States can be attributed to fibrotic disorders. In the lungs, fibrosis restricts breathing, so understanding how scarring occurs, and ultimately how to stop it, ...

Department of Energy funds new center for decarbonization of steelmaking

Department of Energy funds new center for decarbonization of steelmaking
Center to develop cost-effective method for decarbonized manufacturing for steelmaking without a blast furnace. Steel has a major impact on everyone’s lives and our economy. It is crucial to cars, trucks, airplanes, buildings and more. However, there is a significant issue with its production process. Globally, it accounts for a large percentage of greenhouse gas emissions from the industrial sector. The U.S. Department of Energy (DOE) recently announced $19 million in funding over four years for DOE’s Argonne National Laboratory ...

New criteria to assess progression in glioma aims to speed discovery of new medicines

Study Title: RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults Publication: Journal of Clinical Oncology Dana-Farber Cancer Institute author: Patrick Y. Wen, MD Summary: In order to accurately assess the efficacy of novel therapies for brain tumors it is necessary to have reliable criteria to determine response or progression. Response assessment in brain tumors is difficult because of the irregular shapes of the tumors and the fact that many therapies used to treat these tumors can also produce imaging changes that resemble tumor ...

NPS team makes key breakthrough on path to electric aircraft propulsion

NPS team makes key breakthrough on path to electric aircraft propulsion
As an institution renowned for innovation efforts grounded in education and research, the Naval Postgraduate School (NPS) has often been called upon to tackle some of the most difficult technological challenges facing the Navy and the nation. Such a challenge emerged in 2020, when NASA charged NPS and two other research teams with solving a critical barrier facing the development of electric aircraft propulsion (EAP): the creation of a circuit breaker that could support large electric platforms running on direct current (DC) electricity. Thanks to the efforts of a diverse team of faculty and students, as well as several Navy and academic research partners, NPS delivered ...

Berkeley Lab awarded two new centers to counter climate change

Berkeley Lab awarded two new centers to counter climate change
The Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) will host two new centers dedicated to advancing clean energy technology and combating climate change. The awards are part of DOE’s Energy Earthshots Initiative that launched in 2021 with the goal of speeding up technological breakthroughs and lowering costs.  DOE has so far launched seven Earthshots spanning clean energy and carbon reduction technologies. The Berkeley Lab programs announced today will address two of them: the Hydrogen ...

Stanford researchers unveil new material infused with gold in an exotic chemical state

For the first time, Stanford researchers have found a way to create and stabilize an extremely rare form of gold that has lost two negatively charged electrons, denoted Au2+. The material stabilizing this elusive version of the valued element is a halide perovskite—a class of crystalline materials that holds great promise for various applications including more-efficient solar cells, light sources, and electronics components. Surprisingly, the Au2+ perovskite is also quick and simple to make using off-the-shelf ingredients at room temperature. "It was a real surprise that we were able to synthesize a stable material containing Au2+—I didn't even believe it at ...

Research Highlights for September 2023

Research Highlights for September 2023
Huntsman Cancer Institute shines the spotlight on new discoveries and cutting-edge cancer research. This month, researchers found that increasing access for Black people with prostate cancer may save lives. Also, the first patient in a new small cell lung cancer clinical trial has been enrolled, researchers are using an app to help adolescents and young adults manage cancer symptoms, and investigators are trying to reduce cognitive side-effects after chemotherapy.  Increasing access to Black people with prostate cancer may decrease mortality rate In a study published ...

JMIR Publications places No, 348 on The Globe and Mail's annual ranking of Canada's Top Growing Companies

JMIR Publications places No, 348 on The Globe and Mails annual ranking of Canadas Top Growing Companies
(Toronto, September 29, 2023) JMIR Publications is pleased to announce it placed No. 348 on the 2023 Report on Business ranking of Canada’s Top Growing Companies, making the ranking over the past three consecutive years. Canada’s Top Growing Companies ranks Canadian companies on three-year revenue growth. JMIR Publications earned its spot with three-year growth of 105%. “Being ranked on this list, year over year, showcases JMIR Publications’ national and global leadership in publishing high-quality open access ...


Scientists uncover a multibillion-year epic written into the chemistry of life

Monitoring diseases through sweat becomes accessible to everyone

Mathematical model driven evolutionary therapy dosing exploiting cancer cell plasticity

Biodiversity in the margins: Merging farmlands affects natural pest control

1 in 8 pregnant people have a disability, but significant gaps exist in the provision of accessible care

Statins associated with decreased risk for CVD and death, even in very old adults

Climate change is moving tree populations away from the soil fungi that sustain them

Secrets of sargassum: Scientists advance knowledge of seaweed causing chaos in the Caribbean and West Africa

Bioinformatics approach could help optimize soldiers’ training for improved readiness and recovery

Earth scientists describe a new kind of volcanic eruption

Warmer wetter climate predicted to bring societal and ecological impact to the Tibetan Plateau

Feeding infants peanut products protects against allergy into adolescence

Who will like beetle skewers? What Europeans think about alternative protein food

ETRI wins ‘iF Design Award’ for mobile collaborative robot

Combating carbon footprint: novel reactor system converts carbon dioxide into usable fuel

Investigating the origin of circatidal rhythms in freshwater snails

Altering cellular interactions around amyloid plaques may offer novel Alzheimer’s treatment strategies

Brain damage reveals part of the brain necessary for helping others

Surprising properties of elastic turbulence discovered

Study assesses cancer-related care at US hospitals predominantly serving minority populations compared with non-minority serving hospitals

First in-human investigator-initiated clinical trial to launch for refractory prostate cancer patients: Novel alpha therapy targets prostate-specific membrane antigen

Will generative AI change the way universities communicate?

Artificial Intelligence could help cure loneliness, says expert

Echidnapus identified from an ‘Age of Monotremes’

Semaglutide may protect kidney function in individuals with overweight or obesity and cardiovascular disease

New technique detects novel biomarkers for kidney diseases with nephrotic syndrome

Political elites take advantage of anti-partisan protests to disrupt politics

Tiny target discovered on RNA to short-circuit inflammation, UC Santa Cruz researchers find

Charge your laptop in a minute? Supercapacitors can help; new research offers clues

Scientists discover CO2 and CO ices in outskirts of solar system

[] Embargoed Sylvester Comprehensive Cancer Center ASTRO 2023 Tip Sheet
Sylvester physician-scientists to present findings at ASTRO 2023 Oct. 1-4