(Press-News.org) Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimise outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely.
“Diabetes recommendations often focus on what works well for the average person. However, because diabetes is an incredibly heterogeneous disease, few people are Mr or Mrs “average” and one-size-fits-all approaches fail many people in need. Precision medicine seeks to address this major problem,” says Professor Paul Franks, of Lund University, Sweden, who chaired the Consensus Report.
He goes on to highlight that “precision medicine seeks to improve diabetes prevention and care by combining data about a person’s health or disease state and response to medications. The aim is to tailor the advice given about diabetes prevention or treatment to the person in question, rather than having them make do with generic advice. Precision medicine very much focuses on treating the person and not the disease.”
Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications.
This second international consensus report on precision diabetes medicine was written by the American Diabetes Association (ADA)/ European Association for the Study of Diabetes (EASD) Precision Medicine in Diabetes Initiative, including around 200 experts from around the world.
The report, published in Nature Medicine, summarises the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Key ongoing issues are discussed, and milestones are outlined for the broad clinical implementation of precision diabetes medicine.
Complimentary papers will also be published in The Lancet Diabetes & Endocrinology.
The report will be presented by Professor Paul Franks, Lund University, Sweden and the Novo Nordisk Foundation, Denmark at a special session in the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg (2-6 Oct).
END
Second international consensus report - clinical translation of precision diabetes medicine
2023-10-05
ELSE PRESS RELEASES FROM THIS DATE:
Wastewater surveillance research provides a 12-day lead time for RSV season: new study
2023-10-04
In a first-of-its-kind study, researchers using wastewater surveillance over conventional indicators have predicted the start of the annual respiratory syncytial virus (RSV) season 12 days early, providing more lead time for hospital preparedness and the timely initiation of RSV prevention therapy provided by the province for at risk-infants and young children.
Published in Frontiers in Public Health, the study is the first to describe the relationship between wastewater measurements and clinical data for RSV and to use near real-time wastewater measurements to accurately identify the start of the RSV season.
Working in close collaboration with CHEO Research Institute (RI) ...
Unmet health needs for HIV, hypertension and diabetes in rural South Africa
2023-10-04
The burden of non-communicable diseases like hypertension and diabetes is increasing globally, especially in low-income and middle-income countries where they occur alongside epidemics of communicable diseases like HIV. A large public health survey in South Africa led by Emily Wong, M.D., has assessed the multimorbidity health needs of individuals and communities in rural KwaZulu-Natal and established a framework to quantify met and unmet health needs for individuals living with infectious and non-communicable diseases. The study is published in The Lancet Global Health.
“Applying ...
Blood-based biomarker may redefine the future treatment for advanced melanoma
2023-10-04
Circulating tumor DNA (ctDNA) is emerging as a blood-based biomarker for many solid tumor types, including melanoma. A new study that assessed ctDNA in the blood of patients with BRAF wild-type (BRAF WT) stage III and IV melanoma concludes that measuring ctDNA may lead to alternative treatment options and better outcomes for these patients, report investigators in The Journal of Molecular Diagnostics, published by Elsevier.
For patients with BRAF WT stage III and IV melanoma, there is an urgent clinical need to identify prognostic biomarkers and biomarkers to predict treatment ...
Advances from MSK researchers reported at 2023 ASTRO Meeting
2023-10-04
Researchers from Memorial Sloan Kettering Cancer Center (MSK) were recognized for their achievements at the 2023 meeting of ASTRO, the American Society for Therapeutic Radiology and Oncology. Teams reported new findings about radiation-induced secondary cancers, a new guidance system for radiation therapy, and the consequences of insurance denials, among other topics.
At the meeting, held from October 1 to October 4, 2023, in San Diego, Simon Powell, MD, PhD, FRCP, Chair of MSK’s Department of Radiation Oncology and Enid A. Haupt Chair in Radiation Oncology, was honored with ASTRO’s Gold Medal Award. This award is ASTRO’s highest honor, bestowed upon ...
Ketamine-related drug gives better treatment for difficult to treat clinical depression
2023-10-04
Type of work: peer-reviewed/clinical trial/people
A major clinical trial shows that the drug, esketamine, one of the two main forms of ketamine, outperforms one of the standard treatments for treatment-resistant major depression. This industry-funded work is presented for the first time at the 36th ECNP Congress in Barcelona, with publication in the peer-reviewed journal the New England Journal of Medicine (see Notes for details).
Clinical depression (also known as MDD, major depressive disorder) affects a significant number of people at any one time, giving ...
Esketamine nasal spray: an option for patients with treatment-resistant depression
2023-10-04
Understanding Treatment-Resistant Depression
Treatment-resistant depression (TRD) is a particularly challenging form of major depressive disorder. As Albino Oliveira-Maia, head of the Champalimaud Foundation’s Neuropsychiatry Unit and the study’s national coordinator for Portugal, explains, “TRD is defined as the persistence of depressive symptoms despite adequate courses of at least two different antidepressant medications”. Despite repeated therapeutic attempts, these patients’ depressive symptoms ...
Navigating moiré physics and photonics with band offset tuning
2023-10-04
When two lattices with distinct angles or periodicities come together, they conjure a moiré superlattice — a realm where astonishing phenomena like superconductivity and optical solitons spring to life. At the heart of this realm lies the moiré flatband, a key player in shaping advanced light–matter interactions, such as laser emission and second harmonic generation. In moiré physics and its relevant applications, wielding control over flatbands is a pivotal superpower.
Moiré flatbands are typically generated with special structures, often manipulated ...
Aging in place: U-M study highlights racial disparities among older adults
2023-10-04
Audio
Roughly 40% of older Black adults live with a disability, compared to only one-third of older adults overall.
Disability is one of various disparities highlighted in a new study from the University of Michigan, which used data from the National Poll on Healthy Aging to examine the extent to which 50- to 80-year-olds were prepared to age in place and the racial and ethnic disparities that exist to that end.
Sheria Robinson-Lane, U-M assistant professor of nursing and principal investigator, said many of the disparities were related to "weathering"—stressors connected to environmental, ...
U.S. drinking water often contains toxic contaminants, UNM scientist warns
2023-10-04
Most Americans take it for granted that the water that comes out of their taps is clean and safe to drink.
But a new study published by a University of New Mexico scientist with colleagues from across the U.S. warns that water from many wells and community water systems contains unsafe levels of toxic contaminants, exposing millions to health risks, including cancer.
The review in the Journal of Exposure Science and Environmental Epidemiology also finds that people living on tribal lands or ...
AI model for age-related disease target discovery
2023-10-04
“In this work, we focused on the application of the established pipeline to the identification of the potential targets related to aging [...]”
A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.”
Target discovery is crucial for the development of innovative therapeutics and diagnostics. However, current approaches often face ...