Is there an association between HPV vaccination and anti-NMDA receptor encephalitis?

The article by Dr. Hsiuying Wang is published in the journal, Current Medicinal Chemistry

2024-04-22

(Press-News.org) Anti-N-methyl-d-aspartate (Anti-NMDA) receptor encephalitis is an acute
autoimmune disorder that develops both neurological symptoms and psychiatric
symptoms, including hallucination, cognitive disturbance, epilepsy, movement
disorder, and impaired consciousness. This disease may be misdiagnosed at the early
stage as a psychosis disease because of primary psychiatric symptoms. The
misdiagnosis may delay appropriate therapeutic intervention. Most patients with
anti-NMDA receptor encephalitis respond to immunotherapy [1, 2].
The pathology of this disease is an autoimmunity reaction that anti-NMDA
antibodies attack patients’ brains. Tumors might induce anti-NMDA receptor
immune responses due to cross-reactivity with NMDA receptors in teratomas
containing brain cells. Ovarian teratomas could trigger anti-NMDA receptor
encephalitis, and other tumors including neuroendocrine tumors, mediastinal
teratomas, testicular teratomas, and small-cell lung carcinoma have been reported
to be associated with anti-NMDA antibodies [3]. Recently, it was reported that stress
might cause this disease, and stress management may prevent relapse.
In addition to tumors and stress, other types of encephalitis or vaccinations may
trigger anti-NMDA receptor encephalitis [4-7]. Japanese encephalitis (JE) and herpes
simplex virus (HSV) encephalitis might induce anti-NMDA receptor encephalitis.
Several anti-NMDA receptor encephalitis cases have been reported to be associated
with vaccination, including JE, influenza A virus subtype H1N1,
odiphtheria/pertussis/tetanus/poliomyelitis vaccination or coronavirus disease 2019
(COVID-19) vaccinations.
In addition to these vaccines, cases of papillomavirus (HPV) vaccination triggering
anti-NMDA receptor encephalitis have been reported, but the underlying mechanism
has not been explored. HPV vaccination prevents infections with HPV, which can
cause cervical cancer (CC). CC is one of the most common cancers threatening
women's health that develops in a woman's cervix. Cases of adverse events related

to HPV vaccination including chronic fatigue syndrome, postural orthostatic
tachycardia syndrome (POTS), orthostatic intolerance, and complex regional pain
syndrome have been reported. Compared to these adverse events, only a few
studies reported anti-NMDA receptor encephalitis cases that were associated with
HPV vaccination. Since cases of HPV vaccination triggering anti-NMDA receptor
encephalitis have been reported, this study investigates the underlying mechanism
from a molecular perspective. The method is based on the phylogenetic analyses of
microRNA (miRNA) biomarkers. miRNA biomarkers have been used to explore the
relationship between anti-NMDA receptor encephalitis and vaccination (or tumors).
In addition, it is worth mentioning that HPV can cause cancers, and anti-NMDA
receptor encephalitis is associated with tumors. Ovarian teratomas were the most
commonly reported anti-NMDA receptor encephalitis-associated tumor in females.
Testicular teratomas were reported to be associated with anti-NMDA receptor
encephalitis in males. HPV might induce CC and cancers of the vulva, the vagina, the
penis, and the anus. Both HPV and anti-NMDA receptor encephalitis have been
associated with tumors or cancers of the male and female reproductive systems. This
may shed light on investigating the mechanism of the association between HPV
vaccination and anti-NMDA receptor encephalitis.

While the risk of HPV triggering encephalitis appears low, the study emphasizes the
need for vigilance. Those who develop psychiatric or neurological symptoms
following HPV vaccination should undergo an evaluation for anti-NMDA receptor
encephalitis, with a thorough examination to rule out other potential complications.

References
1. Wang, H.* (2016). Efficacies of treatments for anti-NMDA receptor encephalitis,
Frontiers in Bioscience-Landmark, 21:651-63.
2. Wang, H.* (2020). Anti-NMDA Receptor Encephalitis: Efficacy of Treatment for
Male Patients and miRNA Biomarker, Current Medicinal Chemistry, 27(24):4138-
4151.
3. Wang, H.* (2019). Phylogenetic Analysis to Explore the Association Between Anti-
NMDA Receptor Encephalitis and Tumors Based on microRNA Biomarkers,
Biomolecules, 9(10), 572.
4. Wang, H.* (2017). Anti-NMDA Receptor Encephalitis and Vaccination,
International Journal of Molecular Sciences, 18, 193.
5. Wang, H.* (2018). A protocol for investigating the association of vaccination and
anti-NMDA receptor encephalitis. Frontiers in Bioscience (Scholar Edition), 10:229-
237. 6. Wang, H.* (2019). Anti-NMDA Receptor Encephalitis, Vaccination and
Viruses. Current Pharmaceutical Design, 25(43),4579-88.
7. Wang, H.* (2022). COVID-19, Anti-NMDA Receptor Encephalitis and MicroRNA.
Fronters in Immunology, 13:825103.

END

[Attachments] See images for this press release:

Is there an association between HPV vaccination and anti-NMDA receptor encephalitis? 2

ELSE PRESS RELEASES FROM THIS DATE:

Blood-based multi-omics guided detection of a precancerous pancreatic tumor

2024-04-22

A new case report published in the peer-reviewed OMICS: A Journal of Integrative Biology describes how longitudinal multi-omics monitoring (LMOM) helped to detect a precancerous pancreatic tumor and led to a successful surgical intervention. Click here to read the article now. The patient had undergone annual blood-based LMOM, in which 143 endogenous metabolites in serum and a panel of 140 proteins in plasma were measured. David Wishart, PhD, from the University of Alberta, ...

Eye-opener: Pupils enlarge when people focus on tasks

2024-04-22

Working memory is one of the brain’s executive functions, a skill that allows humans to process information without losing track of what they’re doing. In the short term, working memory allows the brain to complete an immediate task, like loading the dishwasher. Long term, it helps the brain decide what to store for future use, such as whether more dishwasher soap will be needed. University of Texas at Arlington researchers know that working memory varies greatly among individuals, but they aren’t sure exactly why. To better understand, Matthew Robison, assistant professor of psychology, and doctoral student Lauren D. Garner conducted an experiment to see if ...

Current Nanomaterials and Current Analytical Chemistry have been indexed in Ei Compendex

2024-04-22

Bentham Science is pleased to announce that two of its journals, Current Nanomaterials and Current Analytical Chemistry, have been officially indexed in the EI Compendex. EI Compendex is one of the most comprehensive subject-specific literature databases, encompassing high-quality research articles from prominent engineering and applied science journals worldwide. Current Nanomaterials, a leading peer-reviewed journal devoted to the exploration and dissemination of cutting-edge research in the field of nanomaterials, covers a broad spectrum ...

International balance of power determined by Chinese control over emerging technologies, study shows

2024-04-22

The fierce competition between China and the United States of America for control of emerging technologies such as AI and 5G will determine the international balance of power, a new study says. Developments in quantum computing, the Internet of Things, and Big Data have transformed the global order and have led to new alliances and dynamics, the analysis shows. Forming new allies has become imperative for the USA because the country cannot address the challenges posed by China in isolation. This has involved sharing sensitive advanced technologies with national security and ...

New writing therapy helps late-stage cancer patients face biggest fears

2024-04-22

Imagine your greatest fear. Now, write it down and tell it in first-person, as if it’s happening right now. Vividly describe what it looks, sounds, smells, tastes and feels like. Don’t hold back. Such an exercise could be daunting for anyone, dredging up feelings we try to avoid. But for late-stage cancer patients struggling with anxiety and other mental health issues, it can be remarkably therapeutic, new CU Boulder research has found. “It’s often easier to write about something traumatic than to speak it out loud, especially to someone ...

National Jewish Health researchers identify connection between air pollutants and allergic diseases

2024-04-22

A new study by researchers at National Jewish Health published this month in the Annals of Allergy, Asthma & Immunology reports that air pollutants — including particulate matter, pollen, greenhouse gases, and other harmful substances — can contribute to the development and exacerbation of allergic diseases by disrupting the skin barrier. “People are aware of the connection between pollution and respiratory disease, but we wanted to take the next step and investigate how global warming is damaging ...

In the United States, the election of progressive prosecutors led to higher relative rates of property and overall crime, but not to higher relative rates of violent crime

2024-04-22

In the United States, the number of so-called progressive prosecutors focused on criminal justice reform has risen, but few studies have addressed the relation between these prosecutors’ policies and crime rates. In a new study, researchers examined whether progressive prosecutors in the 100 most populated counties affected crime rates from 2000 to 2020. They found that the inauguration of these prosecutors led to higher relative rates of property crime and total crime, but not to higher relative rates of violent crime. The study was conducted by researchers ...

European Court of Human Rights is “backsliding” on legal protections for asylum seekers, study says

2024-04-22

The European Court of Human Rights is “backsliding” by surreptitiously reversing its principles established to protect asylum seekers, a new study says. It is a decade since the Court first established that asylum seekers are inherently and particularly vulnerable in law. The research shows that in recent years the Court has moved away from this position, albeit without actually acknowledging this or explaining why. The research warns that it is now uncertain what exactly is needed for any particular asylum applicant to be judged as sufficiently vulnerable to receive special protection under the European Convention on Human Rights. The ...

Being treated by a female physician associated with lower risk for death

2024-04-22

Embargoed for release until 5:00 p.m. ET on Monday 22 April 2024    Annals of Internal Medicine Tip Sheet     @Annalsofim    Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.    ----------------------------    1. Being ...

Treatment from female doctors leads to lower mortality and hospital readmission rates

2024-04-22

Patients have lower rates of mortality and hospital readmissions when treated by female physicians, with female patients benefitting more than their male counterparts, new research suggests. The mortality rate for female patients was 8.15% when treated by female physicians vs. 8.38% when the physician was male—a clinically significant difference, the researchers found. While the difference for male patients was smaller, female physicians still had the edge with a 10.15% mortality rate compared with male doctors’ 10.23% rate. The researchers ...

Phase III trial finds hypofractionated radiotherapy with chemotherapy offers comparable survival and lower toxicity to conventional schedule in LS-SCLC

EA5181 phase 3 trial finds no OS benefit for concurrent and consolidative durvalumab vs consolidation alone in unresectable stage 3 NSCLC

First-in-human trial shows promising results for DLL3-targeted antibody-drug conjugate SHR-4849 in relapsed small cell lung cancer

Ifinatamab deruxtecan demonstrates high response rate in previously treated extensive-stage small cell lung cancer: Phase 2 IDeate-Lung01 trial

Zidesamtinib shows durable responses in ROS1 TKI pre-treated NSCLC, including patients with CNS disease and ROS1 G2032R mutations

Crizotinib fails to improve disease-free survival in resected early-stage ALK+ NSCLC

Ivonescimab plus chemotherapy improves progression-free survival in patients with EGFR+ NSCLC following 3rd-generation EGFR-TKI therapy

FLAURA2 trial shows osimertinib plus chemotherapy improves overall survival in eGFR-mutated advanced NSCLC

Aumolertinib plus chemotherapy improves progression-free survival in NSCLC with EGFR and concomitant tumor suppressor genes: ACROSS 2 phase III study

New antibody-drug conjugate shows promising efficacy in EGFR-mutated NSCLC patients

Iza-Bren in combination with osimertinib shows 100% response rate in EGFR-mutated NSCLC, phase II study finds

COMPEL study shows continuing osimertinib treatment through progression with the addition of chemotherapy improves progression-free survival in EGFR-mutated NSCLC

Is there an association between HPV vaccination and anti-NMDA receptor encephalitis?

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: