PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner

2024-05-15
(Press-News.org) https://doi.org/10.1016/j.apsb.2024.02.020

 

This new article publication from Acta Pharmaceutica Sinica B, discusses how 5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner.

 

Aberrant changes in the gut microbiota are implicated in many diseases, including inflammatory bowel disease (IBD). Gut microbes produce diverse metabolites that can shape the immune system and impact the intestinal barrier integrity, indicating that microbe-mediated modulation may be a promising strategy for preventing and treating IBD.

 

Although fecal microbiota transplantation and probiotic supplementation are well-established IBD therapies, novel chemical agents that are safe and exert strong effects on the gut microbiota are urgently needed.

 

The authors of this article report the total synthesis of heudelotinone and the discovery of 5S-heudelotinone (an enantiomer) as a potent agent against experimental colitis that acts by modulating the gut microbiota. 5S-Heudelotinone alters the diversity and composition of the gut microbiota and increases the concentration of short-chain fatty acids (SCFAs); thus, it regulates the intestinal immune system by reducing proinflammatory immune cell numbers, and maintains intestinal mucosal integrity by modulating tight junctions (TJs). Moreover, 5S-heudelotinone (2) ameliorates colitis-associated colorectal cancer (CAC) in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced in situ carcinoma model.

 

Together, these findings reveal the potential of a novel natural product, namely, 5S-heudelotinone, to control intestinal inflammation and highlight that this product is a safe and effective candidate for the treatment of IBD and CAC.

 

Keywords: 5S-heudelotinone; Total synthesis; Inflammatory bowel disease; Gut microbiota; Short-chain fatty acids; Immune system; Intestinal barrier; Drug discovery

Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383524000583-ga1.jpg  

Natural product 5S-heudelotinone alleviated experimental colitis in a gut microbiota-dependent manner. This work provided a novel candidate for the treatment of IBD.

# # # # # #

The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 19.4

Impact Factor: 14.5

JIF without self-citation: 13.7

ISSN 2211-3835

 # # # # #

Qing Meng, Jianshuang Guo, Ke Lv, Yang Liu, Jin Zhang, Mingyue Li, Xirui Cheng, Shenghua Chen, Xiaoguang Huo, Quan Zhang, Yue Chen, Jing Li, 5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner, Acta Pharmaceutica Sinica B, Volume 14, Issue 5, 2024, Pages 2153-2176, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2024.02.020

END



ELSE PRESS RELEASES FROM THIS DATE:

ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction

2024-05-15
https://doi.org/10.1016/j.apsb.2024.02.004   This new article publication from Acta Pharmaceutica Sinica B, discusses how ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction.   Growing evidence indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two neurodegenerative disorders. The GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72 (C9orf72) ...

Carbon-capture batteries developed to store renewable energy, help climate

Carbon-capture batteries developed to store renewable energy, help climate
2024-05-15
Researchers at the Department of Energy’s Oak Ridge National Laboratory are developing battery technologies to fight climate change in two ways, by expanding the use of renewable energy and capturing airborne carbon dioxide.  This type of battery stores the renewable energy generated by solar panels or wind turbines. Utilizing this energy when wind and sunlight are unavailable requires an electrochemical reaction that, in ORNL’s new battery formulation, captures carbon dioxide from industrial emissions and converts it to value-added products.   ORNL researchers recently created and tested two different formulations for batteries that ...

From roots to resilience: investigating the vital role of microbes in coastal plant health

From roots to resilience: investigating the vital role of microbes in coastal plant health
2024-05-15
Georgia’s saltwater marshes — living where the land meets the ocean — stretch along the state’s entire 100-mile coastline. These rich ecosystems are largely dominated by just one plant: grass. Known as cordgrass, the plant is an ecosystem engineer, providing habitats for wildlife, naturally cleaning water as it moves from inland to the sea, and holding the shoreline together so it doesn’t collapse. Cordgrass even protects human communities from tidal surges. Understanding how these ...

Q&A: How did the COVID-19 pandemic affect older adults’ technology use?

2024-05-15
The onset of the COVID-19 pandemic changed how nearly everyone mediated their social interactions through technology. Some moved happy hours into video chats. Others delved deeper into social media, or took a step back from it. Millions of people worked or learned through computers. University of Washington researchers took particular interest in how this tech shift affected older adults’ social relationships. The team interviewed 16 older adults in Washington and Oregon, ages 65 to 80, about how their technology ...

Blood pressure drugs more than double bone-fracture risk in nursing home patients

2024-05-15
Records from nearly 30,000 nursing home residents indicate that blood pressure medications more than double the risk of life-threatening bone fractures, according to Rutgers Health research. The authors of the study, which appears in JAMA Internal Medicine, said the increased risk stems from the medications’ tendency to impair balance, particularly when patients first stand up and temporarily experience low blood pressure that deprives the brain of oxygen. Interactions with other drugs and low baseline balance in many nursing home patients compound the problem. “Bone fractures often start nursing home patients on a downward spiral,”  ...

Regenerating worms have genetic control over their algal partners

Regenerating worms have genetic control over their algal partners
2024-05-15
Many organisms are far more complex than just a single species. Humans, for example, are full of a variety of microbes. Some creatures have even more special connections, though. Acoels, unique marine worms that regenerate their bodies after injury, can form symbiotic relationships with photosynthetic algae that live inside them. These collections of symbiotic organisms are called a holobiont, and the ways that they “talk” to each other are something scientists are trying to understand – especially ...

Pre- and post-surgical immunotherapy improves outcomes for patients with operable lung cancer

Pre- and post-surgical immunotherapy improves outcomes for patients with operable lung cancer
2024-05-15
Compared with pre-surgical (neoadjuvant) chemotherapy alone, adding perioperative immunotherapy – given before and after surgery – significantly improved event-free survival (EFS) in patients with resectable early-stage non-small cell lung cancer(NSCLC), according to researchers from The University of Texas MD Anderson Cancer Center. Results from the Phase III CheckMate 77T study were published today in the New England Journal of Medicine. At a median follow-up of 25.4 months, the median EFS with chemotherapy alone was 18.4 months, while the median had not yet ...

'Trojan horse' weight loss drug more effective than available therapies

2024-05-15
“I consider the drugs available on the marked today as the first generation of weight-loss drugs. Now we have developed a new type of weight-loss drug that affects the plasticity of the brain and appears to be highly effective.” So says Associate Professor and Group Leader Christoffer Clemmensen, from the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen, who is senior author of the new study, which has been published in the prestigious scientific journal Nature. In the study, Christoffer Clemmensen and colleagues demonstrate a new use of the weight loss hormone GLP-1. GLP-1 can be used as a ‘Trojan ...

Reduced risk of breast cancer following bariatric surgery in women with hyperinsulinemia

Reduced risk of breast cancer following bariatric surgery in women with hyperinsulinemia
2024-05-15
Bariatric surgery is associated with a reduced risk of breast cancer in women with obesity. These are the findings of a study conducted at the University of Gothenburg. The risk reduction is greatest for those with high blood insulin levels at the time of surgery. The study, published in JAMA Surgery, is based on data from 2,867 women with obesity, half of whom had undergone bariatric surgery at 25 surgical departments. The remaining women, comprising the control group, received standard obesity treatment at 480 healthcare centers. The groups were otherwise comparable in terms of age and body composition. The results show that a total of ...

Copper can't be mined fast enough to electrify the US

2024-05-15
Copper cannot be mined quickly enough to keep up with current U.S. policy guidelines to transition the country's electricity and vehicle infrastructure to renewable energy, according to a University of Michigan study.   The Inflation Reduction Act, signed into law in 2022, calls for 100% of cars manufactured to be electric vehicles by 2035. But an electric vehicle requires three to five times as much copper as an internal combustion engine vehicle—not to mention the copper required for upgrades to the electric grid.     "A ...

LAST 30 PRESS RELEASES:

Nucleoporin93: A silent protector in vascular health

Can we avert the looming food crisis of climate change?

Alcohol use and antiobesity medication treatment

Study reveals cause of common cancer immunotherapy side effect

New era in amphibian biology

Harbor service, VAST Data provide boost for NCSA systems

New prognostic model enhances survival prediction in liver failure

China focuses on improving air quality via the coordinated control of fine particles and ozone

Machine learning reveals behaviors linked with early Alzheimer’s, points to new treatments

Novel gene therapy trial for sickle cell disease launches

Engineering hypoallergenic cats

Microwave-induced pyrolysis: A promising solution for recycling electric cables

Cooling with light: Exploring optical cooling in semiconductor quantum dots

Breakthrough in clean energy: Scientists pioneer novel heat-to-electricity conversion

Study finds opposing effects of short-term and continuous noise on western bluebird parental care

Quantifying disease impact and overcoming practical treatment barriers for primary progressive aphasia

Sports betting and financial market data show how people misinterpret new information in predictable ways

Long COVID brain fog linked to lung function

Concussions slow brain activity of high school football players

Study details how cancer cells fend off starvation and death from chemotherapy

Transformation of UN SDGs only way forward for sustainable development 

New study reveals genetic drivers of early onset type 2 diabetes in South Asians 

Delay and pay: Tipping point costs quadruple after waiting

Magnetic tornado is stirring up the haze at Jupiter's poles

Cancers grow uniformly throughout their mass

Researchers show complex relationship between Arctic warming and Arctic dust

Brain test shows that crabs process pain

Social fish with low status are so stressed out it impacts their brains

Predicting the weather: New meteorology estimation method aids building efficiency

Inside the ‘swat team’ – how insects react to virtual reality gaming 

[Press-News.org] 5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner