Role of innate immunity in SARS-CoV-2 infection
2023-10-24
(Press-News.org) https://doi.org/10.1016/j.bsheal.2023.08.005
During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activated macrophages, dendritic cells, neutrophils, and natural killer cells are the first defense against infection. These immune effectors trap and ingest the virus, kill infected epithelial cells, or produce anti-viral cytokines. Evidence suggests that aging, obesity, and mental illness can lead to weakened innate immunity and, thus, are all associated with elevated infection and severe disease progression of coronavirus disease 2019 (COVID-19). Innate immune defense networks play a fundamental role in suppressing viral replication, infection establishment, and viral pathogenesis of SARS-CoV-2 and other respiratory viruses.
Key points
The innate immune is the first line of defense against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Aging, obesity, and mental illness can be detrimental to innate immunity.
Nutrition, traditional Chinese medicine (TCM), and heat shock proteins (HSPs) are conducive to innate immunity.
Innate immunity plays a double-edged role in coronavirus disease 2019 (COVID-19) patients.
Keywords: Innate immunity, SARS-CoV-2, Traditional Chinese medicine, Depression, Heat shock protein
# # # # # #
Biosafety and Health is sponsored by the Chinese Medical Association, managed by National Institute for Viral
Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC).
For more information, please visit https://www.journals.elsevier.com/biosafety-and-health
Editorial Board: https://www.sciencedirect.com/journal/biosafety-and-health/about/editorial-board
Biosafety and Health is available on ScienceDirect (https://www.sciencedirect.com/journal/biosafety-and-health).
Submissions to Biosafety and Health may be made using Editorial Manager®
(https://www.editorialmanager.com/bsheal/default.aspx).
CiteScore: 4.8
ISSN 2590-0536
# # # # # #
Zihao Wang, Fang Cheng, Yuxiu Xu, Xin Li, Songdong Meng, Role of innate immunity in SARS-CoV-2 infection, Biosafety and Health, 2023, ISSN 2590-0536, https://doi.org/10.1016/j.bsheal.2023.08.005
END
ELSE PRESS RELEASES FROM THIS DATE:
2023-10-24
https://doi.org/10.1016/j.bsheal.2023.08.004
Data on the viral rebound and safety of nirmatrelvir/ritonavir in lung transplant (LTx) recipients are limited. The study prospectively followed four LTx recipients. Clinical characteristics, viral RNA dynamic in throat swabs, and tacrolimus blood concentration were monitored regularly. All four LTx recipients, aged 35–74 years, were not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They got coronavirus disease 2019 (COVID-19) after ...
2023-10-23
TORONTO, October 23, 2023 –This year, Canada saw the worst wildfire season in its history, with fires destroying homes, displacing thousands of residents, and burning the largest area since contemporary records began in 1983. Much of this damage to communities could be reduced with better wildfire preparedness – but wildland urban interface (WUI) communities often face significant barriers in implementing these improvements, according to a study by York University’s Disaster and Emergency Management researchers.
According to the study, Determinants of residential wildfire mitigation uptake: A ...
2023-10-23
A new publication from Opto-Electronic Advances, 10.29026/oea.2023.230039 discusses diffraction-limited visible imaging for large aperture telescopes.
The deformable mirror used in adaptive optics can change its surface to instantly correct the static wavefront aberration of the optical system and atmospheric turbulence wavefront disturbance. This allows the optical system to automatically adapt to changes in the environment and maintain optimal performance. High-resolution astronomical observation, laser atmospheric transmission, and biomedical imaging all make extensive use ...
2023-10-23
Texas A&M University is joining a multi-university team on a major research project to track objects orbiting the moon. The Air Force Research Laboratory is awarding up to $5 million over five years for the Space University Research Initiative (SURI).
“The SURI is an outstanding initiative to train our next-generation workforce. We look forward to carrying out creative research aimed at addressing astronautical challenges in cislunar space,” said Dr. Manoranjan Majji, an associate professor and Josey Family Foundation Faculty Fellow in the Department of Aerospace Engineering at ...
2023-10-23
Embargoed for release until 5:00 p.m. ET on Monday 23 October 2023
Annals of Internal Medicine Tip Sheet
@Annalsofim
Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization ...
2023-10-23
In 2021, a team of University of Arizona astronomers suggested that a recently discovered near-Earth asteroid, Kamo`oalewa, could be a chunk of the moon. Two years after the striking discovery, another UArizona research group has found that a rare pathway could have enabled this to happen.
So far, only distant asteroids from beyond the orbit of Mars have been considered a source of near-Earth asteroids, said Renu Malhotra, Regents Professor of Planetary Sciences and a senior author on the paper.
"We are now establishing that the moon is a more likely source ...
2023-10-23
A new study by University of Iowa researchers finds that rare lung cells known as pulmonary ionocytes facilitate the absorption of water and salt from the airway surface. This function is exactly the opposite of what was expected of these cells and may have implications for cystic fibrosis (CF) lung disease.
Five years ago, scientists reported the unexpected discovery that ionocytes—a cell type commonly found in fish gills and frog skin—are also present in the lining of human lungs and airways. These pulmonary ionocytes were particularly interesting to CF researchers because although they only account for about 1% of all the cells in the airway ...
2023-10-23
ORLANDO, Oct. 23, 2023 – Researchers from the University of Central Florida, University of Texas at Dallas and Vanderbilt University have received a three-year, $927,203 grant for advancing future quantum education by using virtual reality (VR) and machine learning to identify and address misconceptions regarding quantum information science (QIS).
The U.S. National Science Foundation-funded project started in August 2023 and leverages QubitVR, a quantum-education VR application previously developed ...
2023-10-23
In exploratory analyses of results from the SWOG S1801 trial in patients with stage III-IV resectable melanoma, researchers saw a major pathologic response in more than half of surgical specimens taken from patients who had been treated with neoadjuvant (pre-operative) pembrolizumab.
These and other results of the analyses are presented as a proffered paper (Abstract LBA48) at the European Society of Medical Oncology (ESMO) Congress 2023 in Madrid, Spain, on Monday, October 23, by Sapna P. Patel, MD, chair of the SWOG melanoma committee and associate professor of melanoma medical oncology at the University of Texas MD Anderson Cancer Center. Patel is principal investigator ...
2023-10-23
The New York Stem Cell Foundation (NYSCF) today announced the 2023 class of NYSCF – Robertson Investigators, welcoming three outstanding stem cell researchers into the NYSCF Innovator community.
The NYSCF – Robertson Stem Cell Investigator Awards support promising early career scientists whose cutting-edge research holds the potential to accelerate treatments and cures through the NYSCF – Robertson Stem Cell Investigator Awards.
The awards provide unrestricted seed funding – $1.5 million over five years – for scientists who have established their own, ...
LAST 30 PRESS RELEASES:
[Press-News.org] Role of innate immunity in SARS-CoV-2 infection
