(Press-News.org)
“[...] people of the northeastern region [of India] consume betel quid, consisting of raw areca nut [...]. People often swallow the entire betel-quid after chewing, which is believed to contribute to the development of oral, esophageal, and gastric cancers.”
BUFFALO, NY- February 12, 2024 – A new research paper was published in Oncotarget's Volume 15 on February 5, 2024, entitled, “Differential expression of Mad2 gene is consequential to the patterns of histone H3 post-translational modifications in its promoter region in human esophageal cancer samples.”
Raw areca nut (AN) consumption increases esophageal squamous cell carcinoma (ESCC) due to overexpression of securin (pituitary tumor transforming gene1), causing chromosomal instability. Mitotic arrest deficient protein 2 (Mad2), a crucial spindle assembly checkpoint protein, is at risk of aneuploidy and tumor development when overexpressed or underexpressed. In this new study, researchers Chongtham Sovachandra Singh, Nabamita Boruah, Atanu Banerjee, Sillarine Kurkalang, Pooja Swargiary, Hughbert Dakhar, and Anupam Chatterjee from The Assam Royal Global University, University of Pennsylvania, LN Mithila University, University of Chicago Medicine, Nazareth Hospital, Laitumkhrah, and North-Eastern Hill University evaluated Mad2 status in human ESCC with AN consumption habits, revealing unclear molecular mechanisms.
Human ESCC samples (n = 99) were used for loss of heterozygosity analysis at 4q25-28, while 32 samples were used for expression analysis of Mad2, E2F1 genes, and Rb-phosphorylation. Blood samples were used for metaphase preparation. The Mad2 deregulation was assessed using chromatin immunoprecipitation-qPCR assay in the core promoter region, establishing its association with the pRb-E2F1 circuit for the first time.
“The study revealed overexpression and underexpression of Mad2, premature anaphase, and chromosome missegregation in all the samples.”
LOH pattern identified a deletion in D4S2975 in 40% of ESCC samples. The study reveals the deregulation of pRb-E2F1 circuit in all samples. 4q27 disruption could be a factor for Mad2 underexpression in AN-induced esophageal carcinogenesis, while overexpression may be due to the deregulation of the Rb-E2F1 circuit and consequently elevation of H3K4me3 and H3K9ac.
“Mad2 expression levels with chromosomal abnormalities can be a clinical biomarker, but further research is needed to understand pRb’s role in Mad2 down-regulation.”
Read the full paper: DOI: https://doi.org/10.18632/oncotarget.28554
Correspondence to: Anupam Chatterjee
Emails: achatterjee@rgu.ac, chatterjeeanupam@hotmail.com
Keywords: Mad2 gene, histone methylation, histone acetylation, Rb-phosphorylation, esophageal cancer
Click here to sign up for free Altmetric alerts about this article.
About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:
X, formerly Twitter
Facebook
YouTube
Instagram
LinkedIn
Pinterest
Reddit
Spotify, and available wherever you listen to podcasts
Click here to subscribe to Oncotarget publication updates.
For media inquiries, please contact media@impactjournals.com.
Oncotarget Journal Office
6666 East Quaker Street., Suite 1A
Orchard Park, NY 14127
Phone: 1-800-922-0957 (option 2)
###
END
Rochester Institute of Technology’s Center for Detectors has been chosen by NASA for two research programs: Early Stage Innovations (ESI) and Strategic Astrophysics Technology (SAT), with the hope of helping future spacecraft find new discoveries in the vast universe.
Under the leadership of Center for Detectors Director Don Figer, the team will be advancing and characterizing single-photon sensing complementary metal-oxide semiconductor (CMOS) image sensors to determine if they can survive the harsh radiation environments in NASA missions. The intent is to fly these types of detectors on future missions to find life on Jupiter’s ...
University of Wyoming archaeology Professor Todd Surovell and his team of collaborators have discovered a tube-shaped bead made of bone that is about 12,940 years old.
The bead, found at the La Prele Mammoth site in Converse County, is the oldest known bead in the Americas.
Surovell’s research was published in the peer-reviewed journal Scientific Reports; the paper is titled “Use of hare bone for the manufacture of a Clovis bead.” Members of the research team included people from UW, the Office of the Wyoming State Archaeologist, the University of Manchester, Weber ...
BIRMINGHAM, Ala. – Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain. The resulting pathogenesis features neuroinflammation, demyelination and neurodegeneration. Oligodendrocytes produce myelin, an insulating sheath on the axons of nerves.
In 2020, Ashley Harms, Ph.D., and University of Alabama at Birmingham colleagues published an Acta Neuropathologica study that used a mouse model to show that the ...
UNIVERSITY PARK, Pa. — Pumpkin toadlets are in trouble. Progressively severe droughts are disrupting the microbiomes of the thumbnail-sized orange frogs, potentially leaving them vulnerable to a deadly fungal disease, according to a new study by an international research team. The finding suggests that abnormal rainfall patterns, which are expected to worsen due to climate change and deforestation, may upset mutually beneficial relationships between wildlife and microorganisms, leading to biodiversity decline.
The researchers, led by Penn State doctoral ...
UNDER EMBARGO UNTIL: Feb. 12, 2024, 4:30 PM EST
Media Contacts: Karen Addis, APR, karen@addispr.com, +1 (301) 787-2394; Kerri Wade, MPA, kwade@smfm.org, +1 (202) 236-1780
National ...
Your morning cereal, a jar of nuts, the sands of distant planets, and even the concrete in your city are all examples of granular systems surrounding us. And such systems are harboring secrets that could change the way we mix things up.
In a new paper published in the journal Proceedings of the National Academy of Sciences (PNAS), scientists at the University of Rochester, including Rachel Glade, an assistant professor of earth and environmental sciences and of mechanical engineering; Fernando David Cúñez, a former postdoctoral research associate ...
You can mend a broken heart this valentine’s day now that researchers invented a new hydrogel that can be used to heal damaged heart tissue and improve cancer treatments.
University of Waterloo chemical engineering researcher Dr. Elisabeth Prince teamed up with researchers from the University of Toronto and Duke University to design the synthetic material made using cellulose nanocrystals, which are derived from wood pulp. The material is engineered to replicate the fibrous nanostructures and properties of human tissues, thereby recreating its unique biomechanical properties.
"Cancer is a diverse disease and two patients with the same type of cancer will often respond ...
Hypertensive disorders of pregnancy (HDP) and gestational diabetes (GDM) are two of the most common pregnancy complications and put pregnant people at increased risk of developing cardiovascular disease later in life.
Now, in a new study to be presented today at the Society for Maternal-Fetal Medicine’s (SMFM) annual meeting, The Pregnancy Meeting™, researchers will unveil findings that suggest these pregnancy complications may also result in worse cardiovascular health for the child.
In a secondary analysis of 3,317 maternal-child pairings from the prospective Hyperglycemia ...
Anyone who has ever been to a loud concert knows the feeling of ringing ears. Some people experience temporary or even permanent hearing loss or drastic changes in their perception of sound after the loud noises stop. Thanos Tzounopoulos, Ph.D., director of the Pittsburgh Hearing Research Center at the University of Pittsburgh School of Medicine has focused his scientific career on investigating how hearing works and developing ways to treat tinnitus and hearing loss.
In a paper published today in ...
As you scroll through any social media feed, you are likely to be prompted to follow or friend another person, expanding your personal network and contributing to the growth of the app itself. The person suggested to you is a result of link prediction: a widespread machine learning (ML) task that evaluates the links in a network — your friends and everyone else’s — and tries to predict what the next links will be.
Beyond being the engine that drives social media expansion, link prediction is also used in a wide range of scientific research, such as predicting the interaction between genes and proteins, and is used by researchers as a benchmark for ...
