PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Older organs accelerate aging in transplant recipients

2023-12-05
(Press-News.org) Most organ transplantations involve supply from older donors to younger recipients. Aging cells can become senescent, a condition in which they stop multiplying and secrete chemicals that negatively affect neighboring cells. Senescent cells accumulate in older donor organs, and have the potential to compromise transplant outcomes.

A study led by researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, found that in preclinical models, transplanting older organs can trigger senescence in younger recipients. They observed that young and middle-aged mice that received heart transplants from older mice had impaired physical capacity, with reduced running times and grip strengths. Middle-aged mice who received older hearts also showed increased anxiety-related behavior, impaired memory and poorer learning performances.

The authors found that these accelerated aging-related effects in younger recipients were driven by the release of senescence-associated factors and mitochondrial DNA from older transplants. Treating older donor mice with senolytics, or senescence-inhibiting drugs, before organ extraction reduced symptoms of senescence in the recipient mice.

“Currently, due to insufficient supply in clinical organ transplantation, donor and recipient ages differ substantially,” said principal investigator Stefan G. Tullius, MD, PhD, of the Division of Transplant Surgery. “Our results suggest that senolytic treatments can be a potential therapeutic approach for improving the outcomes of older organs.”

in American Journal of Transplantation.

END


ELSE PRESS RELEASES FROM THIS DATE:

Pregnant women are missing vital nutrients needed for them and their babies – and situation could worsen with plant-based foods

Pregnant women are missing vital nutrients needed for them and their babies – and situation could worsen with plant-based foods
2023-12-05
Pregnant women are not getting the essential nutrients they and their babies need from modern diets say scientists, who have warned that the situation will likely worsen as more people turn to plant-based foods. A study looking at the health of expecting mothers from high-income countries, including the UK, New Zealand and Singapore, found that 90 per cent were lacking key vitamins necessary for healthy pregnancies and the wellbeing of unborn infants. Scientists from the University of Southampton, working with experts worldwide, surveyed more than 1,700 women and found most were missing essential nutrients found in abundance in meat and dairy products. These included vitamins B12, B6 and ...

Cell-type-specific genetic risk contributes to distinct stages of Alzheimer’s disease progression

2023-12-05
Developing treatments for Alzheimer's disease (AD) is difficult because complex underlying mechanisms drive different types of cells that may contribute to the disorder. Microglia and astrocytes, resident immune and support cells in the central nervous system, are known to exclusively express several genes linked to risk of AD — particularly AD dementia. However, it was previously unclear exactly how and when these genetic risk factors contributed to other, distinct stages of AD progression, such as the accumulation of amyloid-β plaques and tau tangles. Researchers led by a team at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare ...

Argonne physicist recognized for “Top Cited Paper” by Institute of Physics

2023-12-05
A paper co-authored by physicist Filip Kondev of the U.S. Department of Energy’s (DOE) Argonne National Laboratory has earned a “Top Cited Paper Award” from IOP Publishing, the publishing arm of the Institute of Physics. The paper, “The NUBASE2020 evaluation of nuclear physics properties,” provides researchers with recommended values of the basic nuclear physics properties for all known atomic nuclei. These data are provided for each nucleus in its ground state, its lowest energy level, and in its excited, isomeric state, a higher energy level that lives longer than what is typical. These data constitute the fundamental ...

Researchers identify altered functional brain connectivity in autism subtypes

Researchers identify altered functional brain connectivity in autism subtypes
2023-12-05
Philadelphia, December 5, 2023 – What happens in the brain to cause many neurodevelopmental disorders, including autism spectrum disorder (ASD), remains a mystery. A major limitation for researchers is the lack of biomarkers, or objective biological outputs, for these disorders, and in the case of ASD, for specific subtypes of disease. Now, a new study uses brain imaging and machine learning to identify altered functional brain connectivity (FC) in people with ASD – importantly, taking ...

Tanyu collecting instrumentation data from RAP-aggregate base project on Minnieville road

2023-12-05
Tanyu Collecting Instrumentation Data From RAP-Aggregate Base Project On Minnieville Road Burak Tanyu, Professor, Civil, Environmental and Infrastructure Engineering (CEIE); Director of CEIE Laboratories, received $36,674 from the Virginia Department of Transportation (VDOT) for: "Collection of Instrumentation Data From the RAP-Aggregate Base Project on Minnieville Road." Mason's Sustainable Geotransportation Infrastructure (SGI) research team has access to an actual roadway site located in Minnieville, Virginia, ...

Three decades of data in Bangladesh show elevated risk of infant mortality In flood-prone areas

2023-12-05
A new study from researchers at UC San Diego’s Scripps Institution of Oceanography and UC San Francisco estimates 152,753 excess infant deaths were attributable to living in flood-prone areas in Bangladesh over the past 30 years. Additionally, across the study period, children born during rainy months faced higher risk of death than those born in dry months.  The paper was published Dec. 5 in the Proceedings of the National Academy of Sciences and supported by the National Institute of Allergy and Infectious Diseases. The findings begin to unspool the long term public health impacts of recurring environmental hazards such as flooding, ...

Mice pass the mirror test, a classic indicator of self-recognition

Mice pass the mirror test, a classic indicator of self-recognition
2023-12-05
Researchers report December 5 in the journal Neuron that mice display behavior that resembles self-recognition when they see themselves in the mirror. When the researchers marked the foreheads of black-furred mice with a spot of white ink, the mice spent more time grooming their heads in front of the mirror—presumably to try and wash away the ink spot. However, the mice only showed this self-recognition-like behavior if they were already accustomed to mirrors, if they had socialized with other mice who looked like them, and if the ink spot was relatively large. The team identified a subset of neurons in the hippocampus that are involved in developing and storing this visual self-image, ...

Tonsil, adenoid removal improved sleep quality, some behavioral problems in children with mild sleep apnea

2023-12-05
The surgery did not improve the children’s neurodevelopmental functioning but was associated with improved quality of life, sleep symptoms, and blood pressure 12-months post-surgery according to a randomized control trial led by researchers at Brigham and Women’s Hospital and the Harvard Pilgrim Health Care Institute Between 6% and 17% of children suffer from sleep-disordered breathing, characterized by habitual snoring, increased respiratory effort, and sleep apnea. If left untreated, the disorder may put children at higher risk of neurodevelopmental impairment, reduced quality of life, and cardiovascular and metabolic diseases. Enlarged tonsils are one of the main risk ...

Harvesting water from air with solar power

Harvesting water from air with solar power
2023-12-05
WASHINGTON, Dec. 5, 2023 – More than 2.2 billion people currently live in water-stressed countries, and the United Nations estimates that 3.5 million die every year from water-related diseases. Because the areas most in need of improved drinking water are also located in some of the sunniest places in the world, there is strong interest in harnessing sunlight to help obtain clean water. Researchers from Shanghai Jiao Tong University in China developed a promising new solar-powered atmospheric water harvesting technology that could help provide enough drinking water for people ...

Pregnancy weight gain after gastric bypass or sleeve gastrectomy

2023-12-05
About The Study: Women with a history of bariatric surgery had lower pregnancy weight gain than matched controls with similar early pregnancy characteristics in this study of 12,000 pregnancies. Pregnancy weight gain was lower in those with a shorter surgery-to-conception interval or lower surgery-to-conception weight loss, but did not differ by surgical procedure.  Authors: Huiling Xu, M.D., M.Sc., of the Karolinska Institutet in Stockholm, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2023.46228) Editor’s Note: Please see the ...

LAST 30 PRESS RELEASES:

It takes two to TANGO: New strategy to tackle fibrosis and scarring

Researchers aim to analyze pangenomes using quantum computing

Ready and vigilant: immune cells on standby

Securing competitiveness of energy-intensive industries through relocation: The pulling power of renewables

CAR T cell therapy targeting HER2 antigen shows promise against advanced sarcoma in phase I trial

Social change may explain decline in genetic diversity of the Y chromosome at the end of the Neolithic period

Aston University research finds that social media can be used to increase fruit and vegetable intake in young people

A vaccine to fight antibiotic resistance

European Hormone Day 2024: Endocrine community unites to raise public awareness and push for policy action on hormone health

Good heart health in middle age may preserve brain function among Black women as they age

The negative effects of racism impact sleep in adolescents

Study uses wearable devices to examine 3- to 6-year-olds’ impulsivity, inattentiveness

Will future hurricanes compromise New England forests’ ability to store and sequester carbon?

Longest study to date assesses cognitive impairment over time in adults with essential tremor

Does a woman’s heart health affect cognition in midlife?

Unveiling the mysteries of cell division in embryos with timelapse photography

Survey finds loneliness epidemic runs deep among parents

Researchers develop high-energy-density aqueous battery based on halogen multi-electron transfer

Towards sustainable food systems: global initiatives and innovations

Coral identified as oldest bioluminescent organism, suggesting a new model of ancient ecology

SRI chosen by DARPA to develop next-generation computational design of metallic parts and intelligent testing of alloys

NJIT engineers muffle invading pathogens with a 'molecular mask'

Perinatal transmission of HIV can lead to cognitive deficits

The consumption of certain food additive emulsifiers could be associated with the risk of developing type 2 diabetes

New cancer research made possible as Surrey scientists study lipids cell by cell 

Bioluminescence first evolved in animals at least 540 million years ago

Squids’ birthday influences mating

Star bars show Universe’s early galaxies evolved much faster than previously thought

Critical minerals recovery from electronic waste

The move by Apple Memories to block potentially upsetting content illustrates Big Tech’s reach and limits, writes Chrys Vilvang

[Press-News.org] Older organs accelerate aging in transplant recipients