PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

KKH-led study reveals low COVID-19 transmission rate from mothers to newborns

COVID-19 vaccination reduces risks of severe outcomes in pregnant women, who show fewer harmful effects from the Omicron variant

KKH-led study reveals low COVID-19 transmission rate from mothers to newborns
2024-03-12
(Press-News.org)

11 March 2024, Singapore – A study[1] by KK Women’s and Children’s Hospital (KKH), Singapore General Hospital (SGH) and National University Hospital (NUH) has revealed that  COVID-19 transmission from mothers to their newborns is low.

The study involving 371 women who had COVID-19 infection during pregnancy and their newborns found that only four infants or 1.1 per cent of the babies were diagnosed with COVID-19 after birth, of which three (1.1 per cent) were from mothers who were COVID-19 vaccinated and one infant (1.3 per cent) was from a mother who was not vaccinated.

Senior Author of the study, Dr Yeo Kee Thai, Senior Consultant, Department of Neonatology, KKH said, “Our study assures expectant parents and healthcare professionals that COVID-19 transmission from mother to baby is extremely low. In comparison to international reports[2] [3], the incidence of transmission is also at a much lower rate. This is likely attributed to the higher vaccination rate amongst our pregnant population, which also explains the comparatively lower occurrence of moderate to severe symptoms and a lesser need for interventions in vaccinated pregnant women who were infected with COVID-19.

Vaccinated pregnant women infected with COVID-19 were found to have milder disease effects (1.8 per cent moderate/severe disease vs 8 per cent moderate/severe disease) and were less likely to require intensive care as compared to unvaccinated pregnant women who were infected (1.4 per cent vs 8 per cent). Amongst the group, one of the unvaccinated pregnant patient who was infected with COVID-19 had required extracorporeal membrane oxygenation (ECMO) support.

The study also found that pregnant women infected with the Omicron variant had milder symptoms (98.3 per cent vs 92.3 per cent), and were less likely to require intensive care (1.0 per cent vs 9.0 per cent), or need mechanical ventilation (0.3 per cent vs 3.8 per cent) as compared to those infected with non-Omicron variants.

Newborns of pregnant women infected with the Omicron variant were also less likely to require intensive care (3.8 per cent vs 14.1 per cent).

This study is part of KKH’s ongoing efforts to build evidence-based perspectives for the limited studies on COVID-19 in Singapore and Asia. The study took place from December 2019 to February 2022, covering the period from when the virus was first identified to the emergence of the Omicron variant in late 2021. Based on timing of the infections and the reported circulating variants, the identified variants were Wild-type (2.2 per cent), Alpha (0.8 per cent), Delta (18.1 per cent) and Omicron (79.9 per cent).

The research participants were categorised into two groups – vaccinated and unvaccinated – as COVID-19 vaccination was made available to pregnant women in June 2021.  Among the 353 pregnant women who provided their COVID-19 vaccination status, 278 (78.8 per cent) had received one or more dose before or during their pregnancy and 75 (21.2 per cent) were unvaccinated.

Refer to figures in Annex A for details.

Dr Yeo added, “As we appreciate these encouraging findings, pregnant women remain a vulnerable group susceptible to severe outcomes from SARS-CoV-2. Hence, it  is crucial that our pregnant women keep up to date with their COVID-19 vaccination, to keep their families safe.”

While this study was not designed to focus on the effects of maternal COVID-19 vaccination in newborns, other studies including an earlier KKH-led study revealed that COVID-19 vaccination during pregnancy was found to be up to 44.4 per cent[4] effective in protecting infants against SARS-CoV-2 infection up to six months after birth[5].

<Ends>

For more information, please contact:                                          

Angeline Chen

Manager

Corporate Communications   

Tel: 6394 2321

Email: media@kkh.com.sg

About KK Women's and Children's Hospital

KK Women’s and Children’s Hospital (KKH) is Singapore’s largest tertiary referral centre for obstetrics, gynaecology, paediatrics and neonatology. The academic medical centre specialises in the management of high-risk conditions in women and children.

Driven by a commitment to deliver compassionate, multidisciplinary care to patients, KKH leverages research and innovation to advance care. In 2021, the hospital launched the SingHealth Duke-NUS Maternal and Child Health Research Institute (MCHRI) to support the growth of every woman and child to their fullest potential, and transform national heath in the region.

Some of the hospital’s breakthroughs include uSINE®, a landmark identification system for the administration of spinal epidural, the discovery of new genetic diseases like Jamuar Syndrome, and a series of guidelines for women and children to improve population health.

The academic medical centre is also a major teaching hospital for Duke-NUS Medical School, Yong Loo Lin School of Medicine and Lee Kong Chian School of Medicine. In addition, KKH runs the largest specialist training programme for Obstetrics and Gynaecology, and Paediatrics in Singapore.

KKH was founded in 1858 and celebrates its 100th year as a maternity hospital in 2024. For more information, visit www.kkh.com.sg

Follow us on

Facebook | Instagram | LinkedIn | YouTube

[1] Lim AM, Low JM, Tan MG, Ngeow AJH, Tong WY, Chua KH, Yung CF, Ho SKY, Amin Z, Yeo KT (31 January 2024). Perinatal outcomes of pregnancies affected by COVID-19 in Singapore: A cohort study. Ann Acad Med Singap Vol 53 No.1, 53-56  https://doi.org/10.47102/annals-acadmedsg.2023278

[2] Vouga M, Favre G, Martinez-Perez O, et al. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Sci Rep 2021;11:13898.

[3] Boettcher LB, Metz TD. Maternal and neonatal outcomes following SARS-CoV-2 infection. Semin Fetal Neonatal Med. 2023 Feb;28(1):101428.

[4] Completed first, second and third doses of vaccination.

 

[5] Goh O, Pang D, Tan J, Lye D, Chong CY, Ong B, Tan KB, Yung CF (10 November 2023). mRNA SARS-CoV-2 Vaccination Before vs During Pregnancy and Omicron Infection Among Infants. Jama Network Open. 2023;6(11):e2342475. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2811644

 

END


[Attachments] See images for this press release:
KKH-led study reveals low COVID-19 transmission rate from mothers to newborns

ELSE PRESS RELEASES FROM THIS DATE:

Scientists identify biodiversity conservation gaps in Madagascar

Scientists identify biodiversity conservation gaps in Madagascar
2024-03-12
Despite the importance of biodiversity and the urgency to conserve it, assessing what aspect of biodiversity requires the highest priority has proven complex, especially when conservation resources are limited. A new study published in Current Biology sheds light on this question.  Prof. CHEN Zhiduan's team from the Institute of Botany of the Chinese Academy of Sciences (IBCAS) and international collaborators have identified the spatial heterogeneity of biodiversity hotspots and endemism centers. With ...

Sting operation out of gas

Sting operation out of gas
2024-03-12
Kyoto, Japan -- Cells possess an innate immune system that defends against invasive pathogens such as bacteria and viruses. Previous studies have mapped out the cytoplasmic cGAS-STING pathway in the cytoplasm, known for responding to foreign nucleic acids, such as double-stranded DNA. Micronuclei -- or MN, abnormal intracellular structures containing the cell's DNA -- have also been suspected of triggering the pathway. However, no conclusive evidence exists of pathway activation by MN-induced cyclic GMP-AMP synthase, or cGAS. Now, Kyoto University and the AIRC Institute of Molecular Oncology, or IFOM, have ...

Have metalenses expanded their reach into the ultraviolet region?

Have metalenses expanded their reach into the ultraviolet region?
2024-03-12
Ultraviolet rays find diverse applications in medical and healthcare, serving purposes such as disinfection, sterilization, and therapy. They are also used in the semiconductor industry for creating microcircuits and patterns. A metalens fabrication process, developed by a team of researchers at Pohang University of Science and Technology (POSTECH), enables control over the optical properties of these UV rays. This innovation has garnered significant attention across industries, sparking interest in potential advancements.   A collaborative research team, comprising Professor Junsuk Rho from the Department of Mechanical Engineering and the Department of Chemical Engineering ...

Key protein linked to immune disorders

Key protein linked to immune disorders
2024-03-12
A new study highlights a potential therapeutic target for immune-related disorders, such as multiple sclerosis and asthma. A new study has shed light on the importance of the protein STAP-1 in activating certain immune cells. Understanding the role of STAP-1 in these cells could give researchers a better glimpse into immune-related disorders and ways to treat them. The researchers found that STAP-1 plays an important role in the activation of T cells, which are white blood cells that play a critical role in defending the body against infections and maintaining overall health. T cells are adept at recognizing foreign molecules that ...

COVID-19 had greater impact on life expectancy than previously known, but child mortality rates continued to decline during the pandemic

2024-03-12
**Embargo:  23:30 UK, 7:30 p.m. ET March 11, 2024** ***Please note the unusual embargo time for the United States due to daylight savings time*** Global Burden of Disease COVID-19 had greater impact on life expectancy than previously known, but child mortality rates continued to decline during the pandemic A new study published in The Lancet reveals never-before-seen details about staggeringly high mortality from the COVID-19 pandemic within and across countries. Places such as Mexico City, Peru, and Bolivia had some of the largest drops in life expectancy from 2019 to 2021. The research, which presents updated ...

NSF CAREER Grant awarded to Dr. Jordon Gilmore Associate Professor of Bioengineering Clemson University

NSF CAREER Grant awarded to Dr. Jordon Gilmore Associate Professor of Bioengineering Clemson University
2024-03-12
Congratulations to Dr. Jordon Gilmore for receiving the prestigious NSF CAREER Award! The project is titled: "A Multi-phase Biosensing Approach towards Point-of-Care Evaluation of Pseudomonas aeruginosa Virulence in Infected Chronic Wounds". The project is in perfect alignment with the ADAPT in SC NSF Award. Dr. Gilmore is a co-leader of the the Explainable AI-Enabled Biomedical Devices for Diagnostics and Planning Applications, and the leader of the Broadening Participation and Diversity project areas of ADAPT in SC. In addition, he serves as a member of the ...

How do neural networks learn? A mathematical formula explains how they detect relevant patterns

2024-03-12
Neural networks have been powering breakthroughs in artificial intelligence, including the large language models that are now being used in a wide range of applications, from finance, to human resources to healthcare. But these networks remain a black box whose inner workings engineers and scientists struggle to understand. Now, a team led by data and computer scientists at the University of California San Diego has given neural networks the equivalent of an X-ray to uncover how they actually learn.  The researchers found that a formula used in statistical analysis provides a streamlined mathematical description of how neural networks, such as GPT-2, a precursor ...

Vaccine monitoring crucial as SARS-CoV-2 variants continue to evolve

2024-03-12
Researchers at the Francis Crick Institute and the National Institute for Health and Care Research Biomedical Research Centre at UCLH have highlighted the importance of continued surveillance of emerging SARS-CoV-2 variants and vaccine performance as the virus continues to evolve. Published today as a research letter in The Lancet, their study compared the newer monovalent COVID vaccine, which specifically targets the XBB variant of Omicron (as recommended by the World Health Organisation), with older bivalent vaccines containing a mix of an Omicron variant and the original strain of COVID-19, which ...

Q&A: How Instagram influencers profit from anti-vaccine misinformation

2024-03-12
While Instagram might have a reputation for superficiality — a realm of exquisitely filtered images — it is now eclipsing other social media as a news source. The platform is increasingly filled with information, some of it pernicious and distributed via influencers. Researchers at the University of Washington studied three prominent Instagram influencers spreading anti-vaccine misinformation as a route to profit. Each account occupies what lead author Rachel E. Moran, a UW senior research scientist at the Center for an Informed Public (CIP) and staff researcher in the ...

Nancy Brown recognized as one of Modern Healthcare’s ‘Top Women Leaders’

2024-03-12
DALLAS, March 11, 2024 — Nancy Brown, Chief Executive Officer of the American Heart Association, a global force for healthier lives for all and celebrating one hundred years of lifesaving service, has been recognized by Modern Healthcare as one of the Top Women Leaders for 2024. The publication’s recognition program acknowledges and honors women executives from all sectors of the healthcare industry for their contributions to care delivery improvement, health equity, policy and gender equity in healthcare leadership. Since 2008, Brown has served as CEO of the Association, which is celebrating its 100th birthday in 2024. Awardees were selected based ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] KKH-led study reveals low COVID-19 transmission rate from mothers to newborns
COVID-19 vaccination reduces risks of severe outcomes in pregnant women, who show fewer harmful effects from the Omicron variant