PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Determine stroke risk at an early stage using tear fluid, mitochondria and AI-based data

Experts present holistic predictive approach for preventive and individualized treatment

Determine stroke risk at an early stage using tear fluid, mitochondria and AI-based data
2024-02-27
(Press-News.org) Every year, over 100 million people worldwide suffer a stroke. Ischemic strokes (cerebral infarction) are the most common, but they can also occur "silently" and therefore often go undetected. This can result in serious illnesses such as dementia, depression or even suicide. In order to determine the risk of stroke at an early stage, Prof. Dr. Olga Golubnitschaja, head of the research group for 3P (predictive, preventive and personalized) medicine at the University Hospital Bonn (UKB), together with the University of Bonn and other authors from 25 institutions from 11 countries, has developed a holistic approach to health risk assessment associated with targeted prevention and individualized treatment algorithms. The research article has now been published in the international journal The EPMA Journal.

The number of strokes has increased worldwide in recent years. "The figures for younger people under 50 are particularly alarming," explains Prof. Golubnitschaja "The number here has doubled within three years. There are also undetected cases. It is estimated that the proportion in the population is around 14 times greater than the proportion of diagnosed cases to which reactive medical measures are applied."

Paradigm shift from "reactive" to "predictive" medicine required

The researchers have therefore developed an innovative concept that aims to help prevent strokes and focuses on "predictive" rather than "reactive" medicine. In other words, the aim is to predict the probability of illness and take measures based on this to reduce the risk of illness instead of reacting to an already established illness. "The development from a predisposition to a clinically proven stroke or cardiac arrest does not happen overnight, but over a period of years. Therefore, the time for targeted prevention is ample and should be used cost-effectively in favor of susceptible population groups. There are various risk factors and parameters that indicate this and which can be investigated in advance," says Prof. Golubnitschaja. Together with her 3PM research group at the University of Bonn and the international 3PM consortium (European Association for Predictive, Preventive and Personalsed Medicine, EPMA), she has developed a non-invasive, painless approach that uses a health risk assessment through tear fluid, mitochondria as a vital biosensor and AI-supported data interpretation.

 

Mitochondria serve as natural biosensors

"Mitochondria are present in every cell of our body and act as a vital partner and strict observer of whether everything runs smoothly with our health," explains Prof. Golubnitschaja "If something is wrong, the mitochondria report through mitophagy and signal to all systems that we have a health problem. These signals can be measured objectively using liquid biopsies." The non-invasive and painless collection and analysis of tear fluid allows an individualized profile of the patient to be created.

Supplemented by additional routine questioning during a regular check-ups, for example including family predispositions, lifestyle, sleeping and eating habits, a series of parameters for individualized risk assessment is created. Due to the large number of parameters recorded, the researchers are using artificial intelligence (AI) to develop algorithms that enable a robust health risk assessment, predictive diagnostics and thus the development of targeted preventive measures.

"The implementation of the 3PM innovation saves both human and financial resources," says Prof. Golubnitschaja "The estimated global economic burden of strokes is over 891 billion US dollars every year. This is an economic disaster that we want to counteract through predictive medicine by using our holistic approach to prevent strokes before they occur."

 

Publication: Olga Golubnitschaja et al.; The paradigm change from reactive medical services to 3PM in ischemic stroke: A holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation; DOI: https://doi.org/10.1007/s13167-024-00356-6

END

[Attachments] See images for this press release:
Determine stroke risk at an early stage using tear fluid, mitochondria and AI-based data

ELSE PRESS RELEASES FROM THIS DATE:

Researchers look at environmental impacts of AI tools

2024-02-27
OAK BROOK, Ill. – As artificial intelligence (AI) is increasingly used in radiology, researchers caution that it’s essential to consider the environmental impact of AI tools, according to a focus article published today in Radiology, a journal of the Radiological Society of North America (RSNA). Health care and medical imaging significantly contribute to the greenhouse gas (GHG) emissions fueling global climate change. AI tools can improve both the practice of and sustainability in radiology through optimized imaging protocols resulting in shorter scan times, improved scheduling ...

New consortium MetrANOVA to create a measurement and analysis toolbox for research and education networks worldwide

New consortium MetrANOVA to create a measurement and analysis toolbox for research and education networks worldwide
2024-02-27
February 27 — Five of the world’s leading research and education (R&E) networking organizations have joined forces to form MetrANOVA, a consortium for Advancing Network Observation, Visualization, and Analysis. Together, founding members Energy Sciences Network (ESnet), GÉANT, GlobalNOC at Indiana University, Internet2, and Texas Advanced Computing Center (TACC) operate and connect a dizzying number of national, regional, and local R&E networks — yet representing a portion of the decentralized fabric linking scientific researchers in hundreds of countries ...

Drug-resistant tuberculosis responds rapidly to bedaquiline-based second-line therapy

Drug-resistant tuberculosis responds rapidly to bedaquiline-based second-line therapy
2024-02-27
Patients who have drug-resistant tuberculosis (TB) have a similar microbiological response to bedaquiline-based second-line medications as patients with drug-sensitive TB taking first-line regimens, according to researchers at Weill Cornell Medicine in New York and GHESKIO Centers in Haiti. Second-line medications are those that are given when one or more of the drugs given first for the disease are not effective. The research could have implications for shortening the duration of treatment for drug-resistant TB, which currently ...

Colorectal Cancer Alliance announces Request for Proposals (RFP) as it launches the largest-ever CRC research investment totaling tens of millions

Colorectal Cancer Alliance announces Request for Proposals (RFP) as it launches the largest-ever CRC research investment totaling tens of millions
2024-02-27
In an effort to expedite its life-saving work, the Colorectal Cancer Alliance (Alliance) Project Cure CRC initiative is excited to open its Request for Proposals (RFP). Tens of millions of dollars will be available to researchers from around the world whose work aims to expedite colorectal cancer (CRC) research to a curable science. Beginning March 1, the program is accepting applications for one to three-year projects from qualifying professionals at research-based institutions and private companies. Priority will be given to proposals that focus on high-risk/high-reward projects to accelerate new CRC therapies and technologies from bench to bedside.   The ...

Reaching federal youth sport participation goal could save US billions of dollars

2024-02-27
First-of-its-kind study suggests increasing the percentage of youth in the United States who participate in sports to meet a Healthy People 2030 goal could improve children’s physical and mental health and save $80 billion. Achieving the Healthy People 2030 youth sports participation goal could save the United States $80 billion in direct medical costs and productivity losses and deliver over 1.8 million more quality years of life to Americans, according to a study that will be published on Feb. 27 in the American Journal of Preventive Medicine. Every decade since 1980, Healthy People has provided science-based, 10-year national objectives and ...

Improving lithium-sulfur batteries with metal organic framework-based materials

Improving lithium-sulfur batteries with metal organic framework-based materials
2024-02-27
Current lithium-ion battery technology does not have the energy density necessary to meet the demands for renewable energy. In theory, lithium-sulfur batteries could be a viable alternative with a higher specific capacity and energy density. However, sulfur has disadvantages that currently limit its practical adoption. A comprehensive review published in Nano Research on February 8 outlines how metal organic frameworks-based cathode materials could improve the performance of lithium-sulfur batteries, making them a practical alternative to lithium-ion batteries.  “The ...

An alternate arrangement: how a propeller-shaped isomer can improve organic solar cells

An alternate arrangement: how a propeller-shaped isomer can improve organic solar cells
2024-02-27
Imagine technology as a race car speeding down a track – it can only go as fast as its engine allows. But just when it seemed like organic solar cells hit a roadblock, along comes 3PNIN, a game-changing molecule shaped like a propeller, ready to turbocharge their progress and break through barriers.   Organic solar cells (OSCs) represent the pinnacle of renewable energy, yet certain components have fallen significantly behind the trajectory of ongoing development. Particularly, cathode interfacial materials (CIMs) have failed to sustain ...

Binghamton University biologist named Fellow of American Academy of Microbiology

Binghamton University biologist named Fellow of American Academy of Microbiology
2024-02-27
BINGHAMTON, N.Y. -- Binghamton University, State University of New York researcher Karin Sauer is among 65 scientists elected as Fellows of the American Academy of Microbiology this year. Fellows are elected by their peers based on their scientific achievements and original contributions to the field of microbiology. Sauer’s lab aims to find ways to control communities of bacteria called biofilms and to curb their extraordinary resistance to antimicrobial agents. The team’s findings could have an impact on a wide range of healthcare practices, from ear infections to wound care. “I’m honored and ...

Community culture shapes ceramics

Community culture shapes ceramics
2024-02-27
Archeologists have long used the shapes and styles of pottery as a proxy for ancient cultures. But how does the cultural alignment of ceramic forms arise? To explore this question, Tetsushi Nonaka and colleagues asked 21 potters in three different communities—one in France in Bourgogne and two in India in Bulandshahar district, Uttar Pradesh—to throw pots with the same unfamiliar shapes. One of the Indian pottery workshops was Hindu, the other was Muslim. In each community, several different potters tried the shapes. Through careful measurement, the authors were able to determine ...

Nano-sized particles emitted from gas stoves

Nano-sized particles emitted from gas stoves
2024-02-27
A study quantifies the emission of extremely tiny particles by gas stoves and finds that the particles could harm human health. Airborne nanoparticles between 1–3 nm, referred to as nanocluster aerosol or NCA, are known to be bioactive and toxic, but measuring such minute particles has been a challenge. Brandon E. Boor and colleagues measured indoor NCA during propane gas cooking in the Purdue zero Energy Design Guidance for Engineers (zEDGE) test house using a novel instrument. Combining measurement data with the general dynamic equation for aerosols, the authors were able to characterize the production and behavior ...

LAST 30 PRESS RELEASES:

UT Health San Antonio ranks at the top 5% globally among universities for clinical medicine research

Fayetteville police positive about partnership with social workers

Optical biosensor rapidly detects monkeypox virus

New drug targets for Alzheimer’s identified from cerebrospinal fluid

Neuro-oncology experts reveal how to use AI to improve brain cancer diagnosis, monitoring, treatment

Argonne to explore novel ways to fight cancer and transform vaccine discovery with over $21 million from ARPA-H

Firefighters exposed to chemicals linked with breast cancer

Addressing the rural mental health crisis via telehealth

Standardized autism screening during pediatric well visits identified more, younger children with high likelihood for autism diagnosis

Researchers shed light on skin tone bias in breast cancer imaging

Study finds humidity diminishes daytime cooling gains in urban green spaces

Tennessee RiverLine secures $500,000 Appalachian Regional Commission Grant for river experience planning and design standards

AI tool ‘sees’ cancer gene signatures in biopsy images

Answer ALS releases world's largest ALS patient-based iPSC and bio data repository

2024 Joseph A. Johnson Award Goes to Johns Hopkins University Assistant Professor Danielle Speller

Slow editing of protein blueprints leads to cell death

Industrial air pollution triggers ice formation in clouds, reducing cloud cover and boosting snowfall

Emerging alternatives to reduce animal testing show promise

Presenting Evo – a model for decoding and designing genetic sequences

Global plastic waste set to double by 2050, but new study offers blueprint for significant reductions

Industrial snow: Factories trigger local snowfall by freezing clouds

Backyard birds learn from their new neighbors when moving house

New study in Science finds that just four global policies could eliminate more than 90% of plastic waste and 30% of linked carbon emissions by 2050

Breakthrough in capturing 'hot' CO2 from industrial exhaust

New discovery enables gene therapy for muscular dystrophies, other disorders

Anti-anxiety and hallucination-like effects of psychedelics mediated by distinct neural circuits

How do microbiomes influence the study of life?

Plant roots change their growth pattern during ‘puberty’

Study outlines key role of national and EU policy to control emissions from German hydrogen economy

Beloved Disney classics convey an idealized image of fatherhood

[Press-News.org] Determine stroke risk at an early stage using tear fluid, mitochondria and AI-based data
Experts present holistic predictive approach for preventive and individualized treatment