PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

COVID-19 associated with increased risk for autoimmune inflammatory rheumatic diseases up to a year after infection

2024-03-04
(Press-News.org) Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.   
----------------------------   

1. COVID-19 associated with increased risk for autoimmune inflammatory rheumatic diseases up to a year after infection

Vaccination showed some protection against AIRDs, depending on severity of infection

Abstract:https://www.acpjournals.org/doi/10.7326/M23-1831  

URL goes live when the embargo lifts    

A large, binational study found that SARS-CoV-2 infection was associated with an increased risk for autoimmune inflammatory rheumatic diseases (AIRDs) that extends up to 12 months after infection. The risk was found to be higher with greater severity of acute COVID-19, even among those who were vaccinated. These findings suggest that care strategies for patients who survive COVID-19 should pay close attention to manifestations of AIRD, particularly after severe illness. The study is published in Annals of Internal Medicine.

Emerging data suggest a higher risk for AIRDs among persons with a history of COVID-19. However, these findings are based entirely on comparisons between groups infected with SARS-CoV-2 and those that are not, which might be biased by differences in health-seeking behavior and inherent risk factors within the groups. In addition, studies have not explored the effect of vaccination and other modifiable factors on prevention of long term COVID-19 complications.

Researchers from Kyung Hee University, Seoul, South Korea used data from two national, large-scale, general population-based cohort studies in Korea and Japan to investigate the effect of COVID-19 on long-term risk for incident AIRD over various follow-up periods. The data comprised of more than 10 million Korean and 12 million Japanese adults, including those with COVID-19 between January 2020 and December 2021, matched to patients with influenza infection and to uninfected control patients. The researchers assessed the data for onset of AIRD at 1, 6, and 12 months after COVID-19 or influenza infection, or the respective matched index date of uninfected control patients. They found increased risk for incident AIRD up to 12 months after COVID-19 diagnosis compared with the other two groups. Greater severity of acute COVID-19 was associated with higher risk for incident AIRD. The authors noted that COVID-19 vaccination was associated with reduced risk for incident AIRD after SARS-CoV-2 infection, except for among those who had severe COVID-19 despite vaccination.

Media contacts: For an embargoed PDF, please contact Angela Collom at acollom@acponline.org. To speak with the corresponding authors Dong Keon Yon, MD, PhD, and Hayeon Lee, PhD, please contact yonkkang@gmail.com or wwhy28@khu.ac.kr.

----------------------------   

2. ACP reviews performance measures for major depressive disorder

Technology improvements would help accurately measure appropriate management

Abstract: https://www.acpjournals.org/doi/10.7326/M23-3077  

URL goes live when the embargo lifts    

A review by the American College of Physicians (ACP) of performance measures designed to evaluate quality of care for those suffering from major depressive disorder (MDD) found only one of eight measures relevant to internal medicine physicians to be valid. The paper is published in Annals of Internal Medicine.

MDD is a severe mood disorder that affects at least 8.4% of the adult population in the U.S. Some characteristics of MDD include persistent sadness, diminished interest in daily activities, and a state of hopelessness. MDD may progress quickly and have devastating consequences if left untreated.  

Eight performance measures are available to evaluate screening, diagnosis, and successful management of MDD. However, many performance measures do not meet the validity, reliability, evidence, and meaningfulness criteria. Out of eight performance measures, ACP’s Performance Measurement Committee found only one measure, Suicide Risk Assessment, valid at all levels of attribution. This performance measure evaluates the frequency of suicide risk assessment for patients with a new diagnosis of MDD. The performance measure is clinically sound, evidence-based, and tested appropriately with valid and reliable results.

A January 2023 ACP clinical guideline recommends monotherapy with cognitive behavioral therapy (CBT) or with a second-generation antidepressant as an initial treatment in patients in the acute phase of moderate to severe MDD. Despite strong evidence around appropriate treatment for MDD after an initial diagnosis, there are currently no performance measures to fill this gap. However, there are feasibility challenges with the data needed for such a performance measure, including but not limited to ICD-10 coding and capturing CBT recommendations.

 

There is a need for systemwide technological improvements to extract the necessary data and support proper coding for MDD management. The paper suggests that data interoperability is needed to improve reporting for performance measures that can move the quality needle and reduce the burden of performance measurement on physicians, group practices and health systems.    

 

Media contacts: For an embargoed PDF, please contact Angela Collom at acollom@acponline.org. To speak with someone from ACP, please contact Andrew Hachadorian at AHachadorian@acponline.org.

---------------------------- 

3. Patterns of all-cause mortality among Hispanic/Latino adults from diverse background groups were altered during the COVID-19 pandemic

Abstract: https://www.acpjournals.org/doi/10.7326/M23-1990   

Editorial: https://www.acpjournals.org/doi/10.7326/M24-0249   

URL goes live when the embargo lifts     

A study of more than 15,000 Hispanic/Latino adults of Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds found that the patterns of all-cause mortality among these groups were altered during the COVID-19 pandemic, persons of Central American and Mexican backgrounds may have been particularly affected. The study is published in Annals of Internal Medicine. 

Hispanic/Latino persons in the United States represent diverse backgrounds and have differing health-related exposures. Previous research showed that mortality varies by Hispanic/Latino background and by proxy measures of acculturation, such as place of birth and age at immigration to the United States, with lower mortality among immigrants than U.S.-born persons and among those who immigrated at older than at younger ages. However, comprehensive data on morbidity and mortality in Hispanic/Latino background groups is still lacking. 

Researchers analyzed data on 15,568 adults aged 18 to 74 years at baseline (2008-2011) who participated in the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). Participants were of Central American, Cuban, Dominican, Mexican, Puerto Rican, South American, and other backgrounds and were recruited from the Bronx, New York; Chicago, Illinois; Miami, Florida; and San Diego, California. The study described cumulative all-cause mortality risk through 2021 by Hispanic/Latino background (and factors underlying any differences), before and during the COVID-19 pandemic. The authors found that prior to the COVID-19 pandemic, 11-year cumulative mortality risks were higher in the Puerto Rican and Cuban background groups and lowest in the South American background group. These differences were explained by lifestyle and clinical factors. However, the mortality risk pattern changed during the COVID-19 pandemic: 2-year cumulative mortality risks ranged from 1%-2% and within that narrow range were highest in persons of Central American and Mexican backgrounds and lowest among those of Puerto Rican and Cuban backgrounds in the fully adjusted analysis. Lifestyle and clinical factors appeared to play a role in this alteration in mortality pattern. 

An accompanying editorial by authors from Columbia University argues that these findings underscore the need to address the major gap in health research on the effects of structural factors, health behaviors, and social factors, such as discrimination and access to health resources, across Hispanic/Latino background groups. The authors also note that HCHS/SOL can help to advance knowledge of the structural and social drivers of health among the various communities on which the study is focused and promote better understanding of the acculturation and lifestyle factors that contribute to different patterns of mortality among Hispanic/Latino background groups. 

 

Media contacts: For an embargoed PDF, please contact Angela Collom at acollom@acponline.org. To speak with the corresponding author, Jianwen Cai, PhD, please contact Meg Palmer at sphcomm@unc.edu. 

 

END


ELSE PRESS RELEASES FROM THIS DATE:

UC Irvine receives $15 million NSF grant for integrative movement research

2024-03-04
Irvine, Calif. March 4, 2024 — The National Science Foundation has granted $15 million to the Integrative Movement Sciences Institute at the University of California, Irvine. This six-year funding, part of the NSF’s Biology Integration Institutes program, will support groundbreaking research led by Monica Daley, professor of ecology & evolutionary biology at the UCI School of Biological Sciences. The research funded by this grant aims to understand the intricate mechanics of muscle control during rapid, unsteady movements in complex environments. Muscle ...

University of Houston engineer Metin Akay featured in study highlighting 50 scientists' contributions to biomedical engineering advancements

University of Houston engineer Metin Akay featured in study highlighting 50 scientists contributions to biomedical engineering advancements
2024-03-04
Metin Akay, founding chair of the Biomedical Engineering Department at the University of Houston and John S. Dunn Professor, is one of 50 top scientists from 34 elite universities to publish a roadmap for groundbreaking research to transform the landscape of medicine in the coming decade.  Published on behalf of the Institute of Electrical and Electronics Engineers (IEEE), the world’s largest technical professional organization dedicated to advancing technology for humanity and the IEEE Engineering in Medicine and Biology Society (IEEE EMBS), the paper focus ...

JWST captures the end of planet formation

JWST captures the end of planet formation
2024-03-04
March 4, 2024, Mountain View, CA – The James Webb Space Telescope (JWST) is helping scientists uncover how planets form by advancing understanding of their birthplaces and the circumstellar disks surrounding young stars, in a paper published in the Astronomical Journal, a team of scientists led by Naman Bajaj of the University of Arizona and including Dr. Uma Gorti at the SETI Institute, image for the first time, winds from an old planet-forming disk (still very young relative to the Sun) which is actively dispersing its gas ...

Good news—MS drugs taken while breastfeeding may not affect child development

2024-03-04
EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, MONDAY, MARCH 4, 2024 MINNEAPOLIS – Certain medications for multiple sclerosis (MS) called monoclonal antibodies, taken while breastfeeding, may not affect the development of a child during the first three years of life, according to a preliminary study released today, March 4, 2024. The study will be presented at the American Academy of Neurology’s 76th Annual Meeting taking place April 13–18, 2024, in person in Denver and online. The study examined four monoclonal antibodies for MS: natalizumab, ocrelizumab, rituximab and ofatumumab. MS is a disease in which the body’s immune system attacks ...

Programs intended to reduce health insurance premiums may make coverage less affordable for the middle class

2024-03-04
PITTSBURGH, March 4, 2024 — Reinsurance programs, which were created to help lower premiums and increase enrollment in the Affordable Care Act’s health insurance marketplaces, may have had the opposite effects for many potential marketplace enrollees, according to a study by health policy researchers at the University of Pittsburgh School of Public Health, Duke University and University of Minnesota. The study, published today in Health Affairs, is the first to examine the effects of a post-American Rescue Plan Act ...

PrEP discontinuation in a US national cohort of sexual and gender minority populations, 2017–22

2024-03-04
In the U.S., sexual and gender minority populations are disproportionately affected by HIV. Pre-exposure prophylaxis (PrEP) is a key prevention method, but its effectiveness relies on consistent usage. While a significant body of research has addressed PreP initiation and adherence, far less attention has been paid to the reasons for and consequences of PrEP discontinuation. A team of investigators conducted a four-year U.S. national cohort study exploring PrEP discontinuation among sexual and gender minority people who initiated PrEP.  “Our cohort was entirely comprised of individuals ...

USC Study: Medicare Part D plans increased restrictions on drug coverage

2024-03-04
Medicare Part D plans significantly increased restrictions on prescription drugs, excluding more compounds from coverage or subjecting more of them to review before patients could access the treatments, according to a new study from USC researchers. Among drugs not in Medicare “protected classes,” the share of drug compounds restricted or excluded by Part D plans surged from an average of 31.9% in 2011 to 44.4% in 2020, according to the study published in the March 2024 issue of Health Affairs. Brand-name-only compounds (those without a generic alternative) were especially limited, with more ...

Sacituzumab govitecan plus platinum-based chemotherapy in breast, bladder, and lung carcinomas

Sacituzumab govitecan plus platinum-based chemotherapy in breast, bladder, and lung carcinomas
2024-03-04
“[...] these results support the rationale and potential for favorable clinical outcomes of combining SG therapy with platinum-based chemotherapeutics in solid tumors.” BUFFALO, NY- March 4, 2024 – A new research paper was published in Oncotarget's Volume 15 on February 22, 2024, entitled, “Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas.” Sacituzumab govitecan (SG) is an antibody-drug conjugate composed of an anti-Trop-2-directed antibody ...

Global study unveils "problematic" use of porn

2024-03-04
A major international study led by a Canadian psychologist sheds light on a hidden phenomenon: how problematic use of pornography is affecting people in different parts of the world, across various genders and sexual orientations.   Published in the journal Addiction, the  research stands out because, among the 82,000 people in 42 countries studied, it looks at groups that were often overlooked in the past, including women and individuals who don't fit traditional gender categories.   In their findings, largely based on ...

Newly discovered protein prevents DNA triplication

Newly discovered protein prevents DNA triplication
2024-03-04
This is a natural 'anti-failure' mechanism in the DNA copying process, hitherto unknown. The DNA molecule is copied each time a cell divides. If, instead of being copied once, the DNA is copied several times, i.e. tripled or even quadrupled, the likelihood of cancer increases.. The new discovered anti-failure system relies on a protein called RAD51 to prevent DNA that has already been copied from being copied again. Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent. This means that millions of times a day ...

LAST 30 PRESS RELEASES:

UK/Portuguese study strongly suggests antibiotic-resistant “superbugs” are being passed from cats and dogs to their owners

Researchers study effects of solvation and ion valency on metallopolymers

Physicists solve puzzle about ancient galaxy found by Webb telescope

Clear guidelines needed for synthetic data to ensure transparency, accountability and fairness study says

Report finds significant gender and racial inequities in the educational measurement profession

University of Houston and Scotland’s Heriot-Watt University forge strategic energy alliance

Rice team demonstrates miniature brain stimulator in humans

Jennifer Stinson receives prestigious Barer-Flood Prize in health services research

First insights into the genetic bottleneck characterizing early sheep husbandry in the Neolithic period

Theories that explain the crisis in democracy are inadequate for Latin America, experts say

Starving cells hijack protein transport stations

Where have all the right whales gone?

Researchers find no link between COVID-19 virus and development of asthma in children

Cell’s ‘garbage disposal’ may have another role: helping neurons near skin sense the environment

Study reveals potential to reverse lung fibrosis using the body’s own healing technique

International team co-led by a BSC researcher discovers more than 50 new deep-sea species in one of the most unexplored areas of the planet

Cleveland Innovation District partners exceeding many targets set by state and JobsOhio

A third of women experience migraines associated with menstruation, most commonly when premenopausal

MD Anderson Research Highlights for April 12, 2024

Soft Robotics appoints new Deputy Editor-in-Chief, Barbara Mazzolai, PhD

Wiley releases Mass Spectra of Designer Drugs 2024 to accelerate forensics analysis of fentanyls, cannabinoids, and more

Freestanding emergency departments are popular, but do they function as intended?

University of Cincinnati experts present at national neurology conference

Bonobos are more aggressive than previously thought

How seaweed became multicellular

Melanomas resist drugs by ‘breaking’ genes

Africa’s iconic flamingos threatened by rising lake levels, study shows

Vaccination timeliness among US children ages 0-19 months

Changes in permanent contraception procedures among young adults following the Dobbs decision

Semaglutide vs endoscopic sleeve gastroplasty for weight loss

[Press-News.org] COVID-19 associated with increased risk for autoimmune inflammatory rheumatic diseases up to a year after infection