(Press-News.org) Illegally manufactured fentanyl kills a significant number of people in the United States and Canada every year. Since the emergence of modern heroin markets in the late 1960s, controlling supply has been associated with important reductions in opioid use and harms in several cases worldwide. But these efforts depend on understanding the dominant drug-trafficking routes.
In a new analysis, researchers developed an index to compare U.S. counties’ proportion of large seizures against their proportion of the national population. Their findings counter some assumptions about the origins of and routes into the United States of illegally manufactured fentanyl.
The analysis, conducted by researchers affiliated with Carnegie Mellon University, appears as a Manhattan Institute report.
“Efforts to counter drug flows need to be grounded in data,” explains Jonathan Caulkins, professor of operations research and public policy at Carnegie Mellon’s Heinz College, who coauthored the report. “Our analysis contradicts views—such as those used to justify certain tariffs—that treat the flows across the southern and northern borders as being comparably important.”
Border counties collectively show significantly higher rates of large fentanyl seizures than do counties in the interior. The authors define large as more than a kilogram of powder or more than 1,000 pills, quantities indicative of wholesale trafficking.
To determine which U.S. counties look like import or transit centers, the authors developed a disproportionality index, using data on fentanyl in 2023 and 2024; the index compares a county’s proportion of large seizures against its proportion of the national population. Drugs seized could be in transit to other places or they might be intended for local consumption, so it is useful to contrast a county’s share of large seizures with its share of the population, which serves as a proxy for the size of the local market.
Counties along the Mexican border account for only 2.35% of the U.S. population, but in 2023-2024, they hosted about 40% of the nationwide quantity of fentanyl appearing in large seizures, for both powder and pills, the analysis found. In contrast, counties in the lower 48 states that border Canada account for 3.1% of the U.S. population but only 1.2% of the powder and just 0.5% of the pills obtained in large seizures.
These findings can guide what policymakers should consider priority targets in efforts to control supply. Among the authors’ suggestions:
Whatever the merits or drawbacks of tariffs on imports from Canada—questions that relate to economics and international relations that the authors did not address—such actions cannot be justified as part of a pragmatic and data-informed response to the threat of fentanyl to the United States.
Greater cooperation between U.S. and Canadian law enforcement could help plug small flows of the drug into the United States and more importantly, could pool intelligence concerning the roles of Chinese and Mexican organized-crime groups that drive the supply chain feeding both countries’ markets.
Energies related to U.S.-Canadian border control might more profitably be directed to the southwestern border or to the many packages and containers that enter the country in ways other than across land borders.
“U.S. counties along the Canadian border are not an important part of this story,” says coauthor Bishu Giri, an alumnus of Heinz College who is a data scientist specializing in natural language processing, machine learning, and geospatial analysis. “Our findings call into question tariffs and other policies and policy justifications that treat the threat from the northern border as comparably severe to that from the southern border.”
END
Findings of study on how illegally manufactured fentanyl enters U.S. contradict common assumptions, undermining efforts to control supply
2025-07-07
ELSE PRESS RELEASES FROM THIS DATE:
Satellite observations provide insight into post-wildfire forest recovery
2025-07-07
FOR IMMEDIATE RELEASE: JULY 7, 2025
Contacts:
Audrey Merket, NSF NCAR and UCAR Science Writer and Public Information Officer
amerket@ucar.edu
303-497-8293
David Hosansky, NSF NCAR and UCAR Manager of Media Relations
hosansky@ucar.edu
720-470-2073
Using satellite observations to evaluate forest recovery following a wildfire could be an innovative, cost-efficient way to assess the effectiveness of land management practices, according to research published earlier this year.
Scientists at the U.S. National Science Foundation National Center for Atmospheric Research ...
Three years in, research shows regional, personal differences in use of 988 lifeline
2025-07-07
Who is most likely to use the 988, the national suicide and crisis lifeline launched on July 16, 2022?
Two studies led by researchers at the NYU School of Global Public Health find both geographic differences and personal factors that shape where people might seek help during mental health crises. For instance, people in western and northeastern states are more likely to have called 988 than those in the South; similarly, Democrats are more inclined to say that they would use 988 than Republicans. In addition, more than 10 percent of calls came from veterans.
The findings, published in JAMA Network ...
Beyond the alpha male
2025-07-07
To the point
Power relationships between males and females are less clear-cut than expected: In most species, neither sex clearly dominates over the other.
Evolutionary factors shape intersexual power: Males have power when they can physically outcompete females, while females rely on different pathways to achieve power over males.
New findings by researchers at the University of Montpellier, the Max Planck Institute for Evolutionary Anthropology in Leipzig, and the German Primate Center in Göttingen resolve why male-female power ...
For fish, hovering is not restful
2025-07-07
Fish make hanging motionless in the water column look effortless, and scientists had long assumed that this meant it was a type of rest. Now, a new study reveals that fish use nearly twice as much energy when hovering in place compared to resting.
The study, led by scientists at the University of California San Diego’s Scripps Institution of Oceanography, also details the biomechanics of fish hovering, which includes constant, subtle fin movements to prevent tipping, drifting or rolling. This more robust understanding of how fish actively maintain their position could inform the design of underwater robots ...
Smithsonian-led team discovers North America’s oldest known pterosaur
2025-07-07
A Smithsonian-led team of researchers have discovered North America’s oldest known pterosaur, the winged reptiles that lived alongside dinosaurs and were the first vertebrates to evolve powered flight. In a paper published today, July 7, in Proceedings of the National Academy of Sciences, researchers led by paleontologist Ben Kligman, a Peter Buck Postdoctoral Fellow at the Smithsonian’s National Museum of Natural History, present the fossilized jawbone of the new species and describe the sea gull-sized ...
A study shakes up received ideas on male domination among primates
2025-07-07
While knowledge of the female dominance spectrum among certain primate species dates back to the 1960s, research precisely quantifying the degree of one gender’s dominance over the other was lacking. A team of scientists collected data from 253 populations representing 121 primate species in order to study confrontations between males and females. It also analysed the contexts in which one or the other tend to dominate.
Scientists then tested five evolutionary hypotheses to better understand these power relations. Females tend to dominate in species [3] where they have strong control over their reproduction. Their dominance is also more frequent in societies ...
LMD strengthens global ties in Italy: Deepening cooperation with Embassy, CNR, and University of Rome Tor Vergata
2025-07-07
To deepen international academic collaboration and enhance the global impact of the journal, Yuan Qing, Party Secretary of the School of Medical Technology at Shanghai Jiao Tong University School of Medicine; Dai Jing, Deputy Director of the Department of Laboratory Medicine at Ruijin Hospital; and Wang Erliang, Director of the Editorial Office of LabMed Discovery (LMD), recently traveled to Europe for a series of academic exchanges. Centered on the core goals of "expanding cooperation, absorbing high-quality manuscript sources, and promoting scientific research projects", the delegation achieved significant outcomes through ...
University of Cincinnati study explores fertility treatment risks for kidney transplant recipients
2025-07-07
Women with kidney transplants who use assisted reproductive technology (ART) to conceive might face higher risks of complications during pregnancy, according to new research from the University of Cincinnati College of Medicine. The study provides some of the first large-scale data on pregnancy outcomes in this unique patient population.
Silvi Shah, MD, associate professor in the Division of Nephrology and Hypertension in the Department of Internal Medicine, led the research in collaboration with the Transplant Pregnancy Registry International (TPRI). It was recently published in the journal Transplantation. The study is among the first of its kind to evaluate ...
Study uncovers how harmful RNA clumps form — and a way to dissolve them
2025-07-07
BUFFALO, N.Y. — Look inside a brain cell with Huntington’s disease or ALS and you are likely to find RNA clumped together.
These solid-like clusters, thought to be irreversible, can act as sponges that soak up surrounding proteins key for brain health, contributing to neurological disorders.
How these harmful RNA clusters form in the first place has remained an open question.
Now, University at Buffalo researchers have not only uncovered that tiny droplets of protein and nucleic acids in cells contribute to the formation of RNA clusters but also demonstrated a way to prevent and disassemble ...
A new perspective on designing urban low-altitude logistics networks subhead: Balancing cost, safety, and noise through co-evolutionary multi-objective optimization
2025-07-07
As cities worldwide begin embracing low-altitude logistics to support rapid, flexible deliveries by drones, urban planners face an increasingly difficult challenge: how to design an aerial delivery network that balances cost efficiency, safety, and noise impact.
A research team from Beihang University has developed a new framework that tackles this challenge head-on. Their study presents a multi-layered, hub-and-spoke logistics network design optimized using a dual-population co-evolutionary algorithm. This method not only improves route planning and facility placement but also explicitly accounts for noise constraints — a key concern for residents living ...