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Should a more individualized model replace the current method for determining which people should be screened for lung cancer?

The alternative model had greater sensitivity for identifying South Dakota Indigenous and non-Indigenous individuals who had lung cancer

2023-10-09
(Press-News.org) A new study found that an alternative model to identify patients with lung cancer eligible for screening was more accurate than the currently used method based on the United States Preventive Services Task Force (USPSTF) criteria. The results are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.

Lung cancer is the leading cause of cancer deaths, and using low-dose computed tomography scans to screen people who are at elevated risk for lung cancer reduces lung cancer deaths. The USPSTF criteria use age and smoking history to determine eligibility for lung cancer screening: individuals aged 50–80 years who currently smoke or used to smoke and quit 15 years ago or less with 20 pack years of smoking history (such as 1 pack a day for 20 years or 2 packs a day for 10 years) are eligible. A more personalized model is the PLCOm2012 lung cancer risk-prediction model based on the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. This model uses additional parameters including personal history of cancer, family history of lung cancer, personal history of chronic obstructive pulmonary disease, education level, body mass index, and race to predict an individual’s risk of lung cancer. (A modified version that does not include race is called PLCOm2012noRace.)

To compare the USPSTF and PLCOm2012 and PLCOm2012noRace methods, Martin Carl Tammemägi, PhD, of Brock University and his colleagues applied them to 1,565 individuals with lung cancer in South Dakota. The PLCOm2012 models had higher sensitivity and identified more people with lung cancer eligible for screening than USPSTF 2013 and USPSTF 2021 criteria. There did not appear to be an eligibility disparity between individuals who self-reported as Indigenous and those who did not, for both the USPSTF criteria and the PLCOm2012noRace model.

The research also indicated that screening people younger than 50 years of age is not warranted, since there were few people who were diagnosed with lung cancer under that age.

“Determining screening eligibility using risk prediction models that consider more individualized lung cancer risk factors has been shown in several studies, including this one, to do a better job in selecting people for screening as compared with USPSTF age and smoking history criteria,” said Dr. Tammemägi. “This research along with similar studies in other underserved populations should be used to encourage policy makers to include the use of more individualized screening eligibility criteria using risk prediction models. Although race is a social construct, until the risk factors for this construct are identified and included in risk prediction models, jurisdictions with large populations of underserved ‘races’ who are found to be at excess risk—including many Indigenous populations—should consider using risk prediction models incorporating race as a predictor variable.” 

 

Additional information 
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. A free abstract of this article will be available via the CANCER Newsroom upon online publication. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, newsroom@wiley.com

Full Citation:
“Sensitivity of US Preventive Services Task Force and PLCOm2012 lung cancer screening eligibility criteria in individuals with lung cancer in South Dakota self‐reporting as Indigenous and non‐Indigenous.” Martin Carl Tammemägi, Kristin Cina, Andrea K. Borondy Kitts, David Koop, Mark A. Petereit, Michele Sargent, and Daniel G. Petereit. CANCER; Published Online: October 9, 2023 (DOI: 10.1002/cncr.34947). 

URL Upon Publication: http://doi.wiley.com/10.1002/cncr.34947

Author Contact: Cathy Majtenyi, Research Communications/Media Relations Specialist at Brock University, at cmajtenyi@brocku.ca or +1 905-688-5550

About the Journal
CANCER is a peer-reviewed publication of the American Cancer Society integrating scientific information from worldwide sources for all oncologic specialties. The objective of CANCER is to provide an interdisciplinary forum for the exchange of information among oncologic disciplines concerned with the etiology, course, and treatment of human cancer. CANCER is published on behalf of the American Cancer Society by Wiley and can be accessed online. Follow CANCER on Twitter @JournalCancer and Instagram @ACSJournalCancer, and stay up to date with the American Cancer Society Journals on LinkedIn.

About Wiley      
Wiley is a knowledge company and a global leader in research, publishing, and knowledge solutions. Dedicated to the creation and application of knowledge, Wiley serves the world’s researchers, learners, innovators, and leaders, helping them achieve their goals and solve the world's most important challenges. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, Twitter, LinkedIn and Instagram.

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[Press-News.org] Should a more individualized model replace the current method for determining which people should be screened for lung cancer?
The alternative model had greater sensitivity for identifying South Dakota Indigenous and non-Indigenous individuals who had lung cancer