PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Children’s Hospital Los Angeles RECOVER Study collaborators publish comprehensive report on long COVID symptoms in children

RECOVER study report could aid doctors in diagnosing pediatric long COVID symptoms

Children’s Hospital Los Angeles RECOVER Study collaborators publish comprehensive report on long COVID symptoms in children
2024-02-12
(Press-News.org) LOS ANGELES (February 9, 2024)—Up to 5.8 million children and youth in the U.S. have experienced symptoms of COVID-19 that persisted long after initial infection. But diagnosing pediatric post acute sequelae of SARS-CoV-2 (PASC)—known as long COVID—in children remains challenging, as it can affect any organ system in the body, symptoms vary widely by individual, and little is known about its trajectory in patients over time. Children’s Hospital Los Angeles is one of 10 pediatric sites involved in the nationwide Researching COVID to Enhance Recovery (RECOVER) Initiative, sponsored by the National Institutes of Health to improve the diagnosis, treatment and prevention of long COVID in children. CHLA researchers and their collaborators in the RECOVER Initiative have published a comprehensive report on pediatric long COVID symptoms in the journal Pediatrics. 

“At our Long COVID Recovery Care clinic, some patients have symptoms for two months and there are others whose symptoms have still not gone away two years later,” says Sindhu Mohandas, MD, co-Director, Immunocompromised Infectious Diseases Program at Children’s Hospital Los Angeles and study co-author. “But we still don’t know which patients are at risk for long-term symptoms. Until this report, doctors looking for information could only refer to small, case-based studies. Pediatric clinicians and researchers can now use this paper to quickly access the latest research on long COVID in children and reference the source studies.

Summarizing the research

The RECOVER collaborators across the country reviewed existing research on long COVID in kids in their respective areas of expertise, including its epidemiology, risk factors, clinical characteristics and outcomes. “Our goal was to summarize all available knowledge from those smaller articles, case reports and clinic-based studies on the full range of long COVID symptoms that we are seeing across the U.S.,” says Dr. Mohandas.

Their findings have so far uncovered a few clues to long COVID risk. For instance, about 45% of the children who developed long COVID experienced COVID-19 symptoms rather than symptomless infections (15%). Other factors include older age, more severe initial COVID-19 infection, the number of different organ systems initially affected, underlying medical conditions and higher weight.

The most common long COVID symptoms in children involve fatigue, persistent headaches, weakness, musculoskeletal pain, shortness of breath, loss of taste and smell, and dizziness. Between 2% to 44% of kids with long COVID can experience difficulties in concentration—known as brain fog—after physical or mental effort. Brain fog/fatigue can also mimic the symptoms of myalgic encephalomyelitis—known as chronic fatigue syndrome.This can last for at least six months and impair daily function.

Long COVID is linked with the new onset of Type 1 or Type 2 diabetes about a month after initial infection. Long COVID is also associated with the development of multisystem inflammatory syndrome in children (MIS-C)—thought to be caused by abnormally high activation of the immune response—involving heart damage, irregular heart rhythms and conduction abnormalities.

“Most MIS-C symptoms disappear after six months, but a minority of children still experience unexplained exercise intolerance and fatigue,” says John C. Wood, MD, PhD, cardiologist and investigator at CHLA, and study co-author.

Pediatricians are under-diagnosing long COVID, Dr. Wood adds. “Some believe children don’t get long COVID and others just don’t know the signs and symptoms. I think the big ’added value’ to this published study is that it provides some of the characteristic ’fingerprints’ that pediatricians can use to recognize long COVID.” 

Worsening pre-existing conditions

Long COVID can aggravate chronic respiratory conditions such as asthma. Several studies showed that while asthma didn’t worsen during initial COVID-19 infection, it did so during the six months after infection.

Long COVID can also worsen rare fibromyalgia and connective tissue disorders such as Ehlers Danlos syndrome or Marfan syndrome. These conditions are also linked with chronic fatigue syndrome and the dysregulation of involuntary body functions such as blood pressure and heart rate, causing dizziness when shifting position or standing, a condition like postural orthostatic tachycardia syndrome (POTS).

“We needed to follow a large group of kids over a long span of time to see the prevalence and clinical course of some of these rare symptoms,” says David Warburton, MD, stem cell researcher and neonatologist at CHLA. “Our hope is that this effort to better understand long COVID can lead to a deeper understanding of these other conditions as well—and to effective treatments. We are now collecting information on symptoms that re-emerge over time during periods of physical and/or psychological stress and re-infection, to learn how to prevent chronic conditions from emerging in adulthood.”

The CHLA RECOVER study is still enrolling volunteers. Physicians and families can find out more about the study or join by emailing the study team at CovidRecover@chla.usc.edu.

###

The first author of the study was Suchitra Rao, MBBS, MSCS, University of Colorado School of Medicine and Colorado Children’s Hospital. Additional contributors include: Rachel S. Gross MD, MS, Cheryl R. Stein, PhD, New York University Grossman School of Medicine; Abigail Case, MD, Children’s Hospital of Philadelphia; Benard Dreyer, MD, CHLA; Nathan M. Pajor, MD, Cincinnati Children's Hospital Medical Center; H. Timothy Bunnell, PhD, Nemours Children’s Hospital; Elizabeth Berg, MD, Jonathan Overdevest, MD, Mark Gorelik, MD, Joshua Milner, MD, Sejal Saxena, BA, Columbia University Vagelos College of Physicians and Surgeons; Ravi Jhaveri, MD, Ann & Robert H. Lurie Children's Hospital of Chicago; Kyung E. Rhee, MD, MSc, MA, UC San Diego School of Medicine; Rebecca Letts, BA, Christine Maughan, BS, Nick Guthe, BA, Leah Castro-Baucom, MA, New York University Grossman School of Medicine; and Melissa S. Stockwell, MD, MPH, Columbia University Vagelos College of Physicians and Surgeons.

About Children’s Hospital Los Angeles

Founded in 1901, Children’s Hospital Los Angeles is at the forefront of pediatric medicine and is the largest provider of hospital care for children in California. Children’s Hospital is home to renowned experts who work together across disciplines to deliver inclusive and compassionate care and drive advances that set pediatric standards across the nation and around the globe.

Children’s Hospital Los Angeles provides a level of care to its diverse population of children that is among the best in the world. The hospital is consistently ranked in the top 10 in the nation on U.S. News & World Report’s Honor Roll of Best Children’s Hospitals, including No. 1 in California and No. 1 in the Pacific U.S. region. Children’s Hospital Los Angeles embraces its mission to create hope and build healthier futures. Children’s Hospital Los Angeles is among the top 10 children’s hospitals for National Institutes of Health funding. The Saban Research Institute of Children's Hospital Los Angeles supports the full continuum of research, allowing physicians and scientists to translate discoveries into treatments and bring answers to families faster. The pediatric academic medical center also is home to one of the largest training programs for pediatricians in the United States, and the hospital’s commitment to building strong communities is evident in CHLA’s efforts to fight food insecurity, enhance health education and literacy, and introduce more people to careers in health care. To learn more, follow CHLA on Facebook, Instagram, LinkedIn, YouTube and X (formerly Twitter), and visit CHLA.org/blog.

END

[Attachments] See images for this press release:
Children’s Hospital Los Angeles RECOVER Study collaborators publish comprehensive report on long COVID symptoms in children Children’s Hospital Los Angeles RECOVER Study collaborators publish comprehensive report on long COVID symptoms in children 2 Children’s Hospital Los Angeles RECOVER Study collaborators publish comprehensive report on long COVID symptoms in children 3

ELSE PRESS RELEASES FROM THIS DATE:

Cyber Readiness Institute and Cybersecurity Manufacturing Innovation Institute launch free cyber readiness program for small and medium-sized manufacturers

2024-02-12
The Cyber Readiness Institute (CRI) and Cybersecurity Manufacturing Innovation Institute (CyManII) at The University of Texas at San Antonio have launched a pilot program aimed at elevating cyber readiness and security within the energy manufacturing sector. This strategic initiative emphasizes CRI and CyManII’s shared commitment to strengthening their defenses against evolving cyber threats by providing essential support and resources for small and medium-sized manufacturers. Through this partnership, CyManII will provide up to 200 U.S. manufacturers in the energy sector with access to CRI’s free Cyber Readiness Program. Focused on human behavior, the Cyber Readiness ...

Sister cells uncover pre-existing resistant states in cancer

2024-02-12
Labeling cancer cells with genetic barcodes  “In ReSisTrace, we label cancer cells uniquely with genetic barcodes and allow them to divide once, so that we get two identical sister cells that share the same barcode. We then analyse single-cell gene expression from half of the cells before the treatment, while treating the other half with chemotherapy, or other anti-cancer treatment. From the surviving cells we can identify the barcodes of resistant cells. Using their sister cells analysed before the treatment, we can discover how the cells that ...

Customers prefer text over video to provide service feedback

2024-02-12
PULLMAN, Wash. – At a time when one viral video can damage a business, some companies are turning to their own commenting platforms rather than letting social media be the main outlet for customer feedback. Only one wrinkle: in this context, customers appear to prefer writing a message rather than leaving a video. In a recent study, more participants indicated they would likely leave written compliments or complaints about service on a restaurant-provided tablet powered by artificial intelligence. ...

A flicker of truth: Piercing the “continuity illusion”

2024-02-12
A study by a team at the Champalimaud Foundation (CF) has cast a new light on the superior colliculus (SC), a deep-seated brain structure often overshadowed by its more prominent cortical neighbour. Their discovery uncovers how the SC may play a pivotal role in how animals see the world in motion, and sheds light on the “continuity illusion”, an essential perceptual process integral to many of our daily activities, from driving vehicles to watching movies. Imagine watching a film. The moving images you see are actually a series of static frames shown rapidly. This is the continuity illusion at work, where our brain perceives ...

Century of progress sets stage for future scientific advances in cardiovascular health

2024-02-12
Embargoed until 4 a.m. CT/5 a.m. ET Monday, Feb. 12, 2024 DALLAS, Feb. 12, 2024 — Dramatic advances in the understanding and treatment of cardiovascular diseases have saved millions of lives in the 100 years since the founding in 1924 of the American Heart Association, the world’s leading voluntary organization focused on heart and brain health for all. As heart disease and stroke remain the top causes of death worldwide, the solutions to challenges of the next century must combine lessons of the past with innovations of ...

Does physical activity lessen pain intensity for cancer survivors?

2024-02-12
People who have had cancer often experience ongoing pain, but a new study reveals that being physically active may help lessen its intensity. The study is published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. Although physical activity has been shown to lessen various types of pain, its effects on cancer-related pain are unclear. To investigate, a team led by senior author Erika Rees-Punia, PhD, MPH, of the American Cancer Society, and first author Christopher T.V. Swain, PhD, ...

Prolonged cough? In most cases, patience is the treatment

2024-02-12
Coughing after a respiratory infection is common and, in most cases, will resolve with time, according to an article in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.231523. With the recent bout of respiratory infections across Canada, many people are suffering from a postinfectious cough, or a cough that lasts for weeks after the initial infection has resolved. "Reassuring patients that postinfectious cough is time limited and self resolving is important and can reduce unnecessary and costly prescriptions, such as asthma puffers or antibiotics," ...

Study finds adolescents with concussion may benefit from more activity earlier

2024-02-12
(COLUMBUS, Ohio) – Researchers at Nationwide Children’s Hospital have found that when it comes to concussion recovery, activity type matters. In a study published today in British Journal of Sports Medicine, researchers found that limiting screen time and returning to school early following a concussion may speed up recovery. “Increased time spent in the classroom, participating in some after-school activities or working a job was associated in our study with faster symptom resolution, especially ...

There is no proof that AI can be controlled, according to extensive survey

2024-02-12
There is no current evidence that AI can be controlled safely, according to an extensive review, and without proof that AI can be controlled, it should not be developed, a researcher warns. Despite the recognition that the problem of AI control may be one of the most important problems facing humanity, it remains poorly understood, poorly defined, and poorly researched, Dr Roman V. Yampolskiy explains. In his upcoming book, AI: Unexplainable, Unpredictable, Uncontrollable, AI Safety expert Dr Yampolskiy looks at the ways that AI has the potential to dramatically reshape society, not always to our advantage. He explains: “We are facing an almost guaranteed event with ...

The Complete Library of Charles Darwin revealed for the first time

The Complete Library of Charles Darwin revealed for the first time
2024-02-11
Charles Darwin – arguably the most influential man of science in history, accumulated a vast personal library throughout his working life. Until now, 85 per cent of its contents were unknown or unpublished.  This year, coinciding with Darwin’s 215th birthday, The Complete Work of Charles Darwin Online, the scholarly project helmed by Dr John van Wyhe at the National University of Singapore (NUS) Department of Biological Sciences, has released an online 300-page catalogue detailing Darwin’s complete personal library, with 7,400 titles across 13,000 volumes and items including books, pamphlets and journals. ...

LAST 30 PRESS RELEASES:

Detection of suicide-related emergencies among children using real-world clinical data: A free webinar from the Brain & Behavior Research Foundation

Editor-in-Chief of Sustainability and Climate Change Madhavi Venkatesan named USA TODAY Woman of the Year for Massachusetts for leading plastic bottle ban efforts

Tests show high-temperature superconducting magnets are ready for fusion

Zika vaccine safe, effective when administered during pregnancy

Firearm ownership is correlated with elevated lead levels in children, study finds

Role of African women and young people in agricultural service provision investigated in new CABI-led study

26th International Conference of the Redox Medicine Society Set for June 2024 in Paris, France

Geologists explore the hidden history of Colorado’s Spanish Peaks

Webb unlocks secrets of one of the most distant galaxies ever seen

3D-printed skin closes wounds and contains hair follicle precursors

Discovered a RNA molecule that helps prevent DNA replication errors

Small and overlooked: Amount of repetitive DNA in blood hints at cancer early

Study determines the original orientations of rocks drilled on Mars

Illinois study: Supporting disease-challenged broiler chickens through nutrition

Communities severed by roads and traffic experience a larger number of collisions in New York City

Study shows new class of antivirals that works against SARS-CoV-2

Cost of direct air carbon capture to remain higher than hoped

Unraveling the mystery of chiton visual systems

Case Western Reserve University-led research team discovers new method to test for oral cancer

Firearm access and gun violence exposure are common in Black and native communities

New AI smartphone tool accurately diagnoses ear infections

Screen time and parent-child talk when children are ages 12 to 36 months

Firearm access and gun violence exposure among American Indian or Alaska native and Black adults

Associations of medical debt with health status, premature death, and mortality in the US

Low-cost liquid tames tooth decay

More than 1/3 illicit drugs sold on the dark web contain unexpected substances

A better way to deliver fetal therapy for serious genetic disorders

Researchers develop amphibian-inspired camouflage skin

Network of quantum sensors boosts precision

Robotic hip exoskeleton shows promise for helping stroke patients regain their stride

[Press-News.org] Children’s Hospital Los Angeles RECOVER Study collaborators publish comprehensive report on long COVID symptoms in children
RECOVER study report could aid doctors in diagnosing pediatric long COVID symptoms