(Press-News.org) Osaka, Japan – From alleviating your allergy symptoms to optimizing herbicide performance, alkylamines are molecules that have many uses. Unfortunately, common methods of producing alkylamines result in harmful waste byproducts. A method of synthesizing alkylamines in a sustainable yet cost-effective way has thus been highly sought after.
Now, in a study recently published in Green Chemistry, a research team led by Osaka University has found a way. The team has developed a method of alkylamine synthesis that works under mild conditions and produces only water as a byproduct. The simple, environmentally friendly reaction conditions reported here will hopefully inspire advances in other chemical syntheses common in industry.
Sports clothing, furniture, and many other everyday products are produced, in part, by using alkylamines. So how do we produce these wonder molecules? Carboxylic acids are an ideal starting point because they can be sourced sustainably, such as from biomass. However, the synthetic procedures currently used also produce a large quantity of waste or require experimentally difficult reaction conditions, such as high pressures and temperatures. Thus, industry generally avoids carboxylic acids as a starting material for alkylamine production. Developing a new synthetic protocol that works at experimentally convenient pressures and temperatures was the goal of the research team's study.
"In our work, we unveil a novel catalyst system, a platinum – molybdenum catalyst, that can transform carboxylic acids into amines," explains Katsumasa Sakoda, lead author of the study. "This produces alkylamines, which can be used for surfactants, pharmaceuticals and more."
The researchers' synthetic protocol offers several advantages: one, the reaction conditions are mild, requiring only atmospheric hydrogen pressure and temperatures up to 160°C. Two, the turnover number, i.e., the number of moles of substrate that a mole of catalyst can convert, is high at 363. Three, the catalyst can be reused at least five times. Four, many carboxylic acid and amine starting materials are compatible with the reactions involved, such as converting fatty acids into fatty amines. Five, the reaction yields are high – up to 99%, with water being the only byproduct.
"We're excited because our research improves the environmental sustainability and simplifies the experimental setup of a common class of chemical syntheses," says Tomoo Mizugaki, senior author. "We hope that this is only the first step toward the development of greener catalyst processes.”
The team’s research is an important step forward in increasing the sustainability of a chemical reaction that is required for synthesizing many everyday products. Because the experimental synthetic procedures are safe and simple, they can be readily used for other catalytic processes.
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The article, "Reductive amination of carboxylic acids under H2 using a heterogeneous Pt–Mo catalyst," was published in Green Chemistry at DOI: https://doi.org/10.1039/D3GC02155F
About Osaka University
Osaka University was founded in 1931 as one of the seven imperial universities of Japan and is now one of Japan's leading comprehensive universities with a broad disciplinary spectrum. This strength is coupled with a singular drive for innovation that extends throughout the scientific process, from fundamental research to the creation of applied technology with positive economic impacts. Its commitment to innovation has been recognized in Japan and around the world, being named Japan's most innovative university in 2015 (Reuters 2015 Top 100) and one of the most innovative institutions in the world in 2017 (Innovative Universities and the Nature Index Innovation 2017). Now, Osaka University is leveraging its role as a Designated National University Corporation selected by the Ministry of Education, Culture, Sports, Science and Technology to contribute to innovation for human welfare, sustainable development of society, and social transformation.
Website: https://resou.osaka-u.ac.jp/en
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A chemical reaction key to various industries just got greener
A multi-institutional research team, led by Osaka University, successfully converts biomass-derived long-chain fatty acids into fatty amines, opening the door to greener catalyst processes
2024-01-09
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[Press-News.org] A chemical reaction key to various industries just got greenerA multi-institutional research team, led by Osaka University, successfully converts biomass-derived long-chain fatty acids into fatty amines, opening the door to greener catalyst processes