PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

The ribosome–depression link 

The ribosome–depression link 
2023-10-10
(Press-News.org) A group of ribosomal protein genes connect animal models of depression to human patients with major depressive disorder. In order to research depression treatments, scientists use a mouse model, inducing a state with similarities to depression though exposure to variable, unpredictable, and uncontrolled stressors over days or weeks. But is this state molecularly akin to what humans with major depressive disorder experience? To find out, Xiaolu Zhang, Mahmoud Ali Eladawi, and colleagues examine transcriptomics data from postmortem human brain tissue and from several mouse models of stress, seeking to pinpoint conserved genes. The authors found that ribosomal protein genes are commonly dysregulated in these stress paradigms. The authors further demonstrated that this dysregulation is potentially triggered by stress hormones and is reversible during remission phase of depression or is attenuated when the receptors of the hormones are blocked. A seeded gene co-expression analysis suggests that the ribosomal proteins in question are important for the homeostatic feedback regulation of pathways associated with synaptic communication. The ribosome is a cellular organelle that carries out translation and protein synthesis, and which is involved in the stress response of organisms as diverse as yeast, bacteria, and animals. Together, the findings indicate that stress-induced ribosome dysregulation underlies human depression in a complex fashion. According to the authors, dysregulation of ribosomes may change the synthesis of alternate proteins, which then alter the way neural synapses function—a change that manifests as a mood disorder.

END

[Attachments] See images for this press release:
The ribosome–depression link  The ribosome–depression link  2

ELSE PRESS RELEASES FROM THIS DATE:

Ionic crystal generates molecular ions upon positron irradiation, finds new study

Ionic crystal generates molecular ions upon positron irradiation, finds new study
2023-10-10
Positron, the antiparticle of electron, has the same mass and charge as that of an electron but with the sign flipped for the charge. It is an attractive particle for scientists because the use of positrons has led to important insights and developments in the fields of elementary particle physics, atomic physics, materials science, astrophysics, and medicine. For instance, positrons are known to be components of antimatter. They are also powerful in detecting lattice defects in solids and semiconductors and in structural analysis of the topmost surface of crystals. Positronic compounds, namely ...

Maternal obesity predicts heart disease risk better than pregnancy complications

2023-10-10
First study to determine the role pre-pregnancy obesity plays in future poor heart health  Those with overweight or obese BMI in early pregnancy had a higher risk of developing hypertensive disorders of pregnancy ‘If pre-pregnancy obesity is the culprit or cause of risk, we should be targeting this with interventions’ Pregnancy complications such as preeclampsia and gestational diabetes have recently been associated with a higher risk of developing heart disease later in life. But a new Northwestern Medicine study has found obesity before or during ...

Pregnancy complications increase and unmask short- and long-term cardiovascular risk for people with obesity

2023-10-10
Having obesity before and during early pregnancy appears to be a strong indicator of risk for developing future cardiovascular disease and was significantly linked with adverse outcomes during pregnancy such as high blood pressure, preeclampsia, and gestational diabetes, according to a study published in Circulation Research that was funded by the National Institutes of Health. Researchers have known obesity is a risk factor for cardiovascular disease and pregnancy complications related to blood pressure. However, they did not know which factors – obesity or the pregnancy complications – played larger roles in influencing a person’s ...

Are we running out of water? Water security threatened by droughts and heatwaves worldwide

2023-10-10
Increased demand for water due to global population growth, coupled with the increasing frequency of extreme weather events, endangers our water security. Nonetheless, little is known about the relationship of water use by sectors and the occurrence of drought-heatwave events, particularly at the large scale. To unveil this issue, a group of researchers from the Department of Physical Geography from Utrecht University evaluated the responses of sectoral water use during droughts, heatwaves and compound (combined) events at a global scale. The study published in Environmental Research Letters shows that stronger sectoral water use responses are found for heatwaves compared to ...

Researchers find pre-Columbian agave plants persisting in Arizona landscapes

Researchers find pre-Columbian agave plants persisting in Arizona landscapes
2023-10-10
A new paper in the Annals of Botany, published by Oxford University Press, reveals that researchers have found unaltered agave plant species cultivated by several early cultures including the Hohokam people, a large Native American group in the Southwest that existed between 300 and 1500 CE. Agave plants have been of great economic and social importance in the Americas for at least 9,000 years. Before people cultivated corn, agave plants were one of their main carbohydrate sources. Archaeological research indicates the Hohokam increased agricultural potential by building terraces for agave dry farming. Agricultural features such as terraces and rock piles were especially characteristic ...

Food taxes, farm subsidies and GM crops: new ‘how-to’ guide launched for tailor-made food policies

Food taxes, farm subsidies and GM crops: new ‘how-to’ guide launched for tailor-made food policies
2023-10-10
October 10, WASHINGTON D.C. – A new tool will help governments customise food and agriculture policies based on country-level circumstances to increase their effectiveness at improving diets, adapting to changing climate and protecting natural resources. The Political Economy and Policy Analysis (PEPA) Sourcebook is the first to compile dozens of frameworks and approaches for designing food and agriculture policies, such as reforming farm subsidies, water policies, food safety regulations and taxes. The authors from the Alliance of Bioversity International and the International Center for Tropical Agriculture (CIAT), and the International Food Policy Research Institute ...

Comprehensive new Canadian guideline for skeletal health and fracture prevention

2023-10-10
A comprehensive guideline from Osteoporosis Canada aims to help primary care professionals deliver care to optimize skeletal health and prevent fractures in postmenopausal females and males who are age 50 years and older. It is published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.221647. With 25 recommendations and 10 good practice statements, this update to the 2010 guideline contains sections on exercise, nutrition, fracture risk assessment, treatment and more, reflecting advances in risk assessment, and nonpharmacologic and pharmacologic management of osteoporosis. In ...

Five years of legal cannabis in Canada: mixed success

2023-10-10
Five years after cannabis legalization in Canada, it appears to be a mixed success, with social justice benefits outweighing health benefits, write authors in a commentary published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.230808. Cannabis use was legalized in Canada in October 2018, with the goal to improve cannabis-related public health and safety, and reduce youth access and illegal activities related to cannabis. There was concern among some health ...

Mental health issues in Latinx middle schoolers may increase risk of sleep problems, obesity and unhealthy behaviors

2023-10-10
WASHINGTON (Oct. 10, 2023)--Latinx kids who experienced depression, anxiety or other mental health issues in middle school had a greater chance of developing sleep problems, unhealthy weight gain and sedentary behavior in high school, according to a study out today.   The research, led by a team at the George Washington University, suggests that unhealthy behaviors linked to mental health issues may start early in life and trigger obesity, high blood pressure, diabetes and other serious health problems.   “Our study suggests signs of depression ...

THE LANCET NEUROLOGY: Stroke could cause nearly 10 million deaths annually by 2050, mostly in LMICs, and cost up to US$2 trillion per year, new report warns

THE LANCET NEUROLOGY: Stroke could cause nearly 10 million deaths annually by 2050, mostly in LMICs, and cost up to US$2 trillion per year, new report warns
2023-10-10
Peer-reviewed / Modelling, Review, and Opinion / People New World Stroke Organization-Lancet Neurology Commission forecasts future epidemiological and economic impacts of stroke, identifies evidence-based recommendations for improving the four pillars namely: surveillance, prevention, treatment and rehabilitation. Epidemiological analysis projects stroke deaths will increase from 6.6 million in 2020 to 9.7 million in 2050, with an ever-widening gap between low- and middle-income countries (LMICs) and high-income countries (HICs). In 2050, 91% of stroke deaths are projected to be in LMICs compared to 9% in HICs, up from 86% in LMICs and 14% HICs ...

LAST 30 PRESS RELEASES:

The Lancet Diabetes & Endocrinology: Higher doses of semaglutide can safely enhance weight loss and improve health for adults living with obesity, two new clinical trials confirm

Trauma focused therapy shows promise for children struggling with PTSD

School meals could drive economic growth and food system transformation

Home training for cerebellar ataxias

Dry eyes affect over half the general population, yet only a fifth receive diagnosis and treatment

Researchers sound warning about women with type 2 diabetes taking oral HRT

Overweight and obesity don’t always increase the risk of an early death, Danish study finds

Cannabis use associated with a quadrupling of risk of developing type 2 diabetes, finds study of over 4 million adults

Gestational diabetes linked to cognitive decline in mothers and increased risk of developmental delays, ADHD and autism among children

Could we use eye drops instead of reading glasses as we age?

Patients who had cataracts removed or their eyesight corrected with a new type of lens have good vision over all distances without spectacles

AI can spot which patients need treatment to prevent vision loss in young adults

Half of people stop taking popular weight-loss drug within a year, national study finds

Links between diabetes and depression are similar across Europe, study of over-50s in 18 countries finds

Smoking increases the risk of type 2 diabetes, regardless of its characteristics

Scientists trace origins of now extinct plant population from volcanically active Nishinoshima

AI algorithm based on routine mammogram + age can predict women’s major cardiovascular disease risk

New hurdle seen to prostate screening: primary-care docs

MSU researchers explore how virtual sports aid mental health

Working together, cells extend their senses

Cheese fungi help unlock secrets of evolution

Researchers find brain region that fuels compulsive drinking

Mental health effects of exposure to firearm violence persist long after direct exposure

Research identifies immune response that controls Oropouche infection and prevents neurological damage

University of Cincinnati, Kent State University awarded $3M by NSF to share research resources

Ancient DNA reveals deeply complex Mastodon family and repeated migrations driven by climate change

Measuring the quantum W state

Researchers find a way to use antibodies to direct T cells to kill Cytomegalovirus-infected cells

Engineers create mini microscope for real-time brain imaging

Funding for training and research in biological complexity

[Press-News.org] The ribosome–depression link