Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
2024-04-10
(Press-News.org)
The inflammation process plays a crucial role in allergic respiratory diseases, such as asthma and allergic rhinitis. Although the pulmonary epithelium, the carpet of cells that forms the inner surface of the lungs, is recognised as a major player in the respiratory inflammation that causes these diseases, the underlying mechanisms are still poorly understood.
A research team has identified one of the molecules responsible for triggering these allergic reactions, in a study co-led by two CNRS and Inserm scientists working at l’Institut de pharmacologie et de biologie structural (CNRS/Université Toulouse III - Paul Sabatier). This molecule from the alarmin family, named TL1A, is released by lung epithelium cells a few minutes after exposure to a mould-type allergen. It cooperates with another alarmin, interleukin-33, to alert the immune system. This double alarm signal stimulates the activity of immune cells, triggering a cascade of reactions responsible for allergic inflammation.
Alarmins, therefore, constitute major therapeutic targets for the treatment of respiratory allergic diseases. In a few years' time, treatments based on antibodies blocking the TL1A alarmin could benefit patients suffering from severe asthma or other allergic diseases. In France, at least 17 million people are affected by allergic diseases2 with the most severe forms of asthma being responsible for several hundred deaths every year3.
Notes :
This study was supported by the ANR.
According to the Ministère du travail, de la santé et des solidarités : https://sante.gouv.fr/sante-et-environnement/air-exterieur/pollens-et-allergies/article/effets-des-pollens-sur-la-sante; 13/04/2023
According to Santé Publique France : https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-liees-au-travail/asthme; 25/10/2023
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2024-04-10
Leiden - also known as the ‘City of Keys’ and the 'City of Discoveries' - was aptly chosen to host the third Empowering Biodiversity Research (EBR III) conference. The two-day conference - this time focusing on the utilisation of biodiversity data as a vehicle for biodiversity research to reach to Policy - was held in a no less fitting locality: the Naturalis Biodiversity Center.
On 25th and 26th March 2024, the delegates got the chance to learn more about the latest discoveries, trends and innovations from scientists, as well as various stakeholders, including representatives of policy-making bodies, research institutions and infrastructures. ...
2024-04-10
COLUMBUS, Ohio – Some Black youth feel less safe when they visit predominantly white areas of their city, a new study in Columbus has found.
And it was those Black kids who spent the most time in white-dominated areas who felt less safe, said Christopher Browning, lead author of the study and professor of sociology at The Ohio State University.
“Familiarity with white neighborhoods doesn’t make Black kids feel more comfortable and safer. In fact, familiarity seems to reveal ...
2024-04-10
LAWRENCE — A survey of orchid bees in the Brazilian Amazon state of Rondônia, carried out in the 1990s, is shedding new light the impact of deforestation on the scent-collecting pollinators, which some view as bellwethers of biodiversity in the neotropics.
The findings, from a researcher at the University of Kansas, are published today in the peer-reviewed journal Biological Conservation.
“This study on orchid bees was an add-on to previous research on stingless bees. Orchid bees are so easy to collect, so we added them to ...
2024-04-10
The Tibetan Plateau is a prevalent region for deep convection owing to its unique thermodynamic forcing. Deep convection can exist as isolated deep convection (IDC), which is small in size, or mesoscale convective systems (MCSs), which are convective storms organized into larger and longer-lived systems. Most previous research has focused on MCSs over the Tibetan Plateau, but less so on IDC systems (hereafter, IDCs).
Dr. Ying Na from Wuxi University, and Dr. Chaofan Li from the Institute of Atmospheric Physics, Chinese Academy of Sciences, China, examined the climatological features of IDCs by using high-resolution satellite observations in June to September ...
2024-04-10
Understanding the mutation and evolution of viruses (such as SARS-CoV-2) is crucial for effective public health management and response. Traditional epidemiological models often assume that viral transmissibility and pathogenicity remain constant during disease transmission, ignoring the fact that viruses continuously evolve through natural selection and random mutations. This simplification limits the accuracy of these models in predicting epidemic trends, especially when facing rapidly mutating viruses.
To overcome these limitations, ...
2024-04-10
SAN ANTONIO, TEXAS — The Valdez Institute for Economic Development (VIED) at UTSA generated an overall direct economic impact of $2.6 billion for the Texas economy in 2023, according to the organization’s 2023 annual report, which was released Tuesday.
The latest figure represents the work of the institute’s portfolio of time-tested economic development strategies and new innovations that enabled business owners and entrepreneurs to start and grow their small businesses.
During the 2023 fiscal year, the institute:
Served 41,231 business ...
2024-04-10
When scuba divers need to say “I’m okay” or “Shark!” to their dive partners, they use hand signals to communicate visually. But sometimes these movements are difficult to see. Now, researchers reporting in ACS Nano have constructed a waterproof “e-glove” that wirelessly transmits hand gestures made underwater to a computer that translates them into messages. The new technology could someday help divers communicate better with each other and with boat crews on the surface.
E-gloves — gloves fitted ...
2024-04-10
BioOne proudly announces the 2024 recipients of the BioOne Ambassador Award. Now in its seventh year, this prestigious award recognizes early-career researchers in the biological, ecological, and environmental sciences who demonstrate creative approaches to science communication thereby fostering greater science literacy and aiding in the understanding of the natural world. BioOne Ambassadors are nominated by BioOne publishing partners, and each winning author will receive a $1,000 award and have their work promoted through BioOne’s multiple channels.
This year’s honorees are:
Dr. Elis Fisk – Draw and Learn: A Bighorn Sheep Mystery; nominated by The Wildlife ...
2024-04-10
When today’s older adults were growing up, urgent care centers and clinics inside retail stores didn’t exist. But most of them have now embraced these non-traditional sites for getting medical care, a new national poll finds.
In the past two years, 60% of people age 50 to 80 have visited an urgent care clinic, or a clinic based in a retail store, workplace or vehicle, according to new findings from the University of Michigan National Poll on Healthy Aging.
Urgent care clinics were the most ...
2024-04-10
A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has made a breakthrough discovery in the understanding of cardiac arrhythmias by unraveling the complexities of Andersen-Tawil syndrome (ATS), an extremely rare inherited cardiac disorder. Led by Dr. José Jalife, head of the CNIC Cardiac Arrhythmia Group, the study demonstrates that a specific genetic mutation (C122Y) in the Kir2.1 potassium channel alters the function not only of Kir2.1 but also of the main cardiac sodium channel NaV1.5, thus establishing a direct link with the life-threatening arrhythmias associated with ATS1.
The study, published in the journal Circulation Research, reveals that ...
LAST 30 PRESS RELEASES:
[Press-News.org] Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
