PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

The roles of USP1 in Ewing sarcoma

The roles of USP1 in Ewing sarcoma
2024-02-14
(Press-News.org)

“This study uncovered important roles for USP1 in Ewing sarcoma.”

BUFFALO, NY- February 14, 2024 – A new research paper was published in Genes & Cancer on February 5, 2024, entitled, “Roles of USP1 in Ewing sarcoma.”

Ewing sarcoma is a cancer of bone and soft tissue in children and young adults that is driven by the EWS-ETS fusion transcription factor, most commonly EWS-FLI1.

Researchers Panneerselvam Jayabal, Xiuye Ma and Yuzuru Shiio from The University of Texas Health Science Center previously reported that Ewing sarcoma harbors two populations of cells, the CD133high population displaying higher growth rate and the CD133low population displaying chemotherapy resistance. In their new study, the researchers now find that the ubiquitin-specific protease 1 (USP1) is a transcriptional target of the EWS-FLI1 fusion oncoprotein, expressed at high and low levels in the CD133high and the CD133low populations, respectively, and determines chemo-sensitivity. 

“Ubiquitin-specific protease 1 (USP1) is a deubiquitinating enzyme that plays important roles in DNA damage response.”

They also found that USP1 inhibits cdc42, increases EWS-FLI1 transcriptional output, and simulates Ewing sarcoma growth. Results show that chemo-sensitization by USP1 is independent of cdc42. A pharmacological inhibitor of USP1 was able to activate cdc42 and inhibit Ewing sarcoma growth. 

“These results uncover critical roles for USP1 in Ewing sarcoma, which regulates growth and chemo-sensitivity via distinct mechanisms.”
 

Read the full study: DOI: https://doi.org/10.18632/genesandcancer.235 

Correspondence: Yuzuru Shiio - Emails: shiio@uthscsa.edu 

Keywords: chemotherapy, Ewing sarcoma; growth, USP1

 

About Genes & Cancer: Genes & Cancer covers all aspects of the structure and function of oncogenes, growth suppressor and apoptotic genes, their role in signal transduction and the mechanisms by which their expression and function are altered during tumor development. In addition to publishing manuscripts that directly relate to these areas of research, Genes & Cancer also aims to attract papers in the areas of genomics, drug development and systems biology.

To learn more about Genes & Cancer, visit www.genesandcancer.com and connect with us on social media:

X, formerly Twitter Facebook YouTube LinkedIn Instagram

 

For media inquiries, please contact: media@impactjournals.com.

 

Genes & Cancer Journal Office

6666 East Quaker Str., Suite 1C

Orchard Park, NY 14127

Phone: 1-212-659-5400

###

END


[Attachments] See images for this press release:
The roles of USP1 in Ewing sarcoma The roles of USP1 in Ewing sarcoma 2 The roles of USP1 in Ewing sarcoma 3

ELSE PRESS RELEASES FROM THIS DATE:

New algorithm disentangles intrinsic brain patterns from sensory inputs

2024-02-14
Maryam Shanechi, Dean’s Professor of Electrical and Computer Engineering and founding director of the USC Center for Neurotechnology, and her team have developed a new machine learning method that reveals surprisingly consistent intrinsic brain patterns across different subjects by disentangling these patterns from the effect of visual inputs.The work has been published in the Proceedings of the National Academy of Sciences (PNAS). When performing various everyday movement behaviors, such as reaching for a book, our brain has to take in information, often in the form of visual input — for example, seeing where the book is. Our brain then has to process ...

A new test could predict how heart attack patients will respond to mechanical pumps

2024-02-14
Every year, around 50,000 people in the United States experience cardiogenic shock — a life-threatening condition, usually caused by a severe heart attack, in which the heart can’t pump enough blood for the body’s needs. Many of these patients end up receiving help from a mechanical pump that can temporarily help the heart pump blood until it recovers enough to function on its own. However, in nearly half of these patients, the extra help leads to an imbalance between the left and right ventricles, which can pose danger to the patient. In a ...

Turning back the clock on photoaging skin

2024-02-14
Chronic exposure of human skin to ultraviolet light causes premature aging, or photoaging. As the skin undergoes photoaging, type I collagen bundles, which are found in the dermis beneath the top layer of the skin and provide strength and support to skin, become fragmented. This leads to wrinkles, fragility and loss of support and elasticity.   “The best way to prevent damage to type I collagen by sunlight is to wear sunscreen consistently, daily if possible and particularly when spending time outdoors,” said Frank Wang, MD,  the William B. Taylor Endowed Professor of Clinical Dermatology at U-M Medical School.  Experts ...

City of Hope research featuring the successful treatment of the oldest patient to achieve remission for leukemia and HIV published in The New England Journal of Medicine (NEJM)

City of Hope research featuring the successful treatment of the oldest patient to achieve remission for leukemia and HIV published in The New England Journal of Medicine (NEJM)
2024-02-14
LOS ANGELES — City of Hope®, one of the largest cancer research and treatment organizations in the United States, treated the oldest person to be cured of a blood cancer and then achieve remission for HIV after receiving a blood stem cell transplant from a donor with a rare genetic mutation. Research published in NEJM today demonstrates that older adults with blood cancers who receive reduced intensity chemotherapy before a stem cell transplant with donor cells that are resistant to HIV may be cured of HIV infection. Paul Edmonds, 68, of Desert Springs, California, is the fifth person in the world to achieve remission for acute myelogenous leukemia ...

A lighthouse in the Gobi desert

A lighthouse in the Gobi desert
2024-02-14
Los Angeles, CA (February 14, 2024) — A new study published in the journal PLOS ONE explores the weight great fossil sites have on our understanding of evolutionary relationships between fossil groups—the lagerstätten effect—and for the first time, quantified the power these sites have on our understanding of evolutionary history. Surprisingly, the authors discovered that the wind-swept sand deposits of the Late Cretaceous Gobi Desert’s extraordinarily diverse and well-preserved ...

Paradigm Shift: How a risk-based program is changing health care use and outcomes for children with high-risk asthma

2024-02-14
Le Bonheur’s risk-based innovation program Changing High-Risk Asthma in Memphis through Partnership (CHAMP) significantly decreased health care use related to asthma by targeting barriers to asthma care, according to research published in the Annals of Allergy, Asthma & Immunology. After one year of enrollment in the program, results analyzing 945 children included a 48% reduction in Emergency Department (ED) visits, 68% reduction in inpatient and observation visits, 42% reduction in urgent care visits and 53% reduction in asthma exacerbations. Asthma exacerbations per patient significantly decreased from 2.97 to 1.4. “Children ...

U of M research advances potential HIV cure strategy

2024-02-14
Published in the Journal of Infectious Diseases Oxford Academic, research led by the University of Minnesota Medical School offers a new avenue of hope in the fight against chronic human immunodeficiency virus (HIV) infection.  The researchers explored the use of Natural Killer (NK) cells aiming to restore their function for better infection control — an approach that could be used in a broader HIV cure strategy as multiple companies are working on mass production of healthy NK cells. “HIV has really excellent therapies thanks to the unprecedented progress in developing antiretroviral therapy, ...

New review finds Indigenous people more likely to have a stroke

2024-02-14
EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, FEBRUARY 14, 2024 MINNEAPOLIS – Indigenous people may be more likely to have a stroke than non-Indigenous people, according to a systematic review that looked at populations around the world. The review is published in the February 14, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. Researchers looked at countries with a very high Human Development Index, which measures average achievements in three areas: health, knowledge ...

UC Irvine-led research team creates novel rabies viral vectors for neural circuit mapping

2024-02-14
Irvine, Calif., Feb. 14, 2024 — A research team led by the University of California, Irvine has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer’s disease brain neurons.   The study published today online in the journal Molecular Psychiatry, introduced proof-of-concept data demonstrating the power of these new vectors, which express a range of improved ...

Broad Institute 2024 Media Boot Camp

2024-02-14
The Broad Institute of MIT and Harvard is now accepting applications for its 2024 Media Boot Camp. This annual program connects health/science journalists and editors with faculty from the Broad Institute, Massachusetts Institute of Technology, Harvard University, and Harvard’s teaching hospitals for a two-day event exploring the latest advances in genomics and biomedicine. Journalists will explore possible future storylines, gain fundamental background knowledge, and build relationships with researchers. The program format ...

LAST 30 PRESS RELEASES:

Preschool education: A key to supporting allophone children

CNIC scientists discover a key mechanism in fat cells that protects the body against energetic excess

Chemical replacement of TNT explosive more harmful to plants, study shows

Scientists reveal possible role of iron sulfides in creating life in terrestrial hot springs

Hormone therapy affects the metabolic health of transgender individuals

Survey of 12 European countries reveals the best and worst for smoke-free homes

First new treatment for asthma attacks in 50 years

Certain HRT tablets linked to increased heart disease and blood clot risk

Talking therapy and rehabilitation probably improve long covid symptoms, but effects modest

Ban medical research with links to the fossil fuel industry, say experts

Different menopausal hormone treatments pose different risks

Novel CAR T cell therapy obe-cel demonstrates high response rates in adult patients with advanced B-cell ALL

Clinical trial at Emory University reveals twice-yearly injection to be 96% effective in HIV prevention

Discovering the traits of extinct birds

Are health care disparities tied to worse outcomes for kids with MS?

For those with CTE, family history of mental illness tied to aggression in middle age

The sound of traffic increases stress and anxiety

Global food yields have grown steadily during last six decades

Children who grow up with pets or on farms may develop allergies at lower rates because their gut microbiome develops with more anaerobic commensals, per fecal analysis in small cohort study

North American Early Paleoindians almost 13,000 years ago used the bones of canids, felids, and hares to create needles in modern-day Wyoming, potentially to make the tailored fur garments which enabl

Higher levels of democracy and lower levels of corruption are associated with more doctors, independent of healthcare spending, per cross-sectional study of 134 countries

In major materials breakthrough, UVA team solves a nearly 200-year-old challenge in polymers

Wyoming research shows early North Americans made needles from fur-bearers

Preclinical tests show mRNA-based treatments effective for blinding condition

Velcro DNA helps build nanorobotic Meccano

Oceans emit sulfur and cool the climate more than previously thought

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Rare, mysterious brain malformations in children linked to protein misfolding, study finds

Newly designed nanomaterial shows promise as antimicrobial agent

Scientists glue two proteins together, driving cancer cells to self-destruct

[Press-News.org] The roles of USP1 in Ewing sarcoma