(Press-News.org)
“Mitochondrial dysfunction is a major cellular change observed in the hippocampus during aging.”
BUFFALO, NY- December 12, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, “Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus.”
In this new study, researchers Hyo Young Jung, Hyun Jung Kwon, Kyu Ri Hahn, Woosuk Kim, Dae Young Yoo, Yeo Sung Yoon, Dae Won Kim, and In Koo Hwang from Seoul National University, Chungnam National University, Gangneung-Wonju National University, Hallym University, and Konkuk University investigated the effects of heat shock protein 10 (HSP10) protein on memory function, hippocampal neurogenesis, and other related genes/proteins in adult and aged mice.
“In the present study, we investigated the effects of HSP10 on hippocampal function in both adult and aged mice.”
To translocate the HSP10 protein into the hippocampus, the Tat-HSP10 fusion protein was synthesized, and Tat-HSP10, not HSP10, was successfully delivered into the hippocampus based on immunohistochemistry and western blotting. Tat-HSP10 (0.5 or 2.0 mg/kg) or HSP10 (control protein, 2.0 mg/kg) was administered daily to 3- and 21-month-old mice for 3 months, and observed the senescence maker P16 was significantly increased in aged mice and the treatment with Tat-HSP10 significantly decreased P16 expression in the hippocampus of aged mice.
In novel object recognition and Morris water maze tests, aged mice demonstrated decreases in exploratory preferences, exploration time, distance moved, number of object contacts, and escape latency compared to adult mice. Treatment with Tat-HSP10 significantly improved exploratory preferences, the number of object contacts, and the time spent swimming in the target quadrant in aged mice but not adults. Administration of Tat-HSP10 increased the number of proliferating cells and differentiated neuroblasts in the dentate gyrus of adult and aged mice compared to controls, as determined by immunohistochemical staining for Ki67 and doublecortin, respectively.
Additionally, Tat-HSP10 treatment significantly mitigated the reduction in sirtuin 1 mRNA level, N-methyl-D-aspartate receptor 1, and postsynaptic density 95 protein levels in the hippocampus of aged mice. In contrast, Tat-HSP10 treatment significantly increased sirtuin 3 protein levels in both adult and aged mouse hippocampus. These suggest that Tat-HSP10 can potentially reduce hippocampus-related aging phenotypes.
“Our results suggest that Tat-HSP10 treatment facilitates mitochondrial function, and Tat-HSP10 supplementation ameliorates the aging phenotypes in the mouse hippocampus.”
Read the full paper: DOI: https://doi.org/10.18632/aging.205182
Corresponding Authors: Dae Won Kim, In Koo Hwang
Corresponding Emails: kimdw@gwnu.ac.kr, vetmed2@snu.ac.kr
Keywords: heat shock protein 10, aging, hippocampus, memory, neurogenesis, synaptic plasticity
Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.https://doi.org/10.18632/aging.205182
About Aging:
Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at www.Aging-US.com and connect with us:
SoundCloud
Facebook
X, formerly known as Twitter
Instagram
YouTube
LabTube
LinkedIn
Reddit
Pinterest
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker Str., Suite 1B
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
###
END
In our everyday classical world, what you see is what you get. A ball is just a ball, and when lobbed through the air, its trajectory is straightforward and clear. But if that ball were shrunk to the size of an atom or smaller, its behavior would shift into a quantum, fuzzy reality. The ball would exist as not just a physical particle but also a wave of possible particle states. And this wave-particle duality can give rise to some weird and sneaky phenomena.
One of the stranger prospects comes from a thought experiment known as the “quantum bomb tester.” The experiment proposes that a quantum particle, such ...
Smoking shrinks the brain, according to a study by researchers at Washington University School of Medicine in St. Louis. The good news is that quitting smoking prevents further loss of brain tissue — but still, stopping smoking doesn’t restore the brain to its original size. Since people’s brains naturally lose volume with age, smoking effectively causes the brain to age prematurely, the researchers said.
The findings, published in Biological Psychiatry: Global Open Science, help explain why smokers are at high risk of age-related cognitive decline and Alzheimer’s disease.
“Up until recently, scientists have overlooked ...
PHILADELPHIA— Having the ability to self-schedule mammograms was associated with a 15 percentage point increase following through with getting the screening, according to research from the Perelman School of Medicine at the University of Pennsylvania. The paper was published today in the American Journal of Preventive Medicine.
“Self-scheduling helps make the path to mammogram completion a little smoother, where you don’t have to find the time to call a scheduling line, wait on hold, or go back and forth trying to find an appointment that works for your schedule,” said the study’s lead author, Kimberly Waddell, ...
PORTLAND, Oregon -- New research from Oregon Health & Science University could one day lead to therapies that prevent or treat diseases and infections tied to a protein that’s found in all human cells.
A study published today in the journal Molecular Cell describes how the protein ubiquitin is modified during a bacterial infection. The study details the steps taken to create a form of the protein known as lysine 6 polyubiquitin, where a long chain of ubiquitin molecules are linked through ...
More than one-eighth of the randomized trials of cancer drugs seeking regulatory approval in China in recent years used inappropriate controls to test the effectiveness and safety of the drugs, according to a new study published December 12th in the open access journal PLOS Medicine by Professor Xiaodong Guan of Peking University, China, and colleagues.
In randomized trials, patients are assigned to either a control arm, in which they receive the current optimal treatment, or an experimental arm, in which they receive the new drug being tested. However, studies have previously ...
MADISON – An interdisciplinary team led by University of Wisconsin–Madison scientists has developed a new technique that could help farmers extract useful nutrients such as ammonia and potassium from livestock manure to efficiently make fertilizer and other useful chemical products. While the strategy still needs to be scaled up beyond a proof-of-concept stage, the group's preliminary analyses show it could offer considerable benefits by cutting water and air pollution while simultaneously creating products that farmers could use or sell.
Manure stinks in part because it contains ammonia, one of the more ...
DENVER/Dec. 12, 2023 – A new article published in the journal Methods in Ecology and Evolution by Morris Animal Foundation-funded researchers describes a simplified method to detect a deadly fungus killing European salamanders. The ability to rapidly find the fungus is significant as the disease, although not detected in the U.S., could impact the millions of amphibians and salamanders annually imported.
The fungal pathogen Batrachochytrium salamandrivorans, or Bsal, threatens salamander diversity. Initially identified in northern Europe, evidence suggests it was introduced from Southeast Asia via the pet trade.
“The impacts of Bsal ...
EMBO launches a new award for laboratory sustainability: The EMBO Lab Sustainability Award will recognize new and significant contributions to the development of sustainable wet and dry labs with a focus on their environmental impact. The award will be presented to an individual representing the initiative or project. Applications can be submitted between 15 January and 15 March 2024.
The award winner will have the opportunity to present their initiative or project at scientific events and publish a commentary in EMBO Reports. In addition, the winning project will be supported with a grant of 10,000 euros. The award is one of ...
ROCHESTER, Minn. — Stem cell-based therapy improved quality of life for patients with advanced heart failure, Mayo Clinic researchers and international collaborators discovered in a late-stage multinational clinical trial. In one of the largest studies of cell intervention after a heart attack, patients reported their daily hardship lessened when stem cells optimized for heart repair supplemented standard of care. This clinical study further documented lower death and hospitalization rates among those treated with cell therapy. This research ...
ABSTRACT: LBA-2
SAN DIEGO ― The targeted therapy combination of ibrutinib and venetoclax significantly improved progression-free survival (PFS) and achieved an overall remission rate in 82% of patients with relapsed/refractory mantle cell lymphoma (MCL), according to researchers at The University of Texas MD Anderson Cancer Center. Results from the Phase III SYMPATICO trial were presented at the 2023 American Society of Hematology (ASH) Annual Meeting.
At a median follow-up of 51.2 months, median PFS was 31.9 months with the combination compared to 22.1 months with ibrutinib plus placebo. PFS benefits were consistent across patient subgroups, including those with blastoid-variant ...
