PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

AI can help improve ER admission decisions, Mount Sinai study finds

2024-05-21
(Press-News.org) New York, NY [May 21, 2024]—Generative artificial intelligence (AI), such as GPT-4, can help predict whether an emergency room patient needs to be admitted to the hospital even with only minimal training on a limited number of records, according to investigators at the Icahn School of Medicine at Mount Sinai. Details of the research were published in the May 21 online issue of the Journal of the American Medical Informatics Association (JAMIA/DOI: 10.1093/jamia/ocae103).

In the retrospective study, the researchers analyzed records from seven Mount Sinai Health System hospitals, using both structured data, such as vital signs, and unstructured data, such as nurse triage notes, from more than 864,000 emergency room visits while excluding identifiable patient data. Of these visits, 159,857 (18.5 percent) led to the patient being admitted to the hospital.

The researchers compared GPT-4 against traditional machine-learning models such as Bio-Clinical-BERT for text and XGBoost for structured data in various scenarios, assessing its performance to predict hospital admissions independently and in combination with the traditional methods.

“We were motivated by the need to test whether generative AI, specifically large language models (LLMs) like GPT-4, could improve our ability to predict admissions in high-volume settings such as the Emergency Department,” says co-senior author Eyal Klang, MD, Director of the Generative AI Research Program in the Division of Data-Driven and Digital Medicine (D3M) at Icahn Mount Sinai. “Our goal is to enhance clinical decision-making through this technology. We were surprised by how well GPT-4 adapted to the ER setting and provided reasoning for its decisions. This capability of explaining its rationale sets it apart from traditional models and opens up new avenues for AI in medical decision-making.”

While traditional machine-learning models use millions of records for training, LLMs can effectively learn from just a few examples. Moreover, according to the researchers, LLMs can incorporate traditional machine-learning predictions, improving performance

“Our research suggests that AI could soon support doctors in emergency rooms by making quick, informed decisions about patient admissions. This work opens the door for further innovation in health care AI, encouraging the development of models that can reason and learn from limited data, like human experts do,” says co-senior author Girish N. Nadkarni, MD, MPH, Irene and Dr. Arthur M. Fishberg Professor of Medicine at Icahn Mount Sinai, Director of The Charles Bronfman Institute of Personalized Medicine, and System Chief of D3M. “However, while the results are encouraging, the technology is still in a supportive role, enhancing the decision-making process by providing additional insights, not taking over the human component of health care, which remains critical.”

The research team is investigating how to apply large language models to health care systems, with the goal of harmoniously integrating them with traditional machine-learning methods to address complex challenges and decision-making in real-time clinical settings.

“Our study informs how LLMs can be integrated into health care operations. The ability to rapidly train LLMs highlights their potential to provide valuable insights even in complex environments like health care,” says Brendan Carr, MD, MA, MS, a study co-author and emergency room physician who is Chief Executive Officer of Mount Sinai Health System. “Our study sets the stage for further research on AI integration in health care across the many domains of diagnostic, treatment, operational, and administrative tasks that require continuous optimization.”

The paper is titled “Evaluating the accuracy of a state-of-the-art large language model for prediction of admissions from the emergency room.”

The remaining authors of the paper, all with Icahn Mount Sinai, are Benjamin S. Glicksberg, PhD; Dhaval Patel, BS; Ashwin Sawant, MD; Akhil Vaid, MD; Ganesh Raut, BS; Alexander W. Charney, MD, PhD; Donald Apakama, MD; and Robert Freeman, RN.

The work was supported by the National Heart Lung and Blood Institute NIH grant 5R01HL141841-05. -####-

About the Icahn School of Medicine at Mount Sinai

The Icahn School of Medicine at Mount Sinai is internationally renowned for its outstanding research, educational, and clinical care programs. It is the sole academic partner for the eight- member hospitals* of the Mount Sinai Health System, one of the largest academic health systems in the United States, providing care to a large and diverse patient population.  

Ranked 13th nationwide in National Institutes of Health (NIH) funding and among the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges, Icahn Mount Sinai has a talented, productive, and successful faculty. More than 3,000 full-time scientists, educators, and clinicians work within and across 44 academic departments and 36 multidisciplinary institutes, a structure that facilitates tremendous collaboration and synergy. Our emphasis on translational research and therapeutics is evident in such diverse areas as genomics/big data, virology, neuroscience, cardiology, geriatrics, as well as gastrointestinal and liver diseases. 

Icahn Mount Sinai offers highly competitive MD, PhD, and Master’s degree programs, with current enrollment of approximately 1,300 students. It has the largest graduate medical education program in the country, with more than 2,000 clinical residents and fellows training throughout the Health System. In addition, more than 550 postdoctoral research fellows are in training within the Health System. 

A culture of innovation and discovery permeates every Icahn Mount Sinai program. Mount Sinai’s technology transfer office, one of the largest in the country, partners with faculty and trainees to pursue optimal commercialization of intellectual property to ensure that Mount Sinai discoveries and innovations translate into healthcare products and services that benefit the public.

Icahn Mount Sinai’s commitment to breakthrough science and clinical care is enhanced by academic affiliations that supplement and complement the School’s programs.

Through the Mount Sinai Innovation Partners (MSIP), the Health System facilitates the real-world application and commercialization of medical breakthroughs made at Mount Sinai. Additionally, MSIP develops research partnerships with industry leaders such as Merck & Co., AstraZeneca, Novo Nordisk, and others.

The Icahn School of Medicine at Mount Sinai is located in New York City on the border between the Upper East Side and East Harlem, and classroom teaching takes place on a campus facing Central Park. Icahn Mount Sinai’s location offers many opportunities to interact with and care for diverse communities. Learning extends well beyond the borders of our physical campus, to the eight hospitals of the Mount Sinai Health System, our academic affiliates, and globally.

------------------------------------------------------- 

* Mount Sinai Health System member hospitals: The Mount Sinai Hospital; Mount Sinai Beth Israel; Mount Sinai Brooklyn; Mount Sinai Morningside; Mount Sinai Queens; Mount Sinai South Nassau; Mount Sinai West; and New York Eye and Ear Infirmary of Mount Sinai.

 

 

 

 

 

 

 

 

 

 

  END



ELSE PRESS RELEASES FROM THIS DATE:

Matcha mouthwash inhibits bacteria that causes periodontitis

2024-05-21
Highlights: Periodontitis is linked to tooth loss and other health concerns. Past studies suggest that green tea products can act against P. gingivalis, which causes periodontitis. In a new study, researchers tested matcha extract, made from green tea, against the pathogen. Lab studies suggest matcha inhibits the growth of the bacteria. A clinical trial showed that matcha mouthwash inhibited P. gingivalis populations in saliva. Washington, D.C.—Periodontitis is an inflammatory gum disease driven by bacterial infection and left untreated it can lead to complications including tooth loss. ...

Oncology events in Poland solidify collaboration with NCCN

Oncology events in Poland solidify collaboration with NCCN
2024-05-21
WARSAW, POLAND [May 21, 2024] — The National Comprehensive Cancer Network® (NCCN®)—a global nonprofit responsible for leading cancer treatment guidelines—is taking part in two events in Warsaw focused on advancing cancer care and highlighting the Poland-US bilateral achievements in health care from May 21-22, 2024. The meetings will be organized by Maria Sklodowska-Curie National Research Institute of Oncology, the Polish Oncological Society, and the Alliance for Innovation. ...

City of Hope awarded $5.4 million CIRM grant to create a stem cell laboratory and expand access to state-of-the-art disease models and technology among a diverse scientific community

City of Hope awarded $5.4 million CIRM grant to create a stem cell laboratory and expand access to state-of-the-art disease models and technology among a diverse scientific community
2024-05-21
LOS ANGELES — City of Hope®, one of the largest cancer research and treatment organizations in the United States, has been awarded $5.4 million from the California Institute for Regenerative Medicine (CIRM) to build and fund a stem cell research laboratory on its Duarte, California, campus that will further expand its scientific capabilities. The mission of the unique Stem Cell-Based Disease Modeling Laboratory is two-fold. First, it will advance stem cell-based disease modeling to spur innovation in regenerative medicine. The laboratory leverages City of Hope’s infrastructure ...

Meeting preview: Hot topics at NUTRITION 2024

2024-05-21
Thousands of top nutrition experts will gather next month for a dynamic program of research announcements, policy discussions and award lectures at NUTRITION 2024, the annual flagship meeting of the American Society for Nutrition. Reporters and bloggers are invited to apply for a complimentary press pass to attend the meeting in Chicago from June 29–July 2.   Explore the meeting schedule and register for a press pass to attend.   Hot topics to be explored at NUTRITION 2024 include:   Diet and cancer ...

Study models how ketamine’s molecular action leads to its effects on the brain

Study models how ketamine’s molecular action leads to its effects on the brain
2024-05-21
A World Health Organization Essential Medicine, ketamine is widely used at varying doses for sedation, pain control, general anesthesia and as a therapy for treatment-resistant depression. While scientists know its target in brain cells and have observed how it affects brain-wide activity, they haven’t known entirely how the two are connected. A new study by a research team spanning four Boston-area institutions uses computational modeling of previously unappreciated physiological details to fill that gap and offer new insights into how ketamine works. “This modeling work has helped decipher likely mechanisms through which ...

A diaspora-based model of human migration

A diaspora-based model of human migration
2024-05-21
How do migrants choose their destinations? Existing models, known as “gravity models,” use population size and travel distance as explanatory variables—and often fail, especially at the neighborhood scale. Many migrants prefer to move to a location near friends, family, or co-nationals. This pattern might be partly driven by factors that repeat (such as the cost of living) and partly driven by homophily, the tendency to interact with similar others. Early migrants tend to reduce uncertainty and provide information for later arrivals. Building on these observations, Rafael Prieto-Curiel and colleagues construct a migration model based on the power of the diaspora to ...

Black and Hispanic Americans experience wider temperature swings

Black and Hispanic Americans experience wider temperature swings
2024-05-21
Extreme heat can harm human health, but so can temperature extreme swings. Large daily temperature variation (DTV) has been associated with elevated mortality in studies around the world. Trees and other vegetation can lower DTV, as trees reduce temperature through transpiration during the day and also trap long-wave radiation in the atmosphere under the canopy at night, increasing temperature. But green space is not equally distributed in most cities. Shengjie Liu and Emily Smith-Greenaway examined inequality in DTV exposure in the US, using monthly nighttime and daytime land surface temperature data from satellites. ...

Gamers say they hate ‘smurfing,’ but admit they do it

2024-05-21
COLUMBUS, Ohio – Online video game players believe the behavior known as “smurfing” is generally wrong and toxic to the gaming community – but most admit to doing it and say some reasons make the behavior less blameworthy, new research finds.   The new study suggests that debates about toxicity in gaming may sometimes be more complex and nuanced than is often acknowledged, according to the researchers.   Online video games use what are called “matchmaking systems” to pair players based on skill. “Smurfing” is when players cheat these systems by creating new accounts so that they can play against people lower ...

How immune cells recognize the abnormal metabolism of cancer cells

2024-05-21
When cells become tumor cells, their metabolism changes fundamentally. Researchers at the University of Basel and the University Hospital Basel have now demonstrated that this change leaves traces that could provide targets for cancer immunotherapies. Cancer cells function in turbo mode: Their metabolism is programmed for rapid proliferation, whereby their genetic material is also constantly copied and translated into proteins. As researchers led by Professor Gennaro De Libero from the University of Basel and the University ...

How plants mate for life and repel other suitors

How plants mate for life and repel other suitors
2024-05-21
A group of scientists from Nagoya University in Japan has used a specialized microscopic technique to observe the internal reproduction process of the Arabidopsis plant. Their findings, published in EMBO Reports, reveal the mechanism behind a female flower selectively attracting a single male counterpart. These findings provide insights that may help optimize seed production and improve agricultural breeding practices. Angiosperms, commonly referred to as flowering plants, have male and female reproductive organs. In the process of plant reproduction, when a pollen grain that ...

LAST 30 PRESS RELEASES:

Discovery of spontaneous inflow and outflow states of high-temperature plasma by energetic ions

Tax the rich, say a majority of adults across 17 G20 countries surveyed

Semaglutide leads to greater weight loss in women than men with HF, improves HF symptoms in both sexes

12.5, the 1st Impact Factor of COMMTR released!

Circadian clock impact on cluster headaches funded by $2.4M NIH grant for UTHealth Houston research

Study identifies first drug therapy for sleep apnea

How old is your bone marrow?

Boosting biodiversity without hurting local economies

ChatGPT is biased against resumes with credentials that imply a disability — but it can improve

Simple test for flu could improve diagnosis and surveillance

UT Health San Antonio researcher awarded five-year, $2.53 million NIH grant to study alcohol-assisted liver disease

Giving pre-med students hands-on clinical training

CAMH research suggests potential targets for prevention and early identification of psychotic disorders

Mapping the heart to prevent damage caused by a heart attack

Study challenges popular idea that Easter islanders committed ‘ecocide’

Chilling discovery: Study reveals evolution of human cold and menthol sensing protein, offering hope for future non-addictive pain therapies.

Elena Beccalli, new rector of Università Cattolica del Sacro Cuore, takes office on 1st July

Pacific Northwest Research Institute uncovers hidden DNA mechanisms of rare genetic diseases

Empowering older adults: Wearable tech made easier with personalized support

Pennington Biomedical researchers partner on award-winning Long Covid study

Cooling ‘blood oranges’ could make them even healthier – a bonus for consumers

Body image and overall health found important to the sexual health of older gay men, according to new studies

Lab-grown muscles reveal mysteries of rare muscle diseases

Primary hepatic angiosarcoma: Treatment options for a rare tumor

Research finds causal evidence tying cerebral small-vessel disease to Alzheimer’s, dementia

Navigating the Pyrocene: Recent Cell Press papers on managing fire risk

Restoring the Great Salt Lake would have environmental justice as well as ecological benefits

Cannabis, tobacco use, and COVID-19 outcomes

A 5:2 intermittent fasting meal replacement diet and glycemic control for adults with diabetes

Scientists document self-propelling oxygen decline in the oceans

[Press-News.org] AI can help improve ER admission decisions, Mount Sinai study finds