(Press-News.org) Old people who follow a Mediterranean diet are at a lower risk of cognitive decline, according to a study published in the journal Molecular Nutrition and Food Research. The study provides new evidence for a better understanding of the biological mechanisms related to the impact of the diet on cognitive health in the ageing population.
The study is led by Mireia Urpí-Sardá, adjunct lecturer and member of the Biomarkers and Nutritional & Food Metabolomics research group of the Faculty of Pharmacy and Food Sciences, the Institute for Nutrition and Food Safety (INSA-UB), the Food and Nutrition Torribera Campus of the University of Barcelona, and the CIBER on Frailty and Healthy Ageing (CIBERFES).
This European study, part of the Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL) was carried out over twelve years and it involved 840 people over 65 years of age (65% of whom were women) in the Bourdeaux and Dijon regions of France.
Healthy diet and cognitive performance
According to Cristina Andrés-Lacueva, UB professor and head of the CIBERFES group, “within the framework of the study, a dietary metabolomic index has been designed —based on biomarkers obtained from the participants’ serum— on the food groups that form part of the Mediterranean diet. Once this index is known, its association with cognitive impairment is evaluated”.
in the study, baseline levels of saturated and unsaturated fatty acids, gut microbiota-derived polyphenol metabolites and other phytochemicals in serum that reflect individual bioavailability were chosen as biomarkers. Some of these indicators have not only been recognized as marks of exposure to the main food groups of the Mediterranean diet but have also been held responsible for the health benefits of the Mediterranean dietary pattern.
The metabolome or set of metabolites — related to food and derived from gut microbiota activity — was studied through a large-scale quantitative metabolomic analysis from the serum of the participants without dementia, from the beginning of the study. Cognitive impairment was assessed by five neuropsychological tests over twelve years.
As a result, the study reveals a protective association between the score of the Mediterranean diet based on serum biomarkers and cognitive decline in older people.
Biomarkers to study the benefits of the diet
According to Mercè Pallàs, professor at the UB Neurosciences Institute (UBneuro), "the use of dietary pattern indices based on food-intake biomarkers is a step forward towards the use of more accurate and objective dietary assessment methodologies that take into account important factors such as bioavailability".
Expert Alba Tor-Roca, first author of the study and CIBERFES researcher at the UB, explains that “we found that adherence to Mediterranean diet assessed by a panel of dietary biomarkers is inversely associated with long-term cognitive decline in older people. These results support the use of these indicators in long-term follow-up assessments to observe the health benefits associated with the Mediterranean diet or other dietary patterns and therefore, guide personalized counselling at older ages”.
The study was carried out in collaboration with teams from the Department of Genetics, Microbiology and Statistics of the Faculty of Biology and the Department of Pharmacology, Toxicology and Therapeutic Chemistry of the Faculty of Pharmacy and Food Sciences of the UB. Teams from the University of Bordeaux and the INRAE centre at Clermont-Ferrand University (France), King’s College London (United Kingdom), the University of Amsterdam (the Netherlands) and the Parcelsus Medical University in Salzburg (Austria) have also participated.
Funding was obtained through the International Joint Programming Actions PCIN-2015-229, the European Regional Development Funds (ERDF) and from the former Ministry of Economy, Industry and Competitiveness (MINECO) through the Joint Programming Initiative “A Healthy Diet for a Healthy Life”.
Following a Mediterranean diet reduces the risk of cognitive decline in older people
Healthy diet and cognitive performance
ELSE PRESS RELEASES FROM THIS DATE:
A deep-sea fish inspired researchers to develop supramolecular light-driven machinery
The vision system, evolved over millions of years, is highly complex. To make vision sensitive throughout the whole range of visible wavelengths, Nature employs a supramolecular chemistry approach. The visual pigment, cis-retinal, changes its shape upon capturing a photon. This shape transformation is accompanied by changes in the supramolecular organization of the surrounding proteins, subsequently triggering a cascade of chemical signaling events that get amplified and eventually lead to visual perception in the brain. “Some deep-sea fish have evolved antenna-like ...
Shedding light on unique conduction mechanisms in a new type of perovskite oxide
The remarkable proton and oxide-ion (dual-ion) conductivities of hexagonal perovskite-related oxide Ba7Nb3.8Mo1.2O20.1 are promising for next-generation electrochemical devices, as reported by scientists at Tokyo Tech. The unique ion-transport mechanisms they unveiled will hopefully pave the way for better dual-ion conductors, which could play an essential role in tomorrow’s clean energy technologies. Clean energy technologies are the cornerstone of sustainable societies, and solid-oxide fuel cells (SOFCs) and proton ceramic fuel cells (PCFCs) are among the most promising types of electrochemical devices for green power generation. These devices, however, still ...
UK’s Rural Physician Leadership Program, Anthem Medicaid announce new rural medicine scholarships
MOREHEAD, Ky. (Nov. 17, 2023) — In celebration of National Rural Health Day, yesterday the University of Kentucky College of Medicine and Anthem Blue Cross and Blue Shield Medicaid in Kentucky announced new scholarship opportunities for UK’s Rural Physician Leadership Program (RPLP). The Anthem Rural Medicine Scholarships will provide $100,000 to offset the cost of medical school for students in the RPLP. In a state that suffers from high rates for many chronic, ...
Heart repair via neuroimmune crosstalk
Unlike humans, zebrafish can completely regenerate their hearts after injury. They owe this ability to the interaction between their nervous and immune systems, as researchers led by Suphansa Sawamiphak from the Max Delbrück Center now report in the journal Developmental Cell. Each year, more than 300,000 people in Germany have a myocardial infarction – the technical term for heart attack. The number of people surviving a heart attack has increased significantly, but this severe cardiac event causes irreparable damage to their hearts. A heart attack ...
BU researchers develop new method to help with analysis of single cell data
(Boston)—CITE-seq (cellular indexing of transcriptomes and epitopes) is an RNA sequencing-based method that simultaneously quantifies cell surface protein and transcriptomic data within a single cell readout. The ability to study cells concurrently offers unprecedented insights into new cell types, disease states or other conditions. While CITE-seq solves the problem of detecting a limited number of proteins while using single-cell sequencing in an unbiased way, one of its limitations is the high levels of background noise that can hinder analysis. To rectify ...
Azerbaijan women behind global average for thalassemia screening and genetic counselling | BGI Insight
5.2% of the global population carry hemoglobin abnormalities, resulting in 300,000 to 400,000 children born with severe hemoglobinopathies annually. Thalassemia, a hereditary hemoglobinopathy, occurs in 4.4 out of every 10,000 live births, and is prevalent in Mediterranean coastal areas, Africa, the Middle East, Southeast Asia, and southern China. To facilitate greater understanding of thalassemia, a hereditary hemoglobinopathy, BGI Genomics today released its State of Thalassemia Awareness Report. This report assesses the level of knowledge and attitudes related to the associated health risks, thalassemia carrier ...
Alliance and WEF sign agreement for Food Action Alliance
The Alliance Bioversity International and CIAT signed an agreement with the World Economic Forum that enables the Alliance to manage initiatives under the Food Action Alliance, a movement led by the World Economic Forum for transforming sustainable food systems. The Alliance would establish and manage initiatives in Latin America, the Caribbean, and other regions under the Food Action Alliance to boost the transformation of food systems, facilitating and scaling up multi-stakeholder flagship initiatives in specific countries mostly with multi-national companies such as Bayer, Microsoft, PepsiCo, AB InBev; among others. The Food Action Alliance will continue to grow initiatives ...
USDA introduces a multi-year plan to strengthen U.S. genebank management of plant germplasm
WASHINGTON, November 17, 2023 – The U.S. Department of Agriculture (USDA) released today the National Strategic Germplasm and Cultivar Collection Assessment and Utilization Plan in support of the Agricultural Research Service (ARS) U.S. National Plant Germplasm System’s (NPGS) mission. The USDA-ARS NPGS is confident that implementing this plan will address current operational and research challenges. The collection is vital for maintaining the nation’s food supply by providing breeders and researchers the germplasm they need to furnish U. S. consumers with abundant, ...
Unravelling the secrets of neurodegenerative diseases, one protein at a time
Proteins misfolding and clumping together, a process known as aggregation, is a key feature seen in several neurological conditions, including Alzheimer's and Parkinson's diseases. These disorders involve the formation of small, potentially harmful structures called oligomers, which could serve as valuable indicators for early diagnosis. They are incredibly small, however, and much rarer than the healthy non-aggregated proteins. This makes it hard to detect and measure them accurately. In collaboration with UCB Biopharma, researchers from the University of Edinburgh’s ...
A world's first in validating a UNFCCC report by a cost-efficient and transparent method to measure CO2 emission estimates using GOSAT
Researchers in Japan and Mongolia have carried out the world's first instance of incorporating satellite-based CO2 emission estimates into a GHG emission report as the verification on the Second Biennial Update Report (BUR2) of Mongolia submitted to the UNFCCC on 15 November 2023, resulting in high accuracy match with actual reported values, reports a new study published online in Scientific Reports in 2023. Countries have reported their CO2 emissions to the UNFCCC, primarily from human activities and a significant contributor to climate change. ...
LAST 30 PRESS RELEASES:
Tracing how the infant brain responds to touch with near-infrared spectroscopy
These are the world's most effective charities
When is an aurora not an aurora?
Advisory panel issues field-defining recommendations for US government investments in particle physics research
Doctors discover many patients at UNC’s Inflammatory Bowel Disease Clinic screen positive for malnutrition
BNL: Advisory panel issues field-defining recommendations for U.S. government investments in particle physics research
International collaboration uses faculty member’s research on ancient Roman migration, seeks to understand Balkan genomic history
USF Health Heart Institute doctors are upbeat about cardiac regeneration
AI-driven breakthroughs in cells study: SFU-UBC collaboration introduces "MCS-detect" for advancements in super-resolution microscopy
Advisory panel issues field-defining recommendations for investments in particle physics research
$3.8 million NIH grant to fund Southwest Center on Resilience for Climate Change and Health
What happens when the brain loses a hub?
Study reveals Zika’s shape-shifting machinery—and a possible vulnerability
RIT leading STEM co-mentoring network
Genetic mutations that promote reproduction tend to shorten human lifespan, study shows
CAMH develops potential new drug treatment for multiple sclerosis
Polyethylene waste could be a thing of the past
A dynamic picture of how we respond to high or low oxygen levels
University of Toronto researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects.
Evolving insights in blood-based liquid biopsies for prostate cancer interrogation
Finding the most heat-resistant substances ever made
Time-tested magnesium oxide: Unveiling CO2 absorption dynamics
Engaging heterosexual men more effectively could slash HIV infections in Uganda
A fork in the rhod: Janelia researchers unveil comprehensive collection of rhodamine-based fluorescent dyes
The Gerontological Society of America congratulates new 2023 awardees
Texas A&M Institute part of national effort to harness nuclear laser fusion for limitless energy
How health system hesitancies contributed to COVID risks
Stand Up to Cancer names Julian Adams, Ph.D., President and CEO
Immersive VR goggles for mice unlock new potential for brain science
Racial and ethnic differences in hospice use among Medicaid-only and dual-eligible decedents[Press-News.org] Following a Mediterranean diet reduces the risk of cognitive decline in older people
Healthy diet and cognitive performance