(Press-News.org) Men with high-grade prostate cancer and low prostate-specific antigen (PSA) levels have a poor prognosis. The question remains as to whether the chemotherapy drug docetaxel, which increases survival in metastatic prostate cancer, can improve the cure rate in these patients.
In a new study, investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, a meta-analysis of five prospective randomized clinical trials (RCTs) found that adding docetaxel to standard-of-care (SOC) treatment was associated with a 70% reduction in death from prostate cancer-specific mortality (PCSM). The study was published today in JAMA Network Open.
Investigators performed a meta-analysis of the RCTs evaluating SOC treatment with radiotherapy and androgen deprivation therapy or with radical prostatectomy versus SOC plus docetaxel. The final study cohort of 2,184 patients included 145 eligible patients (6.6%) across four eligible RCTs.
"Of these 145 patients, 139 had excellent performance status [PS] and were the main focus of the study. An excellent PS identifies patients who can tolerate the full course of chemotherapy and therefore benefit if the treatment proves effective," says Anthony Victor D'Amico, MD, PhD, chief of Genitourinary Radiation Oncology at Brigham and Women's Hospital and senior author of the study.
Among these 139 patients, SOC plus docetaxel was associated with a significant 70% reduction in PCSM and nearly halved all-cause mortality. Remarkably, this treatment regiment dropped the 10-year PCSM rate from nearly 40% to less than 10%, leading to a 10-year overall survival of 80% as compared to 60%.
"It's a marked improvement in survival for these patients, who currently do not have any highly effective treatments," Dr. D'Amico says.
Disclosures: None
Funding: None
Paper cited: Mortality Risk for Docetaxel-Treated, High-Grade Prostate Cancer With Low PSA Levels
END
Docetaxel use associated with significant reduction in prostate cancer death in very poor prognostic group
2023-11-01
ELSE PRESS RELEASES FROM THIS DATE:
Pet ownership may contribute to health care barriers for people with HIV
2023-11-01
People living with HIV may face hard choices when balancing their own health needs with caring for a pet, a study led by a University of Florida College of Public Health and Health Professions researcher finds.
For the study, which appears in the journal PLOS ONE, 36% of people with HIV who own pets reported delaying health care, not seeking it or said they expect to do so in the future. Financial and other resource concerns, including not having access to pet sitting or boarding services, are among the leading factors that may contribute to health care barriers among pet owners ...
Test detects co-infection by novel species of parasite in severe cases of visceral leishmaniasis
2023-11-01
In recent years, physicians and scientists in parts of Brazil where visceral leishmaniasis (VL) is endemic have seen rising numbers of cases of co-infection by Leishmania infantum and Crithidia, also a protozoan but hitherto believed to be a mosquito parasite that cannot infect humans or other mammals. Accurate diagnosis is hindered by a lack of simple specific tests (more at: https://agencia.fapesp.br/42072 and https://agencia.fapesp.br/31581).
To accelerate and facilitate detection of the pathogens involved, supporting appropriate decisions regarding treatment, researchers at the Federal University of São Carlos (UFSCar) have developed a PCR test ...
Dr. Zainab Mahmoud to receive the 2023 Dr. Nanette K. Wenger Research Goes Red® Award
2023-11-01
DALLAS, Nov. 1, 2023 – The American Heart Association will present the 2023 Dr. Nanette K. Wenger Research Goes Red® Award to Zainab Mahmoud, M.D., M.Sc., of Washington University School of Medicine in St. Louis. This award will be presented during the opening session of the Association’s Scientific Sessions 2023 on Saturday, Nov. 11. The meeting, to be held in Philadelphia, Saturday, Nov. 11 through Monday, Nov. 13, is a premier global exchange of the latest scientific advancements, ...
Lepore chosen to lead Public Policy & Aging Report
2023-11-01
The Gerontological Society of America (GSA) — the nation’s largest interdisciplinary organization devoted to the field of aging — has named Michael Lepore, PhD, of the University of Massachusetts (UMass) Amherst as the next editor-in-chief of the journal Public Policy & Aging Report, effective January 2024.
“I am honored to serve as editor-in-chief of Public Policy & Aging Report, which for nearly 30 years has provided non-partisan analyses of aging-related policy issues,” Lepore said. “This venerable journal has been a mainstay of my training and professional ...
Dr. Mary McGrae McDermott to be awarded the 2023 Clinical Research Prize
2023-11-01
DALLAS, Nov. 1, 2023 — The American Heart Association will present the 2023 Clinical Research Prize to Mary McGrae McDermott, M.D., FAHA, of Northwestern University’s Feinberg School of Medicine in Chicago. The Clinical Research Prize is awarded annually to physicians or scientists who are advancing clinical science in support of the Association’s mission.
Dr. McDermott has dedicated her career to advancing medical knowledge of peripheral artery disease (PAD). She will be recognized during the presidential session on Sunday, Nov. 12, 2023 at the Association’s Scientific Sessions ...
Dr. Olugbenga Ogedegbe to receive the 2023 Population Health Research Prize
2023-11-01
DALLAS, Nov. 1, 2023 — The American Heart Association will present its 2023 Population Health Research Prize to Olugbenga “Gbenga” Ogedegbe, M.D., M.P.H., FAHA, of New York University’s Grossman School of Medicine. He will be recognized during the presidential session of the Association’s Scientific Sessions 2023 on Sunday, Nov. 12. The meeting will be held in Philadelphia, Saturday, Nov. 11 through Monday, Nov. 13 and is a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science.
Dr. ...
Dr. Marc A. Pfeffer to be receive the 2023 Eugene Braunwald Academic Mentorship Award
2023-11-01
DALLAS, Nov. 1, 2023 — The American Heart Association will present its 2023 Eugene Braunwald Academic Mentorship Award to Marc A. Pfeffer, M.D., Ph.D., FAHA, of Harvard Medical School and Brigham and Women’s Hospital. The Eugene Braunwald Academic Mentorship Award will be recognized during the Presidential Session on Sunday, Nov. 12, 2023, at the Association’s Scientific Sessions 2023. The meeting, to be held in Philadelphia, Saturday, Nov. 11 through Monday, Nov. 13, is a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science.
The Eugene Braunwald Academic ...
What happens when cats get fat? Scientists weigh in
2023-11-01
URBANA, Ill. – Cat owners want Kitty to be happy, but providing an abundance of food and snacks can have unintended consequences. Feline obesity is on the rise, impacting the health, longevity, and wellbeing of cats. A new study from the University of Illinois Urbana-Champaign looks at what happens in the digestive system and gut microbiota when cats eat too much.
“About 60% of cats in the U.S. are overweight, which can lead to health problems such as diabetes and chronic inflammation. While many studies have investigated feline weight loss, there has been little focus on the opposite process, ...
Dr. Marlene Rabinovitch to receive the 2023 Research Achievement Award
2023-11-01
DALLAS, Nov. 1, 2023 – The American Heart Association will present its 2023 Research Achievement Award to Marlene Rabinovitch, M.D., of Stanford University. The Research Achievement Award will be recognized during the Presidential Session on Sunday, Nov. 12, 2023, at the Association’s Scientific Sessions 2023. The meeting, to be held in Philadelphia, Saturday, Nov. 11 through Monday, Nov. 13, is a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science.
Throughout her nearly 40-year career as a physician scientist, Dr. Rabinovitch’s research ...
Dr. Yibin Wang of Duke-NUS to receive the 2023 Basic Research Prize
2023-11-01
DALLAS, Nov. 1, 2023 — The American Heart Association will present its 2023 Basic Research Prize to Yibin Wang, Ph.D., FAHA, of Duke-NUS Medical School in Singapore and Duke University School of Medicine, Durham, NC. He will be recognized during the Presidential Session of the Association’s Scientific Sessions 2023 on Sunday, Nov. 12. The meeting, to be held in Philadelphia, Saturday, Nov. 11 through Monday, Nov. 13, is a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science.
Dr. ...