(Press-News.org) University of Maryland School of Medicine (UMSOM) researchers, as part of the Infectious Diseases Clinical Research Consortium (IDCRC), provided an interim analysis showing that the pentavalent (NmCV-5) meningitis vaccine is safe for use in 9-month-old infants in the meningitis belt of sub-Saharan Africa. They presented their results to the World Health Organization’s (WHO) Strategic Advisory Group of Experts (SAGE) on Immunization on September 26.
SAGE recommended that all countries in the African meningitis belt introduce the novel pentavalent meningococcal conjugate vaccine targeting serogroups A, C, Y, W and X (Men5CV) into their routine immunization programs in a single-dose schedule at 9 to 18 months of age.
Meningococcal meningitis, caused by invasive strains of Neisseria meningitidis bacteria, is a major public health concern in sub-Saharan Africa because it causes high rates of death and permanent disability. Case fatality during meningococcal meningitis epidemics can surpass 15 percent, and rates of long-term complications among meningitis survivors in Africa are twice as high as in high-income countries. Because of the rapid onset of invasive bacterial meningitis and difficulties in accessing care in the African meningitis belt, prevention by vaccination is the optimal way to reduce meningitis cases.
Receiving WHO approval could lead to a monumental shift in the burden of meningitis in susceptible parts of Africa. “I’m excited to lead this critical clinical study of a vaccine that has the potential to curtail invasive meningococcal disease from the meningitis belt,” said Wilbur Chen, MD, MS, professor of medicine at UMSOM’s Center for Vaccine Development and Global Health (CVD) and protocol chair for this study.
Study participants included infants randomized to receive a meningococcal vaccine at 9 months. Infants randomized to the 9-month age group were then further randomized in a 2:1 ratio to receive a single dose of the experimental meningococcal vaccine (NmCV-5) or a single dose of the comparator meningococcal vaccine (MenACWY-TT, Nimenrix). The interim results of the 9-month-old infants found NmCV-5 is proven to protect against meningococcal serogroups A, C, W, X, and Y. These are all epidemic-causing strains currently circulating in the African meningitis belt in young infants.
NmCV-5 can be stored at room temperature for up to 12 weeks and is affordable for African countries. NmCV-5 has already been found safe and immunogenic for people ages 1 to 29 in Africa.
“This collaboration among global partners that has resulted in the development of a safe, effective and inexpensive vaccine brings us one giant step closer to more effectively preventing the devastating epidemics of meningococcal meningitis in sub-Saharan Africa,” said Karen Kotloff, MD, professor of pediatrics, associate director for clinical research in UMSOM’s CVD, and principal investigator of the UMSOM VTEU. Researchers at the Vaccine Treatment and Evaluation Unit (VTEU) at UMSOM are performing the study in partnership with the Center for Vaccine Development-Mali (CVD-Mali).
Visit ClinicalTrials.gov for additional details. The IDCRC, in partnership with the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health, is conducting this study. The research is supported by NIAID cooperative agreement UM1AI148689.
About Infectious Disease Clinical Research Consortium (IDCRC)
This activity is supported by the Infectious Diseases Clinical Research Consortium (IDCRC) through NIAID (UM1AI148684). The IDCRC, consisting of the Vaccine Treatment and Evaluation Units (VTEUs) and the IDCRC Leadership Group, was formed in 2019 to support the planning and implementation of infectious diseases clinical research that efficiently addresses the scientific priorities of NIAID. The consortium includes infectious diseases leaders and clinical researchers from Emory University, University of Maryland School of Medicine, Baylor College of Medicine, Cincinnati Children’s Medical Center and University of Cincinnati, FHI360, Fred Hutchinson Cancer Research Center, Johns Hopkins University, Kaiser Permanente Washington Health Research Institute, New York University, Saint Louis University, Vanderbilt University Medical Center, University of Alabama at Birmingham, University of Rochester, University of Washington, and NIAID. For more information about the IDCRC, please visit www.IDCRC.org.
About the University of Maryland School of Medicine Vaccine Treatment and Evaluation Unit (VTEU)
NIAID established the Vaccine and Treatment Evaluation Units (VTEUs) in 1962 as a consortium comprising centers of excellence for conducting clinical trials to develop new and improved vaccines and therapies against infectious diseases. University of Maryland School of Medicine (UMSOM) investigators have been the recipients of this award for over four decades (current award number 5UM1AI148689) and have conducted hundreds of clinical trials to develop products that can be used to reduce disease burden and to counteract existing and emerging public health threats. In keeping with the program’s focus on bringing vaccines to underserved populations globally, the VTEU at UMSOM performs international studies of vaccines to prevent the major killers of children in the world, including malaria, meningitis, diarrheal disease, and pneumonia. With its rapid response capability, the VTEU at UMSOM plays leadership roles in pivotal trials that support approval and licensure of vaccines and therapeutics to control pandemics including the 2009 swine flu and COVID-19. Other trials have strengthened the national stockpile of vaccines to prevent infections that could be used as a bioterrorist weapon against the U.S., such as smallpox and anthrax. Innovative strategies are used to expand the array of pathogens that can be prevented with vaccines, and to improve delivery, strengthen effectiveness, and expand supply and access to these life-saving measures. The VTEU at UMSOM conducted the first clinical study of an edible vaccine that that might protect against travelers’ diarrhea, evaluated numerous needle-free vaccine administration strategies, developed combination vaccines so fewer inoculations could prevent more infections, and tested a topical antibiotic to prevent serious infections among critically ill infants. The broad opportunities provided by the VTEU has contributed to the training of generations of vaccinologists.
New recommendation on meningitis vaccines for infants in sub-Saharan Africa
IDCRC study assessing meningococcal pentavalent (five in one) vaccine for infants in Africa shows vaccine provides protection against meningococcal meningitis
ELSE PRESS RELEASES FROM THIS DATE:
Organizing can give tenants power to effect change
ITHACA, N.Y. – A renter doesn’t generally hold much sway with a landlord or management company, but when tenants organize, their power can be formidable. Jamila Michener, associate professor of government and public policy, who has spent years researching tenant organizing, asserts that tenants acting collectively can wield power in “Racism, Power, And Health Equity: The Case Of Tenant Organizing,” which published Oct. 2 in Health Affairs. “It can feel like these families ...
The World Mitochondria Society will host Targeting Mitochondria 2023 with challenging visions in Berlin
Targeting Mitochondria 2023 Location: Steigenberger Hotel Am Kanzleramt, Berlin Date: October 11-13 Network with over 210 participants and stay updated with the latest advancements and research on mitochondria. With more than 83 communications, this year's event promises to expand your understanding of mitochondria and its pivotal role in health and disease. Mitochondria will pave the way for the next breakthroughs in medicine, stated Prof. Volkmar Weissig, president of the World Mitochondria Society (WMS), and Prof. Marvin Edeas Chairman of the scientific committee. We are impressed with the caliber of speakers and the groundbreaking ...
New strategy for eye condition could replace injections with eyedrops
A new compound developed at the University of Illinois Chicago potentially could offer an alternative to injections for the millions of people who suffer from an eye condition that causes blindness. Wet age-related macular degeneration causes vision loss due to the uncontrolled growth and leakage of blood vessels in the back of the eye. A new paper in Cell Reports Medicine led by UIC researcher Yulia Komarova finds that a small-molecule inhibitor can reverse damage from AMD and promote regenerative and healing processes. The drug can also be delivered via eyedrops — an improvement over current ...
Aston University engineering graduate launches first AI powered grill
Graduate Suraj Sudera created an AI powered grill to cook the perfect steak. His love of engineering led him to create the device called Perfecta™ He founded Birmingham based start-up SEERGRILLS which applies AI and advanced technologies to improve cooking. An Aston University engineering graduate has created the world’s first AI powered grill. Suraj Sudera has created a cooking device called Perfecta™ which cooks the perfect steak in 90 seconds. Suraj graduated from Aston University in 2015 with a BEng in Mechanical Engineering and ...
IU cancer researcher receives $2.2 million grant for metastatic breast cancer research
INDIANAPOLIS— A breast cancer researcher at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center received a five-year, $2.2 million grant from the National Cancer Institute to examine how certain immune cells support metastatic breast cancer development—and how to stop it. Cells called macrophages usually perform essential tasks as part of the immune system, but breast cancer cells can hijack them to protect cancer cells and help them grow. When this happens, they become tumor-associated macrophages (TAMs). “Our goal is to interrupt that communication process between those two cell ...
Using recent diagnostic scans can substantially cut time to treatment for patients needing urgent palliation
SAN DIEGO, October 3, 2023 — Using previously taken diagnostic computed tomography (CT) scans in place of CT simulation scans to plan simple palliative radiation treatments can substantially reduce the time some people spend waiting for urgent treatment, improving the patient experience, a new study suggests. Patients who may benefit from this expedited process typically are experiencing pain or other debilitating symptoms, such as an airway blockage. Relying upon existing, recent scans instead of taking new ones reduced the time these patients spent at a cancer treatment center, from nearly five hours to under 30 minutes, ...
Brain regions identified that may play a role in Sudden Unexpected Death in Epilepsy
New findings may take scientists a step closer to understanding what causes SUDEP—Sudden Unexpected Death in Epilepsy—a rare but fatal complication of epilepsy. There are about 3,000 deaths from SUDEP each year in the U.S. The biggest risk factor is epilepsy that is not well controlled with medication or surgery, but the exact cause of SUDEP is not known. However, increasing evidence suggests that loss of breathing, or apnea, that persists after a seizure is a major cause of SUDEP. In the new study, University of Iowa neuroscientists found that stimulating a specific ...
Researchers report protein mutation creates ‘super’ T cells with potential to fight off cancer and infections
Using laboratory-grown cells from humans and genetically engineered mice, scientists at Johns Hopkins Medicine say they have evidence that modifying a specific protein in immune white blood cells known as CD8+ T cells can make the cells more robust, potentially opening the door for better use of people’s own immune system T cells to fight cancer. The findings were published Oct. 3 in the journal JCI-Insight. “Maximizing the effectiveness of T-cell-based therapies remains a critical challenge,” says David Kass, M.D., Abraham and Virginia Weiss Professor of Cardiology at the Johns Hopkins University School of ...
Enhancing the efficiency of plant regeneration
Crop modification can be traced to the beginning of agriculture and human civilization. Native Americans, for example, developed corn from a wild grass called teosinte more than 7,000 years ago. Methods to increase crop resiliency and sustainability have evolved, and improved, over time. Biotechnology, or the use of biology to develop new products and organisms, is an application that holds great promise for impactful changes to the agricultural systems. Through this method, the DNA in plant cells is modified — for instance ...
Registration now open for Energy Department’s National Science Bowl®
Washington, D.C. – Registration is open for the 34th National Science Bowl® (NSB), hosted by the U.S. Department of Energy (DOE) Office of Science. Thousands of students compete in the contest annually as it has grown into one of the largest academic math and science competitions in the country. Teams – four or five students and a teacher who serves as a coach – can sign up to participate in the NSB by registering with the coordinator for their regional competition. Details can be found on the NSB registration page. The competition is divided into two categories: high school and middle school. Regional competitions typically last one or two days ...
LAST 30 PRESS RELEASES:
ASH: Novel combination therapy significantly reduces spleen volume in patients with myelofibrosis
ASH: Novel menin inhibitors show promise for patients with advanced acute myeloid leukemias
ASH: Targeted oral therapy reduced disease burden and improved symptoms for patients with rare blood disorder
New Sylvester cancer study provides insight into underlying gene mutations in myelodysplastic syndromes
First-in-human clinical trial of CAR T cell therapy with new binding mechanism shows promising early responses
Long-term results show combination treatment that skips chemotherapy is effective for older patients with Ph+ ALL
Mindfulness could help women with opioid use disorder better control drug urges
TTUHSC’s ARPA-H membership will spur innovation, improve access for West Texas patients
Global annual finance flows of $7 trillion fueling climate, biodiversity, and land degradation crises
Tracing how the infant brain responds to touch with near-infrared spectroscopy
These are the world's most effective charities
When is an aurora not an aurora?
Advisory panel issues field-defining recommendations for US government investments in particle physics research
Doctors discover many patients at UNC’s Inflammatory Bowel Disease Clinic screen positive for malnutrition
BNL: Advisory panel issues field-defining recommendations for U.S. government investments in particle physics research
International collaboration uses faculty member’s research on ancient Roman migration, seeks to understand Balkan genomic history
USF Health Heart Institute doctors are upbeat about cardiac regeneration
AI-driven breakthroughs in cells study: SFU-UBC collaboration introduces "MCS-detect" for advancements in super-resolution microscopy
Advisory panel issues field-defining recommendations for investments in particle physics research
$3.8 million NIH grant to fund Southwest Center on Resilience for Climate Change and Health
What happens when the brain loses a hub?
Study reveals Zika’s shape-shifting machinery—and a possible vulnerability
RIT leading STEM co-mentoring network
Genetic mutations that promote reproduction tend to shorten human lifespan, study shows
CAMH develops potential new drug treatment for multiple sclerosis
Polyethylene waste could be a thing of the past
A dynamic picture of how we respond to high or low oxygen levels
University of Toronto researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects.
Evolving insights in blood-based liquid biopsies for prostate cancer interrogation
Finding the most heat-resistant substances ever made[Press-News.org] New recommendation on meningitis vaccines for infants in sub-Saharan Africa
IDCRC study assessing meningococcal pentavalent (five in one) vaccine for infants in Africa shows vaccine provides protection against meningococcal meningitis