(Press-News.org) About The Study: Among patients with heart failure with mildly reduced ejection fraction or heart failure with preserved ejection fraction treated with dapagliflozin in this randomized clinical trial, an initial estimated glomerular filtration rate (eGFR) decline was frequent but not associated with subsequent risk of cardiovascular or kidney events. These data reinforce clinical guidance that sodium-glucose cotransporter-2 inhibitors should not be interrupted or discontinued in response to an initial eGFR decline.
Authors: Finnian R. Mc Causland, M.B.B.Ch., M.M.Sc., of Brigham and Women’s Hospital in Boston, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamacardio.2023.4664)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
# # #
Media advisory: This study is being released to coincide with presentation at the American Heart Association’s Scientific Sessions 2023.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2023.4664?guestAccessKey=a781b965-6d63-46b9-9d1b-5eb7e7a6e4e6&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=111223
END
Decline in estimated glomerular filtration rate after dapagliflozin in heart failure with mildly reduced or preserved ejection fraction
JAMA Cardiology
2023-11-12
ELSE PRESS RELEASES FROM THIS DATE:
2023 Joseph A. Johnson Award goes to Yale University professor of physics
2023-11-12
AIP and the National Society of Black Physicists congratulate Charles D. Brown II as the winner of the 2023 Joseph A. Johnson Award for Excellence. Dante O’Hara and Danielle Speller are also being recognized with Honorable Mentions.
The Johnson Award, now in its fourth year, is given by AIP and NSBP to recognize early-career scientists who demonstrate scientific ingenuity and impactful mentorship and service – the core values of NSBP founder Joseph A. Johnson.
“We are excited to recognize Dr. Brown’s impact on the physics community,” said Michael Moloney, CEO of AIP. ...
A high-risk antiphospholipid antibody profile matters in pediatric patients with antiphospholipid syndrome
2023-11-12
San Diego, CA, November 12, 2023 - A new study by Hospital for Special Surgery (HSS) investigators has found that an initial high-risk antibody profile for antiphospholipid syndrome (APS) tended to remain high in pediatric patients. The results were presented today in a poster session at American College of Rheumatology (ACR) Convergence 2023, the ACR’s annual meeting.1
“There are a lot of unanswered questions about how APS affects pediatric patients since evidence to date has been very limited,” said Jheel Pandya, MD, a pediatric rheumatology fellow at HSS and lead author of the research. “Our study reveals that an initial high-risk ...
Hormonal contraceptives in teens may alter risk assessment
2023-11-12
[Embargoed until 1 p.m. (ET) Sunday, Nov. 12]
WASHINGTON – Hormonal contraceptives taken by adolescents may influence development of the brain in a way that alters the recognition of risks, a new study in rats suggests.
Scientists at The Ohio State University are exploring how common synthetic hormones used for birth control affect the prefrontal cortex, an area of the brain that continues to develop throughout adolescence.
The researchers found that myelination, the formation of protective coating on axons projecting from the main body of brain cells, increased in rats given hormonal birth control compared to untreated rats, while the number ...
Early-life stress changes more genes in brain than a head injury
2023-11-12
WASHINGTON – A surprising thing happened when researchers began exploring whether early-life stress compounds the effects of a childhood head injury on health and behavior later in life: In an animal study, stress changed the activation level of many more genes in the brain than were changed by a bump to the head.
It’s already known that head injuries are common in young kids, especially from falling, and can be linked to mood disorders and social difficulties that emerge later in life. Adverse childhood experiences are also very ...
Summer wildfire and winter air pollution and particulates linked to different risks of heart attack and severe chest pain, new study finds
2023-11-12
Short-term increases in air pollution can cause problems for a lot of people, but especially to those with diagnosed or undiagnosed heart disease. But it’s not just a potential issue for pollution coming from cars and industrial processes.
New research from Intermountain Health in Salt Lake City shows that pollutants trapped in lower, colder layers of air in mountain-region communities present sometimes higher risk for this population, while wildfire smoke from often distant locales may also impact risk.
“We’re finding that air pollution is affecting ...
New study finds current dosing recommendations may not help patients achieve optimal vitamin D levels
2023-11-12
Low levels of Vitamin D have been shown to be associated with a higher risk of having a cardiac event, like a heart attack or stroke. For this reason, treatment by Vitamin D pills or injections are being investigated as a possible preventative method in these patients.
However, two new studies from Intermountain Health in Salt Lake City have found that current dosing recommendations are not helping patients achieve optimal Vitamin D levels, suggesting that trials looking into the effectiveness of Vitamin D treatment to prevent cardiac events were not using appropriately sufficient doses, leading to inaccurate results.
In their studies, Intermountain ...
Study finds poor ventilation use during CPR for out-of-hospital cardiac arrest
2023-11-12
The ventilation technique, also known as rescue breathing, commonly used during cardiopulmonary resuscitation (CPR) for people with cardiac arrest is often performed poorly by professional emergency responders, and this ineffective strategy is linked to significantly worse patient survival rates, according to a study supported by the National Institutes of Health. Ventilation involves administering breaths to a patient to provide life-sustaining oxygen and inflate the lungs when they stop breathing or during cardiac arrest, when the heart suddenly stops pumping blood. Among the nearly 2,000 ...
Blood thinner apixaban prevents strokes in patients with device-detected atrial fibrillation
2023-11-12
The widely available blood thinner apixaban substantially reduced stroke in at-risk patients with a type of atrial fibrillation only detectable by a pacemaker or other implanted cardiac electronic device, a global study has found.
The oral anticoagulant medication, which helps to prevent dangerous blood clots by thinning the blood, reduced the risk of stroke and blood clotting by 37% and reduced fatal or disabling stroke by 49% in individuals with device-detected atrial fibrillation, also known as sub-clinical atrial ...
New study finds genetic testing can effectively identify patients with family history of high cholesterol to prevent heart attack, stroke, and death
2023-11-12
Familial hypercholesteremia (FH) is an inherited condition that affects about 1 in 250 people, and often shows no signs until they have a heart attack. For individuals with FH the lowering of “bad” cholesterol levels can’t be done by dietary or behavioral changes, the problem is in their genes, and targeted medications therapy is needed.
Now, new research from the Intermountain Health in Salt Lake City has found that genetic screening can identify these patients and make them candidates for treatment that could prevent heart attack, stroke, and death.
“Most of these patients already had tests that ...
New study finds genetic testing is effective in identifying patients with inherited risk of cardiomyopathy to improve quality of life and reduce deaths
2023-11-12
New research from Intermountain Health in Salt Lake City finds that genetic screening is effective in identifying patients who have a heart condition known as cardiomyopathy to improve their quality of life and reduce deaths.
By undergoing genetic screening to identity those with the potentially-fatal heart condition, clinicians can more closely monitor them and use medical interventions, when necessary, that could improve the quality of these patients’ lives, and potentially save them, researchers say in a new study of more than 30,000 heart patients.
“Our findings show that we’re ...
LAST 30 PRESS RELEASES:
ASU researchers to lead AAAS panel on water insecurity in the United States
ASU professor Anne Stone to present at AAAS Conference in Phoenix on ancient origins of modern disease
Proposals for exploring viruses and skin as the next experimental quantum frontiers share US$30,000 science award
ASU researchers showcase scalable tech solutions for older adults living alone with cognitive decline at AAAS 2026
Scientists identify smooth regional trends in fruit fly survival strategies
Antipathy toward snakes? Your parents likely talked you into that at an early age
Sylvester Cancer Tip Sheet for Feb. 2026
Online exposure to medical misinformation concentrated among older adults
Telehealth improves access to genetic services for adult survivors of childhood cancers
Outdated mortality benchmarks risk missing early signs of famine and delay recognizing mass starvation
Newly discovered bacterium converts carbon dioxide into chemicals using electricity
Flipping and reversing mini-proteins could improve disease treatment
Scientists reveal major hidden source of atmospheric nitrogen pollution in fragile lake basin
Biochar emerges as a powerful tool for soil carbon neutrality and climate mitigation
Tiny cell messengers show big promise for safer protein and gene delivery
AMS releases statement regarding the decision to rescind EPA’s 2009 Endangerment Finding
Parents’ alcohol and drug use influences their children’s consumption, research shows
Modular assembly of chiral nitrogen-bridged rings achieved by palladium-catalyzed diastereoselective and enantioselective cascade cyclization reactions
Promoting civic engagement
AMS Science Preview: Hurricane slowdown, school snow days
Deforestation in the Amazon raises the surface temperature by 3 °C during the dry season
Model more accurately maps the impact of frost on corn crops
How did humans develop sharp vision? Lab-grown retinas show likely answer
Sour grapes? Taste, experience of sour foods depends on individual consumer
At AAAS, professor Krystal Tsosie argues the future of science must be Indigenous-led
From the lab to the living room: Decoding Parkinson’s patients movements in the real world
Research advances in porous materials, as highlighted in the 2025 Nobel Prize in Chemistry
Sally C. Morton, executive vice president of ASU Knowledge Enterprise, presents a bold and practical framework for moving research from discovery to real-world impact
Biochemical parameters in patients with diabetic nephropathy versus individuals with diabetes alone, non-diabetic nephropathy, and healthy controls
Muscular strength and mortality in women ages 63 to 99
[Press-News.org] Decline in estimated glomerular filtration rate after dapagliflozin in heart failure with mildly reduced or preserved ejection fractionJAMA Cardiology