(Press-News.org) Boston, MA - A new international consensus report on precision medicine in diabetes prevention and care highlights the significant advancements in precision medicine in diabetes prevention, diagnosis, treatment, and prognosis while also shedding light on numerous knowledge gaps.
The report, Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine, was published in Nature Medicine on October 5, 2023.
Supported by the American Diabetes Association (ADA), the European Association for the Study of Diabetes (EASD), and the Novo Nordisk Foundation, the consensus report was made possible through a huge collaborative effort involving 200 academic experts from 28 countries under the banner of the Precision Medicine in Diabetes Initiative (PMDI) including Marie-France Hivert, Harvard Medical School associate professor of population medicine at the Harvard Pilgrim Health Care Institute.
Diabetes is a significant global health concern, impacting hundreds of millions of people and posing a substantial risk of life-threatening complications and premature death. The disease is categorized into several types, with the two most prevalent being type 1 and type 2 diabetes, along with gestational diabetes, monogenic diabetes, and other rare forms of the disease. The heterogeneous nature of diabetes, encompassing various causes, clinical manifestations, and prognoses adds to the complexity of treating the disease. These issues underscore the need for more precise diagnostic, prevention, and treatment strategies than exist today.
Among the many findings, the consensus report shows that precision medicine plays an essential role in diagnosing and treating monogenic diabetes and shows potential in managing gestational diabetes. The report also presents evidence that routine clinical features can help predict how well different types of drugs work when treating type 2 diabetes.
“Precision medicine could help refine our diagnosis for sub-types of diabetes and predict treatment responses or outcomes, all of which could help us better target our clinical management, treatment recommendations, and reduce diabetes-related complications,” says Dr. Hivert. Her research has focused on understanding the determinants of diabetes, including gestational diabetes mellitus (GDM), using genetics and other omics approaches, and their interaction with lifestyle and environmental factors. As part of this report, Dr. Hivert led the efforts of four working groups focused on precision medicine for GDM (prevention, treatment, diagnostic, and prognostic).
While the consensus report highlights areas where precision medicine can have an impact on clinical practice, it also provides a framework for the direction of future research. When asked about the impact of this work, Dr. Hivert states, “Through the effort of the multiple working groups for each type of diabetes, we know that bringing together international diabetes experts from all around the world is already forging new collaborations. We hope that these relationships will flourish to accelerate the field of precision medicine in diabetes and make meaningful strides towards improving the lives of people living with diabetes.”
The report summarizes the findings of 15 systematic reviews of published evidence and expert opinions in prioritized areas of precision diabetes medicine, conducted under the umbrella of the PMDI. The PMDI was established in 2018 by the ADA in collaboration with the EASD to confront the unsustainable health and economic challenges associated with diabetes management and prevention.
Read the full report HERE.
About the Harvard Pilgrim Health Care Institute’s Department of Population Medicine
The Harvard Pilgrim Health Care Institute's Department of Population Medicine is a unique collaboration between Harvard Pilgrim Health Care and Harvard Medical School. Created in 1992, it is the first appointing medical school department in the United States based in a health plan. The Institute focuses on improving health care delivery and population health through innovative research and education, in partnership with health plans, delivery systems, and public health agencies. Point32Health is the parent company of Harvard Pilgrim Health Care and Tufts Health Plan. Follow us on Twitter and LinkedIn.
International consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
ELSE PRESS RELEASES FROM THIS DATE:
Depression, constipation, and urinary tract infections may precede MS diagnosis
EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, TUESDAY, DECEMBER 5, 2023 MINNEAPOLIS – In some diseases, the underlying processes can start years before a diagnosis is made. A new study finds that people who later develop multiple sclerosis (MS) are more likely to have conditions like depression, constipation and urinary tract infections five years before their MS diagnosis than people who do not develop MS. The study, which is published in the December 5, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology, also found that sexual problems and bladder infections, or cystitis, ...
Chemists create organic molecules in a rainbow of colors
CAMBRIDGE, MA -- Chains of fused carbon-containing rings have unique optoelectronic properties that make them useful as semiconductors. These chains, known as acenes, can also be tuned to emit different colors of light, which makes them good candidates for use in organic light-emitting diodes. The color of light emitted by an acene is determined by its length, but as the molecules become longer, they also become less stable, which has hindered their widespread use in light-emitting applications. MIT chemists have now come up with a way to make these molecules more stable, allowing them to synthesize acenes of varying lengths. Using their new approach, ...
NCCN summit navigates solutions for financial and other cancer-related hardships
PLYMOUTH MEETING, PA [December 5, 2023] — Today, the National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers—hosted a Patient Advocacy Summit to explore the role of navigation throughout the cancer process. A diverse group of subject matter experts addressed the impact patient navigation has on care and how to utilize navigators to reduce economic burdens and disparities in care. The speakers included patients and advocates, policymakers, health care providers, and health data analysts. The summit featured a series of best practice presentations highlighting some of the tools available to assist in various ...
Incarcerated women punished at higher rates for minor infractions than men, UTEP study shows
EL PASO, Texas (Dec. 5, 2023) – A new study from The University of Texas at El Paso reveals a gender disparity in prison infractions that disproportionately affects women. The study, led by Melinda Tasca, Ph.D., an associate professor in the Department of Criminal Justice and Security Studies at UTEP, and published in Justice Quarterly, analyzed the disciplinary infraction records of more than 20,000 males and females in a large western state prison, who were released between 2010 and 2013. The researchers set out to answer three questions: ...
Conference on microplastics in water: characterization, cure and prevention
Plastics are ubiquitous in all aspects of modern life, including food packaging, health care and household products. There has been a massive increase in plastics production over the past several decades and there has been serious attention paid to managing plastic wastes, particularly focused on recycling/reuse. However, as of the present time it has not been feasible, either technically or economically, to achieve a fully circular system. Those plastic materials that are not processed for reuse, known as end-of-life pastics, end up in landfillsor in other waste processing systems (e.g., incineration) or advanced recycling (eg., pyrolysis) or directly disposed in the ...
Dorothee Dormann receives an ERC Consolidator Grant to support her research into neurodegenerative diseases
The protein TDP-43 is present in all cells of our body and important for their biochemical processes. However, this protein can aggregate into large clumps in the brain, which can cause degenerative diseases such as Alzheimer's and other dementias. How exactly this happens and how these protein clumps are linked to disease is a subject of intense research. Professor Dorothee Dormann of Johannes Gutenberg University Mainz (JGU) suspects that these proteins may also assemble in healthy cells – and that this assembly on a much smaller scale is important for the normal function of the TDP-43 protein. Her research group investigates the reason for these assemblies in ...
Reducing the energy consumption of software: Sebastian Erdweg receives ERC Consolidator Grant
The energy consumption of data centers and information and communication technology (ICT) devices is growing at an alarming rate, projected to constitute up to 20 percent of global energy consumption by 2030. To support the digital transformation effectively, we need to enhance software efficiency. A promising avenue in this endeavor is incremental computing, where computations react to input changes rather than recomputing results from scratch. However, existing approaches to incrementality have limited applicability: They either demand expert knowledge, support only specialized domains (e.g., ...
Study finds plant nurseries are exacerbating the climate-driven spread of 80% of invasive species
AMHERST, Mass. – Researchers at the University of Massachusetts Amherst recently published a pair of papers that, together, provide the most detailed maps to date of how 144 common invasive plants species will react to 2° Celsius of climate change in the eastern U.S., as well as the role that garden centers currently play in seeding future invasions. Together, the papers, published in Diversity and Distributions and BioScience, and the publicly available maps, which track species at the county level, promise to give invasive species managers in the U.S. the tools they need ...
Jefferson Lab site grows with addition of Applied Research Center
NEWPORT NEWS, VA – The Applied Research Center (ARC) is tying the knot with the U.S. Department of Energy’s Thomas Jefferson National Accelerator Facility. Today, the City of Newport News announced the transfer of the Applied Research Center to Jefferson Lab and the DOE. The announcement was made in a ribbon-tying ceremony for the facility. “Newport News is a hub of innovation and research, thanks in large part to Jefferson Lab’s robust educational and scientific offerings,” said Newport News Mayor Phillip Jones. “Since 1985, the city has invested more than $64 ...
Texas A&M receives $1.8 million NIH grant to support bone health in people with down syndrome
By Courtney Price, Texas A&M University School of Veterinary Medicine & Biomedical Sciences Texas A&M University researchers have been awarded a $1.8 million grant from the National Institutes of Health (NIH) to study bone regeneration throughout the lifespan to ultimately benefit individuals with Down syndrome. The new INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project grant will help scientists understand whether bone regeneration holds the key to helping people ...